{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:38:56Z","timestamp":1778837936727,"version":"3.51.4"},"reference-count":151,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR127"],"award-info":[{"award-number":["TRR127"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["Large Animal Platform"],"award-info":[{"award-number":["Large Animal Platform"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Coronary heart diseases are of high relevance for health care systems in developed countries regarding patient numbers and costs. Disappointingly, the enormous effort put into the development of innovative therapies and the high numbers of clinical studies conducted are counteracted by the low numbers of therapies that become clinically effective. Evidently, pre-clinical research in its present form does not appear informative of the performance of treatments in the clinic and, even more relevant, it appears that there is hardly any consent about how to improve the predictive capacity of pre-clinical experiments. According to the steadily increasing relevance that pig models have gained in biomedical research in the recent past, we anticipate that research in pigs can be highly predictive for ischemia-reperfusion injury (IRI) therapies as well. Thus, we here describe the significance of pig models in IRI, give an overview about recent developments in evaluating such models by clinically relevant methods and present the latest insight into therapies applied to pigs under IRI.<\/jats:p>","DOI":"10.3390\/ijms20194749","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T03:06:51Z","timestamp":1569467211000},"page":"4749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluating Novel Targets of Ischemia Reperfusion Injury in Pig Models"],"prefix":"10.3390","volume":"20","author":[{"given":"Andrea","family":"Baehr","sequence":"first","affiliation":[{"name":"Klinikum Rechts der Isar, Internal Medicine I, Technical University of Munich, 81675 Munich, Germany"},{"name":"German Centre for Cardiovascular Research, Munich Heart Alliance, 80802 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Klymiuk","sequence":"additional","affiliation":[{"name":"Klinikum Rechts der Isar, Internal Medicine I, Technical University of Munich, 81675 Munich, Germany"},{"name":"German Centre for Cardiovascular Research, Munich Heart Alliance, 80802 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kupatt","sequence":"additional","affiliation":[{"name":"Klinikum Rechts der Isar, Internal Medicine I, Technical University of Munich, 81675 Munich, Germany"},{"name":"German Centre for Cardiovascular Research, Munich Heart Alliance, 80802 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/CIRCRESAHA.113.300987","article-title":"Historical perspective on the pathology of myocardial ischemia\/reperfusion injury","volume":"113","author":"Jennings","year":"2013","journal-title":"Circ. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pharmthera.2007.06.005","article-title":"Preconditioning and postconditioning: united at reperfusion","volume":"116","author":"Hausenloy","year":"2007","journal-title":"Pharm. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current Mechanistic Concepts in Ischemia and Reperfusion Injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1161\/CIRCULATIONAHA.111.059253","article-title":"Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection","volume":"124","author":"Horstkotte","year":"2011","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature22082","article-title":"The mitochondrial Na(+)\/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability","volume":"545","author":"Luongo","year":"2017","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease","volume":"99","author":"Amgalan","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00395-017-0662-x","article-title":"The RISK pathway and beyond","volume":"113","author":"Rossello","year":"2018","journal-title":"Basic. Res. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00395-018-0670-5","article-title":"The SAFE pathway for cardioprotection: Is this a promising target?","volume":"113","author":"Hadebe","year":"2018","journal-title":"Basic. Res. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: The evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-0037-1615263","article-title":"Heart and Mitochondria: Pathophysiology and Implications for Cardiac Surgeons","volume":"66","author":"Niemann","year":"2018","journal-title":"Thorac. Cardiovasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5966\/sctm.2015-0092","article-title":"Injection of Human Cord Blood Cells With Hyaluronan Improves Postinfarction Cardiac Repair in Pigs","volume":"5","author":"Chang","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1089\/ars.2016.6795","article-title":"Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia\/Reperfusion Injury in the Heart","volume":"26","author":"Jakobs","year":"2017","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.yjmcc.2015.11.011","article-title":"Lost