{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:59:50Z","timestamp":1791921590203,"version":"4.3.4"},"reference-count":63,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009068","name":"Conicyt","doi-asserted-by":"publisher","award":["21151622"],"award-info":[{"award-number":["21151622"]}],"id":[{"id":"10.13039\/501100009068","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PiE Qumibio, Universidad de Talca","award":["2017-2019"],"award-info":[{"award-number":["2017-2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Maresin-1 (MaR1) is a specialized pro-resolving mediator, derived from omega-3 fatty acids, whose functions are to decrease the pro-inflammatory and oxidative mediators, and also to stimulate cell division. We investigated the hepatoprotective actions of MaR1 in a rat model of liver ischemia-reperfusion (IR) injury. MaR1 (4 ng\/gr body weight) was administered prior to ischemia (1 h) and reperfusion (3 h), and controls received isovolumetric vehicle solution. To analyze liver function, transaminases levels and tissue architecture were assayed, and serum cytokines TNF-\u03b1, IL-6, and IL-10, mitotic activity index, and differential levels of NF-\u03baB and Nrf-2 transcription factors, were analyzed. Transaminase, TNF-\u03b1 levels, and cytoarchitecture were normalized with the administration of MaR1 and associated with changes in NF-\u03baB. IL-6, mitotic activity index, and nuclear translocation of Nrf-2 increased in the MaR1-IR group, which would be associated with hepatoprotection and cell proliferation. Taken together, these results suggest that MaR1 alleviated IR liver injury, facilitated by the activation of hepatocyte cell division, increased IL-6 cytokine levels, and the nuclear localization of Nrf-2, with a decrease of NF-\u03baB activity. All of them were related to an improvement of liver injury parameters. These results open the possibility of MaR1 as a potential therapeutic tool in IR and other hepatic pathologies.<\/jats:p>","DOI":"10.3390\/ijms21020540","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T10:30:27Z","timestamp":1579084227000},"page":"540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Maresin 1, a Proresolving Lipid Mediator, Ameliorates Liver Ischemia-Reperfusion Injury and Stimulates Hepatocyte Proliferation in Sprague-Dawley Rats"],"prefix":"10.3390","volume":"21","author":[{"given":"Gonzalo","family":"Soto","sequence":"first","affiliation":[{"name":"Escuela de Tecnolog\u00eda Medica, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Ciencias menci\u00f3n Investigaci\u00f3n y Desarrollo de Productos Bioactivos, Instituto de Qu\u00edmica de los Recursos Naturales, Universidad de Talca, Talca 3460000, Chile"},{"name":"Escuela de Medicina, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-502X","authenticated-orcid":false,"given":"Roberto","family":"Fuentealba","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Ciencias menci\u00f3n Investigaci\u00f3n y Desarrollo de Productos Bioactivos, Instituto de Qu\u00edmica de los Recursos Naturales, Universidad de Talca, Talca 3460000, Chile"},{"name":"Departamento de Ciencias B\u00e1sicas Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana V.","family":"Treuer","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile"},{"name":"Centro de Bioinform\u00e1tica, Simulaci\u00f3n y Modelado, Facultad de Ingenier\u00eda, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Castillo","sequence":"additional","affiliation":[{"name":"Unidad de Anatom\u00eda Patol\u00f3gica, Hospital Regional de Talca, Talca 3460001, Chile"},{"name":"Centro Oncol\u00f3gico, Facultad de Medicina, Universidad Cat\u00f3lica del Maule, Talca 3466706, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-8998","authenticated-orcid":false,"given":"Daniel R.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas Biom\u00e9dicas, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-0228","authenticated-orcid":false,"given":"Jessica","family":"Z\u00fa\u00f1iga-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad de Talca, Talca 3460000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"513192","DOI":"10.6064\/2012\/513192","article-title":"Regulatory Mechanisms of Injury and Repair after Hepatic Ischemia\/Reperfusion","volume":"2012","author":"Lentsch","year":"2012","journal-title":"Scientifica"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"906965","DOI":"10.1155\/2014\/906965","article-title":"Global Consequences of Liver Ischemia\/Reperfusion Injury","volume":"2014","author":"Nastos","year":"2014","journal-title":"Oxidative Med. 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