{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:26:41Z","timestamp":1791919601652,"version":"4.3.4"},"reference-count":168,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI.<\/jats:p>","DOI":"10.3390\/ijms20205238","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T11:46:59Z","timestamp":1571831219000},"page":"5238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity"],"prefix":"10.3390","volume":"20","author":[{"given":"Daniela Maria","family":"Tanase","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700111 Iasi, Romania"},{"name":"Internal Medicine Clinic, \u201cSf. Spiridon\u201d County Clinical Emergency Hospital Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-9306","authenticated-orcid":false,"given":"Evelina Maria","family":"Gosav","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700111 Iasi, Romania"},{"name":"Internal Medicine Clinic, \u201cSf. Spiridon\u201d County Clinical Emergency Hospital Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-2887","authenticated-orcid":false,"given":"Smaranda","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700111 Iasi, Romania"},{"name":"Cardiology Clinic, \u201cProf. Dr. George I.M. Georgescu\u201d Institute of Cardiovascular Diseases, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Florida","family":"Costea","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"2nd Ophthalmology Clinic, \u201cProf. Dr. Nicolae Oblu\u201d Emergency Clinical Hospital, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Ciocoiu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9112-7039","authenticated-orcid":false,"given":"Alexandru","family":"Carauleanu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9012-5901","authenticated-orcid":false,"given":"Cristina Mihaela","family":"Lacatusu","sequence":"additional","affiliation":[{"name":"Unit of Diabetes, Nutrition and Metabolic Diseases, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Clinical Center of Diabetes, Nutrition and Metabolic Diseases, \u201cSf. 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Spiridon\u201d County Clinical Emergency Hospital Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Rezus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700111 Iasi, Romania"},{"name":"Internal Medicine Clinic, \u201cSf. Spiridon\u201d County Clinical Emergency Hospital Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2013). Global Action Plan. for the Prevention and Control. of Noncommunicable Diseases, 2013\u20132020, World Health Organization."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/S0140-6736(15)60126-X","article-title":"International Society of Nephrology\u2019s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): A human rights case for nephrology","volume":"385","author":"Mehta","year":"2015","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/bcp.12554","article-title":"Drug-induced acute kidney injury in children","volume":"80","author":"Faught","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_4","unstructured":"Tintinalli, J.E., Stapczynski, J.S., Ma, A.J., Yealy, D.M., Mecklern, G.D., and Cline, D.M. (2016). Acute kidney injury. Tintinalli\u2019s Emergency Medicine, McGraw-Hill. [8th ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.2215\/CJN.00150118","article-title":"Pharmacology behind common drug nephrotoxicities","volume":"13","author":"Perazella","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.5455\/2319-2003.ijbcp20140826","article-title":"Drug-induced nephrotoxicity","volume":"3","author":"Dhodi","year":"2014","journal-title":"Int. J. Basic Clin. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1517\/14740338.2012.691964","article-title":"Detection and management of nephrotoxicity during drug development","volume":"11","author":"Ciorciaro","year":"2012","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nbt0510-436","article-title":"Next-generation biomarkers for detecting kidney toxicity","volume":"28","author":"Bonventre","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000349962","article-title":"Implementation of novel biomarkers in the diagnosis, prognosis, and management of acute kidney Injury: Executive summary from the tenth consensus conference of the acute dialysis quality initiative (ADQI)","volume":"Volume 182","author":"McCullough","year":"2013","journal-title":"ADQI Consensus on AKI Biomarkers and Cardiorenal Syndromes"},{"key":"ref_10","first-page":"576","article-title":"Nephrotoxic Effects of Drugs Poisoning in the Modern World","volume":"41","author":"Sari","year":"2019","journal-title":"Ren. Fail."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/his.13064","article-title":"Druginduced nephropathies","volume":"70","author":"Paueksakon","year":"2017","journal-title":"Histopathology"},{"key":"ref_12","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kellum","year":"2012","journal-title":"Kidney Int. Suppl."