{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:27:40Z","timestamp":1762918060388,"version":"build-2065373602"},"reference-count":49,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A1B03032168"],"award-info":[{"award-number":["2017R1D1A1B03032168"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI15C2483"],"award-info":[{"award-number":["HI15C2483"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>It has been reported Human Leukocyte Antigen (HLA) gene polymorphism is a risk factor for the development of Beh\u00e7et\u2019s disease (BD). In this study, the association of HLA class II subtypes HLA-DP, DQ, DR, and T cell subsets in BD patients with arthritis was evaluated. Frequencies of HLA-DP, DQ, DR positive cells, and T cell subsets in peripheral blood leukocytes (PBL) were measured by flow cytometric analysis in BD, and compared to rheumatoid arthritis as disease controls and healthy controls. Frequencies of HLA-DQ were significantly decreased in whole PBL and granulocytes of BD active patients as compared to healthy controls. In monocytes populations, proportions of HLA-DR positive cells were significantly increased in BD active patients as compared to healthy controls. Proportions of CD4+CCR7+ and CD8+CCR7+ cells were significantly higher in BD active patients than in BD inactive in whole PBL. Frequencies of CD4+CD62L- and CD8+CD62L- cells in lymphocytes were significantly decreased in active BD than those in inactive BD. There were also correlations between disease activity markers and T cell subsets. Our results revealed HLA-DP, DQ, and DR expressing cell frequencies and several T cell subsets were significantly correlated with BD arthritis symptoms.<\/jats:p>","DOI":"10.3390\/ijms20205044","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T10:53:03Z","timestamp":1570791183000},"page":"5044","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Beh\u00e7et\u2019s Disease with Arthritis"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-1698","authenticated-orcid":false,"given":"S. M. Shamsul","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-3367","authenticated-orcid":false,"given":"Hyoun-Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bunsoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Yang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-393X","authenticated-orcid":false,"given":"Chang-Hee","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seonghyang","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Korea"},{"name":"Department of Microbiology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"ref_1","first-page":"638273","article-title":"Immunopathogenic Role of Herpes Simplex Virus in Behcet\u2019s Disease","volume":"2013","author":"Kim","year":"2013","journal-title":"Genet. 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