{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:21:30Z","timestamp":1790738490690,"version":"4.1.0"},"reference-count":130,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Ministry of Research and Innovation, PCCDI - UEFISCDI","award":["PN-III-P1-1.2-PCCDI-2017-0833\/ 68\/2018"],"award-info":[{"award-number":["PN-III-P1-1.2-PCCDI-2017-0833\/ 68\/2018"]}]},{"name":"Competitiveness Operational Program 2014\u20132020, co-financed by the European Funds for Regional Development and Romanian Government funds","award":["POC 146\/2016"],"award-info":[{"award-number":["POC 146\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>G-coupled protein receptors (GCPR) involve several signaling pathways, some of them being coupled with intracellular calcium (Ca2+) mobilization. GPCRs were involved in migration, invasion and metastasis of different types of cancers, including ovarian cancer. Many studies have discussed the essential contribution of GPCRs activated by steroid hormones in ovarian cancer. However, ovarian cancer is also associated with altered signals coming from the nervous system, the immune system or the inflammatory environment, in which GPCRs are \u2018sensing\u2019 these molecular signals. Many studies have been oriented so far on ovarian cell lines (most of them being of human cell lines), and only few studies based on animal models or clinical studies have been devoted to the expression changes or functional role of GPCRs in ovarian cancer. In this paper, we review the alterations of GPCRs activated by neurotransmitters (muscarinic receptors, serotonin receptors, dopamine receptors, adrenoceptors) or inflammation-associated molecules (bradykinin receptors, histamine receptors, chemokine receptors) in ovarian cancer and we discuss their potential as histological biomarkers.<\/jats:p>","DOI":"10.3390\/ijms20225568","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T11:30:19Z","timestamp":1573212619000},"page":"5568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["G Protein-Coupled Receptors (GPCRs)-Mediated Calcium Signaling in Ovarian Cancer: Focus on GPCRs activated by Neurotransmitters and Inflammation-Associated Molecules"],"prefix":"10.3390","volume":"20","author":[{"given":"Drago\u0219-Valentin","family":"Predescu","sequence":"first","affiliation":[{"name":"Department of General Surgery, Sf. Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy, 37-39 Ion Mihalache Blvd., 011172 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-4880","authenticated-orcid":false,"given":"Sanda Maria","family":"Cre\u021boiu","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drago\u0219","family":"Cre\u021boiu","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Fetal Medicine Excellence Research Center, Alessandrescu-Rusescu National Institute of Mother and Child Health, Polizu Clinical Hospital, 38-52 Gh. Polizu Street, 020395 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Alexandra","family":"Pavelescu","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolae","family":"Suciu","sequence":"additional","affiliation":[{"name":"Fetal Medicine Excellence Research Center, Alessandrescu-Rusescu National Institute of Mother and Child Health, Polizu Clinical Hospital, 38-52 Gh. Polizu Street, 020395 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Alessandrescu-Rusescu National Institute of Mother and Child Health, Polizu Clinical Hospital, 38-52 Gh. Polizu Street, 020395 Bucharest, Romania"},{"name":"Division of Obstetrics and Gynecology and Neonatology, Carol Davila University of Medicine and Pharmacy, Polizu Clinical Hospital, 38-52 Gh. Polizu Street, 020395 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4421-2163","authenticated-orcid":false,"given":"Beatrice Mihaela","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independen\u0163ei, 050095 Bucharest, Romania"},{"name":"Life, Environmental and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB), University of Bucharest, 91-95 Splaiul Independen\u0163ei, 050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silviu-Cristian","family":"Voinea","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Prof. Dr. Alexandru Trestioreanu Oncology Institute, Carol Davila University of Medicine and Pharmacy, 252 Fundeni Rd., 022328 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/1874467210902030237","article-title":"G protein--mediated signaling: Same receptor, multiple effectors","volume":"2","author":"Woehler","year":"2009","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/prot.10362","article-title":"Structure-based identification of binding sites, native ligands and potential inhibitors for G-protein coupled receptors","volume":"51","author":"Cavasotto","year":"2003","journal-title":"Proteins"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.tips.2007.06.012","article-title":"Modulating G-protein-coupled receptors: From traditional pharmacology to allosterics","volume":"28","author":"Gilchrist","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/aps.2011.183","article-title":"GPCRs and cancer","volume":"33","author":"Lappano","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bar-Shavit, R., Maoz, M., Kancharla, A., Nag, J.K., Agranovich, D., Grisaru-Granovsky, S., and Uziely, B. (2016). G Protein-Coupled Receptors in Cancer. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17081320"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.2741\/2805","article-title":"Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer","volume":"13","author":"Bhola","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.tips.2011.04.002","article-title":"Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms: Out of the shadow?","volume":"32","author":"Pyne","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wang, Z. (2016). Transactivation of Epidermal Growth Factor Receptor by G Protein-Coupled Receptors: Recent Progress, Challenges and Future Research. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17010095"},{"key":"ref_9","first-page":"171","article-title":"High-affinity binding of peptide agonists to the human B1 bradykinin receptor depends on interaction between the peptide N-terminal L-lysine and the fourth extracellular domain of the receptor","volume":"57","author":"Fathy","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.peptides.2012.02.007","article-title":"N-terminal extended conjugates of the agonists and antagonists of both bradykinin receptor subtypes: Structure-activity relationship, cell imaging using ligands conjugated with fluorophores and prospect for functionally active cargoes","volume":"34","author":"Gera","year":"2012","journal-title":"Peptides"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jcp.21246","article-title":"Mitogenic signaling pathways induced by G protein-coupled receptors","volume":"213","author":"Rozengurt","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrd3320","article-title":"G protein-coupled receptors: Novel targets for drug discovery in cancer","volume":"10","author":"Lappano","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cellsig.2017.09.005","article-title":"GPCRs: Emerging anti-cancer drug targets","volume":"41","author":"McDonald","year":"2018","journal-title":"Cell. Signal."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fendo.2017.00066","article-title":"The Role of Endocrine G Protein-Coupled Receptors in Ovarian Cancer Progression","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1001\/jama.285.11.1460","article-title":"Estrogen replacement therapy and ovarian cancer mortality in a large prospective study of US women","volume":"285","author":"Rodriguez","year":"2001","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ygyno.2009.05.015","article-title":"GPR30 predicts poor survival for ovarian cancer","volume":"114","author":"Smith","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-013-1579-9","article-title":"The novel estrogen receptor GPER regulates the migration and invasion of ovarian cancer cells","volume":"378","author":"Yan","year":"2013","journal-title":"Mol. Cell Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1757-2215-6-51","article-title":"GPER-1 acts as a tumor suppressor in ovarian cancer","volume":"6","author":"Ignatov","year":"2013","journal-title":"J. Ovarian Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Heublein, S., Mayr, D., Vrekoussis, T., Friese, K., Hofmann, S.S., Jeschke, U., and Lenhard, M. (2013). The G-protein coupled estrogen receptor (GPER\/GPR30) is a gonadotropin receptor dependent positive prognosticator in ovarian carcinoma patients. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071791"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/cbin.10243","article-title":"A novel estrogen receptor GPER mediates proliferation induced by 17beta-estradiol and selective GPER agonist G-1 in estrogen receptor alpha (ERalpha)-negative ovarian cancer cells","volume":"38","author":"Liu","year":"2014","journal-title":"Cell Biol. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/cbf.3154","article-title":"Role of GPER on proliferation, migration and invasion in ligand-independent manner in human ovarian cancer cell line SKOV3","volume":"33","author":"Yan","year":"2015","journal-title":"Cell Biochem. Funct."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/0300060517717625","article-title":"Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer","volume":"46","author":"Zhu","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12020-010-9363-z","article-title":"G protein-coupled receptor 30 in tumor development","volume":"38","author":"Wang","year":"2010","journal-title":"Endocrine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29395","DOI":"10.18632\/oncotarget.12561","article-title":"The role of the androgen receptor in ovarian cancer carcinogenesis and its clinical implications","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mizushima, T., and Miyamoto, H. (2019). The Role of Androgen Receptor Signaling in Ovarian Cancer. Cells, 8.","DOI":"10.3390\/cells8020176"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/sj.bjc.6605153","article-title":"Androgen-related expression of G-proteins in ovarian cancer","volume":"101","author":"Sheach","year":"2009","journal-title":"Br. J. Cancer."