{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:16:42Z","timestamp":1790144202311,"version":"4.0.1"},"reference-count":166,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012651","name":"Fondation Institut de Cardiologie de Montr\u00e9al","doi-asserted-by":"publisher","award":["FRICM2018"],"award-info":[{"award-number":["FRICM2018"]}],"id":[{"id":"10.13039\/501100012651","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Platelets are megakaryocyte-derived fragments lacking nuclei and prepped to maintain primary hemostasis by initiating blood clots on injured vascular endothelia. Pathologically, platelets undergo the same physiological processes of activation, secretion, and aggregation yet with such pronouncedness that they orchestrate and make headway the progression of atherothrombotic diseases not only through clot formation but also via forcing a pro-inflammatory state. Indeed, nuclear factor-\u03baB (NF-\u03baB) is largely implicated in atherosclerosis and its pathological complication in atherothrombotic diseases due to its transcriptional role in maintaining pro-survival and pro-inflammatory states in vascular and blood cells. On the other hand, we know little on the functions of platelet NF-\u03baB, which seems to function in other non-genomic ways to modulate atherothrombosis. Therein, this review will resemble a rich portfolio for NF-\u03baB in platelets, specifically showing its implications at the levels of platelet survival and function. We will also share the knowledge thus far on the effects of active ingredients on NF-\u03baB in general, as an extrapolative method to highlight the potential therapeutic targeting of NF-\u03baB in coronary diseases. Finally, we will unzip a new horizon on a possible extra-platelet role of platelet NF-\u03baB, which will better expand our knowledge on the etiology and pathophysiology of atherothrombosis.<\/jats:p>","DOI":"10.3390\/ijms20174185","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T11:13:30Z","timestamp":1566904410000},"page":"4185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Role of NF-\u03baB in Platelet Function"],"prefix":"10.3390","volume":"20","author":[{"given":"Kevin","family":"Kojok","sequence":"first","affiliation":[{"name":"The Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Research Centre, 5000 Belanger Street, Montreal, H1T 1C8, QC, Canada"},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, H3T 1J4, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abed El-Hakim","family":"El-Kadiry","sequence":"additional","affiliation":[{"name":"The Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Research Centre, 5000 Belanger Street, Montreal, H1T 1C8, QC, Canada"},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, H3T 1J4, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahye","family":"Merhi","sequence":"additional","affiliation":[{"name":"The Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Research Centre, 5000 Belanger Street, Montreal, H1T 1C8, QC, Canada"},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, H3T 1J4, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.phrs.2016.09.040","article-title":"Prevalence and prevention of cardiovascular disease and diabetes mellitus","volume":"113","author":"Balakumar","year":"2016","journal-title":"Pharm. 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