{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:06:07Z","timestamp":1792789567321,"version":"4.5.0"},"reference-count":59,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Research Area Network on Sustainable Animal Production (ERA-NET SusAn)","award":["2817ERA02D"],"award-info":[{"award-number":["2817ERA02D"]}]},{"name":"undefined  &lt;span style=&quot;color:gray;font-size:10px;&quot;&gt;undefined&lt;\/span&gt;","award":["2817ERA02D"],"award-info":[{"award-number":["2817ERA02D"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sodium\/phosphate co-transporters are considered to be important mediators of phosphorus (P) homeostasis. The expression of specific sodium\/phosphate co-transporters is routinely used as an immediate response to dietary interventions in different species. However, a general understanding of their tissue-specificity is required to elucidate their particular contribution to P homeostasis. In this study, the tissue-wide gene expression status of all currently annotated sodium\/phosphate co-transporters were investigated in two pig trials focusing on a standard commercial diet (trial 1) or divergent P-containing diets (trial 2). A wide range of tissues including the gastrointestinal tract (stomach, duodenum, jejunum, ileum, caecum, and colon), kidney, liver, bone, muscle, lung, and aorta were analyzed. Both trials showed consistent patterns in the overall tissue-specific expression of P transporters. While SLC34A2 was considered as the most important intestinal P transporter in other species including humans, SLC34A3 appeared to be the most prominent intestinal P transporter in pigs. In addition, the P transporters of the SLC17 family showed basal expression in the pig intestine and might have a contribution to P homeostasis. The expression patterns observed in the distal colon provide evidence that the large intestine may also be relevant for intestinal P absorption. A low dietary P supply induced higher expressions of SLC20A1, SLC20A2, SLC34A1, and SLC34A3 in the kidney cortex. The results suggest that the expression of genes encoding transcellular P transporters is tissue-specific and responsive to dietary P supply, while underlying regulatory mechanisms require further analyses.<\/jats:p>","DOI":"10.3390\/ijms20225576","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T11:30:19Z","timestamp":1573212619000},"page":"5576","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Tissue-Wide Gene Expression Analysis of Sodium\/Phosphate Co-Transporters in Pigs"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-1073","authenticated-orcid":false,"given":"Aisanjiang","family":"Wubuli","sequence":"first","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-0434","authenticated-orcid":false,"given":"Henry","family":"Reyer","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-6255","authenticated-orcid":false,"given":"Eduard","family":"Mur\u00e1ni","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-1057","authenticated-orcid":false,"given":"Siriluck","family":"Ponsuksili","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Wolf","sequence":"additional","affiliation":[{"name":"Nutrition Physiology and Animal Nutrition, University of Rostock, Justus-von-Liebig-Weg 6b, 18059 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6835-7562","authenticated-orcid":false,"given":"Michael","family":"Oster","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9523-6790","authenticated-orcid":false,"given":"Klaus","family":"Wimmers","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany"},{"name":"Animal Breeding and Genetics, University of Rostock, Justus-von-Liebig-Weg 7, 18059 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9420","DOI":"10.1074\/jbc.M109.013011","article-title":"Inorganic polyphosphate and energy metabolism in mammalian cells","volume":"285","author":"Pavlov","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Oster, M., Reyer, H., Ball, E., Fornara, D., McKillen, J., Sorensen, K.U., Poulsen, H.D., Andersson, K., Ddiba, D., and Rosemarin, A. (2018). Bridging Gaps in the Agricultural Phosphorus Cycle from an Animal Husbandry Perspective- The Case of Pigs and Poultry. Sustainability, 10.","DOI":"10.3390\/su10061825"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Campbell, B.M., Beare, D.J., Bennett, E.M., Hall-Spencer, J.M., Ingram, J.S.I., Jaramillo, F., Ortiz, R., Ramankutty, N., Sayer, J.A., and Shindell, D. (2017). Agriculture production as a major driver of the Earth system exceeding planetary boundaries. Ecol. Soc., 22.","DOI":"10.5751\/ES-09595-220408"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/03601234.2017.1292096","article-title":"Effect of low levels of dietary available phosphorus on phosphorus utilization, bone mineralization, phosphorus transporter mRNA expression and performance in growing pigs","volume":"52","author":"Pokharel","year":"2017","journal-title":"J. Env. Sci. Health B"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.2527\/jas.2007-0692","article-title":"Response to dietary phosphorus deficiency is affected by genetic background in growing pigs","volume":"86","author":"Alexander","year":"2008","journal-title":"J. Anim. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3389\/fgene.2019.00590","article-title":"Genetic Contribution to Variation in Blood Calcium, Phosphorus, and Alkaline Phosphatase Activity in Pigs","volume":"10","author":"Reyer","year":"2019","journal-title":"Front. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.1073\/pnas.95.9.5372","article-title":"Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities","volume":"95","author":"Beck","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1681\/ASN.2009050559","article-title":"Intestinal Npt2b Plays a Major Role in Phosphate Absorption and Homeostasis","volume":"20","author":"Sabbagh","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1681\/ASN.2007121360","article-title":"A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis","volume":"19","author":"Iwaki","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1210\/jc.2005-2840","article-title":"Intronic deletions in the SLC34A3 gene cause hereditary hypophosphatemic rickets with hypercalciuria","volume":"91","author":"Ichikawa","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.med.051308.111339","article-title":"Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23","volume":"61","author":"Bergwitz","year":"2010","journal-title":"Annu. Rev. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"F282","DOI":"10.1152\/ajprenal.90742.2008","article-title":"FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1","volume":"297","author":"Gattineni","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1073\/pnas.88.21.9608","article-title":"Cloning and Expression of Cdna for a Na\/Pi Cotransport System of Kidney Cortex","volume":"88","author":"Werner","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00424-003-1072-5","article-title":"The sodium phosphate cotransporter family SLC34","volume":"447","author":"Murer","year":"2004","journal-title":"Pflug. Arch."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00424-003-1088-x","article-title":"The SLC20 family of proteins: Dual functions as sodium-phosphate cotransporters and viral receptors","volume":"447","author":"Collins","year":"2004","journal-title":"Pflug. Arch."},{"key":"ref_16","first-page":"1391","article-title":"Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1","volume":"286","author":"Yabuuchi","year":"1998","journal-title":"J. Pharm. Exp."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/geno.1993.1476","article-title":"Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23","volume":"18","author":"Chong","year":"1993","journal-title":"Genomics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1042\/bj3050081","article-title":"Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression","volume":"305","author":"Miyamoto","year":"1995","journal-title":"Biochem. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/art.38884","article-title":"NPT1\/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout","volume":"67","author":"Chiba","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0005-2728(93)90138-6","article-title":"Sodium-dependent transport of phosphate by rat liver plasma membrane vesicles","volume":"1143","author":"Younus","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_21","first-page":"197","article-title":"Ontogeny of phosphate transport by rat liver plasma membrane vesicles","volume":"19","author":"Ghishan","year":"1993","journal-title":"J. Dev. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1152\/physrev.2000.80.4.1373","article-title":"Proximal tubular phosphate reabsorption: Molecular mechanisms","volume":"80","author":"Murer","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1073\/pnas.93.11.5347","article-title":"Expression of a renal type I sodium\/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions","volume":"93","author":"Busch","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/hmg\/6.8.1233","article-title":"Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders","volume":"6","author":"Lloyd","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"26107","DOI":"10.1074\/jbc.M110.122721","article-title":"Type 1 Sodium-dependent Phosphate Transporter (SLC17A1 Protein) Is a Cl(-)-dependent Urate Exporter","volume":"285","author":"Iharada","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1002\/jps.22614","article-title":"Sodium-dependent phosphate cotransporters: Lessons from gene knockout and mutation studies","volume":"100","author":"Miyamoto","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"C71","DOI":"10.1152\/ajpcell.00048.2015","article-title":"Wide expression of type I Na+-phosphate cotransporter 3 (NPT3\/SLC17A2), a membrane potential-driven organic anion transporter","volume":"309","author":"Togawa","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_28","first-page":"1723","article-title":"[Role of the type 3 sodium-dependent phosphate transporter in the calcification of growth plate chondrocytes]","volume":"16","author":"Sugita","year":"2006","journal-title":"Clin. Calcium."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/path.2440","article-title":"The Human Protein Atlas\u2014a tool for pathology","volume":"216","author":"Uhlen","year":"2008","journal-title":"J. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1080\/15257770.2011.616564","article-title":"Apical voltage-driven urate efflux transporter NPT4 in renal proximal tubule","volume":"30","author":"Jutabha","year":"2011","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"35123","DOI":"10.1074\/jbc.M110.121301","article-title":"Human sodium phosphate transporter 4 (hNPT4\/SLC17A3) as a common renal secretory pathway for drugs and urate","volume":"285","author":"Jutabha","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"C1652","DOI":"10.1152\/ajpcell.00015.2012","article-title":"A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter","volume":"302","author":"Togawa","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sreedharan, S., Shaik, J.H., Olszewski, P.K., Levine, A.S., Schioth, H.B., and Fredriksson, R. (2010). Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: Evolution and tissue expression. BMC Genom., 11.","DOI":"10.1186\/1471-2164-11-17"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00041552-200109000-00002","article-title":"Molecular aspects in the regulation of renal inorganic phosphate reabsorption: The type IIa sodium\/inorganic phosphate co-transporter as the key player","volume":"10","author":"Murer","year":"2001","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00424-003-1010-6","article-title":"Cloning, gene structure and dietary regulation of the type-IIc Na\/Pi cotransporter in the mouse kidney","volume":"446","author":"Ohkido","year":"2003","journal-title":"Pflug. Arch."