},{"key":"ref_27","unstructured":"Willis, R.A. (1973). The Spread of Tumors in the Human Body, Butterworths. [3rd ed.]."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.3892\/ol.2013.1168","article-title":"Role of the nervous system in cancer metastasis","volume":"5","author":"Li","year":"2013","journal-title":"Oncol. Lett."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.21037\/atm.2018.01.01","article-title":"Tumor progression: The neuronal input","volume":"6","author":"Arese","year":"2018","journal-title":"Ann. Transl Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11481-012-9395-7","article-title":"Neurotransmitters as regulators of tumor angiogenesis and immunity: The role of catecholamines","volume":"8","author":"Sarkar","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.celrep.2019.03.036","article-title":"Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer","volume":"27","author":"Nguyen","year":"2019","journal-title":"Cell Rep."},{"key":"ref_32","first-page":"369","article-title":"Stress hormone-mediated invasion of ovarian cancer cells. Clin","volume":"12","author":"Sood","year":"2006","journal-title":"Cancer Res."},{"key":"ref_33","first-page":"17","article-title":"Neurotransmitters and their Receptors as the Upstream Regulators of the Most Common Human Cancers and their Stem Cells","volume":"3","author":"Schuller","year":"2018","journal-title":"J. Neurol. Neuromed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/156652410791316968","article-title":"Molecular pathways linking inflammation and cancer","volume":"10","author":"Mantovani","year":"2010","journal-title":"Curr. Mol. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12199-018-0740-1","article-title":"Inflammation and cancer","volume":"23","author":"Murata","year":"2018","journal-title":"Environ. Health Prev Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/jemt.10228","article-title":"Ovarian acetylcholine and muscarinic receptors: Hints of a novel intrinsic ovarian regulatory system","volume":"59","author":"Mayerhofer","year":"2002","journal-title":"Microsc. Res. Tech."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"30129","DOI":"10.1038\/srep30129","article-title":"In vivo blockade of acetylcholinesterase increases intraovarian acetylcholine and enhances follicular development and fertility in the rat","volume":"6","author":"Urra","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_39","first-page":"1744","article-title":"Functional and molecular characterization of a muscarinic receptor type and evidence for expression of choline-acetyltransferase and vesicular acetylcholine transporter in human granulosa\u2013luteal cells","volume":"84","author":"Fritz","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s12020-014-0524-3","article-title":"Ovulation requires the activation on proestrus of M1 muscarinic receptors in the left ovary","volume":"49","author":"Cruz","year":"2015","journal-title":"Endocrine"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1124\/mol.117.109678","article-title":"Teaching an old drug new tricks: Agonism, antagonism, and biased signaling of pilocarpine through M3 muscarinic acetylcholine receptor","volume":"92","author":"Pronin","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jsbmb.2014.02.012","article-title":"Effects of ovarian hormone treatment on the gene expression of muscarinic acetylcholine receptors in the ovariectomized rat myometrium","volume":"143","author":"Yasuda","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/gyno.2002.6597","article-title":"Muscarinic receptors in cell lines from ovarian carcinoma: Negative correlation with survival of patients","volume":"85","author":"Oppitz","year":"2002","journal-title":"Gynecol. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/0959-8049(93)90078-T","article-title":"Characterisation of muscarinic cholinergic receptors in human ovaries, ovarian tumours and tumour cell lines","volume":"29A","author":"Batra","year":"1993","journal-title":"Eur. J. Cancer."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/978-3-642-23274-9_19","article-title":"Muscarinic receptor agonists and antagonists: Effects on cancer","volume":"208","author":"Spindel","year":"2012","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_46","first-page":"453","article-title":"Muscarinic acetylcholine and histamine-receptor mediated calcium mobilization and cell-growth in human ovarian-cancer cells","volume":"4","author":"Popper","year":"1994","journal-title":"Int. J. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1158\/1055-9965.EPI-16-0534","article-title":"Association of Ovarian Tumor \u03b22-Adrenergic Receptor Status with Ovarian Cancer Risk Factors and Survival","volume":"25","author":"Huang","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/onc.2015.302","article-title":"Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis","volume":"35","author":"Nagaraja","year":"2016","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s12576-016-0500-1","article-title":"Altered uterine contractility in response to \u03b2-adrenoceptor agonists in ovarian cancer","volume":"67","author":"Modzelewska","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1158\/1078-0432.CCR-10-2441","article-title":"Dopamine blocks stress-mediated ovarian carcinoma growth","volume":"17","author":"Lu","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_51","first-page":"1713","article-title":"Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer. Clin","volume":"22","author":"Kang","year":"2016","journal-title":"Cancer Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"29919","DOI":"10.1074\/jbc.M611539200","article-title":"Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism","volume":"282","author":"Nilsson","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"118","DOI":"10.5317\/wjog.v5.i1.118","article-title":"Alpha1B adrenoceptor expression is a marker of reduced survival and increased tumor recurrence in patients with endometrioid ovarian cancer","volume":"5","author":"Deutsch","year":"2016","journal-title":"World J. Obstet. Gynecol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1021\/cr078224o","article-title":"Serotonin receptors","volume":"108","author":"Nichols","year":"2008","journal-title":"Chem. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0091-3057(01)00670-0","article-title":"The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels","volume":"71","author":"Young","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-3-319-66653-2_3","article-title":"Regulation of Bone Metabolism by Serotonin","volume":"1033","author":"Lavoie","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10911-013-9304-6","article-title":"Serotonin and serotonin transport in the regulation of lactation","volume":"19","author":"Marshall","year":"2014","journal-title":"J. Mammary Gland Biol. Neoplasia."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbr.2014.08.065","article-title":"Serotonin controlling feeding and satiety","volume":"277","author":"Voigt","year":"2015","journal-title":"Behav. Brain Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pbb.2013.11.008","article-title":"Pharmacology of serotonin and female sexual behavior","volume":"121","author":"Uphouse","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.patbio.2014.07.004","article-title":"Exercise and sleep in aging: Emphasis on serotonin","volume":"62","author":"Melancon","year":"2014","journal-title":"Pathol. Biol. (Paris)"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","article-title":"Serotonin, tryptophan metabolism and the brain-gut-microbiome axis","volume":"277","author":"Clarke","year":"2015","journal-title":"Behav. Brain Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00221-013-3818-4","article-title":"The role of serotonin in memory: Interactions with neurotransmitters and downstream signaling","volume":"232","author":"Seyedabadi","year":"2014","journal-title":"Exp. Brain Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2174\/1566524015666150114113411","article-title":"Serotonin and cancer: What is the link?","volume":"15","author":"Sarrouilhe","year":"2015","journal-title":"Curr. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biochi.2018.06.016","article-title":"Serotonin and human cancer: A critical view","volume":"161","author":"Sarrouilhe","year":"2019","journal-title":"Biochimie"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4172\/2471-2663.1000132","article-title":"Serotonin as a Marker to the Response of Patients with Advanced Stages of Cancer during Treatment with Chemotherapy and Radiotherapy","volume":"3","author":"Jasim","year":"2017","journal-title":"Clin. Med. Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jad.2019.02.063","article-title":"Plasma serotonin levels are associated with antidepressant response to SSRIs","volume":"250","author":"Holck","year":"2019","journal-title":"J. Affect. Disord."