in translation: miRNAs and mRNAs in ischemic preconditioning and ischemia\/reperfusion injury","volume":"95","author":"Gottlieb","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1177\/2048872618812148","article-title":"Editor\u2019s Choice- Reperfusion cardiac arrhythmias and their relation to reperfusion-induced cell death","volume":"8","author":"Prinzen","year":"2019","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jacep.2017.01.007","article-title":"Do Myofibroblasts Represent a Hidden Factor for Impaired Conduction and Tachyarrhythmia in Post-Myocardial Infarction?","volume":"3","year":"2017","journal-title":"Jacc Clin. Electrophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2174\/1566524014666140603101520","article-title":"Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage","volume":"14","author":"Ghavami","year":"2014","journal-title":"Curr. Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbadis.2014.05.010","article-title":"The role of the autophagy in myocardial ischemia\/reperfusion injury","volume":"1852","author":"Ma","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4137\/CMC.S33164","article-title":"Inflammation and Inflammatory Cells in Myocardial Infarction and Reperfusion Injury: A Double-Edged Sword","volume":"10","author":"Liu","year":"2016","journal-title":"Clin. Med. Insights Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1172\/JCI81321","article-title":"Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction","volume":"125","author":"Liu","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1089\/ars.2016.6940","article-title":"Lymphocyte Communication in Myocardial Ischemia\/Reperfusion Injury","volume":"26","author":"Boag","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10495-006-4350-9","article-title":"Mechanisms of apoptosis after ischemia and reperfusion: role of the renin-angiotensin system","volume":"11","author":"Kossmehl","year":"2006","journal-title":"Apoptosis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1111\/ajt.12448","article-title":"Necroptosis in immunity and ischemia-reperfusion injury","volume":"13","author":"Linkermann","year":"2013","journal-title":"Am. J. Transpl."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/cvr\/cvx049","article-title":"Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart","volume":"113","author":"Hausenloy","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/heartjnl-2015-307855","article-title":"Reducing myocardial infarct size: challenges and future opportunities","volume":"102","author":"Bulluck","year":"2016","journal-title":"Heart"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/eurheartj\/ehw113","article-title":"Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure","volume":"37","author":"Madonna","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1161\/CIRCULATIONAHA.116.027039","article-title":"Is Cardioprotection Dead?","volume":"136","author":"Lefer","year":"2017","journal-title":"Circulation"},{"key":"ref_29","first-page":"288","article-title":"Remote ischaemic conditioning reduces infarct size in animal in vivo models of ischaemia-reperfusion injury: a systematic review and meta-analysis","volume":"113","author":"Bromage","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1177\/1074248417702481","article-title":"Remote Ischemic Conditioning for Patients With STEMI","volume":"22","author":"Schmidt","year":"2017","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"H1225","DOI":"10.1152\/ajpheart.00027.2018","article-title":"Clinical translation of myocardial conditioning","volume":"314","author":"Botker","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/cvr\/27.5.720","article-title":"Severe neutrophil depletion by leucocyte filters or cytotoxic drug does not improve recovery of contractile function in stunned porcine myocardium","volume":"27","author":"Juneau","year":"1993","journal-title":"Cardiovasc. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00395-018-0696-8","article-title":"Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection","volume":"113","author":"Hausenloy","year":"2018","journal-title":"Basic. Res. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12967-015-0547-4","article-title":"Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction","volume":"13","author":"Hanes","year":"2015","journal-title":"J. Transl. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1476-5381.1962.tb01444.x","article-title":"Ectopic ventricular rhythms and myocardial infarction in the domestic pig and their response to nialamide, a monoamine oxidase inhibitor","volume":"19","author":"Arora","year":"1962","journal-title":"Br. J. Pharm. Chemother."