{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:10:45Z","timestamp":1790485845008,"version":"4.1.0"},"reference-count":124,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"David and Alice Van Buuren Fund","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aquaporins are a family of transmembrane proteins permeable to water. In mammals, they are subdivided into classical aquaporins that are permeable to water; aquaglyceroporins that are permeable to water, glycerol and urea; peroxiporins that facilitate the diffusion of H2O2 through cell membranes; and so called unorthodox aquaporins. Aquaporins ensure important physiological functions in both exocrine and endocrine pancreas. Indeed, they are involved in pancreatic fluid secretion and insulin secretion. Modification of aquaporin expression and\/or subcellular localization may be involved in the pathogenesis of pancreatic insufficiencies, diabetes and pancreatic cancer. Aquaporins may represent useful drug targets for the treatment of pathophysiological conditions affecting pancreatic function, and\/or diagnostic\/predictive biomarker for pancreatic cancer. This review summarizes the current knowledge related to the involvement of aquaporins in the pancreas physiology and physiopathology.<\/jats:p>","DOI":"10.3390\/ijms20205052","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T10:53:03Z","timestamp":1570791183000},"page":"5052","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases"],"prefix":"10.3390","volume":"20","author":[{"given":"Tatjana","family":"Arsenijevic","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Gastroenterology, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"},{"name":"Department of Gastroenterology, Hepatology and Digestive Oncology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, 808, Route de Lennik, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Perret","sequence":"additional","affiliation":[{"name":"Laboratory of Pathophysiological and Nutritional Biochemistry, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Van Laethem","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Gastroenterology, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"},{"name":"Department of Gastroenterology, Hepatology and Digestive Oncology, H\u00f4pital Erasme, Universit\u00e9 Libre de Bruxelles, 808, Route de Lennik, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-5824","authenticated-orcid":false,"given":"Christine","family":"Delporte","sequence":"additional","affiliation":[{"name":"Laboratory of Pathophysiological and Nutritional Biochemistry, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0168-8227(11)70010-9","article-title":"The dual control of insulin secretion by glucose involves triggering and amplifying pathways in \u03b2-cells","volume":"93","author":"Henquin","year":"2011","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/112_2013_14","article-title":"The exocrine pancreas: The acinar-ductal tango in physiology and pathophysiology","volume":"165","author":"Hegyi","year":"2013","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hu, F., Qiu, X., and Bu, S. (2018). Pancreatic islet dysfunction in type 2 diabetes mellitus. Arch. Physiol. Biochem., 1\u20137.","DOI":"10.1080\/13813455.2018.1510967"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11154-019-09501-3","article-title":"Structure and function of the exocrine pancreas in patients with type 1 diabetes","volume":"20","author":"Mallone","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000499138","article-title":"Etiology and Risk Factors of Acute and Chronic Pancreatitis","volume":"35","author":"Weiss","year":"2019","journal-title":"Visc. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3389\/fphys.2018.01585","article-title":"Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas","volume":"9","author":"Pallagi","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_7","first-page":"10","article-title":"Current standards and new innovative approaches for treatment of pancreatic cancer","volume":"57","author":"Conroy","year":"2016","journal-title":"Eur. J. Cancer Oxf. Engl. 1990"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/MOG.0000000000000562","article-title":"Management of pancreatic exocrine insufficiency","volume":"35","year":"2019","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.bbagen.2013.08.007","article-title":"Aquaporins in salivary glands and pancreas","volume":"1840","author":"Delporte","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-94-024-1057-0_4","article-title":"Aquaporins and Gland Secretion","volume":"969","author":"Delporte","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3389\/fphys.2018.00851","article-title":"Aquaglyceroporins: Drug Targets for Metabolic Diseases?","volume":"9","author":"Calamita","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbamem.2015.10.004","article-title":"Mammalian aquaglyceroporin function in metabolism","volume":"1858","author":"Laforenza","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fchem.2018.00099","article-title":"Pancreatic Aquaporin-7: A Novel Target for Anti-diabetic Drugs?","volume":"6","author":"Ezquerro","year":"2018","journal-title":"Front. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1007\/s00018-018-2781-4","article-title":"Revisiting the metabolic syndrome: The emerging role of aquaglyceroporins","volume":"75","author":"Rodrigues","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1002\/anie.200460804","article-title":"Aquaporin water channels (Nobel Lecture)","volume":"43","author":"Agre","year":"2004","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev.physiol.70.113006.100452","article-title":"A current view of the mammalian aquaglyceroporins","volume":"70","author":"Rojek","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"R566","DOI":"10.1152\/ajpregu.90464.2008","article-title":"The evolutionary aspects of aquaporin family","volume":"300","author":"Ishibashi","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1074\/jbc.M603761200","article-title":"Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes","volume":"282","author":"Bienert","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1089\/ars.2013.5505","article-title":"Mitochondrial aquaporin-8: A functional peroxiporin?","volume":"19","author":"Marinelli","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yang, B. (2017). Transport Characteristics of Aquaporins. Aquaporins, Springer Netherlands. Advances in Experimental Medicine and Biology.","DOI":"10.1007\/978-94-024-1057-0"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Prata, C., Hrelia, S., and Fiorentini, D. (2019). Peroxiporins in Cancer. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061371"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101326","DOI":"10.1016\/j.redox.2019.101326","article-title":"Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane","volume":"28","author":"Bestetti","year":"2019","journal-title":"Redox Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/febs.12653","article-title":"Structural determinants of the hydrogen peroxide permeability of aquaporins","volume":"281","author":"Almasalmeh","year":"2014","journal-title":"FEBS J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1086\/BBLv229n1p6","article-title":"Evolution and functional diversity of aquaporins","volume":"229","author":"Finn","year":"2015","journal-title":"Biol. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.bbagen.2013.12.001","article-title":"Diversity and evolution of membrane intrinsic proteins","volume":"1840","author":"Abascal","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Laloux, T., Junqueira, B., Maistriaux, L.C., Ahmed, J., Jurkiewicz, A., and Chaumont, F. (2018). Plant and Mammal Aquaporins: Same but Different. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020521"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.bbamem.2014.09.001","article-title":"Key roles of aquaporins in tumor biology","volume":"1848","author":"Papadopoulos","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-008-0303-9","article-title":"Aquaporins--new players in cancer biology","volume":"86","author":"Verkman","year":"2008","journal-title":"J. Mol. Med. Berl. Ger."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.canlet.2016.01.003","article-title":"Aquaporins: Their role in gastrointestinal malignancies","volume":"373","author":"Nagaraju","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Moosavi, M.-S., and Elham, Y. (2019). Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets. Pathol. Oncol. Res. POR.","DOI":"10.1007\/s12253-019-00646-9"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1039\/C8MT00072G","article-title":"Aquaporins in cancer development: Opportunities for bioinorganic chemistry to contribute novel chemical probes and therapeutic agents","volume":"10","author":"Aikman","year":"2018","journal-title":"Met. Integr. Biometal Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Delporte, C., Bryla, A., and Perret, J. (2016). Aquaporins in Salivary Glands: From Basic Research to Clinical Applications. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17020166"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/13543776.2017.1236085","article-title":"Aquaporin modulators: A patent review (2010-2015)","volume":"27","author":"Soveral","year":"2017","journal-title":"Expert Opin. Ther. Pat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-94-024-1057-0_16","article-title":"Aquaporin-Targeted Therapeutics: State-of-the-Field","volume":"969","author":"Tradtrantip","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Abir-Awan, M., Kitchen, P., Salman, M.M., Conner, M.T., Conner, A.C., and Bill, R.M. (2019). Inhibitors of Mammalian Aquaporin Water Channels. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071589"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1073\/pnas.94.7.3268","article-title":"Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands","volume":"94","author":"Delporte","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/gt.2016.87","article-title":"Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction","volume":"24","author":"Alevizos","year":"2017","journal-title":"Gene Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/hep.28564","article-title":"Hepatic gene transfer of human aquaporin-1 improves bile salt secretory failure in rats with estrogen-induced cholestasis","volume":"64","author":"Marrone","year":"2016","journal-title":"Hepatol. Baltim. Md"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12967-015-0439-7","article-title":"Aquaporins as diagnostic and therapeutic targets in cancer: How far we are?","volume":"13","author":"Wang","year":"2015","journal-title":"J. Transl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tang, G., and Yang, G.-Y. (2016). Aquaporin-4: A Potential Therapeutic Target for Cerebral Edema. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17101413"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ikarashi, N., Kon, R., and Sugiyama, K. (2016). Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17071172"},{"key":"ref_42","unstructured":"Huang, F.P. (2011). Primary Sj\u00f6gren\u2019s syndrome: Current pathophysiological, diagnostic and therapeutic advances. Autoimmune Disorders, Intech Publishers Inc."