{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:56:50Z","timestamp":1787241410720,"version":"build-2736575974"},"reference-count":110,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Natural Science Foundation of China","award":["31402286, 2015; 31972777, 2019"],"award-info":[{"award-number":["31402286, 2015; 31972777, 2019"]}]},{"name":"the Key Project of Sichuan Education Department","award":["035Z1364"],"award-info":[{"award-number":["035Z1364"]}]},{"name":"the Double Support Project of Discipline Construction of Sichuan Agricultural University","award":["03572781"],"award-info":[{"award-number":["03572781"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Echinococcosis are considered to be potentially lethal zoonotic diseases that cause serious damage to hosts. The metacestode of Echinococcus multilocularis and E. granulosus can result in causing the alveolar and cystic echinococcoses, respectively. Recent studies have shown that non-coding RNAs are widely expressed in Echinococcus spp. and hosts. In this review, the two main types of non-coding RNAs\u2014long non-coding RNAs (lncRNAs) and microRNAs (miRNAs)\u2014and the wide-scale involvement of these molecules in these parasites and their hosts were discussed. The expression pattern of miRNAs in Echinococcus spp. is species- and developmental stage-specific. Furthermore, common miRNAs were detected in three Echinococcus spp. and their intermediate hosts. Here, we primarily focus on recent insights from transcriptome studies, the expression patterns of miRNAs and lncRNAs, and miRNA-related databases and techniques that are used to investigate miRNAs in Echinococcus and echinococcosis. This review provides new avenues for screening therapeutic and diagnostic markers.<\/jats:p>","DOI":"10.3390\/ijms21030730","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T11:17:57Z","timestamp":1579691877000},"page":"730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["miRNAs and lncRNAs in Echinococcus and Echinococcosis"],"prefix":"10.3390","volume":"21","author":[{"given":"Zhi","family":"He","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiming","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deying","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyou","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijpara.2014.12.003","article-title":"High-throughput characterization of Echinococcus spp. metacestode miRNomes","volume":"45","author":"Cucher","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3347\/kjp.2018.56.4.391","article-title":"Genetic Diversity of Echinococcus granulosus Genotype G1 in Xinjiang, Northwest of China","volume":"56","author":"Yan","year":"2018","journal-title":"Korean J. Parasitol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e3866","DOI":"10.1136\/bmj.e3866","article-title":"Diagnosis, treatment, and management of echinococcosis","volume":"344","author":"McManus","year":"2012","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1002\/pmic.200900506","article-title":"Proteomic analysis of the Echinococcus granulosus metacestode during infection of its intermediate host","volume":"10","author":"Monteiro","year":"2010","journal-title":"Proteomics"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zhang, C., Wang, J., L\u00fc, G., Li, J., Lu, X., Mantion, G., Vuitton, D.A., Wen, H., and Lin, R. (2012). Hepatocyte Proliferation\/Growth Arrest Balance in the Liver of Mice during E. multilocularis Infection: A Coordinated 3-Stage Course. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030127"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.intimp.2018.09.004","article-title":"Suppression of mouse miRNA-222-3p in response to Echinococcus multilocularis infection","volume":"64","author":"Zheng","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/bs.apar.2016.09.002","article-title":"Echinococcosis: Control and Prevention","volume":"96","author":"Craig","year":"2017","journal-title":"Adv. Parasitol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Deplazes, P., Rinaldi, L., Rojas, C.A., Torgerson, P., Harandi, M., Romig, T., Antolova, D., Schurer, J., Lahmar, S., and Cringoli, G. (2017). Global Distribution of Alveolar and Cystic Echinococcosis, Elsevier BV.","DOI":"10.1016\/bs.apar.2016.11.001"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10393-008-0174-0","article-title":"Echinococcosis in China, a review of the epidemiology of Echinococcus spp.","volume":"5","author":"Wang","year":"2008","journal-title":"Ecohealth"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Giraudoux, P., Zhao, Y., Afonso, E., Yan, H., Knapp, J., Rogan, M.T., Shi, D., Jia, W., and Craig, P.S. (2019). Long-term retrospective assessment of a transmission hotspot for human alveolar echinococcosis