{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:10:56Z","timestamp":1791288656401,"version":"4.3.0"},"reference-count":54,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-IDEX-0003"],"award-info":[{"award-number":["ANR-15-IDEX-0003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-LABX-0021"],"award-info":[{"award-number":["ANR-11-LABX-0021"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Liver X receptors (LXRs) play a pivotal role in fatty acid (FA) metabolism. So far, the lipogenic consequences of in vivo LXR activation, as characterized by a major hepatic steatosis, has constituted a limitation to the clinical development of pharmacological LXR agonists. However, recent studies provided a different perspective. Beyond the quantitative accumulation of FA, it appears that LXRs induce qualitative changes in the FA profile and in the distribution of FAs among cellular lipid species. Thus, LXRs activate the production of polyunsaturated fatty acids (PUFAs) and their distribution into phospholipids via the control of FA desaturases, FA elongases, lysophosphatidylcholine acyltransferase (LPCAT3), and phospholipid transfer protein (PLTP). Therefore, LXRs control, in a dynamic manner, the PUFA composition and the physicochemical properties of cell membranes as well as the release of PUFA-derived lipid mediators. Recent studies suggest that modulation of PUFA and phospholipid metabolism by LXRs are involved in the control of lipogenesis and lipoprotein secretion by the liver. In myeloid cells, the interplay between LXR and PUFA metabolism affects the inflammatory response. Revisiting the complex role of LXRs in FA metabolism may open new opportunities for the development of LXR modulators in the field of cardiometabolic diseases.<\/jats:p>","DOI":"10.3390\/ijms20153787","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T11:58:16Z","timestamp":1564747096000},"page":"3787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Revisiting the Role of LXRs in PUFA Metabolism and Phospholipid Homeostasis"],"prefix":"10.3390","volume":"20","author":[{"given":"Antoine","family":"Jalil","sequence":"first","affiliation":[{"name":"Universit\u00e9 Bourgogne Franche-Comt\u00e9, LNC UMR1231, F-21000 Dijon, France"},{"name":"INSERM, LNC UMR 1231, F-21000 Dijon, France"},{"name":"FCS Bourgogne-Franche Comt\u00e9, LipSTIC LabEx, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaut","family":"Bourgeois","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Franche-Comt\u00e9, LNC UMR1231, F-21000 Dijon, France"},{"name":"INSERM, LNC UMR 1231, F-21000 Dijon, France"},{"name":"FCS Bourgogne-Franche Comt\u00e9, LipSTIC LabEx, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"M\u00e9n\u00e9gaut","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Franche-Comt\u00e9, LNC UMR1231, F-21000 Dijon, France"},{"name":"INSERM, LNC UMR 1231, F-21000 Dijon, France"},{"name":"FCS Bourgogne-Franche Comt\u00e9, LipSTIC LabEx, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Lagrost","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Franche-Comt\u00e9, LNC UMR1231, F-21000 Dijon, France"},{"name":"INSERM, LNC UMR 1231, F-21000 Dijon, France"},{"name":"FCS Bourgogne-Franche Comt\u00e9, LipSTIC LabEx, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-6698","authenticated-orcid":false,"given":"Charles","family":"Thomas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Franche-Comt\u00e9, LNC UMR1231, F-21000 Dijon, France"},{"name":"INSERM, LNC UMR 1231, F-21000 Dijon, France"},{"name":"FCS Bourgogne-Franche Comt\u00e9, LipSTIC LabEx, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Masson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Franche-Comt\u00e9, LNC UMR1231, F-21000 Dijon, France"},{"name":"INSERM, LNC UMR 1231, F-21000 Dijon, France"},{"name":"FCS Bourgogne-Franche Comt\u00e9, LipSTIC LabEx, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1101\/gad.850400","article-title":"Role of LXRs in control of lipogenesis","volume":"14","author":"Schultz","year":"2000","journal-title":"Genes Dev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1101\/gad.844900","article-title":"Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta","volume":"14","author":"Repa","year":"2000","journal-title":"Genes Dev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41574-018-0037-x","article-title":"Liver X receptors in lipid signalling and membrane homeostasis","volume":"14","author":"Wang","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1074\/jbc.M208687200","article-title":"Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure","volume":"278","author":"Sun","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1074\/jbc.M111041200","article-title":"Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors","volume":"277","author":"Joseph","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1074\/jbc.M111421200","article-title":"Diminished hepatic response to