{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:02:33Z","timestamp":1774677753224,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["2Z05310"],"award-info":[{"award-number":["2Z05310"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Ministry of Health &amp; Welfare","award":["HI15C1142"],"award-info":[{"award-number":["HI15C1142"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The aim of this study was to evaluate the pharmacological efficacy of persimmon leaves in two glaucoma models, microbeads-induced ocular hypertension (OHT) and DBA\/2 mouse. Thus, we demonstrated that Ethanol Extract of Diospyros kaki (EEDK) reduced elevated intraocular pressure (IOP) in both mouse models of glaucoma by measurements with a tonometer. In particular, we revealed that retinal ganglion cell loss and optic nerve damage caused by IOP elevation were markedly diminished as assessed by TUNEL assay, H&amp;E staining, and fluorescent staining, while the expression of soluble guanylate cyclase (sGC\u03b1-1) increased, when EEDK was administered, as revealed by western blot. Moreover, the b-wave magnitude indicating functional scotopic vision was significantly improved in EEDK-administered DBA\/2 mice during the 10-week follow-up study, as observed with electroretinography. Collectively, our results suggested that EEDK could be an effective therapeutic and IOP-lowering agent for preventing and treating retinal degenerative diseases such as glaucoma.<\/jats:p>","DOI":"10.3390\/ijms20215268","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T03:20:36Z","timestamp":1571973636000},"page":"5268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Intraocular Pressure-Lowering Effect of Persimmon leaves (Diospyros kaki) in a Mouse Model of Glaucoma"],"prefix":"10.3390","volume":"20","author":[{"given":"Hong Ryul","family":"Ahn","sequence":"first","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Wook","family":"Yang","sequence":"additional","affiliation":[{"name":"T2B Infrastructure Center for Ocular disease, Department of Ophthalmology, Inje University Busan Paik Hospital, Busan 47392, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Young","family":"Kim","sequence":"additional","affiliation":[{"name":"T2B Infrastructure Center for Ocular disease, Department of Ophthalmology, Inje University Busan Paik Hospital, Busan 47392, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science, Cornell University, Ithaca, NY 14850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-0478","authenticated-orcid":false,"given":"Tae-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Pusan National University, Busan 46241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Jung","sequence":"additional","affiliation":[{"name":"Natural Products Research Center, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea"},{"name":"Department of Food Science, Cornell University, Ithaca, NY 14850, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/bs.pbr.2015.04.007","article-title":"Emerging risk factors for glaucoma onset and progression","volume":"221","author":"Blumberg","year":"2015","journal-title":"Prog. 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