{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:15:16Z","timestamp":1792109716932,"version":"4.4.0"},"reference-count":91,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The skeletal system is the third most common site for cancer metastases, surpassed only by the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and kidneys, have a strong predilection to metastasize to bone, which causes pain, hypercalcemia, pathological skeletal fractures, compression of the spinal cord or other nervous structures, decreased mobility, and increased mortality. Metastatic cancer-induced bone pain (CIBP) is a type of chronic pain with unique and complex pathophysiology characterized by nociceptive and neuropathic components. Its treatment should be multimodal (pharmacological and non-pharmacological), including causal anticancer and symptomatic analgesic treatment to improve quality of life (QoL). The aim of this paper is to discuss the mechanisms involved in the occurrence and persistence of cancer-associated bone pain and to review the treatment methods recommended by experts in clinical practice. The final part of the paper reviews experimental therapeutic methods that are currently being studied and that may improve the efficacy of bone pain treatment in cancer patients in the future.<\/jats:p>","DOI":"10.3390\/ijms20236047","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:50:45Z","timestamp":1575283845000},"page":"6047","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":240,"title":["Bone Pain in Cancer Patients: Mechanisms and Current Treatment"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3511-5169","authenticated-orcid":false,"given":"Renata","family":"Zaj\u0105czkowska","sequence":"first","affiliation":[{"name":"Department of Interdisciplinary Intensive Care, Jagiellonian University Medical College, 31-008 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-2583","authenticated-orcid":false,"given":"Magdalena","family":"Kocot-K\u0119pska","sequence":"additional","affiliation":[{"name":"Department of Pain Research and Treatment, Jagiellonian University Medical College, 31-008 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-2535","authenticated-orcid":false,"given":"Wojciech","family":"Leppert","sequence":"additional","affiliation":[{"name":"Laboratory of Quality of Life Research, Chair and Department of Palliative Medicine, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Wordliczek","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Intensive Care, Jagiellonian University Medical College, 31-008 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,30]]},"reference":[{"key":"ref_1","first-page":"4239","article-title":"Advances in cancer pain from bone metastasis","volume":"9","author":"Zhu","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(96)03267-8","article-title":"Malignant bone pain: Pathophysiology and treatment","volume":"69","author":"Mercadante","year":"1997","journal-title":"Pain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra030831","article-title":"Mechanisms of bone metastasis","volume":"350","author":"Roodman","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.semnuclmed.2014.07.004","article-title":"Evaluation of Osseous Metastasis in Bone Scintigraphy","volume":"45","author":"Davila","year":"2015","journal-title":"Semin. Nucl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm3010001","article-title":"Treatment and prevention of bone metastases from breast cancer: A comprehensive review of evidence for clinical practice","volume":"3","author":"Li","year":"2014","journal-title":"J. Clin. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/leu.2013.258","article-title":"Relationship between initial clinical presentation and the molecular cytogenetic classification of myeloma","volume":"28","author":"Greenberg","year":"2014","journal-title":"Leukemia"},{"key":"ref_7","first-page":"14","article-title":"Painful bone metastases","volume":"1","author":"Smith","year":"2012","journal-title":"Ann. Pall. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/j.semnuclmed.2009.10.003","article-title":"Systemic metabolic radiopharmaceutical therapy in the treatment of metastatic bone pain","volume":"40","author":"Pae","year":"2010","journal-title":"Semin. Nucl. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","article-title":"Metastatic bone disease: Clinical features, pathophysiology and treatment strategies","volume":"27","author":"Coleman","year":"2001","journal-title":"Cancer Treat. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_11","unstructured":"Gunderson, L.L., and Tepper, J.E. (2007). Palliative care for bone, spinal cord, brain and liver metastases. Clinical Radiation Oncology, Elsevier."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yoneda, T., Hiasa, M., Nagata, Y., Okui, T., and White, F.A. (2015). Acidic microenvironment and bone pain in cancer-colonized bone. BoneKEy Rep.","DOI":"10.1038\/bonekey.2015.58"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.hoc.2018.01.006","article-title":"Mechanisms of, and Adjuvants for, Bone Pain","volume":"32","author":"Figura","year":"2018","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pain.2013.07.044","article-title":"Bone cancer pain: Causes, consequences, and therapeutic opportunities","volume":"154","author":"Mantyh","year":"2013","journal-title":"Pain"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jpainsymman.2004.02.024","article-title":"Optimization of opoid therapy for preventing incident pain associated with bone metastases","volume":"28","author":"Mercadante","year":"2004","journal-title":"J. Pain Symptom Manag."