{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:09:46Z","timestamp":1790708986326,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Ministry of Research and Innovation, CNCS\u2013UEFISCDI","award":["PN-III-P4-ID-PCCF-2016\u20130050"],"award-info":[{"award-number":["PN-III-P4-ID-PCCF-2016\u20130050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A series of 2-thio- and 2-seleno-acetamides bearing the benzenesulfonamide moiety were evaluated as Carbonic Anhydrase (CA, EC 4.2.1.1) inhibitors against different pathogenic bacteria such as the Vibrio cholerae (VchCA-\u03b1 and VchCA-\u03b2), Burkholderia pseudomallei (BpsCA-\u03b2 and BpsCA-\u03b3), Mycobacterium tuberculosis (Rv3723-\u03b2) and the Salmonella enterica serovar Typhimurium (StCA2-\u03b2). The molecules represent interesting leads worth developing as innovative antibacterial agents since they possess new mechanism of action and isoform selectivity preferentially against the bacterial expressed CAs. The identification of potent and selective inhibitors of bacterial CAs may lead to tools also useful for deciphering the physiological role(s) of such proteins.<\/jats:p>","DOI":"10.3390\/ijms21020598","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T07:39:02Z","timestamp":1579246742000},"page":"598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angeli","sequence":"first","affiliation":[{"name":"Sezione di Scienze Farmaceutiche, NEUROFARBA Dept., Universit\u00e0 degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy"},{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, 700487 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-0088","authenticated-orcid":false,"given":"Mariana","family":"Pinteala","sequence":"additional","affiliation":[{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, 700487 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelian S.","family":"Maier","sequence":"additional","affiliation":[{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, 700487 Iasi, Romania"},{"name":"Polymeric Release Systems Research Group, Polymers Research Center, \u201cGheorghe Asachi\u201d Technical University of Iasi, 700050 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan C.","family":"Simionescu","sequence":"additional","affiliation":[{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, \u201cPetru Poni\u201d Institute of Macromolecular Chemistry, 700487 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Milaneschi","sequence":"additional","affiliation":[{"name":"Sezione di Scienze Farmaceutiche, NEUROFARBA Dept., Universit\u00e0 degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, P.O.Box 33, Nizwa-616, Sultanate of 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-2411","authenticated-orcid":false,"given":"Damiano","family":"Tanini","sequence":"additional","affiliation":[{"name":"Department of Chemistry \u201cUgo Schiff\u201d, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 13, I-50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1141-6146","authenticated-orcid":false,"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[{"name":"Sezione di Scienze Farmaceutiche, NEUROFARBA Dept., Universit\u00e0 degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Sezione di Scienze 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