{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:23:18Z","timestamp":1786591398940,"version":"build-2736575974"},"reference-count":76,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Major Research and Development Project from the National Health Commission","award":["Grant# 2018ZX10301406"],"award-info":[{"award-number":["Grant# 2018ZX10301406"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["Grant# 31970149"],"award-info":[{"award-number":["Grant# 31970149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of Research and Development of Ningxia Hui Autonomous Region of China","award":["Grant# 2017BN04"],"award-info":[{"award-number":["Grant# 2017BN04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Signal transducer and activator of transcription 3 (STAT3) is a multifunctional factor that regulates inflammation and immunity. Knowledge of its regulatory mechanisms is very limited. Here, we showed that enterovirus 71 (EV71) infection induced the phosphorylation of STAT3 and the expression of its downstream inflammatory regulators. Knockdown of STAT3 with siRNAs significantly restricted viral RNA and protein levels, and also reduced viral titers. With further investigation, we found that importin \u03b1 family member Karyopherin-\u03b11 (KPNA1) was employed by both STAT1 and STAT3 for their nuclear import. The phosphorylated and un-phosphorylated STAT3 competed with STAT1 for binding to the decreased KPNA1 post infection and repressed downstream ISG expression. STAT3 knockdown alleviated the repressed type I IFN-mediated antiviral response upon infection and led to decreased viral replication. Taken together, our data suggested the role of STAT3 in maintaining the balance of inflammation and antiviral responses in the central nervous system (CNS) upon infection.<\/jats:p>","DOI":"10.3390\/ijms20194870","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T13:16:41Z","timestamp":1569849401000},"page":"4870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1"],"prefix":"10.3390","volume":"20","author":[{"given":"Huanru","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Public Health Research, Medical School, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center for Public Health Research, Medical School, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Jinling College, Nanjing University, Nanjing 210089, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Public Health Research, Medical School, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Public Health Research, Medical School, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zou","sequence":"additional","affiliation":[{"name":"Center for Public Health Research, Medical School, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Public Health Research, Medical School, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Public Health Research, Medical School, Nanjing University, Nanjing 210093, China"},{"name":"State Key Lab of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China"},{"name":"Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1523\/JNEUROSCI.0519-10.2010","article-title":"Tyk2\/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: Implications in Alzheimer\u2019s disease","volume":"30","author":"Wan","year":"2010","journal-title":"J. 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