in mid-west China. PLOS Neglected Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007701"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.ijpara.2013.06.002","article-title":"Phylogenetic systematics of the genus Echinococcus (Cestoda: Taeniidae)","volume":"43","author":"Nakao","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13071-015-0686-8","article-title":"microRNA profiling in the zoonotic parasite Echinococcus canadensis using a high-throughput approach","volume":"8","author":"Macchiaroli","year":"2015","journal-title":"Parasit. Vectors"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1002\/1873-3468.13182","article-title":"Noncoding RNAs in disease","volume":"592","author":"Lekka","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"Tsai","year":"2013","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.2757","article-title":"The genome of the hydatid tapeworm Echinococcus granulosus","volume":"45","author":"Zheng","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/9135073","article-title":"Noncoding RNAs in Health and Disease","volume":"2018","author":"Barbagallo","year":"2018","journal-title":"Int. J. Genom."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ijpara.2017.05.003","article-title":"Cestode parasites release extracellular vesicles with microRNAs and immunodiagnostic protein cargo","volume":"47","author":"Ancarola","year":"2017","journal-title":"Int. J. Parasitol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s13071-018-2905-6","article-title":"Microarray analysis of long non-coding RNA expression profiles in monocytic myeloid-derived suppressor cells in Echinococcus granulosus-infected mice","volume":"11","author":"Yu","year":"2018","journal-title":"Parasit. Vectors"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrm3611","article-title":"Diversifying microRNA sequence and function","volume":"14","author":"Ameres","year":"2013","journal-title":"Nat. Rev. Mol. Cell Boil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1002\/jcp.27069","article-title":"New advances of lncRNAs in liver fibrosis, with specific focus on lncRNA\u2013miRNA interactions","volume":"234","author":"Bian","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ebiom.2018.07.036","article-title":"Circular RNAs: Promising Biomarkers for Human Diseases","volume":"34","author":"Zhang","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molbiopara.2017.04.001","article-title":"Genome-wide identification of microRNA targets in the neglected disease pathogens of the genus Echinococcus","volume":"214","author":"Macchiaroli","year":"2017","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_24","first-page":"499","article-title":"MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects","volume":"6","author":"Judice","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/112_2016_7","article-title":"Exosomes: From Functions in Host-Pathogen Interactions and Immunity to Diagnostic and Therapeutic Opportunities","volume":"172","author":"Barnich","year":"2016","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pt.2015.09.003","article-title":"MicroRNAs in Parasitic Helminthiases: Current Status and Future Perspectives","volume":"32","author":"Cai","year":"2016","journal-title":"Trends Parasitol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1111\/jcmm.13866","article-title":"The novel regulatory role of lncRNA-miRNA-mRNA axis in cardiovascular diseases","volume":"22","author":"Huang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fphys.2018.01201","article-title":"Long Non-coding RNA Structure and Function: Is There a Link?","volume":"9","author":"Zampetaki","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yue, Y., Guo, T., Yuan, C., Liu, J., Guo, J., Feng, R., Niu, C., Sun, X., and Yang, B. (2016). Integrated analysis of the roles of long noncoding RNA and coding RNA expression in sheep (Ovis aries) skin during initiation of secondary hair follicle. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156890"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Zhan, S., Dong, Y., Zhao, W., Guo, J., Zhong, T., Wang, L., Li, L., and Zhang, H. (2016). Genome-wide identification and characterization of long non-coding RNAs in developmental skeletal muscle of fetal goat. BMC Genom., 17.","DOI":"10.1186\/s12864-016-3009-3"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kern, C., Wang, Y., Chitwood, J., Korf, I., Delany, M., Cheng, H., Medrano, J.F., Van Eenennaam, A.L., Ernst, C., and Ross, P. (2018). Genome-wide identification of tissue-specific long non-coding RNA in three farm animal species. BMC Genom., 19.","DOI":"10.1186\/s12864-018-5037-7"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.2527\/jas2016.1297","article-title":"LncRNA profiling of skeletal muscles in Large White pigs and Mashen pigs during development","volume":"95","author":"Gao","year":"2017","journal-title":"J. Anim. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Scott, E.Y., Mansour, T., Bellone, R.R., Brown, C.T., Mienaltowski, M.J., Penedo, M.C., Ross, P.J., Valberg, S.J., Murray, J.D., and Finno, C.J. (2017). Identification of long non-coding RNA in the horse transcriptome. BMC Genom., 18.","DOI":"10.1186\/s12864-017-3884-2"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Bai, J., Wu, A., Wang, Y., Zhang, J., Wang, Z., Li, Y., Xu, J., and Li, X. (2015). Co-LncRNA: Investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways based on human RNA-Seq data. Database, 2015.","DOI":"10.1093\/database\/bav082"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1038\/s41598-018-31770-2","article-title":"Characterisation and functional predictions of canine long non-coding RNAs","volume":"8","author":"Wucher","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Woehle, C., Kusdian, G., Radine, C., Graur, D., Landan, G., and Gould, S.B. (2014). The parasite Trichomonas vaginalis expresses thousands of pseudogenes and long non-coding RNAs independently from functional neighbouring genes. BMC Genom., 15.","DOI":"10.1186\/1471-2164-15-906"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13071-018-2697-8","article-title":"Microarray analysis of long non-coding RNA expression profiles uncovers a Toxoplasma-induced negative regulation of host immune signaling","volume":"11","author":"Liu","year":"2018","journal-title":"Parasit. Vectors"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nrm1644","article-title":"MicroRNA biogenesis: Coordinated cropping and dicing","volume":"6","author":"Kim","year":"2005","journal-title":"Nat. Rev. Mol. Cell Boil."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nsmb.2232","article-title":"The N domain of Argonaute drives duplex unwinding during RISC assembly","volume":"19","author":"Kwak","year":"2012","journal-title":"Nat. Struct. Mol. Boil."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nature09092","article-title":"A dicer-independent miRNA biogenesis pathway that requires Ago catalysis","volume":"465","author":"Cheloufi","year":"2010","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.7150\/thno.21299","article-title":"Identifying and Characterizing circRNA-Protein Interaction","volume":"7","author":"Du","year":"2017","journal-title":"Theranostics"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhang, X., Wang, W., Zhu, W., Dong, J., Cheng, Y., Yin, Z., and Shen, F. (2019). Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225573"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1017\/S0031182017000300","article-title":"Expression profiling of circulating miRNAs in mouse serum in response to Echinococcus multilocularis infection","volume":"144","author":"Guo","year":"2017","journal-title":"Parasitology"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Bai, Y., Zhang, Z., Jin, L., Kang, H., Zhu, Y., Zhang, L., Li, X., Ma, F., Zhao, L., and Shi, B. (2014). Genome-wide sequencing of small RNAs reveals a tissue-specific loss of conserved microRNA families in Echinococcus granulosus. BMC Genom., 15.","DOI":"10.1186\/1471-2164-15-736"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ijpara.2010.11.010","article-title":"Identification of Echinococcus granulosus microRNAs and their expression in different life cycle stages and parasite genotypes","volume":"41","author":"Cucher","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ygeno.2016.04.002","article-title":"MicroRNA discovery in the human parasite Echinococcus multilocularis from genome-wide data","volume":"107","author":"Kamenetzky","year":"2016","journal-title":"Genomics"},{"key":"ref_47","first-page":"2477","article-title":"microRNA profile analyses of the protoscoleces in Echinococcus granulosus","volume":"49","author":"Wang","year":"2018","journal-title":"Acta Vet. et Zootech. Sin."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1111\/febs.12395","article-title":"Comparative analysis of known miRNAs across platyhelminths","volume":"280","author":"Jin","year":"2013","journal-title":"FEBS J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.actatropica.2019.04.031","article-title":"The effect of albendazole sulfoxide on the expression of miR-61 and let-7 in different in vitro developmental stages of Echinococcus granulosus","volume":"195","author":"Mortezaei","year":"2019","journal-title":"Acta Trop."