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"R917","DOI":"10.1152\/ajpregu.00215.2015","article-title":"Toward improved phosphorus efficiency in monogastrics-interplay of serum, minerals, bone, and immune system after divergent dietary phosphorus supply in swine","volume":"310","author":"Oster","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1006\/geno.1999.6009","article-title":"Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)","volume":"62","author":"Xu","year":"1999","journal-title":"Genomics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0002-9440(10)64512-9","article-title":"Isolation and localization of type IIb Na\/Pi cotransporter in the developing rat lung","volume":"157","author":"Hashimoto","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1006\/bbrc.1999.0666","article-title":"Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine","volume":"258","author":"Feild","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_40","first-page":"A137","article-title":"Studies on Mechanisms of 1,25 Dihydroxy-Vitamin-D3-Stimulated Intestinal Phosphate Absorption","volume":"56","author":"Walling","year":"1977","journal-title":"J. Dent. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.5713\/ajas.2012.12187","article-title":"Different phosphate transport in the duodenum and jejunum of chicken response to dietary phosphate adaptation","volume":"25","author":"Fang","year":"2012","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"A1064","DOI":"10.1096\/fasebj.20.5.A1064-c","article-title":"Visceral distribution of the type II sodium-dependent phosphate cotransporter (NaPi-II) isomer mRNA and the expression of NaPi-IIc mRNA along the intestinal longitudinal axis in the post-weaned pig","volume":"20","author":"Yang","year":"2006","journal-title":"FASEB J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1086\/499409","article-title":"SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis","volume":"78","author":"Bergwitz","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"F371","DOI":"10.1152\/ajprenal.00090.2008","article-title":"A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport in NaPi-IIc","volume":"295","author":"Jaureguiberry","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"19665","DOI":"10.1074\/jbc.M200943200","article-title":"Growth-related renal type II Na\/Pi cotransporter","volume":"277","author":"Segawa","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_46","first-page":"402","article-title":"Segment-specific expression of sodium-phosphate cotransporters NaPi-IIa and -IIc and interacting proteins in mouse renal proximal tubules","volume":"448","author":"Madjdpour","year":"2004","journal-title":"Pflug. Arch."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"C1135","DOI":"10.1152\/ajpcell.2000.279.4.C1135","article-title":"Cloning and characterization of a type III Na-dependent phosphate cotransporter from mouse intestine","volume":"279","author":"Bai","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1210\/endo.139.4.5925","article-title":"Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands","volume":"139","author":"Tatsumi","year":"1998","journal-title":"Endocrinology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1128\/jvi.66.3.1635-1640.1992","article-title":"GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus","volume":"66","author":"Johann","year":"1992","journal-title":"J. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1073\/pnas.91.3.1168","article-title":"A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family","volume":"91","author":"Johann","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"25426","DOI":"10.1016\/S0021-9258(18)47267-5","article-title":"The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter","volume":"269","author":"Olah","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2016.02.032","article-title":"The type III transporters (PiT-1 and PiT-2) are the major sodium-dependent phosphate transporters in the mice and human brains","volume":"1637","author":"Inden","year":"2016","journal-title":"Brain Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10048-015-0469-6","article-title":"Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid","volume":"17","author":"Jensen","year":"2016","journal-title":"Neurogenetics"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1747-1028-7-7","article-title":"Regulation of cell proliferation and cell density by the inorganic phosphate transporter PiT1","volume":"7","author":"Byskov","year":"2012","journal-title":"Cell Div."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"31363","DOI":"10.1074\/jbc.M109.053132","article-title":"Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity","volume":"284","author":"Beck","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"34408","DOI":"10.1074\/jbc.M110.130989","article-title":"Identification of a novel transport-independent function of PiT1\/SLC20A1 in the regulation of TNF-induced apoptosis","volume":"285","author":"Salaun","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/jbmr.3609","article-title":"PiT1\/Slc20a1 is required for endoplasmic reticulum homeostasis, chondrocyte survival and skeletal development","volume":"34","author":"Couasnay","year":"2018","journal-title":"J. Bone Min. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1074\/jbc.M117.807339","article-title":"Phosphate (Pi)-regulated heterodimerization of the high-affinity sodium-dependent Pi transporters PiT1\/Slc20a1 and PiT2\/Slc20a2 underlies extracellular Pi sensing independently of Pi uptake","volume":"293","author":"Bon","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_59","unstructured":"(2006). Gesellschaft f\u00fcr Ern\u00e4hrungsphysiologie. Empfehlungen zur Energie-und N\u00e4hrstoffversorgung beim Schwein, DLG Verlag. (In German)."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/22\/5576\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:32:50Z","timestamp":1760189570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/22\/5576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":59,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["ijms20225576"],"URL":"https:\/\/doi.org\/10.3390\/ijms20225576","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]}}}