{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:19:45Z","timestamp":1790651985359,"version":"4.1.0"},"reference-count":26,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["18-15-00309"],"award-info":[{"award-number":["18-15-00309"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Melatonin is assumed to confer cardioprotective action via antioxidative properties. We evaluated the association between ventricular tachycardia and\/or ventricular fibrillation (VT\/VF) incidence, oxidative stress, and myocardial electrophysiological parameters in experimental ischemia\/reperfusion under melatonin treatment. Melatonin was given to 28 rats (10 mg\/kg\/day, orally, for 7 days) and 13 animals received placebo. In the anesthetized animals, coronary occlusion was induced for 5 min followed by reperfusion with recording of unipolar electrograms from ventricular epicardium with a 64-lead array. Effects of melatonin on transmembrane potentials were studied in ventricular preparations of 7 rats in normal and \u201cischemic\u201d conditions. Melatonin treatment was associated with lower VT\/VF incidence at reperfusion, shorter baseline activation times (ATs), and activation-repolarization intervals and more complete recovery of repolarization times (RTs) at reperfusion (less baseline-reperfusion difference, \u0394RT) (p &lt; 0.05). Superoxide dismutase (SOD) activity was higher in the treated animals and associated with \u0394RT (p = 0.001), whereas VT\/VF incidence was associated with baseline ATs (p = 0.020). In vitro, melatonin led to a more complete restoration of action potential durations and resting membrane potentials at reoxygenation (p &lt; 0.05). Thus, the antioxidative properties of melatonin were associated with its influence on repolarization duration, whereas the melatonin-related antiarrhythmic effect was associated with its oxidative stress-independent action on ventricular activation.<\/jats:p>","DOI":"10.3390\/ijms20246331","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T05:19:38Z","timestamp":1576473578000},"page":"6331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Association Between Antiarrhythmic, Electrophysiological, and Antioxidative Effects of Melatonin in Ischemia\/Reperfusion"],"prefix":"10.3390","volume":"20","author":[{"given":"Ksenia A.","family":"Sedova","sequence":"first","affiliation":[{"name":"Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Sitna sq. 3105, 27201 Kladno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-1503","authenticated-orcid":false,"given":"Olesya G.","family":"Bernikova","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Federal Research Centre, Komi Science Centre, Ural Branch of Russian Academy of Sciences, Pervomayskaya st. 50, 167982 Syktyvkar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia I.","family":"Cuprova","sequence":"additional","affiliation":[{"name":"Department of Health Care Disciplines and Population Protection, Faculty of Biomedical Engineering, Czech Technical University in Prague, Sportovcu st. 2311, 27201 Kladno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-7036","authenticated-orcid":false,"given":"Alexandra D.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Department of Human and Animal Physiology, Lomonosov Moscow State University, Leninskiye gory, 1, 12, 119234 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina A.","family":"Kutaeva","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Medicine of Pitirim Sorokin Syktyvkar State University, Starovskii st., 55, 167001 Syktyvkar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Pliss","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Akkuratov st., 2, 197341 St Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina V.","family":"Lopatina","sequence":"additional","affiliation":[{"name":"Department of Normal Physiology, Pavlov First State Medical University of Saint Petersburg, Lev Tolstoy st., 6-8, 197022 St Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7530-5904","authenticated-orcid":false,"given":"Marina A.","family":"Vaykshnorayte","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Federal Research Centre, Komi Science Centre, Ural Branch of Russian Academy of Sciences, Pervomayskaya st. 50, 167982 Syktyvkar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-3703","authenticated-orcid":false,"given":"Emiliano R.","family":"Diez","sequence":"additional","affiliation":[{"name":"Instituto de Medicina y Biolog\u00eda Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), CP 5500 Mendoza, Argentina"},{"name":"Instituto de Fisiolog\u00eda, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Av. Libertador 80, Centro Universitario, CP 5500 Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-273X","authenticated-orcid":false,"given":"Jan E.","family":"Azarov","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Federal Research Centre, Komi Science Centre, Ural Branch of Russian Academy of Sciences, Pervomayskaya st. 50, 167982 Syktyvkar, Russia"},{"name":"Department of Physiology, Institute of Medicine of Pitirim Sorokin Syktyvkar State University, Starovskii st., 55, 167001 Syktyvkar, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.yjmcc.2009.11.011","article-title":"Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization","volume":"48","author":"Brown","year":"2010","journal-title":"J. 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