{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:24:12Z","timestamp":1788942252639,"version":"build-2803163510"},"reference-count":123,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T00:00:00Z","timestamp":1564272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"President Grant for Government Support of Young Russian Scientists","award":["075-15-2019-1120"],"award-info":[{"award-number":["075-15-2019-1120"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The proper functioning of the monocyte\u2013macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte\u2013macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial gestation disorder characterized by pronounced inflammation in the maternal body that affects the work of the monocyte\u2013macrophage system. The effects of inflammation at preeclampsia manifest in changes in monocyte counts and their subset composition, and changes in placental macrophage counts and their polarization. Here we summarize the recent data on this issue for both the maternal organism and the fetus. The influence of estrogen on macrophages and their altered levels in preeclampsia are also discussed.<\/jats:p>","DOI":"10.3390\/ijms20153695","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T03:06:58Z","timestamp":1564369618000},"page":"3695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Role of the Monocyte\u2013Macrophage System in Normal Pregnancy and Preeclampsia"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-8240","authenticated-orcid":false,"given":"Polina","family":"Vishnyakova","sequence":"first","affiliation":[{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-4439","authenticated-orcid":false,"given":"Andrey","family":"Elchaninov","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997 Moscow, Russia"},{"name":"Peoples\u2019 Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timur","family":"Fatkhudinov","sequence":"additional","affiliation":[{"name":"Peoples\u2019 Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"},{"name":"Scientific Research Institute of Human Morphology, 3 Tsurupa Street, 117418 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennady","family":"Sukhikh","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,28]]},"reference":[{"key":"ref_1","unstructured":"(2016, May 23). World Health Organization WHO Recommendations for Prevention and Treatment of Pre-Eclampsia and Eclampsia, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK140561\/."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Saito, S. (2018). Preeclampsia Basic, Genomic, and Clinical, Springer Nature Singapore Pte Ltd.","DOI":"10.1007\/978-981-10-5891-2"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Cornelius, D.C. (2018). Preeclampsia: From inflammation to immunoregulation. Clin. Med. 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