{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:29:53Z","timestamp":1790108993320,"version":"4.0.1"},"reference-count":35,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T00:00:00Z","timestamp":1573862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2011-02347991"],"award-info":[{"award-number":["GR-2011-02347991"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2009-1470633"],"award-info":[{"award-number":["GR-2009-1470633"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente 2019 IRCCS \u201cS. de Bellis\u201d"],"award-info":[{"award-number":["Ricerca Corrente 2019 IRCCS \u201cS. de Bellis\u201d"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003852","name":"Regione Campania","doi-asserted-by":"publisher","award":["PO FESR 2014-2020 \u2013 \"Piattaforme tecnologiche di ricerca collaborativa per la lotta alle patologie oncologiche"],"award-info":[{"award-number":["PO FESR 2014-2020 \u2013 \"Piattaforme tecnologiche di ricerca collaborativa per la lotta alle patologie oncologiche"]}],"id":[{"id":"10.13039\/501100003852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009886","name":"Regione Puglia","doi-asserted-by":"publisher","award":["SiCURA \u201cSoluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA\u201d"],"award-info":[{"award-number":["SiCURA \u201cSoluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA\u201d"]}],"id":[{"id":"10.13039\/501100009886","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammatory bowel diseases (IBDs) are chronic and relapsing immune disorders that result, or possibly originate, from epithelial barrier defects. Intestinal organoids are a new reliable tool to investigate epithelial response in models of chronic inflammation. We produced organoids from the ulcerative colitis murine model Winnie to explore if the chronic inflammatory features observed in the parental intestine were preserved by the organoids. Furthermore, we investigated if quercetin administration to in vitro cultured organoids could suppress LPS-induced inflammation in wild-type organoids (WT-organoids) and spontaneous inflammation in ulcerative colitis organoids (UC-organoids). Our data demonstrate that small intestinal organoids obtained from Winnie mice retain the chronic intestinal inflammatory features characteristic of the parental tissue. Quercetin administration was able to suppress inflammation both in UC-organoids and in LPS-treated WT-organoids. Altogether, our data demonstrate that UC-organoids are a reliable experimental system for investigating chronic intestinal inflammation and pharmacological responses.<\/jats:p>","DOI":"10.3390\/ijms20225771","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T04:31:10Z","timestamp":1574051470000},"page":"5771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Quercetin Exposure Suppresses the Inflammatory Pathway in Intestinal Organoids from Winnie Mice"],"prefix":"10.3390","volume":"20","author":[{"given":"Manuela","family":"Dicarlo","sequence":"first","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Teti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences-DBNS, Universit\u00e0 di Bologna, Via Irnerio 48, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-0370","authenticated-orcid":false,"given":"Giulio","family":"Verna","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-1869","authenticated-orcid":false,"given":"Marina","family":"Liso","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-0053","authenticated-orcid":false,"given":"Elisabetta","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Sila","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathuwarman","family":"Raveenthiraraj","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Mastronardi","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-0747","authenticated-orcid":false,"given":"Angelo","family":"Santino","sequence":"additional","affiliation":[{"name":"ISPA-CNR, Institute of Science of Food Production, C.N.R. Unit of Lecce, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-0802","authenticated-orcid":false,"given":"Grazia","family":"Serino","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lippolis","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Sobolewski","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Falconi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences-DBNS, Universit\u00e0 di Bologna, Via Irnerio 48, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Chieppa","sequence":"additional","affiliation":[{"name":"National Institute of Gastroenterology \u201cS. de Bellis\u201d, Institute of Research, 70013 Castellana Grotte (BA), Italy"},{"name":"Department of Immunology and Cell Biology, European Biomedical Research Institute of Salerno (EBRIS), 84125 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/ibd\/izy085","article-title":"Determinants of IBD Heritability: Genes, Bugs, and More","volume":"24","author":"Turpin","year":"2018","journal-title":"Inflamm. 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