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/bja\/aen100","article-title":"Translational medicine: Cancer pain mechanisms and management","volume":"101","author":"Delaney","year":"2008","journal-title":"Br. J. Anaesth."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.clon.2011.03.003","article-title":"Mechanisms of cancer\u2013induced bone pain","volume":"23","author":"Middlemiss","year":"2011","journal-title":"Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1748-717X-8-85","article-title":"Continuous controversy about radiation oncologists\u2019 choice of treatment regimens for bone metastases: Should we blame doctors, cancer-related features, or design of previous clinical studies?","volume":"8","author":"Nieder","year":"2013","journal-title":"Radiat. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijsu.2008.12.035","article-title":"Ablation of painful metastatic bone tumors: A systematic review","volume":"6","author":"Carrafiello","year":"2008","journal-title":"Int. J. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1200\/JCO.2013.51.7219","article-title":"Pain and nociception: Mechanisms of cancer\u2013induced bone pain","volume":"32","author":"Falk","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","article-title":"Epithelial-mesenchymal transitions in development and disease","volume":"139","author":"Thiery","year":"2009","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Matrix metalloproteinases: Regulators of the tumor microenvironment","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2217\/fon.11.112","article-title":"Mechanisms of cancer cell metastasis to the bone: A multistep process","volume":"7","author":"Patel","year":"2011","journal-title":"Future Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13046-017-0578-1","article-title":"Current concepts in bone metastasis, contemporary therapeutic strategies and ongoing clinical trials","volume":"36","author":"Gdowski","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/nature02765","article-title":"Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB","volume":"430","author":"Douma","year":"2004","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1238856","article-title":"Engineered SIRPalpha variants as immunotherapeutic adjuvants to anticancer antibodies","volume":"341","author":"Weiskopf","year":"2013","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","article-title":"CXCL12 (SDF-1)\/CXCR4 pathway in cancer","volume":"16","author":"Teicher","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/pros.20500","article-title":"Expression and activation of alpha v beta 3 integrins by SDF-1\/CXC12 increases the aggressiveness of prostate cancer cells","volume":"67","author":"Sun","year":"2007","journal-title":"Prostate"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4137\/CGM.S12769","article-title":"The Osteoblastic and Osteoclastic Interactions in Spinal Metastases Secondary to Prostate Cancer","volume":"6","author":"Dushyanthen","year":"2013","journal-title":"Cancer Growth Metast."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/bonekey.2015.57","article-title":"Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors","volume":"4","author":"Shiozawa","year":"2015","journal-title":"Bonekey Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jbo.2012.11.002","article-title":"The role of the bone microenvironment in skeletal metastasis","volume":"2","author":"Zheng","year":"2013","journal-title":"J. Bone Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Park, S.H., Eber, M.R., Widner, D.B., and Shiozawa, Y. (2018). Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases. Cancers, 10.","DOI":"10.3390\/cancers10050141"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Buijs, J.T., Stayrook, K.R., and Guise, T.A. (2012). The role of TGF-\u03b2 in bone metastasis: Novel therapeutic perspectives. BoneKEy Rep.","DOI":"10.1038\/bonekey.2012.96"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.biopha.2017.07.023","article-title":"Managing metastatic bone pain: New perspectives, different solutions","volume":"93","author":"Hoffmann","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_36","first-page":"293","article-title":"Bone cancer pain and the role of RANKL\/OPG","volume":"4","author":"Clohisy","year":"2004","journal-title":"J. Musculoskelet. Neuronal Interact"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/SPC.0000000000000048","article-title":"Bone cancer: From mechanism to therapy","volume":"8","author":"Mantyh","year":"2014","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1200\/JCO.2010.29.7101","article-title":"Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study","volume":"28","author":"Stopeck","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"14649","DOI":"10.1523\/JNEUROSCI.3300-10.2010","article-title":"Pathological sprouting of adult nociceptors in chronic prostate cancer\u2013induced bone pain","volume":"30","author":"Bloom","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jpain.2010.12.016","article-title":"Breast cancer\u2013induced bone remodeling, skeletal pain and sprouting of sensory nerve fibers","volume":"12","author":"Bloom","year":"2011","journal-title":"J. Pain"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neulet.2003.12.012","article-title":"The many functions of nerve growth factor: Multiple actions on nociceptors","volume":"361","author":"Petruska","year":"2004","journal-title":"Neurosci. Lett."},{"key":"ref_42","first-page":"52","article-title":"Mechanisms of cancer-induced bone pain","volume":"17","author":"Vanderah","year":"2013","journal-title":"Neurosci. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.neuroscience.2010.08.056","article-title":"Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain","volume":"171","author":"Mantyh","year":"2010","journal-title":"Neuroscience"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/annonc\/mdy152","article-title":"ESMO Guidelines Committee. