{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:49:15Z","timestamp":1760240955563,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)\/colony stimulating factor 1 (CSF1) region. The first exon of this transcript from Hodgkin lymphoma cells (THOLE) starts in the predicted exon 4 of LINC01768 and is part of an endogenous retrovirus (ERV) from the HUERS-P1\/LTR8 family. High expression of THOLE was only detectable in HL cell line L-1236. The expression of THOLE in L-1236 cell is another example for ERV\/LTR-associated gene expression in HL cells. At the genome level, the HUERS-P1\/LTR8 region including THOLE is only present in Hominoidea. The influence of ERV\/LTRs on gene expression might explain the characteristic phenotype of human HL.<\/jats:p>","DOI":"10.3390\/ijms20215320","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T11:05:18Z","timestamp":1572001518000},"page":"5320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells"],"prefix":"10.3390","volume":"20","author":[{"given":"Jana","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Surgical and Conservative Pediatrics and Adolescent Medicine, Martin Luther University Halle-Wittenberg, 06097 Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Volkmer","sequence":"additional","affiliation":[{"name":"Department of Surgical and Conservative Pediatrics and Adolescent Medicine, Martin Luther University Halle-Wittenberg, 06097 Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Surgical and Conservative Pediatrics and Adolescent Medicine, Martin Luther University Halle-Wittenberg, 06097 Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4272-8887","authenticated-orcid":false,"given":"Alexander","family":"Emmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Martin Luther University Halle-Wittenberg, 06097 Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin S.","family":"Staege","sequence":"additional","affiliation":[{"name":"Department of Surgical and Conservative Pediatrics and Adolescent Medicine, Martin Luther University Halle-Wittenberg, 06097 Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/eji.1830190828","article-title":"Species specificity of interleukin 2 binding to individual receptor components","volume":"19","author":"Collins","year":"1989","journal-title":"Eur. 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