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0022-5223(19)42477-X","article-title":"Ventricular fibrillation area thresholds in the dog and pig. Determined by a new experimental model for the production of myocardial infarction","volume":"59","author":"Myers","year":"1970","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/nprot.2012.075","article-title":"Myocardial infarction and intramyocardial injection models in swine","volume":"7","author":"McCall","year":"2012","journal-title":"Nat. Protoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jacc.2016.10.058","article-title":"Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium","volume":"69","author":"Hinkel","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.ymthe.2018.06.004","article-title":"Tbeta4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs","volume":"26","author":"Ziegler","year":"2018","journal-title":"Mol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/path.1711750312","article-title":"Combined enzyme histochemical and ultrastructural study on cryostat sections of pig heart to detect early reperfusion damage after ischaemia","volume":"175","author":"Frederiks","year":"1995","journal-title":"J. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jacc.2014.11.004","article-title":"Myocardial edema after ischemia\/reperfusion is not stable and follows a bimodal pattern: imaging and histological tissue characterization","volume":"65","author":"Aguero","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.ijcard.2014.07.179","article-title":"Intra-scar perfusion heterogeneity by cardiac magnetic resonance in a porcine model of non-reperfused myocardial infarction","volume":"176","author":"Moral","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1161\/CIRCULATIONAHA.113.002863","article-title":"Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction","volume":"128","author":"Malliaras","year":"2013","journal-title":"Circulation"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lopez, D., Pan, J.A., Pollak, P.M., Clarke, S., Kramer, C.M., Yeager, M., and Salerno, M. (2017). Multiparametric CMR imaging of infarct remodeling in a percutaneous reperfused Yucatan mini-pig model. Nmr. Biomed., 30.","DOI":"10.1002\/nbm.3693"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/mrm.26402","article-title":"Multicontrast reconstruction using compressed sensing with low rank and spatially varying edge-preserving constraints for high-resolution MR characterization of myocardial infarction","volume":"78","author":"Zhang","year":"2017","journal-title":"Magn. Reson. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/jmri.25423","article-title":"In vivo quantification of myocardial stiffness in hypertensive porcine hearts using MR elastography","volume":"45","author":"Mazumder","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/jmri.25432","article-title":"In vivo magnetic resonance elastography to estimate left ventricular stiffness in a myocardial infarction induced porcine model","volume":"45","author":"Mazumder","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00395-015-0513-6","article-title":"Elevated mean neutrophil volume represents altered neutrophil composition and reflects damage after myocardial infarction","volume":"110","author":"Gijsberts","year":"2015","journal-title":"Basic. Res. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Van den Broek, H.T., De Jong, L., Doevendans, P.A., Chamuleau, S.A.J., Van Slochteren, F.J., and Van Es, R. (2017). 3D Whole-heart Myocardial Tissue Analysis. J. Vis. Exp.","DOI":"10.3791\/54974"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1038\/s41598-018-19758-4","article-title":"Deciphering microvascular changes after myocardial infarction through 3D fully automated image analysis","volume":"8","author":"Gkontra","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature26001","article-title":"Electromechanical vortex filaments during cardiac fibrillation","volume":"555","author":"Christoph","year":"2018","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1177\/1535370218788517","article-title":"Integration of \u201comics\u201d techniques: Dronedarone affects cardiac remodeling in the infarction border zone","volume":"243","author":"Chilukoti","year":"2018","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"H125","DOI":"10.1152\/ajpheart.00842.2016","article-title":"Quantitative cardiac phosphoproteomics profiling during ischemia-reperfusion in an immature swine model","volume":"313","author":"Ledee","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Qi, K., Li, L., Li, X., Zhao, J., Wang, Y., You, S., Hu, F., Zhang, H., Cheng, Y., and Kang, S. (2015). Cardiac microvascular barrier function mediates the protection of Tongxinluo against myocardial ischemia\/reperfusion injury. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119846"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ellenbroek, G.H., van Hout, G.P., Timmers, L., Doevendans, P.A., Pasterkamp, G., and Hoefer, I.E. (2016). Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction. J. Vis. Exp.","DOI":"10.3791\/54021-v"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Koudstaal, S., Jansen of Lorkeers, S., Gho, J.M., van Hout, G.P., Jansen, M.S., Grundeman, P.F., Pasterkamp, G., Doevendans, P.A., Hoefer, I.E., and Chamuleau, S.A. (2014). Myocardial infarction and functional outcome assessment in pigs. J. Vis. Exp.","DOI":"10.3791\/51269-v"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lukovic, D., Gugerell, A., Zlabinger, K., Winkler, J., Pavo, N., Baranyai, T., Giricz, Z., Varga, Z.V., Riesenhuber, M., and Spannbauer, A. (2019). Transcriptional Alterations by Ischaemic Postconditioning in a Pig Infarction Model: Impact on Microvascular Protection. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020344"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1093\/cvr\/cvz050","article-title":"Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities","volume":"115","author":"Andreadou","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1093\/cvr\/cvy314","article-title":"Circulating blood cells and extracellular vesicles in acute cardioprotection","volume":"115","author":"Davidson","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Hausenloy, D.J., Kharbanda, R.K., M\u00f8ller, U.K., Ramlall, M., Aar\u00f8e, J., Butler, R., Bulluck, H., Clayton, T., Dana, A., and Dodd, M. (2019). Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI): a single-blind randomised controlled trial. Lancet.","DOI":"10.1093\/cvr\/cvz242"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"H1883","DOI":"10.1152\/ajpheart.00617.2006","article-title":"Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: First demonstration of remote ischemic perconditioning","volume":"292","author":"Schmidt","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/14017431.2016.1197417","article-title":"Effects of liraglutide and ischemic postconditioning on myocardial salvage after I\/R injury in pigs","volume":"51","author":"Ekstrom","year":"2017","journal-title":"Scand. Cardiovasc. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ijcard.2013.11.020","article-title":"Remote ischemic preconditioning with--but not without--metabolic support protects the neonatal porcine heart against ischemia-reperfusion injury","volume":"170","author":"Schmidt","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yjmcc.2009.03.019","article-title":"Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?","volume":"47","author":"Lecour","year":"2009","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.117.306878","article-title":"Across-Species Transfer of Protection by Remote Ischemic Preconditioning With Species-Specific Myocardial Signal Transduction by Reperfusion Injury Salvage Kinase and Survival Activating Factor Enhancement Pathways","volume":"117","author":"Skyschally","year":"2015","journal-title":"Circ. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10557-011-6364-y","article-title":"Investigating the signal transduction pathways underlying remote ischemic conditioning in the porcine heart","volume":"26","author":"Hausenloy","year":"2012","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"43958","DOI":"10.1038\/srep43958","article-title":"Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling","volume":"7","author":"Pavo","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00395-017-0660-z","article-title":"STAT3 as a common signal of ischemic conditioning: a lesson on \u201crigor and reproducibility\u201d in preclinical studies on cardioprotection","volume":"113","author":"Kleinbongard","year":"2018","journal-title":"Basic. Res. Cardiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"H159","DOI":"10.1152\/ajpheart.00152.2018","article-title":"Humoral transfer and intramyocardial signal transduction of protection by remote ischemic perconditioning in pigs, rats, and mice","volume":"315","author":"Skyschally","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00395-017-0605-6","article-title":"Bloodless reperfusion with the oxygen carrier HBOC-201 in acute myocardial infarction: A novel platform for cardioprotective probes delivery","volume":"112","author":"Aguero","year":"2017","journal-title":"Basic. Res. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jtcvs.2008.09.025","article-title":"Hypoxic reoxygenation during initial reperfusion attenuates cardiac dysfunction and limits ischemia-reperfusion injury after cardioplegic arrest in a porcine model","volume":"137","author":"Risteski","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/j.jvca.2006.02.028","article-title":"Inhibition of thrombin during reperfusion improves immediate postischemic myocardial function and modulates apoptosis in a porcine model of cardiopulmonary bypass","volume":"21","author":"Jormalainen","year":"2007","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1096\/fj.03-0996fje","article-title":"Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs","volume":"18","author":"Lavitrano","year":"2004","journal-title":"FASEB J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000079139","article-title":"S-nitroso human serum albumin improves oxygen metabolism during reperfusion after severe myocardial ischemia","volume":"72","author":"Dworschak","year":"2004","journal-title":"Pharmacology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1096\/fj.02-0673fje","article-title":"VEGF165 transfection decreases postischemic NF-kappa B-dependent myocardial reperfusion injury in vivo: role of eNOS phosphorylation","volume":"17","author":"Kupatt","year":"2003","journal-title":"Faseb. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.surg.2007.03.005","article-title":"Real-time monitoring of cardiac metabolism using biosensors shows myocardial protection during ischemia-reperfusion injury with glucose-insulin-potassium administration","volume":"142","author":"Eiferman","year":"2007","journal-title":"Surgery"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1136\/hrt.2010.194563","article-title":"Comparison of glucose-insulin-potassium and insulin-glucose as adjunctive therapy in acute myocardial infarction: A contemporary meta-analysis of randomised controlled trials","volume":"96","author":"Zhao","year":"2010","journal-title":"Heart"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S0022-5223(03)00811-0","article-title":"Direct inhibition of the sodium\/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability","volume":"126","author":"Yarbrough","year":"2003","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/00005344-200305000-00004","article-title":"Na+\/H+ exchange inhibition with cardioplegia reduces cytosolic [Ca2+] and myocardial damage after cold ischemia","volume":"41","author":"Camara","year":"2003","journal-title":"J. Cardiovasc. Pharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0008-6363(02)00840-4","article-title":"Pre-treatment with the Na+\/H+ exchange inhibitor cariporide delays cell-to-cell electrical uncoupling during myocardial ischemia","volume":"58","author":"Padilla","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S1053-2498(02)01237-8","article-title":"Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia\/ischemia in porcine hearts","volume":"22","author":"Fedalen","year":"2003","journal-title":"J. Heart Lung Transpl."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.cardiores.2003.11.012","article-title":"Selective retroinfusion of GSH and cariporide attenuates myocardial ischemia-reperfusion injury in a preclinical pig model","volume":"61","author":"Kupatt","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/01.CIR.102.25.3032","article-title":"Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) Investigators","volume":"102","author":"Theroux","year":"2000","journal-title":"Circulation"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"55","DOI":"10.12659\/MSMBR.890444","article-title":"Eprosartan improves cardiac function in swine working heart model of ischemia-reperfusion injury","volume":"20","author":"Weymann","year":"2014","journal-title":"Med. Sci. Monit. Basic Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.ajem.2017.02.051","article-title":"Cardioprotective effect of nicorandil against myocardial injury following cardiac arrest in swine","volume":"35","author":"Liang","year":"2017","journal-title":"Am. J. Emerg. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3892\/ijmm.2016.2737","article-title":"Enalapril protects against myocardial ischemia\/reperfusion injury in a swine model of cardiac arrest and resuscitation","volume":"38","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"E153","DOI":"10.1532\/hsf.1790","article-title":"Diazoxide Attenuates Ischemic Myocardial Injury in a Porcine Model","volume":"20","author":"Sarja","year":"2017","journal-title":"Heart Surg. Forum"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2015.04.009","article-title":"Differences in the profile of protection afforded by TRO40303 and mild hypothermia in models of cardiac ischemia\/reperfusion injury","volume":"760","author":"Hansson","year":"2015","journal-title":"Eur. J. Pharm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/eurheartj\/ehu331","article-title":"Effect of intravenous TRO40303 as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: MITOCARE study results","volume":"36","author":"Atar","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1056\/NEJMoa071142","article-title":"Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction","volume":"359","author":"Piot","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJMoa1505489","article-title":"Cyclosporine before PCI in Patients with Acute Myocardial Infarction","volume":"373","author":"Cung","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1177\/1074248410362074","article-title":"Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion model","volume":"15","author":"Karlsson","year":"2010","journal-title":"J. Cardiovasc. Pharm."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/FJC.0000000000000267","article-title":"TVP1022: A Novel Cardioprotective Drug Attenuates Left Ventricular Remodeling After Ischemia\/Reperfusion in Pigs","volume":"66","author":"Malka","year":"2015","journal-title":"J. Cardiovasc. Pharm."