{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:35:08Z","timestamp":1790778908245,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["19\u201301159S"],"award-info":[{"award-number":["19\u201301159S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["CZ.02.2.69\/0.0\/16_027\/0008355"],"award-info":[{"award-number":["CZ.02.2.69\/0.0\/16_027\/0008355"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P30332"],"award-info":[{"award-number":["P30332"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We study the reactivity of misonidazole with low-energy electrons in a water environment combining experiment and theoretical modelling. The environment is modelled by sequential hydration of misonidazole clusters in vacuum. The well-defined experimental conditions enable computational modeling of the observed reactions. While the NO     2 \u2212     dissociative electron attachment channel is suppressed, as also observed previously for other molecules, the OH     \u2212     channel remains open. Such behavior is enabled by the high hydration energy of OH     \u2212     and ring formation in the neutral radical co-fragment. These observations help to understand the mechanism of bio-reductive drug action. Electron-induced formation of covalent bonds is then important not only for biological processes but may find applications also in technology.<\/jats:p>","DOI":"10.3390\/ijms20184383","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:14:41Z","timestamp":1567998881000},"page":"4383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ring Formation and Hydration Effects in Electron Attachment to Misonidazole"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4801-3068","authenticated-orcid":false,"given":"Milan","family":"On\u010d\u00e1k","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik, Leopold-Franzens Universit\u00e4t Innsbruck, Technikerstrasse 25, Innsbruck A-6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3928-8964","authenticated-orcid":false,"given":"Rebecca","family":"Mei\u00dfner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik, Leopold-Franzens Universit\u00e4t Innsbruck, Technikerstrasse 25, Innsbruck A-6020, Austria"},{"name":"Atomic and Molecular Collisions Laboratory, CEFITEC, Department of Physics, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-8361","authenticated-orcid":false,"given":"Eugene","family":"Arthur-Baidoo","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik, Leopold-Franzens Universit\u00e4t Innsbruck, Technikerstrasse 25, Innsbruck A-6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Denifl","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Ionenphysik und Angewandte Physik, Leopold-Franzens Universit\u00e4t Innsbruck, Technikerstrasse 25, Innsbruck A-6020, Austria"},{"name":"Center for Biomolecular Sciences Innsbruck, Leopold-Franzens Universit\u00e4t Innsbruck, Technikerstrasse 25, Innsbruck A-6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F. M.","family":"Luxford","sequence":"additional","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry v.v.i., The Czech Academy of Sciences, Dolej\u0161kova 3, 18223 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy","family":"Pysanenko","sequence":"additional","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry v.v.i., The Czech Academy of Sciences, Dolej\u0161kova 3, 18223 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-0719","authenticated-orcid":false,"given":"Michal","family":"F\u00e1rn\u00edk","sequence":"additional","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry v.v.i., The Czech Academy of Sciences, Dolej\u0161kova 3, 18223 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-0802","authenticated-orcid":false,"given":"Ji\u0159\u00ed","family":"Pinkas","sequence":"additional","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry v.v.i., The Czech Academy of Sciences, Dolej\u0161kova 3, 18223 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6071-2144","authenticated-orcid":false,"given":"Jaroslav","family":"Ko\u010di\u0161ek","sequence":"additional","affiliation":[{"name":"J. Heyrovsk\u00fd Institute of Physical Chemistry v.v.i., The Czech Academy of Sciences, Dolej\u0161kova 3, 18223 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-physchem-040513-103605","article-title":"Biomolecular Damage Induced by Ionizing Radiation: The Direct and Indirect Effects of Low-Energy Electrons on DNA","volume":"66","author":"Alizadeh","year":"2015","journal-title":"Annu. Rev. Phys. Chem."},{"key":"ref_2","unstructured":"Gomez-Tejedor, G.G., and Fuss, M.C. (2012). Radiation Damage in Biomolecular Systems, Springer."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5578","DOI":"10.1021\/cr300063r","article-title":"Precursors of Solvated Electrons in Radiobiological Physics and Chemistry","volume":"112","author":"Alizadeh","year":"2012","journal-title":"Chem. 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