{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:47:42Z","timestamp":1773168462655,"version":"3.50.1"},"reference-count":97,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UCB-PHARMA","award":["IIS-2014-101617"],"award-info":[{"award-number":["IIS-2014-101617"]}]},{"name":"AICE-FIRE","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"European Union's Seventh Framework Program","award":["FP7\/2007\u20102013"],"award-info":[{"award-number":["FP7\/2007\u20102013"]}]},{"name":"EPITARGET","award":["602102"],"award-info":[{"award-number":["602102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>\u03b3-Aminobutyric acid type A receptors (GABAARs) are the main inhibitory mediators in the central nervous system (CNS). GABAARs are pentameric ligand gated ion channels, and the main subunit composition is usually 2\u03b12\u03b2\u03b3, with various isotypes assembled within a set of 19 different subunits. The inhibitory function is mediated by chloride ion movement across the GABAARs, activated by synaptic GABA release, reducing neuronal excitability in the adult CNS. Several studies highlighted the importance of GABA-mediated transmission during neuro-development, and its involvement in different neurological and neurodevelopmental diseases, from anxiety to epilepsy. However, while it is well known how different classes of drugs are able to modulate the GABAARs function (benzodiazepines, barbiturates, neurosteroids, alcohol), up to now little is known about GABAARs and cannabinoids interaction in the CNS. Endocannabinoids and phytocannabinoids are lately emerging as a new class of promising drugs for a wide range of neurological conditions, but their safety as medication, and their mechanisms of action are still to be fully elucidated. In this review, we will focus our attention on two of the most promising molecules (\u03949-tetrahydrocannabinol; \u03949-THC and cannabidiol; CBD) of this new class of drugs and their possible mechanism of action on GABAARs.<\/jats:p>","DOI":"10.3390\/ijms21030723","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T11:17:57Z","timestamp":1579691877000},"page":"723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Phytocannabinoids in Neurological Diseases: Could They Restore a Physiological GABAergic Transmission?"],"prefix":"10.3390","volume":"21","author":[{"given":"Pierangelo","family":"Cifelli","sequence":"first","affiliation":[{"name":"IRCCS Neuromed, Pozzilli, 86077 Isernia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Ruffolo","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Pisana, 00163 Rome, Italy"},{"name":"Department of Physiology and Pharmacology, laboratory affiliated to Istituto Pasteur Italia, University of Rome Sapienza, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"De Felice","sequence":"additional","affiliation":[{"name":"IRCCS San Raffaele Pisana, 00163 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Alfano","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, laboratory affiliated to Istituto Pasteur Italia, University of Rome Sapienza, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-3202","authenticated-orcid":false,"given":"Erwin Alexander","family":"van Vliet","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of (Neuro) Pathology, 1105 Amsterdam, The Netherlands"},{"name":"Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1090 Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Aronica","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, University of Amsterdam, Department of (Neuro) Pathology, 1105 Amsterdam, The Netherlands"},{"name":"Stichting Epilepsie Instellingen Nederland (SEIN), 0397 Heemstede, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-927X","authenticated-orcid":false,"given":"Eleonora","family":"Palma","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, laboratory affiliated to Istituto Pasteur Italia, University of Rome Sapienza, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40224","DOI":"10.1074\/jbc.R112.386664","article-title":"Structure, function, and modulation of GABAA receptors","volume":"287","author":"Sigel","year":"2012","journal-title":"J. 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