},{"key":"ref_43","first-page":"229","article-title":"Neuromyelitis Optica: Review and Utility of Testing Aquaporin-4 Antibody in Typical Optic Neuritis","volume":"7","author":"Seay","year":"2018","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"32345","DOI":"10.18632\/oncotarget.16017","article-title":"The potential roles of aquaporin 4 in malignant gliomas","volume":"8","author":"Lan","year":"2017","journal-title":"Oncotarget"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20170066","DOI":"10.1098\/rsfs.2017.0066","article-title":"Aquaporin-graphene interface: Relevance to point-of-care device for renal cell carcinoma and desalination","volume":"8","author":"Jakowiecki","year":"2018","journal-title":"Interface Focus"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"He, J., and Yang, B. (2019). Aquaporins in Renal Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020366"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00018-016-2142-0","article-title":"Aquaporin-5: From structure to function and dysfunction in cancer","volume":"73","author":"Direito","year":"2016","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/jso.24605","article-title":"Differential expression of aquaporin-3 and aquaporin-5 in pancreatic ductal adenocarcinoma","volume":"115","author":"Direito","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Tomita, Y., Dorward, H., Yool, A.J., Smith, E., Townsend, A.R., Price, T.J., and Hardingham, J.E. (2017). Role of Aquaporin 1 Signalling in Cancer Development and Progression. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020299"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"36392","DOI":"10.18632\/oncotarget.26351","article-title":"Water transport proteins-aquaporins (AQPs) in cancer biology","volume":"9","author":"Dajani","year":"2018","journal-title":"Oncotarget"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Da Silva Xavier, G. (2018). The Cells of the Islets of Langerhans. J. Clin. Med., 7.","DOI":"10.3390\/jcm7030054"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Wang, X., Misawa, R., Zielinski, M.C., Cowen, P., Jo, J., Periwal, V., Ricordi, C., Khan, A., Szust, J., and Shen, J. (2013). Regional differences in islet distribution in the human pancreas--preferential beta-cell loss in the head region in patients with type 2 diabetes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0067454"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4161\/isl.3.4.16417","article-title":"An improved protocol for optical projection tomography imaging reveals lobular heterogeneities in pancreatic islet and \u03b2-cell mass distribution","volume":"3","author":"Cheddad","year":"2011","journal-title":"Islets"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"14634","DOI":"10.1038\/srep14634","article-title":"A 3D map of the islet routes throughout the healthy human pancreas","volume":"5","author":"Gagniuc","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s00125-008-1219-1","article-title":"Metabolic consequences of a 50% partial pancreatectomy in humans","volume":"52","author":"Menge","year":"2009","journal-title":"Diabetologia"},{"key":"ref_56","unstructured":"Granger, D.N., and Granger, J.P. (2010). The Exocrine Pancreas. Colloquium Series on Integrated Systems Physiology: From Molecule to Function to Disease, Morgan & Claypool Life Sciences."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ydbio.2008.10.024","article-title":"Developmental biology of the pancreas: A comprehensive review","volume":"326","author":"Gittes","year":"2009","journal-title":"Dev. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/dom.13019","article-title":"\u03b2-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells","volume":"19","author":"Avrahami","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000218172","article-title":"Contrasting effects of glycerol and urea transport on rat pancreatic beta-cell function","volume":"23","author":"Best","year":"2009","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000337588","article-title":"A new role for aquaporin 7 in insulin secretion","volume":"29","author":"Louchami","year":"2012","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6026","DOI":"10.1128\/MCB.00384-07","article-title":"Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion","volume":"27","author":"Matsumura","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"10993","DOI":"10.1073\/pnas.0503291102","article-title":"Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase","volume":"102","author":"Hibuse","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jcp.21872","article-title":"Functional role of aquaglyceroporin 7 expression in the pancreatic beta-cell line BRIN-BD11","volume":"221","author":"Delporte","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.biocel.2010.10.018","article-title":"Pancreatic beta-cells: Role of glycerol and aquaglyceroporin 7","volume":"43","author":"Virreira","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/ijo.2017.135","article-title":"Role of aquaporin-7 in ghrelin- and GLP-1-induced improvement of pancreatic \u03b2-cell function after sleeve gastrectomy in obese rats","volume":"41","author":"Becerril","year":"2017","journal-title":"Int. J. Obes."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41574-018-0132-z","article-title":"Modelling the endocrine pancreas in health and disease","volume":"15","author":"Bakhti","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"051001","DOI":"10.1088\/1478-3975\/ab2a9d","article-title":"Tripartite cell networks for glucose homeostasis","volume":"16","author":"Song","year":"2019","journal-title":"Phys. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pharmthera.2017.05.003","article-title":"Mechanisms of the amplifying pathway of insulin secretion in the \u03b2 cell","volume":"179","author":"Kalwat","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1469-7793.1997.00191.x","article-title":"Glucose-induced swelling in rat pancreatic beta-cells","volume":"504","author":"Miley","year":"1997","journal-title":"J. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1113\/expphysiol.1996.sp003993","article-title":"Activation of an anion conductance and beta-cell depolarization during hypotonically induced insulin release","volume":"81","author":"Best","year":"1996","journal-title":"Exp. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-90-481-3271-3_7","article-title":"Electrophysiology of islet cells","volume":"654","author":"Drews","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s004240100566","article-title":"Expression of the Na+K+-2CI- cotransporter in alpha and beta cells isolated from the rat pancreas","volume":"442","author":"Majid","year":"2001","journal-title":"Pflugers Arch."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1113\/jphysiol.2010.194738","article-title":"Cotransport of water by the Na+-K+-2Cl(-) cotransporter NKCC1 in mammalian epithelial cells","volume":"588","author":"Hamann","year":"2010","journal-title":"J. Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-94-024-1057-0_15","article-title":"Aquaporins in Obesity","volume":"969","author":"Soveral","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Iena, F.M., and Lebeck, J. (2018). Implications of Aquaglyceroporin 7 in Energy Metabolism. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010154"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.mam.2012.02.004","article-title":"Implications of aquaglyceroporins 7 and 9 in glycerol metabolism and metabolic syndrome","volume":"33","author":"Maeda","year":"2012","journal-title":"Mol. Aspects Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1086\/338629","article-title":"Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: The Botnia study","volume":"70","author":"Lindgren","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1210\/jc.2003-030553","article-title":"HERITAGE Family Study Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study","volume":"88","author":"Loos","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1210\/jc.2007-0531","article-title":"Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes","volume":"92","author":"Miranda","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.2337\/db06-1389","article-title":"A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities","volume":"56","author":"Prudente","year":"2007","journal-title":"Diabetes"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"8167538","DOI":"10.1155\/2018\/8167538","article-title":"Associations between Aquaglyceroporin Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus","volume":"2018","author":"Wang","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1046\/j.1432-1033.2002.02821.x","article-title":"Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation","volume":"269","author":"Kondo","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"17801","DOI":"10.1073\/pnas.0406230101","article-title":"Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue","volume":"101","author":"Maeda","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.bbrc.2005.03.046","article-title":"Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells","volume":"330","author":"Itoh","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molmet.2019.04.009","article-title":"Epigenetic regulation of diabetogenic adipose morphology","volume":"25","author":"Kerr","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2003.08.042","article-title":"Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion","volume":"481","author":"Konturek","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00232-005-0852-6","article-title":"The role of aquaporin water channels in fluid secretion by the exocrine pancreas","volume":"210","author":"Burghardt","year":"2006","journal-title":"J. Membr. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Isokpehi, R.D., Rajnarayanan, R.V., Jeffries, C.D., Oyeleye, T.O., and Cohly, H.H.P. (2009). Integrative sequence and tissue expression profiling of chicken and mammalian aquaporins. BMC Genomics, 10.","DOI":"10.1186\/1471-2164-10-S2-S7"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1073\/pnas.072083499","article-title":"Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles","volume":"99","author":"Cho","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cellbi.2003.11.003","article-title":"Regulation of the water channel aquaporin-1: Isolation and reconstitution of the regulatory complex","volume":"28","author":"Cho","year":"2004","journal-title":"Cell Biol. Int."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/gut.52.7.1008","article-title":"Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas","volume":"52","author":"Burghardt","year":"2003","journal-title":"Gut"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"G701","DOI":"10.1152\/ajpgi.2001.280.4.G701","article-title":"Expression and immunolocalization of aquaporin water channels in rat exocrine pancreas","volume":"280","author":"Hurley","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"G324","DOI":"10.1152\/ajpgi.00198.2001","article-title":"Aquaporins in rat pancreatic interlobular ducts","volume":"282","author":"Ko","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00441-002-0527-x","article-title":"Distribution of aquaporin 1 in the rat pancreatic duct system examined with light- and electron-microscopic immunohistochemistry","volume":"308","author":"Furuya","year":"2002","journal-title":"Cell Tissue Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/physrev.00011.2011","article-title":"Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion","volume":"92","author":"Lee","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"C1161","DOI":"10.1152\/ajpcell.00564.2004","article-title":"Phenotype analysis of aquaporin-8 null mice","volume":"288","author":"Yang","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"C126","DOI":"10.1152\/ajpcell.2001.280.1.C126","article-title":"Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels","volume":"280","author":"Ma","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"C1368","DOI":"10.1152\/ajpcell.00117.2009","article-title":"Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis","volume":"297","author":"Ohta","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3389\/fphys.2018.00854","article-title":"The Importance of Aquaporin 1 in Pancreatitis and Its Relation to the