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e000023","DOI":"10.1161\/JAHA.113.000023","article-title":"Selective inhibition of the master regulator transcription factor Egr-1 with catalytic oligonucleotides reduces myocardial injury and improves left ventricular systolic function in a preclinical model of myocardial infarction","volume":"2","author":"Rayner","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s40265-016-0567-2","article-title":"Ivabradine: Cardioprotection By and Beyond Heart Rate Reduction","volume":"76","author":"Heusch","year":"2016","journal-title":"Drugs"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e12266","DOI":"10.1111\/1755-5922.12266","article-title":"Ivabradine vs metoprolol in patients with acute inferior wall myocardial infarction\u2014\u201cExpanding arena for ivabradine\u201d","volume":"35","author":"Priti","year":"2017","journal-title":"Cardiovasc. Ther."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Hesen, N.A., Riksen, N.P., Aalders, B., Brouwer, M.A., Ritskes-Hoitinga, M., El Messaoudi, S., and Wever, K.E. (2017). A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183664"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1007\/s00125-017-4287-2","article-title":"Metformin prevents ischaemic ventricular fibrillation in metabolically normal pigs","volume":"60","author":"Lu","year":"2017","journal-title":"Diabetologia"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11748-016-0704-6","article-title":"Atrial natriuretic peptide induces peroxisome proliferator activated receptor gamma during cardiac ischemia-reperfusion in swine heart","volume":"65","author":"Suzuki","year":"2017","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.athoracsur.2013.09.059","article-title":"Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis","volume":"97","author":"Lassaletta","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1177\/1535370216684041","article-title":"Featured Article: Pharmacological postconditioning with delta opioid attenuates myocardial reperfusion injury in isolated porcine hearts","volume":"242","author":"Seewald","year":"2017","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1540-8191.2006.00226.x","article-title":"Chemically modified tetracycline improves contractility in porcine coronary ischemia\/reperfusion injury","volume":"21","author":"Swartz","year":"2006","journal-title":"J. Card. Surg."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jtcvs.2008.08.074","article-title":"Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia\/reperfusion injury","volume":"138","author":"Sodha","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCINTERVENTIONS.111.967596","article-title":"Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia\/reperfusion injury in pigs","volume":"5","author":"Arslan","year":"2012","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1113\/expphysiol.2011.057885","article-title":"Effect of rosiglitazone on cardiac electrophysiology, infarct size and mitochondrial function in ischaemia and reperfusion of swine and rat heart","volume":"96","author":"Palee","year":"2011","journal-title":"Exp. Physiol."},{"key":"ref_106","first-page":"204","article-title":"Deleterious effects of methylprednisolone in patients with myocardial infarction","volume":"53","author":"Roberts","year":"1976","journal-title":"Circulation"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/bph.14155","article-title":"Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges","volume":"175","author":"Huang","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/sj.gt.3301673","article-title":"Retroinfusion of NFkappaB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs","volume":"9","author":"Kupatt","year":"2002","journal-title":"Gene Ther."},{"key":"ref_109","first-page":"828","article-title":"The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction","volume":"38","author":"Bosch","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jacc.2015.04.064","article-title":"Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model","volume":"66","author":"Hinkel","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1038\/ncomms4970","article-title":"MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2","volume":"5","author":"Hinkel","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Dorn, T., Kornherr, J., Parrotta, E.I., Zawada, D., Ayetey, H., Santamaria, G., Iop, L., Mastantuono, E., Sinnecker, D., and Goedel, A. (2018). Interplay of cell-cell contacts and RhoA\/MRTF-A signaling regulates cardiomyocyte identity. EMBO J., 37.","DOI":"10.15252\/embj.201798133"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2017\/6848271","article-title":"Thymosin\u00df4 Improves Differentiation and Vascularization of EHTs","volume":"2017","author":"Ziegler","year":"2017","journal-title":"Stem Cells Int."