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/ki.2013.374","article-title":"Potential use of biomarkers in acute kidney injury: Report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference","volume":"85","author":"Murray","year":"2014","journal-title":"Kidney Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1517\/17425255.2010.497140","article-title":"Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs","volume":"6","author":"Nagai","year":"2010","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4062\/biomolther.2012.20.3.268","article-title":"Drug-Induced Nephrotoxicity and Its Biomarkers","volume":"20","author":"Kim","year":"2012","journal-title":"Biomol. Ther"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"967826","DOI":"10.1155\/2014\/967826","article-title":"Pathophysiology of cisplatin-induced acute kidney injury","volume":"2014","author":"Ozkok","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/ndt\/gfh826","article-title":"Renal toxicity of oxaliplatin","volume":"20","author":"Labaye","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s12032-009-9263-3","article-title":"Acute renal failure related to oxaliplatin-induced intravascular hemolysis","volume":"27","author":"Ulusakarya","year":"2010","journal-title":"Med. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1177\/1060028014526160","article-title":"Oxaliplatin-induced renal tubular vacuolization","volume":"48","author":"Sarbaz","year":"2014","journal-title":"Ann. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"De Broe, M., Porter, G., Bennett, W., and Deray, G. (2008). Anticancer drugs. Clinical Nephrotoxins Renal Injury from Drug and Chemicals, Springer Scientific. [3rd ed.].","DOI":"10.1007\/978-0-387-84843-3"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.1128\/JVI.72.8.6621-6628.1998","article-title":"The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor","volume":"72","author":"Feigelstock","year":"1998","journal-title":"J. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/0192623310362244","article-title":"Kidney injury molecule-1 expression in rat proximal tubule after treatment with segment-specific nephrotoxicants: A tool for early screening of potential kidney toxicity","volume":"38","author":"Chiusolo","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nbt.1623","article-title":"Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies","volume":"28","author":"Vaidya","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/1354750X.2011.613123","article-title":"Comparison of the course of biomarker changes and kidney injury in a rat model of drug-induced acute kidney injury","volume":"16","author":"Sasaki","year":"2011","journal-title":"Biomarkers"},{"key":"ref_25","unstructured":"(2019, July 26). [Internet] FDA, Available online: http:\/\/www.fda.gov\/bbs\/topics\/NEWS\/2008 \/NEW01850.html."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nbt.1625","article-title":"Renal biomarker qualification submission: A dialog between the FDA-EMEA and Predictive Safety Testing Consortium","volume":"28","author":"Dieterle","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/toxsci\/kfr112","article-title":"Nephrotoxicity","volume":"122","author":"Harpur","year":"2011","journal-title":"Toxicol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1074\/jbc.273.7.4135","article-title":"Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury","volume":"273","author":"Ichimura","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1093\/nar\/22.25.5640","article-title":"Identifying differences in mRNA expression by representational difference analysis of cDNA","volume":"22","author":"Hubank","year":"1994","journal-title":"Nucl. Acids Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0065-2776(06)91006-2","article-title":"TIM family of genes in immunity and tolerance","volume":"91","author":"Kuchroo","year":"2006","journal-title":"Adv. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1093\/ndt\/gfp010","article-title":"Kidney injury molecule-1 (KIM-1), \u201cA urinary biomarker and much more\u201d","volume":"24","author":"Bonventre","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/path.2175","article-title":"Tubular kidney injury molecule-1 (KIM-1) in human renal disease","volume":"212","author":"Bailly","year":"2007","journal-title":"J. Pathol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"39739","DOI":"10.1074\/jbc.M200562200","article-title":"Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration","volume":"277","author":"Bailly","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/jcp.24267","article-title":"Kidney injury molecule-1: More than just an injury marker of tubular epithelial cells?","volume":"228","author":"Lim","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/0886022X.2014.996843","article-title":"Renoprotectiveeffect of berberine via intonation on apoptosis andmitochondrial-dependent pathway in renal ischemia reperfusion-induced mutilation","volume":"37","author":"Visnagri","year":"2015","journal-title":"Ren. Fail."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/MCC.0b013e32834008d3","article-title":"Kidney injury molecule-1","volume":"16","author":"Bonventre","year":"2010","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"44059","DOI":"10.18632\/oncotarget.6623","article-title":"KIM-1\/TIM-1 in proximal tubular cell immune response","volume":"6","author":"Brooks","year":"2015","journal-title":"Oncotarget"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.15252\/embj.201489838","article-title":"KIM-1-\/TIM-1-mediated phagocytosis links ATG5-\/ULK1-dependent clearance of apoptotic cells to antigen presentation","volume":"34","author":"Brooks","year":"2015","journal-title":"EMBO J."