{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:54:47Z","timestamp":1792144487391,"version":"4.4.0"},"reference-count":91,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["OL 437\/1"],"award-info":[{"award-number":["OL 437\/1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1134, project C01"],"award-info":[{"award-number":["SFB 1134, project C01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Methyl CpG binding protein 2 (MeCP2) was first identified as a nuclear protein with a transcriptional repressor role that recognizes DNA methylation marks. MeCP2 has a well-established function in neurodevelopment, as evidenced by the severe neurological impairments characteristic of the Rett syndrome (RTT) pathology and the MeCP2 duplication syndrome (MDS), caused by loss or gain of MeCP2 function, respectively. Research aimed at the underlying pathophysiological mechanisms of RTT and MDS has significantly advanced our understanding of MeCP2 functions in the nervous system. It has revealed, however, that MeCP2 has more varied and complex roles than previously thought. Here we review recent insights into the functions of MeCP2 in neurodevelopment and the less explored requirement for MeCP2 in adult brain function. We focus on the emerging view that MeCP2 is a global chromatin organizer. Finally, we discuss how the individual functions of MeCP2 in neurodevelopment and adulthood are linked to its role as a chromatin regulator.<\/jats:p>","DOI":"10.3390\/ijms20184577","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T03:31:46Z","timestamp":1568691106000},"page":"4577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["MeCP2: A Critical Regulator of Chromatin in Neurodevelopment and Adult Brain Function"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4358-4846","authenticated-orcid":false,"given":"Kubra","family":"Gulmez Karaca","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany"},{"name":"Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, 6525 EN Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-9347","authenticated-orcid":false,"given":"David V.C.","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-9036","authenticated-orcid":false,"given":"Ana M.M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: From clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41583-018-0006-3","article-title":"Rett syndrome: Insights into genetic, molecular and circuit mechanisms","volume":"19","author":"Ip","year":"2018","journal-title":"Nat. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1172\/JCI78167","article-title":"MECP2 disorders: From the clinic to mice and back","volume":"125","author":"Lombardi","year":"2015","journal-title":"J. Clin. Invest."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev-cellbio-092910-154121","article-title":"The role of MeCP2 in the brain","volume":"27","author":"Guy","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.celrep.2018.07.099","article-title":"Affinity for DNA Contributes to NLS Independent Nuclear Localization of MeCP2","volume":"24","author":"Lyst","year":"2018","journal-title":"Cell Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1021\/bi9019753","article-title":"Unique physical properties and interactions of the domains of methylated DNA binding protein 2","volume":"49","author":"Ghosh","year":"2010","journal-title":"Biochemistry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1093\/cercor\/bhv078","article-title":"Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms","volume":"26","author":"Bedogni","year":"2016","journal-title":"Cereb. Cortex."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/hmg\/11.2.115","article-title":"Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation","volume":"11","author":"Shahbazian","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrn.2018.16","article-title":"Dendritic structural plasticity and neuropsychiatric disease","volume":"19","author":"Forrest","year":"2018","journal-title":"Nat. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/08830738050200091001","article-title":"Dissecting MECP2 function in the central nervous system","volume":"20","author":"Kishi","year":"2005","journal-title":"J. Child Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(02)00768-7","article-title":"Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3","volume":"35","author":"Shahbazian","year":"2002","journal-title":"Neuron"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14169","DOI":"10.1073\/pnas.1018979108","article-title":"Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome","volume":"108","author":"Kim","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.braindev.2005.03.014","article-title":"Abnormal general movements in girls with Rett disorder: The first four months of life","volume":"27","author":"Einspieler","year":"2005","journal-title":"Brain Dev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1203\/01.PDR.0000155945.94249.0A","article-title":"Is the early development of girls with Rett disorder really normal?","volume":"57","author":"Einspieler","year":"2005","journal-title":"Pediatric Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.ridd.2013.01.014","article-title":"Changing the perspective on early development of Rett syndrome","volume":"34","author":"Marschik","year":"2013","journal-title":"Res. Dev. Disabil."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.expneurol.2009.05.001","article-title":"Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP2","volume":"219","author":"Tsujimura","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13041-015-0121-2","article-title":"Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage","volume":"8","author":"Akamatsu","year":"2015","journal-title":"Mol. Brain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1091\/mbc.e11-09-0784","article-title":"Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: New perspective for Rett syndrome","volume":"23","author":"Squillaro","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/cercor\/bhx360","article-title":"Lack of Methyl-CpG Binding Protein 2 (MeCP2) Affects Cell Fate Refinement During Embryonic Cortical Development","volume":"28","author":"Scaramuzza","year":"2018","journal-title":"Cereb. Cortex."