CFTR Cl- Channel","volume":"9","author":"Venglovecz","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/MPA.0b013e318249938e","article-title":"Down-regulation of aquaporin 1 in rats with experimental acute necrotizing pancreatitis","volume":"41","author":"Feng","year":"2012","journal-title":"Pancreas"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"15052","DOI":"10.1073\/pnas.0808097105","article-title":"Pancreatic exocrine insufficiency in LXRbeta-\/- mice is associated with a reduction in aquaporin-1 expression","volume":"105","author":"Gabbi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/1440-1681.12627","article-title":"Emodin ameliorates acute lung injury induced by severe acute pancreatitis through the up-regulated expressions of AQP1 and AQP5 in lung","volume":"43","author":"Xu","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_103","first-page":"841","article-title":"The mechanism underlying alpinetin-mediated alleviation of pancreatitis-associated lung injury through upregulating aquaporin-1","volume":"10","author":"Liang","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_104","first-page":"437","article-title":"Fluid resuscitation via the rectum ameliorates hemodynamic disorders through adjusting aquaporin expression in an experimental severe acute pancreatitis model","volume":"17","author":"Xie","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1053\/j.gastro.2017.06.011","article-title":"Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice","volume":"153","author":"Zeng","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Kamimura, K., Yokoo, T., and Terai, S. (2018). Gene Therapy for Pancreatic Diseases: Current Status. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113415"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"22070","DOI":"10.1074\/jbc.271.36.22070","article-title":"Adenovirus-mediated expression of aquaporin-5 in epithelial cells","volume":"271","author":"Delporte","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-016-2391-y","article-title":"Role of CFTR in epithelial physiology","volume":"74","author":"Gray","year":"2017","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.bbrc.2011.06.093","article-title":"Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells","volume":"410","author":"Ko","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1111\/cas.14079","article-title":"Cell volume regulation in cancer cell migration driven by osmotic water flow","volume":"110","author":"Morishita","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1177\/1533034615607693","article-title":"Aquaporins: New Targets for Cancer Therapy","volume":"15","author":"Wang","year":"2016","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA. Cancer J. Clin."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.bbrc.2017.03.168","article-title":"Aquaporin 3 facilitates tumor growth in pancreatic cancer by modulating mTOR signaling","volume":"486","author":"Huang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3892\/mmr.2012.966","article-title":"Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3","volume":"6","author":"Liu","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/PAI.0000000000000523","article-title":"AQP1 and AQP3 Expression are Associated With Severe Symptoms and Poor-prognosis of the Pancreatic Ductal Adenocarcinoma","volume":"27","author":"Zou","year":"2019","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.foodchem.2018.09.029","article-title":"Phytocompounds modulating Aquaporins: Clinical benefits are anticipated","volume":"274","author":"Portincasa","year":"2019","journal-title":"Food Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.2174\/0929867324666170523123010","article-title":"Modulation of Aquaporins by dietary patterns and plant bioactive compounds","volume":"26","author":"Cataldo","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fmolb.2018.00030","article-title":"Aquaporins as Targets of Dietary Bioactive Phytocompounds","volume":"5","author":"Tesse","year":"2018","journal-title":"Front. Mol. Biosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbamem.2005.11.006","article-title":"Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction","volume":"1758","author":"Baum","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fchem.2018.00238","article-title":"The Emerging Role of microRNAs in Aquaporin Regulation","volume":"6","author":"Gomes","year":"2018","journal-title":"Front. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.molmet.2013.09.002","article-title":"Genetic and epigenetic control of metabolic health","volume":"2","author":"Schwenk","year":"2013","journal-title":"Mol. Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.molonc.2011.11.001","article-title":"Aquaporins mediate the chemoresistance of human melanoma cells to arsenite","volume":"6","author":"Gao","year":"2012","journal-title":"Mol. Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"16087","DOI":"10.1038\/cddiscovery.2016.87","article-title":"Aquaporin 3 facilitates chemoresistance in gastric cancer cells to cisplatin via autophagy","volume":"14","author":"Dong","year":"2016","journal-title":"Cell Death Discov."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1139\/bcb-2017-0162","article-title":"Knockdown of aquaporin-5 sensitizes colorectal cancer cells to 5-fluorouracil via inhibition of the Wnt\u2013\u03b2-catenin signaling pathway","volume":"96","author":"Li","year":"2018","journal-title":"Biochem. Cell Biol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/20\/5052\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:25:25Z","timestamp":1760189125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/20\/5052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":124,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["ijms20205052"],"URL":"https:\/\/doi.org\/10.3390\/ijms20205052","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,11]]}}}