{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:07:40Z","timestamp":1792447660406,"version":"4.5.0"},"reference-count":51,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stichting VUmc fonds","award":["-"],"award-info":[{"award-number":["-"]}]},{"DOI":"10.13039\/501100010573","name":"Stichting Dioraphte","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100010573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["733050509"],"award-info":[{"award-number":["733050509"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["733050102"],"award-info":[{"award-number":["733050102"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Federal Ministry of Education and Research","award":["project FTLDc 01GI1007A"],"award-info":[{"award-number":["project FTLDc 01GI1007A"]}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["01ED1512"],"award-info":[{"award-number":["01ED1512"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German science foundation","award":["DFG; SFB 1237"],"award-info":[{"award-number":["DFG; SFB 1237"]}]},{"name":"Regione Sardegna","award":["2012-CRP-60834"],"award-info":[{"award-number":["2012-CRP-60834"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In a previous proteomic study, we identified the neurosecretory protein VGF (VGF) as a potential biomarker for dementia with Lewy bodies (DLB). Here, we extended the study of VGF by comparing levels in cerebrospinal fluid (CSF) from 44 DLB patients, 20 Alzheimer\u2019s disease (AD) patients, and 22 cognitively normal controls selected from the Amsterdam Dementia Cohort. CSF was analyzed using two orthogonal analytical methods: (1) In-house-developed quantitative ELISA and (2) selected reaction monitoring (SRM). We further addressed associations of VGF with other CSF biomarkers and cognition. VGF levels were lower in CSF from patients with DLB compared to either AD patients or controls. VGF was positively correlated with CSF tau and \u03b1-synuclein (0.55 &lt; r &lt; 0.75), but not with A\u03b21-42. In DLB patients, low VGF levels were related to a more advanced cognitive decline at time of first presentation, whereas high levels of VGF were associated with steeper subsequent longitudinal cognitive decline. Hence, CSF VGF levels were lower in DLB compared to both AD and controls across different analytical methods. The strong associations with cognitive decline further points out VGF as a possible disease stage or prognostic marker for DLB.<\/jats:p>","DOI":"10.3390\/ijms20194674","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T10:48:14Z","timestamp":1568976494000},"page":"4674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies"],"prefix":"10.3390","volume":"20","author":[{"given":"Inger","family":"van Steenoven","sequence":"first","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"},{"name":"Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Noli","sequence":"additional","affiliation":[{"name":"NEF-laboratory, Department of Biomedical Sciences, University of Cagliari, 09402 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3915-208X","authenticated-orcid":false,"given":"Cristina","family":"Cocco","sequence":"additional","affiliation":[{"name":"NEF-laboratory, Department of Biomedical Sciences, University of Cagliari, 09402 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2768-349X","authenticated-orcid":false,"given":"Gian-Luca","family":"Ferri","sequence":"additional","affiliation":[{"name":"NEF-laboratory, Department of Biomedical Sciences, University of Cagliari, 09402 Monserrato, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-7023","authenticated-orcid":false,"given":"Patrick","family":"Oeckl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University Hospital, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University Hospital, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen J. A.","family":"Koel-Simmelink","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bridel","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-6224","authenticated-orcid":false,"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"},{"name":"Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afina W.","family":"Lemstra","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-0837","authenticated-orcid":false,"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"},{"name":"Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(15)00462-6","article-title":"Lewy body dementias","volume":"386","author":"Walker","year":"2015","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S1474-4422(11)70213-7","article-title":"Pathological roles of alpha-synuclein in neurological disorders","volume":"10","author":"Vekrellis","year":"2011","journal-title":"Lancet. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1093\/brain\/awx275","article-title":"Synaptic phosphorylated alpha-synuclein in dementia with Lewy bodies","volume":"140","author":"Pegueroles","year":"2017","journal-title":"Brain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00401-010-0711-0","article-title":"The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson\u2019s disease and Parkinson\u2019s disease dementia","volume":"120","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mds.26479","article-title":"Synaptic failure and alpha-synuclein","volume":"31","author":"Calo","year":"2016","journal-title":"Mov. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1210\/er.2010-0027","article-title":"The extended granin family: Structure, function, and biomedical implications","volume":"32","author":"Bartolomucci","year":"2011","journal-title":"Endocr. