{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:50:08Z","timestamp":1790052608201,"version":"4.0.1"},"reference-count":362,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ageing is an inevitable fundamental process for people and is their greatest risk factor for neurodegenerative disease. The ageing processes bring changes in cells that can drive the organisms to experience loss of nutrient sensing, disrupted cellular functions, increased oxidative stress, loss of cellular homeostasis, genomic instability, accumulation of misfolded protein, impaired cellular defenses and telomere shortening. Perturbation of these vital cellular processes in neuronal cells can lead to life threatening neurological disorders like Alzheimer\u2019s Disease, Parkinson\u2019s Disease, Huntington\u2019s Disease, Lewy body dementia, etc. Alzheimer\u2019s Disease is the most frequent cause of deaths in the elderly population. Various therapeutic molecules have been designed to overcome the social, economic and health care burden caused by Alzheimer\u2019s Disease. Almost all the chemical compounds in clinical practice have been found to treat symptoms only limiting them to palliative care. The reason behind such imperfect drugs may result from the inefficiencies of the current drugs to target the cause of the disease. Here, we review the potential role of antioxidant polyphenolic compounds that could possibly be the most effective preventative strategy against Alzheimer\u2019s Disease.<\/jats:p>","DOI":"10.3390\/ijms20205090","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T12:14:05Z","timestamp":1571055245000},"page":"5090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5885-4653","authenticated-orcid":false,"given":"Sudip","family":"Dhakal","sequence":"first","affiliation":[{"name":"School of Science, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8517-3992","authenticated-orcid":false,"given":"Naufal","family":"Kushairi","sequence":"additional","affiliation":[{"name":"Mushroom Research Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia"},{"name":"Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1373-1374","authenticated-orcid":false,"given":"Chia Wei","family":"Phan","sequence":"additional","affiliation":[{"name":"Mushroom Research Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia"},{"name":"Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-7968","authenticated-orcid":false,"given":"Benu","family":"Adhikari","sequence":"additional","affiliation":[{"name":"School of Science, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikineswary","family":"Sabaratnam","sequence":"additional","affiliation":[{"name":"Mushroom Research Centre, University of Malaya, 50603 Kuala Lumpur, Malaysia"},{"name":"Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5335-7220","authenticated-orcid":false,"given":"Ian","family":"Macreadie","sequence":"additional","affiliation":[{"name":"School of Science, RMIT University, Bundoora, Victoria 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/1673-5374.177729","article-title":"Finding chemopreventatives to reduce amyloid beta in yeast","volume":"11","author":"Macreadie","year":"2016","journal-title":"Neural Regen. 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