{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:01:58Z","timestamp":1792789318149,"version":"4.5.0"},"reference-count":191,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zayed bin Sultan Center for Health Sciences","award":["31R138"],"award-info":[{"award-number":["31R138"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Vitamin D is a major steroid hormone that is gaining attention as a therapeutic molecule. Due to the general awareness of its importance for the overall well-being, vitamin D deficiency (VDD) is now recognized as a major health issue. The main reason for VDD is minimal exposure to sunlight. The vitamin D receptor (VDR) is a member of the steroid hormone receptors that induces a cascade of cell signaling to maintain healthy Ca2+ levels that serve to regulate several biological functions. However, the roles of vitamin D and its metabolism in maintaining gastric homeostasis have not yet been completely elucidated. Currently, there is a need to increase the vitamin D status in individuals worldwide as it has been shown to improve musculoskeletal health and reduce the risk of chronic illnesses, including some cancers, autoimmune and infectious diseases, type 2 diabetes mellitus, neurocognitive disorders, and general mortality. The role of vitamin D in gastric homeostasis is crucial and unexplored. This review attempts to elucidate the central role of vitamin D in preserving and maintaining the overall health and homeostasis of the stomach tissue.<\/jats:p>","DOI":"10.3390\/ijms20153832","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T11:17:47Z","timestamp":1565003867000},"page":"3832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6357-4787","authenticated-orcid":false,"given":"Shaima","family":"Sirajudeen","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, United Arab Emirates University (UAEU), Al Ain P.O. Box 15551, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-6083","authenticated-orcid":false,"given":"Iltaf","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, United Arab Emirates University (UAEU), Al Ain P.O. Box 15551, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-561X","authenticated-orcid":false,"given":"Asma","family":"Al Menhali","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, United Arab Emirates University (UAEU), Al Ain P.O. Box 15551, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/ageing\/afu104","article-title":"Understanding vitamin D deficiency","volume":"43","author":"Sahota","year":"2014","journal-title":"Age Ageing"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1530\/EC-15-0037","article-title":"Rising trend in vitamin D status from 1993 to 2013: Dual concerns for the future","volume":"4","author":"McKenna","year":"2015","journal-title":"Endocr. Connect."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1210\/jc.2008-1832","article-title":"Relationships of Serum 25-Hydroxyvitamin D to Bone Mineral Density and Serum Parathyroid Hormone and Markers of Bone Turnover in Older Persons","volume":"94","author":"Kuchuk","year":"2009","journal-title":"J. Clin. Endocrinol. 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