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jchemneu.2011.05.007","article-title":"VGF: An inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers","volume":"42","author":"Ferri","year":"2011","journal-title":"J. Chem. Neuroanat."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10800","DOI":"10.1523\/JNEUROSCI.23-34-10800.2003","article-title":"Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity","volume":"23","author":"Alder","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9857","DOI":"10.1523\/JNEUROSCI.3145-08.2008","article-title":"The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism","volume":"28","author":"Bozdagi","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1096\/fj.13-239509","article-title":"The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure","volume":"28","author":"Fargali","year":"2014","journal-title":"FASEB J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuroscience.2010.06.057","article-title":"Granins as disease-biomarkers: Translational potential for psychiatric and neurological disorders","volume":"170","author":"Bartolomucci","year":"2010","journal-title":"Neuroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/pmic.200300470","article-title":"A panel of cerebrospinal fluid potential biomarkers for the diagnosis of Alzheimer\u2019s disease","volume":"3","author":"Carrette","year":"2003","journal-title":"Proteomics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/brain\/awx352","article-title":"Synaptic markers of cognitive decline in neurodegenerative diseases: A proteomic approach","volume":"141","author":"Bereczki","year":"2018","journal-title":"Brain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00221-010-2182-x","article-title":"Panel of synaptic protein ELISAs for evaluating neurological phenotype","volume":"201","author":"Gottschall","year":"2010","journal-title":"Exp. Brain Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1212\/01.wnl.0000203129.82104.07","article-title":"Identification of potential CSF biomarkers in ALS","volume":"66","author":"Pasinetti","year":"2006","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.7150\/ijms.5.92","article-title":"Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis","volume":"5","author":"Zhao","year":"2008","journal-title":"Int. J. Med. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Brancia, C., Noli, B., Boido, M., Boi, A., Puddu, R., Borghero, G., Marrosu, F., Bongioanni, P., Orru, S., and Manconi, B. (2016). VGF Protein and Its C-Terminal Derived Peptides in Amyotrophic Lateral Sclerosis: Human and Animal Model Studies. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164689"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuroscience.2018.03.023","article-title":"TLQP Peptides in Amyotrophic Lateral Sclerosis: Possible Blood Biomarkers with a Neuroprotective Role","volume":"380","author":"Brancia","year":"2018","journal-title":"Neuroscience"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.expneurol.2005.08.002","article-title":"Identification of CSF biomarkers for frontotemporal dementia using SELDI-TOF","volume":"196","author":"Ruetschi","year":"2005","journal-title":"Exp. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1469-7580.2010.01309.x","article-title":"Distribution of VGF peptides in the human cortex and their selective changes in Parkinson\u2019s and Alzheimer\u2019s diseases","volume":"217","author":"Cocco","year":"2010","journal-title":"J. Anat."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Brinkmalm, G., Sjodin, S., Simonsen, A.H., Hasselbalch, S.G., Zetterberg, H., Brinkmalm, A., and Blennow, K. (2018). A Parallel Reaction Monitoring Mass Spectrometric Method for Analysis of Potential CSF Biomarkers for Alzheimer\u2019s Disease. Proteomics Clin. Appl., 12.","DOI":"10.1002\/prca.201700131"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hendrickson, R.C., Lee, A.Y., Song, Q., Liaw, A., Wiener, M., Paweletz, C.P., Seeburger, J.L., Li, J., Meng, F., and Deyanova, E.G. (2015). High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer\u2019s Disease in Human Cerebrospinal Fluid. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0135365"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/pr501076j","article-title":"An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer\u2019s disease","volume":"14","author":"Holtta","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Jahn, H., Wittke, S., Zurbig, P., Raedler, T.J., Arlt, S., Kellmann, M., Mullen, W., Eichenlaub, M., Mischak, H., and Wiedemann, K. (2011). Peptide fingerprinting of Alzheimer\u2019s disease in cerebrospinal fluid: Identification and prospective evaluation of new synaptic biomarkers. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0026540"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Llano, D.A., Bundela, S., Mudar, R.A., Devanarayan, V., and Alzheimer\u2019s Disease Neuroimaging, I. (2017). A multivariate predictive modeling approach reveals a novel CSF peptide signature for both Alzheimer\u2019s Disease state classification and for predicting future disease progression. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182098"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2174\/138620705774962391","article-title":"Identification of novel biomarker candidates by differential peptidomics analysis of cerebrospinal fluid in Alzheimer\u2019s disease","volume":"8","author":"Selle","year":"2005","journal-title":"Comb. Chem. High Throughput Screen"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000110576","article-title":"A novel panel of cerebrospinal fluid biomarkers for the differential diagnosis of Alzheimer\u2019s disease versus normal aging and frontotemporal dementia","volume":"24","author":"Simonsen","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/prca.201400178","article-title":"Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) CSF","volume":"9","author":"Spellman","year":"2015","journal-title":"Proteomics Clin. Appl."