{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:25:12Z","timestamp":1777368312800,"version":"3.51.4"},"reference-count":121,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T00:00:00Z","timestamp":1564185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["GA17-25710S"],"award-info":[{"award-number":["GA17-25710S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Operational Programme Prague \u2013 Growth Pole of the Czech Republic","award":["OPPR CZ.07.1.02\/0.0\/0.0\/16_040\/0000381"],"award-info":[{"award-number":["OPPR CZ.07.1.02\/0.0\/0.0\/16_040\/0000381"]}]},{"name":"Operational Programme Prague Competitiveness","award":["CZ.2.16\/3.1.00\/21518"],"award-info":[{"award-number":["CZ.2.16\/3.1.00\/21518"]}]},{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NV17-30528A"],"award-info":[{"award-number":["NV17-30528A"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Spa treatment can effectively reestablish mood balance in patients with psychiatric disorders. In light of the adrenal gland\u2019s role as a crossroad of psychosomatic medicine, this study evaluated changes in 88 circulating steroids and their relationships with a consolidation of somatic, psychosomatic and psychiatric components from a modified N-5 neurotic questionnaire in 46 postmenopausal 50+ women with anxiety-depressive complaints. The patients underwent a standardized one-month intervention therapy with physical activity and an optimized daily regimen in a spa in the Czech Republic. All participants were on medication with selective serotonin reuptake inhibitors. An increase of adrenal steroidogenesis after intervention indicated a reinstatement of the hypothalamic-pituitary-adrenal axis. The increases of many of these steroids were likely beneficial to patients, including immunoprotective adrenal androgens and their metabolites, neuroactive steroids that stimulate mental activity but protect from excitotoxicity, steroids that suppress pain perception and fear, steroids that consolidate insulin secretion, and steroids that improve xenobiotic clearance. The positive associations between the initial values of neurotic symptoms and their declines after the intervention, as well as between initial adrenal activity and the decline of neurotic symptoms, indicate that neurotic impairment may be alleviated by such therapy provided that the initial adrenal activity is not seriously disrupted.<\/jats:p>","DOI":"10.3390\/ijms20153687","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T03:06:58Z","timestamp":1564369618000},"page":"3687","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Activation of Adrenal Steroidogenesis and an Improvement of Mood Balance in Postmenopausal Females after Spa Treatment Based on Physical Activity"],"prefix":"10.3390","volume":"20","author":[{"given":"Pavla","family":"Honc\u016f","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, 3rd Faculty of Medicine, Charles University, 12808 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hill","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Bi\u010d\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dobroslava","family":"Jandov\u00e1","sequence":"additional","affiliation":[{"name":"College of Physical Education and Sport Palestra, 19700 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Vel\u00edkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Kajzar","sequence":"additional","affiliation":[{"name":"College of Physical Education and Sport Palestra, 19700 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Kol\u00e1torov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Be\u0161\u0165\u00e1k","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0541-9620","authenticated-orcid":false,"given":"Ludmila","family":"M\u00e1\u010dov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radmila","family":"Kancheva","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milada","family":"Krej\u010d\u00ed","sequence":"additional","affiliation":[{"name":"College of Physical Education and Sport Palestra, 19700 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Novotn\u00fd","sequence":"additional","affiliation":[{"name":"Priessnitz Spa Resort Jesen\u00edk, 79003 Jesen\u00edk, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-6050","authenticated-orcid":false,"given":"\u013duboslav","family":"St\u00e1rka","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology, 11694 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,27]]},"reference":[{"key":"ref_1","first-page":"193","article-title":"The adrenal gland. 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