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"33179","DOI":"10.18632\/oncotarget.8891","article-title":"SSRI use and clinical outcomes in epithelial ovarian cancer","volume":"7","author":"Christensen","year":"2016","journal-title":"Oncotarget"},{"key":"ref_68","first-page":"1361","article-title":"Expression of serotonin receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in ovary and in ovarian tumours","volume":"32","author":"Henriksen","year":"2012","journal-title":"Anticancer Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"481","DOI":"10.55782\/ane-2007-1664","article-title":"Dopamine, learning, and reward-seeking behavior","volume":"67","year":"2007","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.neuroimage.2009.06.008","article-title":"Dopamine release during human emotional processing","volume":"47","author":"Badgaiyan","year":"2009","journal-title":"Neuroimage"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1155\/NP.2003.107","article-title":"The basal ganglia and motor control","volume":"10","author":"Groenewegen","year":"2003","journal-title":"Neural Plast."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1210\/en.2012-1602","article-title":"Dopamine regulation of gonadotropin-releasing hormone neuron excitability in male and female mice","volume":"154","author":"Liu","year":"2013","journal-title":"Endocrinology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s11481-017-9749-2","article-title":"Dopaminergic Regulation of Innate Immunity: A Review","volume":"12","author":"Pinoli","year":"2017","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1136\/jnnp-2017-315985","article-title":"Dopamine dysregulation syndrome in Parkinson\u2019s disease: A systematic review of published cases","volume":"88","author":"Warren","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_75","first-page":"31","article-title":"Dopamine pathology in schizophrenia: Analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra","volume":"3","author":"Rice","year":"2012","journal-title":"Front. Psychiatry"},{"key":"ref_76","first-page":"591","article-title":"The Modulatory Role of Dopamine in Anxiety-like Behavior","volume":"18","author":"Zarrindast","year":"2015","journal-title":"Arch. Iran. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1385\/ENDO:12:3:237","article-title":"Role of dopamine in malignant tumor growth","volume":"12","author":"Basu","year":"2000","journal-title":"Endocrine"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.7150\/jca.27780","article-title":"The Prospective Value of Dopamine Receptors on Bio-Behavior of Tumor","volume":"10","author":"Wang","year":"2019","journal-title":"J. Cancer"},{"key":"ref_79","first-page":"8171","article-title":"DR2 blocker thioridazine: A promising drug for ovarian cancer therapy","volume":"14","author":"Yong","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Sun, X., Zhang, W., Li, H., Niu, C., Ou, Y., Song, L., and Zhang, Y. (2017). Stonin 2 Overexpression is Correlated with Unfavorable Prognosis and Tumor Invasion in Epithelial Ovarian Cancer. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081653"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1593\/neo.121412","article-title":"Biologic effects of dopamine on tumor vasculature in ovarian carcinoma","volume":"15","author":"Lee","year":"2013","journal-title":"Neoplasia"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0006-291X(02)00197-3","article-title":"Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1","volume":"293","author":"Kang","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.bbamcr.2017.07.012","article-title":"Bradykinin B2 and dopamine D2 receptors form a functional dimer","volume":"1864","author":"Polit","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_84","first-page":"525","article-title":"Signal transduction pathways for B1 and B2 bradykinin receptors in bovine pulmonary artery endothelial cells","volume":"47","author":"Smith","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"ref_85","first-page":"128","article-title":"B1 and B2 kinin receptors mediate distinct patterns of intracellular Ca2+ signaling in single cultured vascular smooth muscle cells","volume":"50","author":"Mathis","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1210\/endo-122-6-2540","article-title":"The effects of bradykinin on ovulation and prostaglandin production by the perfused rabbit ovary","volume":"122","author":"Yoshimura","year":"1988","journal-title":"Endocrinology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2165\/00003495-199700545-00007","article-title":"Endothelial function and bradykinin in humans","volume":"54","author":"Hornig","year":"1997","journal-title":"Drugs"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/apha.12420","article-title":"Intrarenal bradykinin elicits reno-renal reflex sympatho-excitation and renal nerve-dependent fluid retention","volume":"213","author":"Barry","year":"2015","journal-title":"Acta Physiol. (Oxf.)"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.1002\/jcb.26100","article-title":"Bradykinin Promotes Cell Proliferation, Migration, Invasion, and Tumor Growth of Gastric Cancer Through ERK Signaling Pathway","volume":"118","author":"Wang","year":"2017","journal-title":"J. Cell Biochem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.2174\/1381612033454171","article-title":"Bradykinin antagonists as anti-cancer agents","volume":"9","author":"Stewart","year":"2003","journal-title":"Curr. Pharm. Des."