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/CIRCULATIONAHA.107.758904","article-title":"Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection","volume":"117","author":"Hinkel","year":"2008","journal-title":"Circulation"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3892\/ijmm.2013.1558","article-title":"Recombinant AAV-PR39-mediated hypoxia-inducible factor 1alpha gene expression attenuates myocardial infarction","volume":"33","author":"Sun","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCRESAHA.111.244442","article-title":"Inhibition of miR-15 protects against cardiac ischemic injury","volume":"110","author":"Hullinger","year":"2012","journal-title":"Circ. Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/CIRCULATIONAHA.113.001904","article-title":"Inhibition of MicroRNA-92a Protects Against Ischemia-Reperfusion Injury in a Large Animal Model","volume":"128","author":"Hinkel","year":"2013","journal-title":"Circulation"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/cvr\/cvw017","article-title":"Lack of MG53 in human heart precludes utility as a biomarker of myocardial injury or endogenous cardioprotective factor","volume":"110","author":"Lemckert","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ijcard.2015.07.084","article-title":"MG53 protein: A promising novel therapeutic target for myocardial ischemia reperfusion injury","volume":"199","author":"Zhou","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2014.12.010","article-title":"Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury","volume":"80","author":"Liu","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Drevinge, C., Karlsson, L.O., Stahlman, M., Larsson, T., Perman Sundelin, J., Grip, L., Andersson, L., Boren, J., and Levin, M.C. (2013). Cholesteryl esters accumulate in the heart in a porcine model of ischemia and reperfusion. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061942"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/bcp.12882","article-title":"Rotigaptide protects the myocardium and arterial vasculature from ischaemia reperfusion injury","volume":"81","author":"Pedersen","year":"2016","journal-title":"Br. J. Clin. Pharm."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jca.21344","article-title":"Selective apheresis of C-reactive protein: a new therapeutic option in myocardial infarction?","volume":"30","author":"Sheriff","year":"2015","journal-title":"J. Clin. Apher."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCULATIONAHA.119.040144","article-title":"Metformin Use and Clinical Outcomes among Patients with Diabetes with or without Heart Failure or Kidney Dysfunction: Observations from the SAVOR-TIMI 53 Trial","volume":"140","author":"Bergmark","year":"2019","journal-title":"Circulation"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.cjca.2017.10.001","article-title":"Autologous Bone Marrow Stem Cell Therapy in Patients With ST-Elevation Myocardial Infarction: A Systematic Review and Meta-analysis","volume":"33","author":"Jeyaraman","year":"2017","journal-title":"Can. J. Cardiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jacc.2017.06.012","article-title":"Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering","volume":"70","author":"Yanamandala","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/CIRCRESAHA.117.311174","article-title":"Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction","volume":"121","author":"Sharp","year":"2017","journal-title":"Circ. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"28250","DOI":"10.1038\/srep28250","article-title":"Bone Marrow Mesenchymal Stem Cells (BM-MSCs) Improve Heart Function in Swine Myocardial Infarction Model through Paracrine Effects","volume":"6","author":"Cai","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/CIRCHEARTFAILURE.114.001484","article-title":"Cellular postconditioning: Allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction","volume":"8","author":"Kanazawa","year":"2015","journal-title":"Circ. Heart Fail."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Kanazawa, H., Tseliou, E., Dawkins, J.F., De Couto, G., Gallet, R., Malliaras, K., Yee, K., Kreke, M., Valle, I., and Smith, R.R. (2016). Durable Benefits of Cellular Postconditioning: Long-Term Effects of Allogeneic Cardiosphere-Derived Cells Infused After Reperfusion in Pigs with Acute Myocardial Infarction. J. Am. Heart Assoc, 5.","DOI":"10.1161\/JAHA.115.002796"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Gallet, R., Tseliou, E., Dawkins, J., Middleton, R., Valle, J., Angert, D., Reich, H., Luthringer, D., Kreke, M., and Smith, R. (2015). Intracoronary delivery of self-assembling heart-derived microtissues (cardiospheres) for prevention of adverse remodeling in a pig model of convalescent myocardial infarction. Circ. Cardiovasc. Interv., 8.","DOI":"10.1161\/CIRCINTERVENTIONS.115.002391"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12967-017-1157-0","article-title":"Non-invasive in vivo imaging of cardiac stem\/progenitor cell biodistribution and retention after intracoronary and intramyocardial delivery in a swine model