{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:10:56Z","timestamp":1788577856301,"version":"build-2803163510"},"reference-count":167,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01945"],"award-info":[{"award-number":["PI17\/01945"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ovarian cancer and endometriosis are two distinct gynaecological conditions that share many biological aspects incuding proliferation, invasion of surrounding tissue, inflammation, inhibition of apoptosis, deregulation of angiogenesis and the ability to spread at a distance. miRNAs are small non-coding RNAs (19\u201322 nt) that act as post-transcriptional modulators of gene expression and are involved in several of the aforementioned processes. In addition, a growing body of evidence supports the contribution of oxidative stress (OS) to these gynaecological diseases: increased peritoneal OS due to the decomposition of retrograde menstruation blood facilitates both endometriotic lesion development and fallopian tube malignant transformation leading to high-grade serous ovarian cancer (HGSOC). Furthermore, as HGSOC develops, increased OS levels are associated with chemoresistance. Finally, continued bleeding within ovarian endometrioma raises OS levels and contributes to the development of endometriosis-associated ovarian cancer (EAOC). Therefore, this review aims to address the need for a better understanding of the dialogue between miRNAs and oxidative stress in the pathophysiology of ovarian conditions: endometriosis, EAOC and HGSOC.<\/jats:p>","DOI":"10.3390\/ijms20215322","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T11:05:18Z","timestamp":1572001518000},"page":"5322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis"],"prefix":"10.3390","volume":"20","author":[{"given":"Josep","family":"Mar\u00ed-Alexandre","sequence":"first","affiliation":[{"name":"Research Laboratory in Biomarkers in Reproduction, Gynaecology and Obstetrics, Fundaci\u00f3n Hospital General Universitario de Valencia, 46014 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Pell\u00edn","family":"Carcel\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universitat de Val\u00e8ncia, 46010 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Agababyan","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomarkers in Reproduction, Gynaecology and Obstetrics, Fundaci\u00f3n Hospital General Universitario de Valencia, 46014 Val\u00e8ncia, Spain"},{"name":"Comprehensive Multidisciplinary Endometriosis Unit, Consorcio Hospital General Universitario de Val\u00e8ncia, 46014 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2996-2505","authenticated-orcid":false,"given":"Andrea","family":"Moreno-Manuel","sequence":"additional","affiliation":[{"name":"Molecular Oncology Laboratory, Fundaci\u00f3n para la Investigaci\u00f3n del Hospital General Universitario de Val\u00e8ncia, 46014, Val\u00e8ncia, Spain"},{"name":"TRIAL Mixed Unit, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe-Fundaci\u00f3n para la Investigaci\u00f3n del Hospital General Universitario de Val\u00e8ncia, 46014 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Garc\u00eda-Oms","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomarkers in Reproduction, Gynaecology and Obstetrics, Fundaci\u00f3n Hospital General Universitario de Valencia, 46014 Val\u00e8ncia, Spain"},{"name":"Comprehensive Multidisciplinary Endometriosis Unit, Consorcio Hospital General Universitario de Val\u00e8ncia, 46014 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-174X","authenticated-orcid":false,"given":"Silvia","family":"Calabuig-Fari\u00f1as","sequence":"additional","affiliation":[{"name":"Molecular Oncology Laboratory, Fundaci\u00f3n para la Investigaci\u00f3n del Hospital General Universitario de Val\u00e8ncia, 46014, Val\u00e8ncia, Spain"},{"name":"TRIAL Mixed Unit, Centro de Investigaci\u00f3n Pr\u00edncipe Felipe-Fundaci\u00f3n para la Investigaci\u00f3n del Hospital General Universitario de Val\u00e8ncia, 46014 Val\u00e8ncia, Spain"},{"name":"Department of Pathology, Universitat de Val\u00e8ncia, 46010 Val\u00e8ncia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en C\u00e1ncer (CIBERONC), 46014 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3992-1929","authenticated-orcid":false,"given":"Juan","family":"Gilabert-Estell\u00e9s","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomarkers in Reproduction, Gynaecology and Obstetrics, Fundaci\u00f3n Hospital General Universitario de Valencia, 46014 Val\u00e8ncia, Spain"},{"name":"Comprehensive Multidisciplinary Endometriosis Unit, Consorcio Hospital General Universitario de Val\u00e8ncia, 46014 Val\u00e8ncia, Spain"},{"name":"Department of Paediatrics, Obstetrics and Gynaecology, University of Val\u00e8ncia, 46010 Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.fertnstert.2016.07.1075","article-title":"Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis","volume":"106","author":"Donnez","year":"2016","journal-title":"Fertil. 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