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-4615-9546-5_18","article-title":"T-kinin in human ovarian carcinoma ascites","volume":"247B","author":"Wunderer","year":"1989","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fonc.2013.00256","article-title":"Getting to know ovarian cancer ascites: Opportunities for targeted therapy-based translational research","volume":"3","author":"Ahmed","year":"2013","journal-title":"Front. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1038\/sj.bjc.6600957","article-title":"Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition","volume":"88","author":"Waters","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1111\/j.1742-4658.2010.07928.x","article-title":"Strong cytotoxic effect of the bradykinin antagonist BKM-570 in ovarian cancer cells\u2014Analysis of the molecular mechanisms of its antiproliferative action","volume":"277","author":"Jutras","year":"2010","journal-title":"FEBS J."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/IGC.0b013e318259d8da","article-title":"Expression patterns of kinin-dependent genes in endometrial cancer","volume":"22","author":"Orchel","year":"2012","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_96","first-page":"6469","article-title":"Synchronous primary ovarian and endometrial cancers: A series of cases and a review of literature","volume":"13","author":"Czernek","year":"2014","journal-title":"Prz Menopauzalny"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"969","DOI":"10.21873\/anticanres.11406","article-title":"Synchronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature","volume":"37","author":"Dogan","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Rozov, S.V., Porkka-Heiskanen, T., and Panula, P. (2015). On the Role of Histamine Receptors in the Regulation of Circadian Rhythms. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144694"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuropharm.2015.04.011","article-title":"Histamine receptor signaling in energy homeostasis","volume":"106","author":"Tabarean","year":"2016","journal-title":"Neuropharmacology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbr.2008.12.010","article-title":"The role of histamine on cognition","volume":"199","author":"Alvarez","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3389\/fimmu.2018.01873","article-title":"The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets","volume":"9","author":"Thangam","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/head.13164","article-title":"Histamine and Migraine","volume":"58","author":"Yuan","year":"2018","journal-title":"Headache"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tins.2014.12.008","article-title":"The human histaminergic system in neuropsychiatric disorders","volume":"38","author":"Shan","year":"2015","journal-title":"Trends Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/cam4.296","article-title":"Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line","volume":"3","author":"Wang","year":"2014","journal-title":"Cancer Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0304-3835(95)90153-1","article-title":"Diamine-oxidase activity and tissue di-and poly-amine contents of human ovarian, cervical and endometrial carcinoma","volume":"89","author":"Chanda","year":"1995","journal-title":"Cancer Lett."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3892\/ijmm.2014.1649","article-title":"Integrative genomic analyses of the histamine H1 receptor and its role in cancer prediction","volume":"33","author":"Wang","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0304-3835(94)90348-4","article-title":"Release of intracellular calcium and stimulation of cell growth by ATP and histamine in human ovarian cancer cells (SKOV-3)","volume":"77","author":"Batra","year":"1994","journal-title":"Cancer Lett."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.lfs.2016.12.008","article-title":"Antihistamines as promising drugs in cancer therapy","volume":"172","author":"Ferreira","year":"2017","journal-title":"Life Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.maturitas.2018.11.014","article-title":"Antihistamine use and risk of ovarian cancer: A population-based case-control study","volume":"120","author":"Verdoodt","year":"2019","journal-title":"Maturitas"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"389","DOI":"10.6004\/jnccn.2014.0040","article-title":"Chemotherapy hypersensitivity reactions in ovarian cancer","volume":"12","author":"Picard","year":"2014","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1002\/ijc.21680","article-title":"Prophylactic effect of pemirolast, an antiallergic agent, against hypersensitivity reactions to paclitaxel in patients with ovarian cancer","volume":"118","author":"Yahata","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/phar.1739","article-title":"Adjunct