{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T06:44:58Z","timestamp":1794465898580,"version":"4.9.1"},"reference-count":155,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T00:00:00Z","timestamp":1577491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MInist\u00e9rio da Sa\u00fade do Brasil","award":["Salary and scholarships"],"award-info":[{"award-number":["Salary and scholarships"]}],"id":[{"id":"https:\/\/ror.org\/02y7p0749","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The microbiome is able to modulate immune responses, alter the physiology of the human organism, and increase the risk of viral infections and development of diseases such as cancer. In this review, we address changes in the cervical microbiota as potential biomarkers to identify the risk of cervical intraepithelial neoplasia (CIN) development and invasive cervical cancer in the context of human papillomavirus (HPV) infection. Current approaches for clinical diagnostics and the manipulation of microbiota with the use of probiotics and through microbiota transplantation are also discussed.<\/jats:p>","DOI":"10.3390\/ijms21010222","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T05:49:41Z","timestamp":1577684981000},"page":"222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer"],"prefix":"10.3390","volume":"21","author":[{"given":"Gislaine","family":"Curty","sequence":"first","affiliation":[{"name":"Programa de Oncovirologia, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20231-050, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro S.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Programa de Oncovirologia, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20231-050, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9013-2570","authenticated-orcid":false,"given":"Marcelo A.","family":"Soares","sequence":"additional","affiliation":[{"name":"Programa de Oncovirologia, Instituto Nacional de C\u00e2ncer, Rio de Janeiro 20231-050, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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