{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:19:22Z","timestamp":1768447162029,"version":"3.49.0"},"reference-count":52,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["667302"],"award-info":[{"award-number":["667302"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Following the failure of acute neuroprotection therapies, major efforts are currently made worldwide to promote neurological recovery and brain plasticity in the subacute and post-acute phases of stroke. Currently, there is hope that stroke recovery might be promoted by cell-based therapies. The field of stem cell therapy for cerebral ischemia has made significant progress in the last five years. A variety of stem cells have been tested in animal models and humans including adipose stem cells, human umbilical cord blood-derived mesenchymal stem cells, human amnion epithelial cells, human placenta amniotic membrane-derived mesenchymal stem cells, adult human pluripotent-like olfactory stem cells, human bone marrow endothelial progenitor cells, electrically-stimulated human neuronal progenitor cells, or induced pluripotent stem cells (iPSCs) of human origin. Combination therapies in animal models include a mix of two or more therapeutic factors consisting of bone marrow stromal cells, exercise and thyroid hormones, endothelial progenitor cells overexpressing the chemokine CXCL12. Mechanisms underlying the beneficial effects of transplanted cells include the \u201cbystander\u201d effects, paracrine mechanisms, or extracellular vesicles-mediated restorative effects. Mitochondria transfer also appears to be a powerful strategy for regenerative processes. Studies in humans are currently limited to a small number of studies using autologous stem cells mainly aimed to assess tolerability and side-effects of human stem cells in the clinic.<\/jats:p>","DOI":"10.3390\/ijms20236029","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T10:58:21Z","timestamp":1575025101000},"page":"6029","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Recent Advances in Mono- and Combined Stem Cell Therapies of Stroke in Animal Models and Humans"],"prefix":"10.3390","volume":"20","author":[{"given":"Roxana","family":"Surugiu","sequence":"first","affiliation":[{"name":"Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy, 20049 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Olaru","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Medicine and Pharmacy, 20049 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk M.","family":"Hermann","sequence":"additional","affiliation":[{"name":"Chair of Vascular Neurology, Dementia and Ageing Research, Department of Neurology, University of Duisburg-Essen, University Hospital Essen, 45122 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Glavan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Medicine and Pharmacy, 20049 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-8722","authenticated-orcid":false,"given":"Bogdan","family":"Catalin","sequence":"additional","affiliation":[{"name":"Experimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 20049 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4574-8605","authenticated-orcid":false,"given":"Aurel","family":"Popa-Wagner","sequence":"additional","affiliation":[{"name":"Chair of Vascular Neurology, Dementia and Ageing Research, Department of Neurology, University of Duisburg-Essen, University Hospital Essen, 45122 Essen, Germany"},{"name":"Griffith University Menzies Health Institute of Queensland, Gold Coast Campus and Queensland Eye Institute, Brisbane QLD 4000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/ana.21127","article-title":"Future of neuroprotection for acute stroke: In the aftermath of the SAINT trials","volume":"61","author":"Savitz","year":"2007","journal-title":"Ann. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.neuropharm.2007.12.007","article-title":"Neuroprotection for ischemic stroke: Past, present and future","volume":"55","author":"Ginsberg","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lener, T., Gimona, M., Aigner, L., B\u00f6rger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F.F., and Del Portillo, H.H. (2015). Applying extracellular vesicles based therapeutics in clinical trials\u2014An ISEV position paper. J. Extracell. Vesicles, 4.","DOI":"10.3402\/jev.v4.30087"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kong, T., Park, J.M., Jang, J.H., Kim, C.Y., Bae, S.H., Choi, Y., Jeong, Y.H., Kim, C., Chang, S.W., and Kim, J. (2018). Immunomodulatory effect of CD200-positive human placenta-derived stem cells in the early phase of stroke. Exp. Mol. Med., 50.","DOI":"10.1038\/emm.2017.233"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/jnr.24197","article-title":"Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia","volume":"96","author":"Hermanto","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1161\/STROKEAHA.117.019136","article-title":"Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke","volume":"49","author":"Evans","year":"2018","journal-title":"Stroke"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1159\/000485533","article-title":"Mesenchymal Stem Cell Treatment Prevents Post-Stroke Dysregulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases","volume":"44","author":"Chelluboina","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.biomaterials.2017.07.020","article-title":"Electrical preconditioning of stem cells with a conductive polymer scaffold enhances stroke recovery","volume":"142","author":"George","year":"2017","journal-title":"Biomaterials"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2019.02.015","article-title":"Conductive polymers to modulate the post-stroke neural environment","volume":"148","author":"Oh","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/stem.2578","article-title":"Intravenously Transplanted Human Bone Marrow Endothelial Progenitor Cells Engraft Within Brain Capillaries, Preserve Mitochondrial Morphology, and Display Pinocytotic Activity Towards BBB Repair in Ischemic Stroke Rats","volume":"35","author":"Haller","year":"2017","journal-title":"Stem cells"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fan, J.R., Lee, H.T., Lee, W., Lin, C.H., Hsu, C.Y., Hsieh, C.H., and Shyu, W.C. (2018). Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model. Cell Death Dis., 9.","DOI":"10.1038\/s41419-018-0519-8"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Baker, E.W., Platt, S.R., Lau, V.W., Grace, H.E., Holmes, S.P., Wang, L., Duberstein, K.J., Howerth, E.W., Kinder, H.A., and Stice, S.L. (2017). Induced Pluripotent Stem Cell-Derived Neural Stem Cell Therapy Enhances Recovery in an Ischemic Stroke Pig Model. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-10406-x"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Lau, V.W., Platt, S.R., Grace, H.E., Baker, E.W., and West, F.D. (2018). Human iNPC therapy leads to improvement in functional neurologic outcomes in a pig ischemic stroke model. Brain Behav., 8.","DOI":"10.1002\/brb3.972"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1440-1789.2002.00450.x","article-title":"Ischemic rat brain extracts induce human marrow stromal cell growth factor production","volume":"22","author":"Chen","year":"2002","journal-title":"Neuropathology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41434-018-0041-8","article-title":"Improved therapeutic potential of MSCs by genetic modification","volume":"25","author":"Wei","year":"2018","journal-title":"Gene Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3390\/ijms15021719","article-title":"Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases","volume":"15","author":"Wyse","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm1239","article-title":"A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease","volume":"11","author":"Tuszynski","year":"2005","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.trsl.2009.07.006","article-title":"Open-labeled study of autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson\u2019s disease","volume":"155","author":"Venkataramana","year":"2010","journal-title":"Transl. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Li, Y., Chang, S., Li, W., Tang, G., Ma, Y., Liu, Y., Yuan, F., Zhang, Z., Yang, G.Y., and Wang, Y. (2018). cxcl12-engineered endothelial progenitor cells enhance neurogenesis and angiogenesis after ischemic brain injury in mice. Stem Cell Res. Ther., 9.","DOI":"10.1186\/s13287-018-0865-6"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainres.2018.05.033","article-title":"Preservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction","volume":"1695","author":"Nagahama","year":"2018","journal-title":"Brain Res."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Grudzenski, S., Baier, S., Ebert, A., Pullens, P., Lemke, A., Bieback, K., Dijkhuizen, R.M., Schad, L.R., Alonso, A., and Hennerici, M.G. (2017). The effect of adipose tissue-derived stem cells in a middle cerebral artery occlusion stroke model depends on their engraftment rate. Stem Cell Res Ther., 8.","DOI":"10.1186\/s13287-017-0545-y"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mu, L., Bakreen, A., Juntunen, M., Korhonen, P., Oinonen, E., Cui, L., Myllyniemi, M., Zhao, S., Miettinen, S., and Jolkkonen, J. (2019). Combined Adipose Tissue-Derived Mesenchymal Stem Cell Therapy and Rehabilitation in Experimental Stroke. Front. Neurol., 10.","DOI":"10.3389\/fneur.2019.00235"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cheng, Z., Wang, L., Qu, M., Liang, H., Li, W., Li, Y., Deng, L., Zhang, Z., and Yang, G.Y. (2018). Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice. J. Neuroinflammat., 15.","DOI":"10.1186\/s12974-018-1153-1"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s10571-016-0445-1","article-title":"Hypoxic Preconditioning Augments the Therapeutic Efficacy of Bone Marrow Stromal Cells in a Rat Ischemic Stroke Model","volume":"37","author":"Chen","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Balseanu, A.T., Buga, A.M., Catalin, B., Wagner, D.C., Boltze, J., Zagrean, A.M., Reymann, K., Schaebitz, W., and Popa-Wagner, A. (2014). Multimodal Approaches for Regenerative Stroke Therapies: Combination of Granulocyte Colony-Stimulating Factor with Bone Marrow Mesenchymal Stem Cells is Not Superior to G-CSF Alone. Front. Aging Neurosci., 6.","DOI":"10.3389\/fnagi.2014.00130"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1567202612666150311112550","article-title":"Granulocyte colony-stimulating factor and bone marrow mononuclear cells for stroke treatment in the aged brain","volume":"12","author":"Buga","year":"2015","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s11011-017-0034-0","article-title":"Effects of the combined treatment of bone marrow stromal cells with mild exercise and thyroid hormone on brain damage and apoptosis in a mouse focal cerebral ischemia model","volume":"4","author":"Akhoundzadeh","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3174\/ajnr.A5586","article-title":"Randomized Assessment of the Safety and Efficacy of Intra-Arterial Infusion of Autologous Stem Cells in Subacute Ischemic Stroke","volume":"39","author":"Bhatia","year":"2018","journal-title":"Am. J. Neuroradiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.46582\/jsrm.1301003","article-title":"Safety and Feasibility of Autologous Mesenchymal Stem Cell Transplantation in Chronic Stroke in Indian patients. A four-year follow up","volume":"13","author":"Bhasin","year":"2017","journal-title":"J. Stem Cells Regen. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1089\/ten.teb.2016.0365","article-title":"Trophic Effects of Mesenchymal Stem Cells in Tissue Regeneration","volume":"23","author":"Fu","year":"2017","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.108.176826","article-title":"Paracrine mechanisms in adult stem cell signaling and therapy","volume":"103","author":"Gnecchi","year":"2008","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1177\/0271678X18776802","article-title":"The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke","volume":"38","author":"Cunningham","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/term.2806","article-title":"Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine","volume":"13","author":"Gunawardena","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/jcp.26931","article-title":"Hypoxic conditioned medium derived from bone marrow mesenchymal stromal cells protects against ischemic stroke in rats","volume":"234","author":"Jiang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Tsai, M.J., Tsai, S.K., Hu, B.R., Liou, D.Y., Huang, S.L., Huang, M.C., Huang, W.-C., Cheng, H., and Huang, S.-S. (2014). Recovery of neurological function of ischemic stroke by application of conditioned medium of bone marrow mesenchymal stem cells derived from normal and cerebral ischemia rats. J. Biomed. Sci., 21.","DOI":"10.1186\/1423-0127-21-5"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/mt.2013.301","article-title":"Efficacious and clinically relevant conditioned medium of human adipose-derived stem cells for therapeutic angiogenesis","volume":"22","author":"Bhang","year":"2014","journal-title":"Mol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1634\/stemcells.2008-0333","article-title":"IFATS collection: The conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats","volume":"27","author":"Wei","year":"2009","journal-title":"Stem Cells"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.nbd.2012.03.002","article-title":"Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats","volume":"46","author":"Wei","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Doeppner, T.R., B\u00e4hr, M., Giebel, B., and Hermann, D.M. (2018). Immunological and non-immunological effects of stem cell-derived extracellular vesicles on the ischaemic brain. Ther. Adv. Neurol. Disord., 11.","DOI":"10.1177\/1756286418789326"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00702-013-1148-0","article-title":"Neurovascular remodeling in the aged ischemic brain","volume":"122","author":"Hermann","year":"2015","journal-title":"J. Neural. Transm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.5966\/sctm.2015-0078","article-title":"Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression","volume":"4","author":"Doeppner","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.imbio.2018.08.002","article-title":"Immunomodulatory effects of mesenchymal stem cells on leukocytes with emphasis on neutrophils","volume":"223","author":"Salami","year":"2018","journal-title":"Immunobiology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1111\/cas.13334","article-title":"Double-edged sword of mesenchymal stem cells: Cancer-promoting versus therapeutic potential","volume":"108","author":"Lee","year":"2017","journal-title":"Cancer Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/jcbfm.2013.152","article-title":"Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats","volume":"33","author":"Xin","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Zagrean, A.M., Hermann, D.M., Opris, I., Zagrean, L., and Popa-Wagner, A. (2018). Multicellular Crosstalk between Exosomes and the Neurovascular Unit after Cerebral Ischemia. Therapeutic Implications. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00811"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-018-0126-4","article-title":"Exosomes\u2014Beyond stem cells for restorative therapy in stroke and neurological injury","volume":"15","author":"Zhang","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.tins.2018.03.006","article-title":"Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair","volume":"41","author":"Holm","year":"2018","journal-title":"Trends Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.bbadis.2016.10.020","article-title":"Mitochondria as a centrally positioned hub in the innate immune response","volume":"1863","author":"Sandhir","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s13287-019-1343-5","article-title":"Correction to: Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities","volume":"10","author":"Paliwal","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Babenko, V.A., Silachev, D.N., Popkov, V.A., Zorova, L.D., Pevzner, I.B., Plotnikov, E.Y., Sukhikh, G.T., and Zorov, D.B. (2018). Miro1 Enhances Mitochondria Transfer from Multipotent Mesenchymal Stem Cells (MMSC) to Neural Cells and Improves the Efficacy of Cell Recovery. Molecules, 23.","DOI":"10.3390\/molecules23030687"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Argibay, B., Trekker, J., Himmelreich, U., Beiras, A., Topete, A., Taboada, P., P\u00e9rez-Mato, M., Vieites-Prado, A., Iglesias-Rey, R., and Rivas, J. (2017). Intraarterial route increases the risk of cerebral lesions after mesenchymal cell administration in animal model of ischemia. Sci. Rep., 7.","DOI":"10.1038\/srep40758"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Nagpal, A., Choy, F.C., Howell, S., Hillier, S., Chan, F., Hamilton-Bruce, M.A., and Koblar, S.A. (2017). Safety and effectiveness of stem cell therapies in early-phase clinical trials in stroke: A systematic review and meta-analysis. Stem Cell Res. Ther., 8.","DOI":"10.1186\/s13287-017-0643-x"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/23\/6029\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:38:47Z","timestamp":1760189927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/23\/6029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":52,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["ijms20236029"],"URL":"https:\/\/doi.org\/10.3390\/ijms20236029","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,29]]}}}