{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:43:18Z","timestamp":1776040998786,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T00:00:00Z","timestamp":1569283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Project of Haikou Ocean and Fisheries Bureau","award":["HHCL201804"],"award-info":[{"award-number":["HHCL201804"]}]},{"name":"the Key Project of Science and Technology of Haikou","award":["2017051"],"award-info":[{"award-number":["2017051"]}]},{"name":"the Scientific Research Foundation of Hainan University","award":["KYQD1609"],"award-info":[{"award-number":["KYQD1609"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Holothuria leucospilota polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg\/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-\u03b1, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia.<\/jats:p>","DOI":"10.3390\/ijms20194738","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T03:51:18Z","timestamp":1569383478000},"page":"4738","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation"],"prefix":"10.3390","volume":"20","author":[{"given":"Yiqiong","family":"Yuan","sequence":"first","affiliation":[{"name":"Hainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qibing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medicine and Life Science, Hainan Medical University, Haikou 571199, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6108-0532","authenticated-orcid":false,"given":"Jun","family":"Cao","sequence":"additional","affiliation":[{"name":"Hainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanri","family":"Shen","sequence":"additional","affiliation":[{"name":"Hainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, China"},{"name":"Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5612-522X","authenticated-orcid":false,"given":"Chuan","family":"Li","sequence":"additional","affiliation":[{"name":"Hainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, China"},{"name":"Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.mpmed.2017.06.002","article-title":"Hyperlipidaemia","volume":"45","author":"Park","year":"2017","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Xu, P., Zhai, Y., and Wang, J. 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