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1038\/ncomms6488","article-title":"Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity","volume":"5","author":"Buck","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13071-015-0656-1","article-title":"Extracellular Onchocerca-derived small RNAs in host nodules and blood","volume":"8","author":"Quintana","year":"2015","journal-title":"Parasit. Vectors"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1093\/nar\/gks293","article-title":"Argonaute identity defines the length of mature mammalian microRNAs","volume":"40","author":"Juvvuna","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.intimp.2016.03.015","article-title":"Effects of Echinococcus multilocularis miR-71 mimics on murine macrophage RAW264.7 cells","volume":"34","author":"Zheng","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2017.10.004","article-title":"Suppression of nemo-like kinase by miR-71 in Echinococcus multilocularis","volume":"183","author":"Guo","year":"2017","journal-title":"Exp. Parasitol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4161\/rna.23716","article-title":"microRNAs in parasites and parasite infection","volume":"10","author":"Zheng","year":"2013","journal-title":"RNA Boil."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1017\/S0031182017001652","article-title":"MicroRNA expression profile in RAW264.7 macrophage cells exposed to Echinococcus multilocularis metacestodes","volume":"145","author":"Guo","year":"2018","journal-title":"Parasitology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1051\/parasite\/2016023","article-title":"MicroRNA profiling of the intestinal tissue of Kazakh sheep after experimental Echinococcus granulosus infection, using a high-throughput approach","volume":"23","author":"Jiang","year":"2016","journal-title":"Parasite"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1002\/eji.201344335","article-title":"Myeloid-derived suppressor cell functionality and interaction with Leishmania major parasites differ in C57BL\/6 and BALB\/c mice","volume":"44","author":"Schmid","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Pan, W., Zhou, H.-J., Shen, Y.-J., Wang, Y., Xu, Y.-X., Hu, Y., Jiang, Y.-Y., Yuan, Z.-Y., Ugwu, C.E., and Cao, J.-P. (2013). Surveillance on the Status of Immune Cells after Echinnococcus granulosus Protoscoleces Infection in Balb\/c Mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059746"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.actatropica.2016.10.024","article-title":"miRNA profiling in the mice in response to Echinococcus multilocularis infection","volume":"166","author":"Jin","year":"2017","journal-title":"Acta Trop."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00432-017-2576-2","article-title":"Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis","volume":"144","author":"Jiang","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.12659\/MSM.910000","article-title":"Long Noncoding RNA (lncRNA) n379519 Promotes Cardiac Fibrosis in Post-Infarct Myocardium by Targeting miR-30","volume":"24","author":"Wang","year":"2018","journal-title":"Med Sci. Monit."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1800087","DOI":"10.1002\/advs.201800087","article-title":"LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365","volume":"5","author":"Gao","year":"2018","journal-title":"Adv. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.2147\/OTT.S165147","article-title":"Long noncoding RNA GAPLINC promotes gastric cancer cell proliferation by acting as a molecular sponge of miR-378 to modulate MAPK1 expression","volume":"11","author":"Diao","year":"2018","journal-title":"OncoTargets Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.ccell.2016.03.004","article-title":"Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA","volume":"29","author":"Qu","year":"2016","journal-title":"Cancer Cell"},{"key":"ref_66","first-page":"3038","article-title":"MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma","volume":"22","author":"Yan","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1089\/gtmb.2018.0151","article-title":"Long Noncoding RNA MRPL39 Inhibits Gastric Cancer Proliferation and Progression by Directly Targeting miR-130","volume":"22","author":"Yu","year":"2018","journal-title":"Genet. Test. Mol. Biomark."},{"key":"ref_68","first-page":"1963","article-title":"Long non-coding RNA Dleu2 affects proliferation, migration and invasion ability of laryngeal carcinoma cells through triggering miR-16-1 pathway","volume":"22","author":"Xie","year":"2018","journal-title":"Eur. Rev. Med Pharmacol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/JLB.3MIR1117-459R","article-title":"miRNA regulation of innate immunity","volume":"103","author":"Bala","year":"2018","journal-title":"J. Leukoc. Boil."