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines","volume":"29","author":"Fallon","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_45","unstructured":"(2018). WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents, World Health Organization."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijrobp.2010.11.026","article-title":"Palliative radiotherapy for bone metastases: An ASTRO evidence-based guideline","volume":"79","author":"Lutz","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.21037\/apm.2016.12.04","article-title":"Efficacy of single fraction conventional radiation therapy for painful uncomplicated bonemetastases: A systematic review and meta-analysis","volume":"6","author":"Chow","year":"2017","journal-title":"Ann. Palliat Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/annonc\/mdu103","article-title":"Bone health in cancer patients: ESMO Clinical Practice Guidelines","volume":"25","author":"Coleman","year":"2014","journal-title":"Ann. Oncol."},{"key":"ref_49","first-page":"CD003347","article-title":"Withdrawn: Radioisotopes for metastatic bone pain","volume":"3","author":"Roque","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S1470-2045(14)70183-4","article-title":"Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: Results from a phase 3, double blind, randomized trial","volume":"15","author":"Sartor","year":"2014","journal-title":"Lancet Oncol"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S254","DOI":"10.1097\/BRS.0000000000001819","article-title":"Evidence-Based review and survey of expert opinion of reconstruction of metastatic spine tumors","volume":"41","author":"Altaf","year":"2016","journal-title":"Spine"},{"key":"ref_52","unstructured":"National Institute for Care and Health Excellence (2019, November 20). Percutaneous Vertebroplasty. NICE Interventional Procedure Guidance [IPG12]. Available online: https:\/\/www.nice.org.uk\/guidance\/ipg12."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41408-019-0187-7","article-title":"The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: A consensus statement from the International Myeloma Working Group (IMWG)","volume":"9","author":"Kyriakou","year":"2019","journal-title":"Blood Cancer J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1055\/s-0042-100477","article-title":"Thermoablation of Bone Tumors","volume":"188","author":"Ringe","year":"2016","journal-title":"Fortschr. R\u00f6ntgenstr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1200\/JCO.2010.32.5209","article-title":"American Society of Clinical Oncology American Society of Clinical Oncology executive summary of the clinical practice guideline update on the role of bone modifying agents in metastatic breast cancer","volume":"29","author":"Temin","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1200\/JCO.2017.75.4614","article-title":"Role of Bone-Modifying Agents in Metastatic Breast Cancer: An American Society of Clinical Oncology-Cancer Care Ontario Focused Guideline Update","volume":"35","author":"Somerfield","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/SPC.0b013e32830baac2","article-title":"RANKL inhibition in the treatment of bone metastases","volume":"2","author":"Lipton","year":"2008","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.neuro.29.051605.112929","article-title":"Neurotrophins: Mediators and modulators of pain","volume":"29","author":"Pezet","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.2003.00203.x","article-title":"Neurotrophins and the immune system","volume":"203","author":"Vega","year":"2003","journal-title":"J. Anat."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/joacp.JOACP_389_15","article-title":"Tanezumab: Therapy targeting nerve growth factor in pain pathogenesis","volume":"34","author":"Patel","year":"2018","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1097\/j.pain.0000000000000211","article-title":"Efficacy and safety of tanezumab in the treatment of pain from bone metastases","volume":"156","author":"Sopata","year":"2015","journal-title":"Pain"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1191\/0269216304pm887ra","article-title":"The pathophysiology of cancer-induced bone pain: Current understanding","volume":"18","author":"Urch","year":"2004","journal-title":"Palliat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.lfs.2011.02.008","article-title":"Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice","volume":"88","author":"Isono","year":"2011","journal-title":"Life Sci."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Derry, S., Wiffen, P.J., Moore, R.A., McNicol, E.D., Bell, R.F., Carr, D.B., McIntyre, M., and Wee, B. (2017). Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD012638"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1470-2045(12)70040-2","article-title":"Use of opioid analgesics in the treatment of cancer pain: Evidence-based recommendations from the EAPC","volume":"13","author":"Caraceni","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Parat, M. (2013). Iatrogenic angiogenesis. Morphine and Metastasis, Springer Science+Business Media.","DOI":"10.1007\/978-94-007-5678-6"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zaj\u0105czkowska, R., Leppert, W., Mika, J., Kocot-K\u0119pska, M., Woro\u0144, J., Wrzosek, A., and Wordliczek, J. (2018). Perioperative immunosupression and risk of cancer progression: The impact of opioids on pain management. Pain Res. Manag., 9293704.","DOI":"10.1155\/2018\/9293704"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jpain.2018.01.002","article-title":"A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain","volume":"19","author":"Edwards","year":"2018","journal-title":"J. Pain"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0885-3924(94)90179-1","article-title":"Corticosteroids as adjuvant analgesics","volume":"9","author":"Bruera","year":"1994","journal-title":"J. Pain Symptom Manag."