of chronic ischemia reperfusion injury","volume":"15","author":"Collantes","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/S0140-6736(11)61590-0","article-title":"Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): Initial results of a randomised phase 1 trial","volume":"378","author":"Bolli","year":"2011","journal-title":"Lancet"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jacc.2013.08.724","article-title":"Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction: Evidence of Therapeutic Regeneration in the Final 1-Year Results of the CADUCEUS Trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction)","volume":"63","author":"Malliaras","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCRESAHA.114.300639","article-title":"Exosomes and Cardiac Repair After Myocardial Infarction","volume":"114","author":"Sahoo","year":"2014","journal-title":"Circ. Res."},{"key":"ref_136","first-page":"201","article-title":"Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction","volume":"38","author":"Gallet","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/CIRCULATIONAHA.116.024590","article-title":"Exosomal MicroRNA Transfer Into Macrophages Mediates Cellular Postconditioning","volume":"136","author":"Gallet","year":"2017","journal-title":"Circulation"},{"key":"ref_138","first-page":"173ra25","article-title":"Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction","volume":"5","author":"Singelyn","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jacc.2016.05.053","article-title":"Bioabsorbable Intracoronary Matrix for Prevention of Ventricular Remodeling After Myocardial Infarction","volume":"68","author":"Rao","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","article-title":"The extracellular matrix protein Agrin promotes heart regeneration in mice","volume":"347","author":"Bassat","year":"2017","journal-title":"Nature"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.stemcr.2019.04.005","article-title":"Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias","volume":"12","author":"Romagnuolo","year":"2019","journal-title":"Stem Cell Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"363ra148","DOI":"10.1126\/scitranslmed.aaf8781","article-title":"Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells","volume":"8","author":"Weinberger","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1038\/s41598-019-46409-z","article-title":"Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model","volume":"9","author":"Pecha","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3389\/fonc.2018.00559","article-title":"Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research","volume":"8","author":"Boettcher","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/0023677217750691","article-title":"Creating effective biocontainment facilities and maintenance protocols for raising specific pathogen-free, severe combined immunodeficient (SCID) pigs","volume":"52","author":"Powell","year":"2018","journal-title":"Lab. Anim."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Bahr, A., Kaser, T., Kemter, E., Gerner, W., Kurome, M., Baars, W., Herbach, N., Witter, K., Wunsch, A., and Talker, S.C. (2016). Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155676"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e12449","DOI":"10.1111\/xen.12449","article-title":"Early weaning completely eliminates porcine cytomegalovirus from a newly established pig donor facility for xenotransplantation","volume":"25","author":"Egerer","year":"2018","journal-title":"Xenotransplantation"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/CIRCULATIONAHA.116.022829","article-title":"Cardioprotection: The Disconnect Between Bench and Bedside","volume":"134","author":"Rossello","year":"2016","journal-title":"Circulation"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.117.310820","article-title":"Critical Issues for the Translation of Cardioprotection","volume":"120","author":"Heusch","year":"2017","journal-title":"Circ. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/cvr\/cvy038","article-title":"Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening","volume":"114","author":"Sorop","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_151","unstructured":"Mendieta, G., Ben-Aicha, S., Gutierrez, M., Casani, L., Arzanauskaite, M., Carreras, F., Sabate, M., Badimon, L., and Vilahur, G. (2019). Intravenous statin administration during MI enhances cardioprotection and improves post-MI healing compared to oral administration. J. Am. Coll. Cardiol., in press."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/19\/4749\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:53Z","timestamp":1760189033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/19\/4749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":151,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["ijms20194749"],"URL":"https:\/\/doi.org\/10.3390\/ijms20194749","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]}}}