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/mp.2017.86","article-title":"MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling","volume":"23","author":"Mellios","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10021","DOI":"10.1523\/JNEUROSCI.1316-12.2012","article-title":"MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain","volume":"32","author":"Nguyen","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/cne.21673","article-title":"Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome","volume":"508","author":"Belichenko","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/cne.22009","article-title":"Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: Evidence for disruption of neuronal networks","volume":"514","author":"Belichenko","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2013.04.020","article-title":"Neuronal morphology in MeCP2 mouse models is intrinsically variable and depends on age, cell type, and Mecp2 mutation","volume":"58","author":"Wang","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2006.09.037","article-title":"Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation","volume":"52","author":"Zhou","year":"2006","journal-title":"Neuron"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/hipo.22360","article-title":"Excitation\/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice","volume":"25","author":"Calfa","year":"2015","journal-title":"Hippocampus"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Jordan, C., Li, H.H., Kwan, H.C., and Francke, U. (2007). Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets. BMC Med. Genet., 8.","DOI":"10.1186\/1471-2350-8-36"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/hmg\/ddi229","article-title":"Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome","volume":"14","author":"Nuber","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15536","DOI":"10.1073\/pnas.242566899","article-title":"Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain","volume":"99","author":"Tudor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Urdinguio, R.G., Lopez-Serra, L., Lopez-Nieva, P., Alaminos, M., Diaz-Uriarte, R., Fernandez, A.F., and Esteller, M. (2008). Mecp2-null mice provide new neuronal targets for Rett syndrome. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003669"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/hmg\/ddp181","article-title":"Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus","volume":"18","author":"Chahrour","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm.4406","article-title":"Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome","volume":"23","author":"Johnson","year":"2017","journal-title":"Nat. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molcel.2010.01.030","article-title":"Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state","volume":"37","author":"Skene","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuron.2011.08.022","article-title":"Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function","volume":"72","author":"Cohen","year":"2011","journal-title":"Neuron"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1073\/pnas.1505909112","article-title":"MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cell.2013.01.038","article-title":"An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders","volume":"152","author":"Baker","year":"2013","journal-title":"Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nn.3434","article-title":"Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR\/SMRT co-repressor","volume":"16","author":"Lyst","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1128\/MCB.00379-10","article-title":"MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites","volume":"30","author":"Ghosh","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"8356","DOI":"10.1093\/nar\/gku564","article-title":"Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping","volume":"42","author":"Kernohan","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1083\/jcb.200502062","article-title":"Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation","volume":"169","author":"Brero","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bertulat, B., De Bonis, M.L., Della Ragione, F., Lehmkuhl, A., Milden, M., Storm, C., Jost, K.L., Scala, S., Hendrich, B., and D\u2019Esposito, M. (2012). MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047848"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nbd.2011.03.011","article-title":"MeCP2 is required for global heterochromatic and nucleolar changes during activity-dependent neuronal maturation","volume":"43","author":"Singleton","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1093\/hmg\/ddr346","article-title":"MeCP2 Rett mutations affect large scale chromatin organization","volume":"20","author":"Agarwal","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.conb.2019.07.002","article-title":"Genomic insights into MeCP2 function: A role for the maintenance of chromatin architecture","volume":"59","author":"Connolly","year":"2019","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1237905","DOI":"10.1126\/science.1237905","article-title":"Global epigenomic reconfiguration during mammalian brain development","volume":"341","author":"Lister","year":"2013","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1101\/gr.147942.112","article-title":"Dynamic DNA methylation across diverse human cell lines and tissues","volume":"23","author":"Varley","year":"2013","journal-title":"Genome Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cell.2011.12.035","article-title":"Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome","volume":"148","author":"Xie","year":"2012","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nn.3607","article-title":"Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain","volume":"17","author":"Guo","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature14319","article-title":"Disruption of DNA-methylation-dependent long gene repression in Rett syndrome","volume":"522","author":"Gabel","year":"2015","journal-title":"Nature"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Lagger, S., Connelly, J.C., Schweikert, G., Webb, S., Selfridge, J., Ramsahoye, B.H., Yu, M., He, C., Sanguinetti, G., and Sowers, L.C. (2017). MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain. PLoS Genet., 13.","DOI":"10.1371\/journal.pgen.1006793"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"15114","DOI":"10.1073\/pnas.1618737114","article-title":"DNA methylation in the gene body influences MeCP2-mediated gene repression","volume":"113","author":"Kinde","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/B978-0-444-63327-9.00002-3","article-title":"Mechanisms of plasticity in the developing and adult visual