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1634\/theoncologist.9-5-571","article-title":"Adjuvant analgesics in cancer pain management","volume":"9","author":"Lussier","year":"2004","journal-title":"Oncologist"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.psyneuen.2009.06.004","article-title":"Evidence for a key role of steroids in the modulation of pain","volume":"34","author":"Meyer","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Haywood, A., Good, P., Khan, S., Leupp, A., Jenkins-Marsh, S., Rickett, K., and Hardy, J.R. (2015). Corticosteroids for the management of cancer-related pain in adults. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD010756.pub2"},{"key":"ref_73","first-page":"751","article-title":"Action of oral methylprednisolone in terminal cancer patients: A prospective randomized double-blind study","volume":"69","author":"Bruera","year":"1985","journal-title":"Cancer Treat Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11916-012-0273-z","article-title":"The role of corticosteroids in the treatment of pain in cancer patients","volume":"16","author":"Leppert","year":"2012","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00000542-200501000-00022","article-title":"Gabapentin normalizes spinal neuronal responses that correlate with behavior in a rat model of cancer-induced bone pain","volume":"102","author":"Dickenson","year":"2005","journal-title":"Anesthesiology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/0269216308089304","article-title":"Gabapentin for breakthrough pain due to bone metastases","volume":"22","author":"Caraceni","year":"2008","journal-title":"Palliat. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40122-013-0009-8","article-title":"Randomized study of pregabalin in patients with cancer\u2013induced bone pain","volume":"2","author":"Yang","year":"2013","journal-title":"Pain Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1200\/JCO.2015.63.8221","article-title":"Randomized Double-Blind Trial of Pregabalin Versus Placebo in Conjunction with Palliative Radiotherapy for Cancer-Induced Bone Pain","volume":"34","author":"Fallon","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1200\/JCO.2010.28.6559","article-title":"Neuropathic pain features in patients with bone metastases referred for palliative radiotherapy","volume":"28","author":"Kerba","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1200\/JCO.2015.64.7545","article-title":"Does Pregabalin Still Have a Role in Treating Cancer-Induced Bone Pain?","volume":"34","author":"Raman","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_82","first-page":"1","article-title":"Effectiveness of gabapentin and pregabalin for cancer-induced bone pain: A systematic review","volume":"7","author":"Miller","year":"2017","journal-title":"BMJ Support. Palliat. Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1080\/00207454.2019.1586687","article-title":"Thalidomide alleviates bone cancer pain by down-regulating expressions of NF-\u03baB and GFAP in spinal astrocytes in a mouse model","volume":"129","author":"Tian","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1097\/j.pain.0000000000000965","article-title":"Targeting the S1P\/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation","volume":"158","author":"Grenald","year":"2017","journal-title":"Pain"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/j.pain.0000000000001197","article-title":"Carbenoxolone as a novel therapy for attenuation of cancer-induced bone pain","volume":"159","author":"Falk","year":"2018","journal-title":"Pain"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1097\/j.pain.0000000000000681","article-title":"The cystine\/glutamate antiporter system xc\u2212 drives breast tumor cell glutamate release and cancer-induced bone pain","volume":"157","author":"Slosky","year":"2016","journal-title":"Pain"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pain.2013.08.030","article-title":"Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain","volume":"155","author":"Ungard","year":"2014","journal-title":"Pain"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2147\/JPR.S125045","article-title":"Identification of capsazepine as a novel inhibitor of system xc- and cancer-induced bone pain","volume":"10","author":"Fazzari","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-015-0858-0","article-title":"Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis","volume":"17","author":"Ebbinghaus","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2008.07.008","article-title":"The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice","volume":"592","author":"Kiguchi","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/j.pain.0000000000001139","article-title":"Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain","volume":"159","author":"Remeniuk","year":"2018","journal-title":"Pain"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/23\/6047\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:38:58Z","timestamp":1760189938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/20\/23\/6047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,30]]},"references-count":91,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["ijms20236047"],"URL":"https:\/\/doi.org\/10.3390\/ijms20236047","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,30]]}}}