Histamine Blockers as Premedications to Prevent Carboplatin Hypersensitivity Reactions","volume":"36","author":"Mach","year":"2016","journal-title":"Pharmacotherapy"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00280-004-0924-9","article-title":"Incidence and risk factors for paclitaxel hypersensitivity during ovarian cancer chemotherapy","volume":"56","author":"Sendo","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.it.2018.06.003","article-title":"Peripheral Tissue Chemokines: Homeostatic Control of Immune Surveillance T Cells","volume":"39","author":"McCully","year":"2018","journal-title":"Trends Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/07388550903187418","article-title":"Chemokines and their receptors: Orchestrating a fine balance between health and disease","volume":"30","author":"Sharma","year":"2010","journal-title":"Crit Rev. Biotechnol."},{"key":"ref_116","first-page":"95","article-title":"Chemokines and chemokine receptors: Their manifold roles in homeostasis and disease","volume":"1","author":"Le","year":"2004","journal-title":"Cell Mol. Immunol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1568-9972(02)00085-X","article-title":"Chemokines in autoimmunity: From pathology to therapeutics","volume":"1","author":"Kunkel","year":"2002","journal-title":"Autoimmun Rev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3390\/ijms15010361","article-title":"Chemokine receptors in epithelial ovarian cancer","volume":"15","author":"Muralidhar","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/gt.2017.69","article-title":"Targeting the CXCR4\/CXCL12 axis in treating epithelial ovarian cancer","volume":"24","author":"Mao","year":"2017","journal-title":"Gene Ther."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1002\/jcp.27163","article-title":"Role of CXCL12-CXCR4 axis in ovarian cancer metastasis and CXCL12-CXCR4 blockade with AMD3100 suppresses tumor cell migration and invasion in vitro","volume":"234","author":"Liu","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_121","first-page":"4961","article-title":"Epithelial cancer cell migration: A role for chemokine receptors?","volume":"61","author":"Scotton","year":"2001","journal-title":"Cancer Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/00029330-200707020-00009","article-title":"Role of CXCL12 in metastasis of human ovarian cancer","volume":"120","author":"Jiang","year":"2007","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1196\/annals.1329.021","article-title":"CXCR4 activation induces epidermal growth factor receptor transactivation in an ovarian cancer cell line","volume":"1030","author":"Porcile","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.yexcr.2005.04.024","article-title":"Stromal cell-derived factor-1alpha (SDF-1alpha\/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation","volume":"308","author":"Porcile","year":"2005","journal-title":"Exp. Cell. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"6868","DOI":"10.1074\/jbc.275.10.6868","article-title":"Chemokine receptors CXCR-1\/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells","volume":"275","author":"Venkatakrishnan","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/bjc.2012.49","article-title":"The chemokine, CXCL12, is an independent predictor of poor survival in ovarian cancer","volume":"106","author":"Popple","year":"2012","journal-title":"Br. J. Cancer."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"426956","DOI":"10.1155\/2010\/426956","article-title":"Role of chemokine network in the development and progression of ovarian cancer: A potential novel pharmacological target","volume":"2010","author":"Barbieri","year":"2010","journal-title":"J. Oncol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3802\/jgo.2015.26.2.87","article-title":"FIGO\u2019s staging classification for cancer of the ovary, fallopian tube, and peritoneum: Abridged republication","volume":"26","author":"Prat","year":"2015","journal-title":"J. Gynecol. Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj20030312","article-title":"Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+","volume":"374","author":"Werry","year":"2003","journal-title":"Biochem. J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2567.2011.03485.x","article-title":"Mechanisms regulating chemokine receptor activity","volume":"134","author":"Bennett","year":"2011","journal-title":"Immunology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/22\/5568\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:32:44Z","timestamp":1760189564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/22\/5568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":130,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["ijms20225568"],"URL":"https:\/\/doi.org\/10.3390\/ijms20225568","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]}}}