},{"key":"ref_39","first-page":"361078","article-title":"Role of new biomarkers: Functional andstructural damage","volume":"2013","author":"Tsigou","year":"2013","journal-title":"Crit. Care Res. Pract."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/ki.2012.11","article-title":"Kim-1\/ Tim-1 and immune cells: Shifting sands","volume":"81","author":"Ichimura","year":"2012","journal-title":"Kidney Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1517\/17425255.2015.1083011","article-title":"Biomarkers of drug-induced acute kidney injury in the adult","volume":"11","author":"Gobe","year":"2015","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref_42","first-page":"456","article-title":"Urinary kidney injury molecule-1 levels as a marker of early kidney injury in hypertensive patients","volume":"68","author":"Kadioglu","year":"2016","journal-title":"Minerva Urol. Nefrol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1681\/ASN.2013070758","article-title":"Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes","volume":"25","author":"Sabbisetti","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/ncpneph0828","article-title":"Kidney injury molecule-1 as a biomarker of acute kidney injury in renal transplant recipients","volume":"4","author":"Perco","year":"2008","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"854070","DOI":"10.1155\/2015\/854070","article-title":"Kidney injury molecule-1 and cardiovascular diseases: From basic science to clinical practice","volume":"2015","author":"Medic","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Shao, X., Tian, L., Xu, W., Zhang, Z., Wang, C., Qi, C., Ni, Z., and Mou, S. (2014). Diagnostic Value of Urinary Kidney Injury Molecule 1 for Acute Kidney Injury: A Meta-Analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0084131"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Schulz, C.A., Engstr\u00f6m, G., Nilsson, J., Almgren, P., Petkovic, M., Christensson, A., Nilsson, P.M., Melander, O., and Melander, M.O. (2019). Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years. Nephrol. Dial. Transplant., 1\u20139.","DOI":"10.1093\/ndt\/gfy382"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ki.2013.333","article-title":"Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery","volume":"85","author":"John","year":"2014","journal-title":"Kidney Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/0192623311432436","article-title":"Evaluation of novel urinary renal biomarkers: Bio- logical variation and reference change values","volume":"40","author":"Pinches","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2131\/jts.42.615","article-title":"Sex differences in the excretion levels of traditional and novel urinary biomarkers of nephrotoxicity in rats","volume":"42","author":"Tsuji","year":"2017","journal-title":"J. Toxicol. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.jacc.2011.08.017","article-title":"Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass","volume":"58","author":"Krawczeski","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sun, I.O., Shin, S.H., Cho, A.Y., Yoon, H.J., Chang, M.Y., and Lee, K.Y. (2017). Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175890"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1159\/000471866","article-title":"Bone Marrow\u2013Derived Mononuclear Cell Therapy Accelerates Renal Ischemia- Reperfusion Injury Recovery by Apoptotic Related Molecules","volume":"41","author":"Ornellas","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.2215\/CJN.01910310","article-title":"Urinary expression of kidney injury markers in renal transplant recipients","volume":"5","author":"Szeto","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1464-5491.2010.03083.x","article-title":"Neutrophil gelatinase-associated lipocalin (ngal) and kidney injury molecule 1 (kim1) in patients with diabetic nephropathy: A cross-sectional study and the effects of lisinopril","volume":"27","author":"Nielsen","year":"2010","journal-title":"Diabet. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11255-013-0522-z","article-title":"Urine kidney injury molecule-1: A potential non-invasive biomarker for patients with renal cell carcinoma","volume":"46","author":"Zhang","year":"2014","journal-title":"Int. Urol. Nephrol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1208\/s12248-011-9301-x","article-title":"Biomarkers for drug-induced renal damage and nephrotoxicity-an overview for applied toxicology","volume":"13","author":"Fuchs","year":"2011","journal-title":"AAPS J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/bcp.12282","article-title":"Urinary kidney biomarkers for early detection of nephrotoxicity in clinical drug development","volume":"77","author":"Moerland","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/theoncologist.2010-S3-03","article-title":"Induction chemotherapy for head and neck cancer: Recent data","volume":"15","author":"Vokes","year":"2010","journal-title":"Oncologist"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1756-8722-4-35","article-title":"Chemotherapy in advanced bladder cancer: Current status and future","volume":"4","author":"Ismaili","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1634\/theoncologist.2010-0087","article-title":"Endometrial carcinoma: A review of chemotherapy, drug resistance, and the search for new agents","volume":"15","author":"Moxley","year":"2010","journal-title":"Oncologist"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"A17","DOI":"10.1186\/1897-4287-10-S4-A17","article-title":"Cisplatin in breast cancer treatment in BRCA1 carriers","volume":"10","author":"Gronwald","year":"2012","journal-title":"Hered Cancer Clin. Pract."