cortex","volume":"207","author":"Sur","year":"2013","journal-title":"Prog. Brain Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.1086446","article-title":"Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1090842","article-title":"DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation","volume":"302","author":"Martinowich","year":"2003","journal-title":"Science"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang","year":"2006","journal-title":"Neuron"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature12348","article-title":"Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR","volume":"499","author":"Ebert","year":"2013","journal-title":"Nature"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/jnc.12523","article-title":"SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development","volume":"128","author":"Cheng","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nchembio.412","article-title":"Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags","volume":"6","author":"Rexach","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1128\/MCB.06728-11","article-title":"Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation","volume":"32","author":"Gonzales","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"695","DOI":"10.4161\/epi.20733","article-title":"SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression","volume":"7","author":"Zocchi","year":"2012","journal-title":"Epigenetics"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fncel.2014.00236","article-title":"MeCP2 post-translational modifications: A mechanism to control its involvement in synaptic plasticity and homeostasis?","volume":"8","author":"Bellini","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.cub.2006.02.062","article-title":"MeCP2-dependent transcriptional repression regulates excitatory neurotransmission","volume":"16","author":"Nelson","year":"2006","journal-title":"Curr. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1073\/pnas.0610593104","article-title":"Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2","volume":"104","author":"Giacometti","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy","year":"2007","journal-title":"Science"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1126\/science.1206593","article-title":"Adult neural function requires MeCP2","volume":"333","author":"McGraw","year":"2011","journal-title":"Science"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1093\/hmg\/dds208","article-title":"Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows","volume":"21","author":"Cheval","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/hmg\/ddw038","article-title":"Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation","volume":"25","author":"Du","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.nlm.2018.02.010","article-title":"Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation","volume":"149","author":"Brito","year":"2018","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nbt.3055","article-title":"In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9","volume":"33","author":"Swiech","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1523\/JNEUROSCI.4225-08.2009","article-title":"MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome","volume":"29","author":"Adachi","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.biopsych.2005.07.025","article-title":"Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice","volume":"59","author":"Gemelli","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"Moretti","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuroscience.2007.02.009","article-title":"Behavioral and anatomical abnormalities in Mecp2 mutant mice: A model for Rett syndrome","volume":"146","author":"Stearns","year":"2007","journal-title":"Neuroscience"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nn.2614","article-title":"MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants","volume":"13","author":"Deng","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13041-016-0263-x","article-title":"Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders","volume":"9","author":"Barco","year":"2016","journal-title":"Mol. Brain"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.conb.2016.12.002","article-title":"In the loop: How chromatin topology links genome structure to function in mechanisms underlying learning and memory","volume":"43","author":"Watson","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neuropharm.2013.12.024","article-title":"Decoding transcriptional repressor complexes in the adult central nervous system","volume":"80","author":"Adachi","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0169-328X(92)90016-5","article-title":"Rearrangement of centromeric satellite DNA in hippocampal neurons exhibiting long-term potentiation","volume":"14","author":"Billia","year":"1992","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1126\/science.3201257","article-title":"Movement of the X chromosome in epilepsy","volume":"242","author":"Borden","year":"1988","journal-title":"Science"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Crepaldi, L., Policarpi, C., Coatti, A., Sherlock, W.T., Jongbloets, B.C., Down, T.A., and Riccio, A. (2013). Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories. PLoS Genet., 9.","DOI":"10.1371\/journal.pgen.1003699"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1523\/JNEUROSCI.1085-12.2013","article-title":"Novel higher-order epigenetic regulation of the Bdnf gene upon seizures","volume":"33","author":"Walczak","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nn.4494","article-title":"Neuronal activity modifies the chromatin accessibility landscape in the adult brain","volume":"20","author":"Su","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41586-019-1190-7","article-title":"Sensory experience remodels genome architecture in neural circuit to drive motor learning","volume":"569","author":"Yamada","year":"2019","journal-title":"Nature"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nn.4170","article-title":"Stimulus-specific combinatorial functionality of neuronal c-fos enhancers","volume":"19","author":"Joo","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_90","first-page":"420","article-title":"MECP2, a multi-talented modulator of chromatin architecture","volume":"15","author":"Vacca","year":"2016","journal-title":"Brief. Funct. Genom."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-53889-1_1","article-title":"MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome","volume":"978","author":"Ausio","year":"2017","journal-title":"Adv. Exp. Med. Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/18\/4577\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:20:38Z","timestamp":1760188838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/18\/4577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,16]]},"references-count":91,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["ijms20184577"],"URL":"https:\/\/doi.org\/10.3390\/ijms20184577","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,16]]}}}