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Dempsey MD Cerebrovascular Research Grant","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"https:\/\/ror.org\/01atcss13","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cerebral cavernous malformation (CCM) is a disease characterized by mulberry shaped clusters of dilated microvessels, primarily in the central nervous system. Such lesions can cause seizures, headaches, and stroke from brain bleeding. Loss-of-function germline and somatic mutations of a group of genes, called CCM genes, have been attributed to disease pathogenesis. In this review, we discuss the impact of CCM gene encoded proteins on cellular signaling, barrier function of endothelium and epithelium, and their contribution to CCM and potentially other diseases.<\/jats:p>","DOI":"10.3390\/ijms21020675","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T03:04:43Z","timestamp":1579575883000},"page":"675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation"],"prefix":"10.3390","volume":"21","author":[{"given":"Shu","family":"Wei","sequence":"first","affiliation":[{"name":"Graduate Program in Public Health and Preventive Medicine, Wuhan University of Science and Technology, Wuhan 430081, China"},{"name":"Department of Pathology, The University of Chicago, Chicago, IL 60615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Chicago, Chicago, IL 60615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3229-5021","authenticated-orcid":false,"given":"Sean P.","family":"Polster","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, The University of Chicago, Chicago, IL 60615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Chicago, Chicago, IL 60615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issam A.","family":"Awad","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Surgery, The University of Chicago, Chicago, IL 60615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-5476","authenticated-orcid":false,"given":"Le","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Chicago, Chicago, IL 60615, USA"},{"name":"Section of Neurosurgery, Department of Surgery, The University of Chicago, Chicago, IL 60615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2019.3.JNS181724","article-title":"Cavernous angiomas: Deconstructing a neurosurgical disease","volume":"131","author":"Awad","year":"2019","journal-title":"J. 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