},{"key":"ref_63","first-page":"S389","article-title":"Treatment of non-small cell lung cancer (NSCLC)","volume":"5","author":"Zarogoulidis","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"ref_64","first-page":"S565","article-title":"Chemotherapy advances in small-cell lung cancer","volume":"5","author":"Chan","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lerma, E.V., Sparks, M.A., and Topf, J. (2018). Medications. Nephrology Secrets, Elsevier. [4th ed.].","DOI":"10.1016\/B978-0-323-47871-7.00003-4"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.2215\/CJN.02780312","article-title":"Onco-nephrology: Renal toxicities of chemotherapeutic agents","volume":"7","author":"Perazella","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00204-012-0821-7","article-title":"Cisplatininduced nephrotoxicity and targets of nephroprotection: An update","volume":"86","author":"Martins","year":"2012","journal-title":"Arch. Toxicol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.3390\/toxins2112490","article-title":"Mechanisms of cisplatin nephrotoxicity","volume":"2","author":"Miller","year":"2010","journal-title":"Toxins"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"F385","DOI":"10.1152\/ajprenal.00335.2015","article-title":"Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury","volume":"310","author":"Bolisetty","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_70","unstructured":"Hughes, P.J. (2018, September 13). Pathophysiologic Mechanisms of Selected Types of Nephrotoxicity. Available online: https:\/\/emedicine.medscape.com\/ article\/1925868."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.toxrep.2016.01.006","article-title":"Nrf2 activators as potential modulators of injury in human kidney cell","volume":"3","author":"Wen","year":"2016","journal-title":"Toxicol. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"269","DOI":"10.14573\/altex.1311152","article-title":"Controversial role of gamma-glutamyl transferase activity in cisplatin nephrotoxicity","volume":"31","author":"Fliedl","year":"2014","journal-title":"ALTEX"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Gowder, S. (2013). Renal transporters and biomarkers in safety assessment. New Insights into Toxicity and Drug Testing, InTech.","DOI":"10.5772\/55886"},{"key":"ref_74","first-page":"547","article-title":"Membrane transporters as mediators of cisplatin side effects","volume":"34","author":"Ciarimboli","year":"2014","journal-title":"Anticancer Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.lfs.2017.08.028","article-title":"Magnesium co-administration decreases cisplatin-induced nephrotoxicity in the multiple cisplatin administration","volume":"189","author":"Saito","year":"2017","journal-title":"Life Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"473829","DOI":"10.6064\/2012\/473829","article-title":"Membrane Transporters as Mediators of Cisplatin Effects and Side Effects","volume":"2012","author":"Ciarimboli","year":"2012","journal-title":"Scientifica"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11010-016-2920-x","article-title":"MATE-1 modulation by kinin B1 receptor enhances cisplatin efflux from renal cells","volume":"428","author":"Estrela","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fphar.2015.00085","article-title":"Role of transporters in the distribution of platinum-based drugs","volume":"6","author":"Harrach","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s00204-015-1633-3","article-title":"DNA damage response in cisplatin-induced nephrotoxicity","volume":"89","author":"Zhu","year":"2015","journal-title":"Arch. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40620-017-0392-z","article-title":"Cisplatin nephrotoxicity: A review of the literature","volume":"31","author":"Manohar","year":"2018","journal-title":"J. Nephrol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1681\/ASN.2014080741","article-title":"A role for Tubular Necroptosis in Cisplatin-Induced AKI","volume":"26","author":"Xu","year":"2015","journal-title":"JASN"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"201367","DOI":"10.4061\/2010\/201367","article-title":"Cellular responses to Cisplatin-induced DNA damage","volume":"2010","author":"Basu","year":"2010","journal-title":"J. Nucl. Acids"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"F560","DOI":"10.1152\/ajprenal.00512.2015","article-title":"Repeated administration of low-dose cisplatin in mice induces fibrosis","volume":"310","author":"Sharp","year":"2016","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbabio.2008.10.005","article-title":"The mitochondrial p53 pathway","volume":"1787","author":"Vaseva","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"F560","DOI":"10.1152\/ajprenal.00512.2015","article-title":"Repeated administration of low-dose cisplatin in mice induces fibrosis","volume":"310","author":"Siskind","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2119\/molmed.2010.00002","article-title":"MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival","volume":"16","author":"Bhatt","year":"2010","journal-title":"Mol. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"F1347","DOI":"10.1152\/ajprenal.00648.2017","article-title":"Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic e_ects","volume":"315","author":"Nakagawa","year":"2018","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"F654","DOI":"10.1152\/ajprenal.00489.2018","article-title":"Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity","volume":"316","author":"Watanabe","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/jcmm.13926","article-title":"Gamma-secretase inhibitor DAPT mitigates cisplatin-induced acute kidney injury by suppressing Notch1 signaling","volume":"23","author":"Soni","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Zhang, W., Hou, J., Yan, X., Leng, J., Li, R., Zhang, J., Xing, J., Chen, C., Wang, Z., and Li, W. (2018). Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-kappaB-Mediated Inflammation and PI3K\/Akt\/Apoptosis Signaling Pathways. Nutrients, 10.","DOI":"10.3390\/nu10091328"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5350161","DOI":"10.1155\/2017\/5350161","article-title":"Total Coumarins from Hydrangea paniculata Protect against Cisplatin-Induced Acute Kidney Damage in Mice by Suppressing Renal Inflammation and Apoptosis","volume":"2017","author":"Sen","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-alpha signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"F248","DOI":"10.1152\/ajprenal.00433.2015","article-title":"Suramin protects from cisplatin-induced acute kidney injury","volume":"310","author":"Dupre","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1194\/jlr.M076745","article-title":"Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury","volume":"58","author":"Dupre","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5301\/jn.5000177","article-title":"Erythropoieti protects against cisplatin-induced nephrotoxicity by attenuating endoplasmic reticulum stress-induced apoptosis","volume":"26","author":"Kong","year":"2013","journal-title":"J. Nephrol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.redox.2018.09.020","article-title":"Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease","volume":"20","author":"Mapuskar","year":"2019","journal-title":"Redox Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1042\/CS20171417","article-title":"Blockade of histone deacetylase 6 protects against cisplatin-induced acute kidney injury","volume":"132","author":"Tang","year":"2018","journal-title":"Clin. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41467-017-00937-2","article-title":"Human mesenchymal stromal cells transplanted into mice stimulate renal tubular cells and enhance mitochondrial function","volume":"8","author":"Perico","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12929-019-0518-9","article-title":"Molecular mechanisms of cisplatin-induced nephrotoxicity: A balance on the knife edge between renoprotection and tumor toxicity","volume":"26","author":"Volarevic","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Hosohata, K. (2016). Role of oxidative stress in drug-induced kidney injury. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111826"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5935\/0101-2800.20130052","article-title":"Acute nephrotoxicity of cisplatin: Molecular mechanisms","volume":"35","author":"Peres","year":"2013","journal-title":"J. Bras. Nefrol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3389\/fphar.2018.01268","article-title":"Nephroprotective E_ects of Benzyl Isothiocyanate and Resveratrol Against Cisplatin-Induced Oxidative Stress and Inflammation","volume":"9","author":"Ibrahim","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Qi, Z., Li, Z., Li, W., Liu, Y., Wang, C., Lin, H., Liu, J., and Li, P. (2018). Pseudoginsengenin DQ Exhibits Therapeutic E_ects in Cisplatin-Induced Acute Kidney Injury via Sirt1\/NF-kappaB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice. Molecules, 23.","DOI":"10.3390\/molecules23113038"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1159\/000492562","article-title":"Kidney Protection E_ect of Ginsenoside Re and Its Underlying Mechanisms on Cisplatin-Induced Kidney Injury","volume":"48","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4048390","DOI":"10.1155\/2016\/4048390","article-title":"New Therapeutic Concept of NAD Redox Balance for Cisplatin Nephrotoxicity","volume":"2016","author":"Oh","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e1394","DOI":"10.1038\/cddis.2014.355","article-title":"Magmas functions as a ROS regulator and provides cytoprotection against oxidative stress-mediated damages","volume":"5","author":"Srivastava","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1681\/ASN.2015111277","article-title":"Mitochondria in Kidney Injury: When the Power Plant Fails","volume":"27","author":"Tang","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MNH.0000000000000228","article-title":"Mitochondria as therapeutic targets in acute kidney injury","volume":"25","author":"Hall","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/ki.2013.330","article-title":"Pharmacological activation of NQO1 increases NAD(+) levels and attenuates cisplatin-mediated acute kidney injury in mice","volume":"85","author":"Oh","year":"2014","journal-title":"Kidney Int."