{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:49:55Z","timestamp":1794030595082,"version":"4.8.0"},"reference-count":89,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T00:00:00Z","timestamp":1578182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["17-15-013418"],"award-info":[{"award-number":["17-15-013418"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["17.7255.2017\/8.9"],"award-info":[{"award-number":["17.7255.2017\/8.9"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC\u2019s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. This higher AI was associated with reduced glycogen content and histological signs of metabolic and hypoxic damage and of impaired contractility. The livers of PTSD rats had reduced glycogen content. Liver and blood alanine and aspartate aminotransferase activities of PTSD rats were significantly increased. PTSD rats had increased norepinephrine concentration and decreased monoamine oxidase A activity in cerebral cortex. The PTSD-induced elevation of carbonylated proteins and lipid peroxidation products in these organs reflects oxidative stress, a known cause of organ pathology. IHC alleviated PTSD-induced metabolic and structural injury and reduced oxidative stress. Therefore, IHC is a promising preventive treatment for PTSD-related morphological and functional damage to organs, due, in part, to IHC\u2019s reduction of oxidative stress.<\/jats:p>","DOI":"10.3390\/ijms21010345","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T03:48:48Z","timestamp":1578282528000},"page":"345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain"],"prefix":"10.3390","volume":"21","author":[{"given":"Eugenia B.","family":"Manukhina","sequence":"first","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"},{"name":"Laboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, Moscow 125315, Russia"},{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim E.","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina N.","family":"Karpenko","sequence":"additional","affiliation":[{"name":"I.P. Pavlov Physiology Department, Institute of Experimental Medicine, St. Petersburg 197376, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina S.","family":"Pestereva","sequence":"additional","affiliation":[{"name":"I.P. Pavlov Physiology Department, Institute of Experimental Medicine, St. Petersburg 197376, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga B.","family":"Tseilikman","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"},{"name":"School of Basic Medicine, Chelyabinsk State University, Chelyabinsk 454001, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria V.","family":"Komelkova","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Kondashevskaya","sequence":"additional","affiliation":[{"name":"Laboratory for Immunomorphology of Inflammation, Research Institute of Human Morphology, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Goryacheva","sequence":"additional","affiliation":[{"name":"Laboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, Moscow 125315, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim S.","family":"Lapshin","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel O.","family":"Platkovskii","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3101-9655","authenticated-orcid":false,"given":"Alexey P.","family":"Sarapultsev","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathophysiology, Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620049, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anatoly V.","family":"Alliluev","sequence":"additional","affiliation":[{"name":"School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-1021","authenticated-orcid":false,"given":"H. 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