fasting\/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c","volume":"277","author":"Liang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1074\/jbc.M605023200","article-title":"The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR","volume":"282","author":"Cha","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1128\/MCB.24.8.3430-3444.2004","article-title":"Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression","volume":"24","author":"Seo","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1194\/jlr.M300135-JLR200","article-title":"The LXR ligand T0901317 induces severe lipogenesis in the db\/db diabetic mouse","volume":"44","author":"Chisholm","year":"2003","journal-title":"J. Lipid Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1194\/jlr.M300432-JLR200","article-title":"Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouse","volume":"45","author":"Masson","year":"2004","journal-title":"J. Lipid Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"34182","DOI":"10.1074\/jbc.M204887200","article-title":"Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles","volume":"277","author":"Grefhorst","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cmet.2016.07.016","article-title":"Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils","volume":"24","author":"Kirchgessner","year":"2016","journal-title":"Cell Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.2337\/db06-1059","article-title":"Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells","volume":"56","author":"Choe","year":"2007","journal-title":"Diabetes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s00125-006-0140-8","article-title":"Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells","volume":"49","author":"Cozzone","year":"2006","journal-title":"Diabetologia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1194\/jlr.M033977","article-title":"LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob\/ob female mice","volume":"54","author":"Archer","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1194\/jlr.M400011-JLR200","article-title":"LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1","volume":"45","author":"Wang","year":"2004","journal-title":"J. Lipid Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1161\/ATVBAHA.115.305539","article-title":"Liver X receptor activation promotes polyunsaturated fatty acid synthesis in macrophages: relevance in the context of atherosclerosis","volume":"35","author":"Varin","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.1128\/MCB.23.16.5780-5789.2003","article-title":"Promoter-specific roles for liver X receptor\/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression","volume":"23","author":"Wagner","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.gene.2010.09.002","article-title":"Regulation of LPCAT3 by LXR","volume":"470","author":"Demeure","year":"2011","journal-title":"Gene"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1128\/MCB.23.6.2182-2191.2003","article-title":"The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions","volume":"23","author":"Laffitte","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"39561","DOI":"10.1074\/jbc.M207187200","article-title":"Phospholipid transfer protein is regulated by liver X receptors in vivo","volume":"277","author":"Cao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/ATVBAHA.112.300812","article-title":"Liver x receptor regulates arachidonic acid distribution and eicosanoid release in human macrophages: a key role for lysophosphatidylcholine acyltransferase 3","volume":"33","author":"Ishibashi","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cell.2012.06.054","article-title":"Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses","volume":"151","author":"Spann","year":"2012","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cmet.2016.11.009","article-title":"SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism","volume":"25","author":"Oishi","year":"2017","journal-title":"Cell Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"16748","DOI":"10.1074\/jbc.271.28.16748","article-title":"Molecular characterization and expression of rat acyl-CoA synthetase 3","volume":"271","author":"Fujino","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1194\/jlr.M032599","article-title":"High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR\/RXR signaling pathway","volume":"54","author":"Dong","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1194\/jlr.M004978","article-title":"Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells","volume":"51","author":"Dalen","year":"2010","journal-title":"J. Lipid Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1073\/pnas.94.7.2880","article-title":"A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis","volume":"94","author":"Kang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbalip.2008.12.003","article-title":"Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c","volume":"1791","author":"Qin","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cell.2013.08.054","article-title":"NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids","volume":"155","author":"Li","year":"2013","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0006-291X(02)00851-3","article-title":"The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids","volume":"296","author":"Nara","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0022-2275(20)30193-0","article-title":"Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha","volume":"43","author":"Matsuzaka","year":"2002","journal-title":"J. Lipid Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1194\/jlr.R800035-JLR200","article-title":"Recent progress on acyl CoA: lysophospholipid acyltransferase research","volume":"50","author":"Shindou","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/jb\/mvt048","article-title":"Generation of membrane diversity by lysophospholipid acyltransferases","volume":"154","author":"Shindou","year":"2013","journal-title":"J. Biochem."