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1462802","DOI":"10.1155\/2018\/1462802","article-title":"Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges","volume":"2018","author":"Perse","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/sj.ki.5002242","article-title":"Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells","volume":"72","author":"Zhang","year":"2007","journal-title":"Kidney Int."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.freeradbiomed.2011.08.006","article-title":"Poly (ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury","volume":"51","author":"Mukhopadhyay","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.kint.2016.11.026","article-title":"M1 macrophage triggered by Mincle leads to a deterioration of acute kidney injury","volume":"91","author":"Inoue","year":"2017","journal-title":"Kidney Int."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1681\/ASN.2011020182","article-title":"Mast cells mediate acute kidney injury through the production of TNF","volume":"22","author":"Summers","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/0886022X.2018.1456938","article-title":"Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding","volume":"40","author":"Soni","year":"2018","journal-title":"Ren. Fail."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1172\/JCI75417","article-title":"KIM-1-mediated phagocytosis reduces acute injury to the kidney","volume":"125","author":"Yang","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000363678","article-title":"Recovery from Acute Kidney Injury: The Role of Biomarkers","volume":"127","author":"Endre","year":"2014","journal-title":"Nephron Clin. Pract."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1159\/000447937","article-title":"Early Predictors of Acute Kidney Injury: A Narrative Review","volume":"41","author":"Liu","year":"2016","journal-title":"Kidney Blood Press. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1159\/000452402","article-title":"Acute Kidney Injury Risk Assessment and the Nephrology Rapid Response Team, Role of the Nephrologist in Multidisciplinary Management of AKI","volume":"43","author":"Rosner","year":"2017","journal-title":"Blood Purif."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"F899","DOI":"10.1152\/ajprenal.00362.2014","article-title":"Signaling Rho-kinase mediates inflammation and apoptosis in T cells and renal tubules in cisplatin nephrotoxicity","volume":"308","author":"Nozaki","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2310\/JIM.0b013e31828233a8","article-title":"Urinary tubular proteinbased biomarkers in the rodent model of cisplatin nephrotoxicity: A comparative analysis of serum creatinine, renal histology, and urinary KIM-1, NGAL, and NAG in the initiation, maintenance, and recovery phases of acute kidney injury","volume":"61","author":"Sinha","year":"2013","journal-title":"J. Investig. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00280-015-2880-y","article-title":"Urinary kidney injury molecule-1 and monocyte chemotactic protein-1 are noninvasive biomarkers of cisplatin-induced nephrotoxicity in lung cancer patients","volume":"76","author":"Shinke","year":"2015","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/COC.0000000000000301","article-title":"Retrospective analysis of cisplatin nephrotoxicity in patients with head and neck Cancer receiving outpatient treatment with concurrent high-dose cisplatin and radiotherapy","volume":"41","author":"Faig","year":"2018","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.7314\/APJCP.2015.16.3.1117","article-title":"Incidence of cisplatin-induced nephrotoxicity and associated factors among cancer patients in Indonesia","volume":"16","author":"Prasaja","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1177\/0004563214528312","article-title":"Does the kidney injury molecule-1 predict cisplatin-induced kidney injury in early stage?","volume":"52","author":"Tekce","year":"2015","journal-title":"Ann. Clin. Biochem."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Abdelsalam, M., Elmorsy, E., and Abdelwahab, H. (2018). Urinary biomarkers for early detection of platinum based drugs induced nephrotoxicity. BMC Nephrol., 19.","DOI":"10.1186\/s12882-018-1022-2"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Oh, S.M., Park, G., Lee, S.H., Seo, C.S., Shin, H.K., and Oh, D.S. (2017). Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposure times. BMC Complement. Altern. Med., 17.","DOI":"10.1186\/s12906-017-2055-y"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2054358117690338","article-title":"Design and Methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood\/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: A Prospective Observational Cohort Study","volume":"4","author":"McMahon","year":"2017","journal-title":"Can. J. Kidney Health Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"9658230","DOI":"10.1155\/2018\/9658230","article-title":"Renoprotective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Rats","volume":"2018","author":"Salem","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Jun, D.Y., Kim, S.Y., Na, J.C., Lee, H.H., Kim, J., Yoon, Y.E., Hong, S.J., and Han, W.K. (2018). Tubular organotypic culture model of human kidney. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0206447"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e00148","DOI":"10.1002\/prp2.148","article-title":"Evaluation of biomarkers for in vitro prediction of druginduced nephrotoxicity: Comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells","volume":"3","author":"Huang","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/toxsci\/kfu130","article-title":"Loss of _(E)-Catenin Potentiates Cisplatin-Induced Nephrotoxicity via Increasing Apoptosis in Renal Tubular Epithelial Cells","volume":"141","author":"Wang","year":"2014","journal-title":"Toxicol. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000335579","article-title":"Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease","volume":"35","author":"Gardiner","year":"2012","journal-title":"Am. J. Nephrol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000469715","article-title":"Dexamethasone Modifies Cystatin C-Based Diagnosis of Acute Kidney Injury During Cisplatin-Based Chemotherapy","volume":"42","author":"Timothy","year":"2017","journal-title":"Kidney Blood Press. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3140680","DOI":"10.1155\/2017\/3140680","article-title":"Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death","volume":"2017","author":"Meng","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1039\/C5TX00497G","article-title":"Cisplatin nephrotoxicity in male beagle dogs: Next-generation protein kidney safety biomarker tissue expression and related changes in urine","volume":"5","author":"McDuffie","year":"2016","journal-title":"Toxicol. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.bcp.2012.12.019","article-title":"Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity","volume":"15","author":"Nishihara","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"DesRochers, T.M., Suter, L., Roth, A., and Kaplan, D.L. (2013). Bioengineered 3D Human Kidney Tissue, a Platform for the Determination of Nephrotoxicity. PLoS ONE, 8.","DOI":"10.1371\/annotation\/fb32f1b8-7397-40be-bbf9-b80e67763043"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Rysz, J., Gluba-Brz\u00f3zka, A., Franczyk, B., Jab\u0142onowski, Z., and Cia\u0142kowska-Rysz, A. (2017). Novel Biomarkers in the Diagnosis of Chronic Kidney Disease and the Prediction of Its Outcome. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081702"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1177\/0192623312444765","article-title":"Tissue Kim-1and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats","volume":"40","author":"Vinken","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1159\/000489210","article-title":"Camel Milk Ameliorates 5-Fluorouracil- Induced Renal Injury in Rats: Targeting MAPKs, NF-\u03baB and PI3K\/Akt\/eNOS Pathways","volume":"46","author":"Hany","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.toxrep.2019.02.006","article-title":"Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats","volume":"6","author":"Abdelrahman","year":"2019","journal-title":"Toxicol. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"F835","DOI":"10.1152\/ajprenal.00285.2017","article-title":"Developing better mouse models to study cisplatin-induced kidney injury","volume":"313","author":"Sharp","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1742-7843.2011.00724.x","article-title":"The effect of sildenafil on cisplatin nephrotoxicity in rats","volume":"109","author":"Ali","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.fct.2009.09.030","article-title":"Interaction of nimesulide, a cyclooxygenase- 2 inhibitor, with cisplatin in normotensive and spontaneously hypertensive rats","volume":"48","author":"Abdelrahman","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"108777","DOI":"10.1016\/j.cbi.2019.108777","article-title":"Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4\/P38 MAPK\/NF\u03ba-B signaling pathway","volume":"311","author":"Khames","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_147","first-page":"1","article-title":"Naringenin prevents doxorubicin-induced toxicity in kidney tissues by regulating the oxidative and inflammatory insult in Wistar rats","volume":"8","author":"Khan","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fct.2014.01.026","article-title":"Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats","volume":"66","author":"Rashid","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/ki.2009.96","article-title":"A rapid urine test for early detection of kidney injury","volume":"76","author":"Vaidya","year":"2009","journal-title":"Kidney Int."