{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:21:17Z","timestamp":1789676477665,"version":"4.0.1"},"reference-count":53,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001769","name":"Charles Sturt University","doi-asserted-by":"publisher","award":["no grant number"],"award-info":[{"award-number":["no grant number"]}],"id":[{"id":"10.13039\/501100001769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graham Centre for Agricultural Innovation","award":["no grant number"],"award-info":[{"award-number":["no grant number"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The extraction of phenolic compounds from canola meal produces functional health products and renders the canola meal a more digestible animal feed. The extracted phenolics may have novel bioactivity worth investigation. In this study, several solvents were evaluated for their ability to extract phenolic compounds from canola meal: water (WE) and various 80% organic solvent\/water mixtures of methanol (ME), acetone (AE), ethanol (EE), butanol (BE), chloroform (CE) and hexane (HE). The in vitro antioxidant and anti-obesity properties of various extracts were investigated. Anti-obesity properties were studied using adipogenic differentiation inhibition of a murine mesenchymal stem cell line (C3H10T1\/2) and a pancreatic lipase inhibition assay. AE, ME, and BE showed significant (p &lt; 0.05) adipogenesis and pancreatic lipase inhibitory activities and may have more pharmacological properties. AE down-regulated the gene expression of the major adipogenic transcription factor, peroxisome proliferator-activated receptor gamma (PPAR\u03b3), correlating to phenolic content in a dose-dependent manner. The chemical characterization of AE revealed the presence of sinapic acid, ferulic acid, and kaempferol derivatives as main bioactive phenols.<\/jats:p>","DOI":"10.3390\/ijms21010001","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T09:50:33Z","timestamp":1576835433000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Phenolic Compounds with Antioxidant Properties from Canola Meal Extracts Inhibit Adipogenesis"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-9515","authenticated-orcid":false,"given":"Saira","family":"Hussain","sequence":"first","affiliation":[{"name":"ARC Industrial Transformation Training Centre for Functional Grains &amp; Graham Centre for Agricultural Innovation, Boorooma Street, Wagga Wagga, NSW 2650, Australia"},{"name":"Graham Centre (an alliance between Charles Sturt University and NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia"},{"name":"School of Biomedical Sciences, Charles Sturt University, Boorooma Street, Wagga Wagga, NSW 2678, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ata Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"ARC Industrial Transformation Training Centre for Functional Grains &amp; Graham Centre for Agricultural Innovation, Boorooma Street, Wagga Wagga, NSW 2650, Australia"},{"name":"Graham Centre (an alliance between Charles Sturt University and NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1687-5413","authenticated-orcid":false,"given":"David J.","family":"Luckett","sequence":"additional","affiliation":[{"name":"Graham Centre (an alliance between Charles Sturt University and NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Blanchard","sequence":"additional","affiliation":[{"name":"ARC Industrial Transformation Training Centre for Functional Grains &amp; Graham Centre for Agricultural Innovation, Boorooma Street, Wagga Wagga, NSW 2650, Australia"},{"name":"Graham Centre (an alliance between Charles Sturt University and NSW Department of Primary Industries), Boorooma Street, Wagga Wagga, NSW 2678, Australia"},{"name":"School of Biomedical Sciences, Charles Sturt University, Boorooma Street, Wagga Wagga, NSW 2678, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-9830","authenticated-orcid":false,"given":"Hassan K.","family":"Obied","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Charles Sturt University, Boorooma Street, Wagga Wagga, NSW 2678, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraig","family":"Strappe","sequence":"additional","affiliation":[{"name":"School of Medical and Applied Sciences, Central Queensland University, Rockhampton, Qld 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rahman, M., Khatun, A., Liu, L., and Barkla, B.J. 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