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Rong, X., Wang, B., Dunham, M.M., Hedde, P.N., Wong, J.S., Gratton, E., Young, S.G., Ford, D.A., and Tontonoz, P. (2015). Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife, 4.","DOI":"10.7554\/eLife.06557"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hashidate-Yoshida, T., Harayama, T., Hishikawa, D., Morimoto, R., Hamano, F., Tokuoka, S.M., Eto, M., Tamura-Nakano, M., Yanobu-Takanashi, R., and Mukumoto, Y. (2015). Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. Elife, 4.","DOI":"10.7554\/eLife.06328"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cmet.2013.10.002","article-title":"LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition","volume":"18","author":"Rong","year":"2013","journal-title":"Cell Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"S201","DOI":"10.1194\/jlr.R800061-JLR200","article-title":"The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis","volume":"50","author":"Masson","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6801","DOI":"10.1074\/jbc.M109.079459","article-title":"LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size","volume":"285","author":"Okazaki","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/89977","article-title":"Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency","volume":"7","author":"Jiang","year":"2001","journal-title":"Nat. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8196","DOI":"10.1074\/jbc.M114.602748","article-title":"Phospholipid transfer protein plays a major role in the initiation of apolipoprotein B-containing lipoprotein assembly in mouse primary hepatocytes","volume":"290","author":"Manchekar","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1172\/JCI93616","article-title":"ER phospholipid composition modulates lipogenesis during feeding and in obesity","volume":"127","author":"Rong","year":"2017","journal-title":"J. Clin. Invest."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1073\/pnas.111138698","article-title":"Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR","volume":"98","author":"Ou","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1074\/jbc.M105711200","article-title":"Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements","volume":"277","author":"Yoshikawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.bbalip.2011.06.003","article-title":"n-3 fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice","volume":"1811","author":"Jung","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molcel.2006.11.022","article-title":"Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma","volume":"25","author":"Ghisletti","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e08009","DOI":"10.7554\/eLife.08009","article-title":"LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling","volume":"4","author":"Ito","year":"2015","journal-title":"Elife"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.celrep.2018.11.100","article-title":"LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux","volume":"25","author":"Thomas","year":"2018","journal-title":"Cell Reports"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/ATVBAHA.113.302781","article-title":"Activation of liver X receptor decreases atherosclerosis in Ldlr\u2212\/\u2212 mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells","volume":"34","author":"Kappus","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1161\/CIRCRESAHA.106.135814","article-title":"Liver X receptor activation potentiates the lipopolysaccharide response in human macrophages","volume":"101","author":"Fontaine","year":"2007","journal-title":"Circ. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.atherosclerosis.2018.05.023","article-title":"LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis","volume":"275","author":"Thomas","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3389\/fcvm.2018.00192","article-title":"Macrophage Lysophosphatidylcholine Acyltransferase 3 Deficiency-Mediated Inflammation Is Not Sufficient to Induce Atherosclerosis in a Mouse Model","volume":"5","author":"Jiang","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1096\/fj.201802445R","article-title":"Omega-3 fatty acids, cardiovascular risk, and the resolution of inflammation","volume":"33","author":"Hansson","year":"2019","journal-title":"FASEB J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1812792","article-title":"Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia","volume":"380","author":"Bhatt","year":"2019","journal-title":"N. Engl. J. 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