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ymeth.2012.03.018","article-title":"A novel peptidomics approach to detect markers of Alzheimer\u2019s disease in cerebrospinal fluid","volume":"56","author":"Wijte","year":"2012","journal-title":"Methods"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1093\/brain\/awu057","article-title":"Accumulation of oligomer-prone alpha-synuclein exacerbates synaptic and neuronal degeneration in vivo","volume":"137","author":"Rockenstein","year":"2014","journal-title":"Brain"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jalz.2016.04.005","article-title":"Synaptic proteins predict cognitive decline in Alzheimer\u2019s disease and Lewy body dementia","volume":"12","author":"Bereczki","year":"2016","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13041-017-0316-9","article-title":"An iTRAQ-based proteomic analysis reveals dysregulation of neocortical synaptopodin in Lewy body dementias","volume":"10","author":"Datta","year":"2017","journal-title":"Mol. Brain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13195-017-0335-x","article-title":"Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer\u2019s disease","volume":"10","author":"Duits","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Llano, D.A., Devanarayan, P., Devanarayan, V., and Alzheimer\u2019s Disease Neuroimaging, I. (2019). VGF in Cerebrospinal Fluid Combined With Conventional Biomarkers Enhances Prediction of Conversion From MCI to AD. Alzheimer Dis. Assoc. Disord.","DOI":"10.1101\/512939"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: Correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1523\/JNEUROSCI.4564-06.2007","article-title":"Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies","volume":"27","author":"Kramer","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0002-9440(10)64573-7","article-title":"Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer\u2019s disease","volume":"157","author":"Hurt","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3233\/JAD-132306","article-title":"Optimizing patient care and research: The Amsterdam Dementia Cohort","volume":"41","author":"Pijnenburg","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.clinbiochem.2013.12.024","article-title":"Biobanking of CSF: International standardization to optimize biomarker development","volume":"47","author":"Teunissen","year":"2014","journal-title":"Clin. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1373\/clinchem.2017.281055","article-title":"Unbiased Approach to Counteract Upward Drift in Cerebrospinal Fluid Amyloid-beta 1-42 Analysis Results","volume":"64","author":"Tijms","year":"2018","journal-title":"Clin. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1373\/clinchem.2009.130518","article-title":"Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease","volume":"56","author":"Mulder","year":"2010","journal-title":"Clin. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jalz.2013.12.023","article-title":"The cerebrospinal fluid \u201cAlzheimer profile\u201d: Easily said, but what does it mean?","volume":"10","author":"Duits","year":"2014","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13195-017-0276-4","article-title":"Differential role of CSF fatty acid binding protein 3, alpha-synuclein, and Alzheimer\u2019s disease core biomarkers in Lewy body disorders and Alzheimer\u2019s dementia","volume":"9","author":"Chiasserini","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1021\/pr1003455","article-title":"A peptidomics strategy for discovering endogenous bioactive peptides","volume":"9","author":"Sasaki","year":"2010","journal-title":"J. Proteome Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Noli, B., Brancia, C., D\u2019Amato, F., Ferri, G.L., and Cocco, C. (2014). VGF changes during the estrous cycle: A novel endocrine role for TLQP peptides?. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108456"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jchemneu.2012.05.001","article-title":"VGF peptides upon osmotic stimuli: Changes in neuroendocrine regulatory peptides 1 and 2 in the hypothalamic-pituitary-axis and plasma","volume":"44","author":"Cocco","year":"2012","journal-title":"J. Chem. Neuroanat."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fncel.2017.00158","article-title":"Profiles of VGF Peptides in the Rat Brain and Their Modulations after Phencyclidine Treatment","volume":"11","author":"Noli","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1074\/mcp.M116.059915","article-title":"Alpha-, Beta-, and Gamma-synuclein Quantification in Cerebrospinal Fluid by Multiple Reaction Monitoring Reveals Increased Concentrations in Alzheimer\u2019s and Creutzfeldt-Jakob Disease but No Alteration in Synucleinopathies","volume":"15","author":"Oeckl","year":"2016","journal-title":"Mol. Cell Proteomics"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/19\/4674\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:22:29Z","timestamp":1760188949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/19\/4674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":51,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["ijms20194674"],"URL":"https:\/\/doi.org\/10.3390\/ijms20194674","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]}}}