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/toxsci\/kfs268","article-title":"Novel Assays for Detection of Urinary KIM-1 in Mouse Models of Kidney Injury","volume":"131","author":"Sabbisetti","year":"2013","journal-title":"Toxicol. Sci."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Ragab, D., Abdallah, D.M., and El-Abhar, H.S. (2014). Cilostazol Renoprotective Effect: Modulation of PPAR-c, NGAL, KIM-1 and IL-18 Underlies Its Novel Effect in a Model of Ischemia-Reperfusion. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095313"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3727\/096504017X15140544654946","article-title":"Targeted Silencing of Kim-1 Inhibits the Growth of Clear Cell Renal Cell Carcinoma Cell Line 786-0 In Vitro and in Vivo","volume":"26","author":"Xu","year":"2018","journal-title":"Oncol. Res."},{"key":"ref_153","first-page":"57","article-title":"Prevention of cisplatin nephrotoxicity","volume":"5","author":"Hayati","year":"2016","journal-title":"J. Nephropharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1634\/theoncologist.2016-0319","article-title":"A systematic review of strategies to prevent cisplatin-induced nephrotoxicity","volume":"22","author":"Crona","year":"2017","journal-title":"Oncologist"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5812\/nephropathol.12116","article-title":"Plants antioxidants: From laboratory to clinic","volume":"2","author":"Baradaran","year":"2013","journal-title":"J. Nephropathol."},{"key":"ref_156","first-page":"S49","article-title":"The effects of vitamin E and selenium on cisplatininduced nephrotoxicity in cancer patients treated with cisplatin-based chemotherapy: A randomized, placebo-controlled study","volume":"17","author":"Hemati","year":"2012","journal-title":"J. Res. Med. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"13502","DOI":"10.1007\/s11356-019-04780-4","article-title":"The nephroprotective effects of allicin and ascorbic acid against cisplatin-induced toxicity in rats","volume":"26","author":"Abushouk","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.2174\/1389557519666190320124438","article-title":"Protective Role of Natural Products in Cisplatin-Induced Nephrotoxicity","volume":"19","author":"Ridzuan","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Cascella, M., Palma, G., Barbieri, A., Bimonte, S., Amruthraj, N.J., Muzio, M.R., Del Vecchio, V., Rea, D., Falco, M., and Luciano, A. (2017). Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies. Nutrients, 9.","DOI":"10.3390\/nu9060625"},{"key":"ref_160","first-page":"44","article-title":"The protective effect of Nigella sativa against cisplatin-induced nephrotoxicity in rats","volume":"6","author":"Hosseinian","year":"2016","journal-title":"Avicenna J. Phytomed."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00280-007-0459-y","article-title":"Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria","volume":"61","author":"Santos","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.heares.2004.08.002","article-title":"Reduction of acute cisplatin ototoxicity and nephrotoxicity in rats by oral administration of allopurinol and ebselen","volume":"201","author":"Lynch","year":"2005","journal-title":"Hear. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1200\/JCO.2008.17.2627","article-title":"American Society of Clinical Oncology 2008 clinical practice guideline update: Use of chemotherapy and radiation therapy protectants","volume":"27","author":"Hensley","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4103\/1319-2442.128528","article-title":"The protective effect of theophylline in cisplatin nephrotoxicity","volume":"25","author":"Mousavi","year":"2014","journal-title":"Saudi J. Kidney Dis. Transpl."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1248\/bpb.33.1867","article-title":"Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumoractivity","volume":"33","author":"Katsuda","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00210-018-1514-4","article-title":"Protective effects of amifostine, curcumin, and melatonin against cisplatin- induced acute kidney injury Naunyn-Schmiedeberg\u2019s","volume":"391","author":"Mercantepe","year":"2018","journal-title":"Arch. Pharmacol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"12006","DOI":"10.4238\/2015.October.5.13","article-title":"AMP-activated protein kinase regulates autophagic protection against cisplatin-induced tissue injury in the kidney","volume":"14","author":"Wei","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_168","first-page":"373","article-title":"Biomarkers of renal recovery after acute kidney injury","volume":"29","author":"Paiva","year":"2017","journal-title":"Rev. Bras. Ter. Intensiva"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/20\/5238\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:28:25Z","timestamp":1760189305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/20\/5238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,22]]},"references-count":168,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["ijms20205238"],"URL":"https:\/\/doi.org\/10.3390\/ijms20205238","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,22]]}}}