{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:59:16Z","timestamp":1787165956073,"version":"build-2736575974"},"reference-count":78,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/09088-1, # 2018\/23015-7 and # 2018\/18440-0"],"award-info":[{"award-number":["2018\/09088-1, # 2018\/23015-7 and # 2018\/18440-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa de Apoio ao Desenvolvimento Cient\u00edfico \u2013 Faculdade de Ci\u00eancias Farmac\u00eauticas - UNESP","award":["PADC-FCF"],"award-info":[{"award-number":["PADC-FCF"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries.<\/jats:p>","DOI":"10.3390\/ijms20143585","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T10:44:51Z","timestamp":1563878691000},"page":"3585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7177-4519","authenticated-orcid":false,"given":"Anal\u00fa Barros","family":"de Oliveira","sequence":"first","affiliation":[{"name":"School of Dentistry, Araraquara, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo 14801-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00falio Morandin","family":"Ferrisse","sequence":"additional","affiliation":[{"name":"School of Dentistry, Araraquara, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo 14801-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-9235","authenticated-orcid":false,"given":"Raquel Souza","family":"Marques","sequence":"additional","affiliation":[{"name":"School of Dentistry, Araraquara, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo 14801-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Raquel","family":"de Annunzio","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara, S\u00e3o Paulo 14800-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-5171","authenticated-orcid":false,"given":"Fernanda Louren\u00e7\u00e3o","family":"Brighenti","sequence":"additional","affiliation":[{"name":"School of Dentistry, Araraquara, S\u00e3o Paulo State University (UNESP), S\u00e3o Paulo 14801-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-3690","authenticated-orcid":false,"given":"Carla Raquel","family":"Fontana","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara, S\u00e3o Paulo 14800-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1111\/jcpe.12682","article-title":"Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. 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