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI88415","article-title":"Excessive expression of miR-27 impairs Treg-mediated immunological tolerance","volume":"127","author":"Cruz","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.18632\/aging.101573","article-title":"Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer","volume":"10","author":"Liu","year":"2018","journal-title":"Aging"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3389\/fphar.2017.00980","article-title":"MicroRNA-145 increases the apoptosis of activated hepatic stellate cells induced by TRAIL through NF-kappaB signaling pathway","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"758","DOI":"10.3389\/fimmu.2017.00758","article-title":"MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation","volume":"8","author":"Ghorbani","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/bies.201300047","article-title":"X-chromosome-encoded microRNA-19 and -18 are possible modulators of female immunity","volume":"35","author":"Gantier","year":"2013","journal-title":"BioEssays"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.biopha.2017.10.152","article-title":"Inhibition of miR-20 promotes proliferation and autophagy in articular chondrocytes by PI3K\/AKT\/mTOR signaling pathway","volume":"97","author":"He","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12935-016-0380-8","article-title":"The inhibition role of miR-22 in hepatocellular carcinoma cell migration and invasion via targeting CD147","volume":"17","author":"Luo","year":"2017","journal-title":"Cancer Cell Int."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"80751","DOI":"10.18632\/oncotarget.13037","article-title":"miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bbrc.2016.12.091","article-title":"MiR-223 modulates hepatocellular carcinoma cell proliferation through promoting apoptosis via the Rab1-mediated mTOR activation","volume":"483","author":"Dong","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1042\/CS20170218","article-title":"miR-223 represents a biomarker in acute and chronic liver injury","volume":"131","author":"Schueller","year":"2017","journal-title":"Clin. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1159\/000480532","article-title":"Long Noncoding RNA CIR Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis by Acting as a Sponge For Mir-27b","volume":"43","author":"Li","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.3892\/etm.2017.4872","article-title":"Immune regulation of miR-30 on the Mycobacterium tuberculosis-induced TLR\/MyD88 signaling pathway in THP-1 cells","volume":"14","author":"Wu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/1759-7714.12597","article-title":"MiR-339 depresses cell proliferation via directly targeting S-phase kinase-associated protein 2 mRNA in lung cancer","volume":"9","author":"Ren","year":"2018","journal-title":"Thorac. Cancer"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/jcb.27461","article-title":"miR-345-5p regulates proliferation, cell cycle, and apoptosis of acute myeloid leukemia cells by targeting AKT2","volume":"120","author":"Ying","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.exer.2017.11.006","article-title":"miR-365 promotes diabetic retinopathy through inhibiting Timp3 and increasing oxidative stress","volume":"168","author":"Wang","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_85","first-page":"3837","article-title":"MicroRNA-378 acts as a prognosis marker and inhibits cell migration, invasion and epithelial-mesenchymal transition in human glioma by targeting IRG1","volume":"22","author":"Shi","year":"2018","journal-title":"Eur. Rev. Med Pharmacol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1164\/rccm.201701-0101OC","article-title":"MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness","volume":"196","author":"Garros","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.gene.2017.06.039","article-title":"gga-miR-99a targets SMARCA5 to regulate Mycoplasma gallisepticum (HS strain) infection by depressing cell proliferation in chicken","volume":"627","author":"Zhao","year":"2017","journal-title":"Gene"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e12507","DOI":"10.1111\/cpr.12507","article-title":"Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124","volume":"51","author":"Pan","year":"2018","journal-title":"Cell Prolif."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00011-018-1184-1","article-title":"Long noncoding RNA MALAT1 acts as a competing endogenous RNA to regulate Amadori-glycated albumin-induced MCP-1 expression in retinal microglia by a microRNA-124-dependent mechanism","volume":"67","author":"Dong","year":"2018","journal-title":"Inflamm. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12943-018-0911-0","article-title":"EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/hep.25613","article-title":"Inhibitory effects of microRNA 19b in hepatic stellate cell-mediated fibrogenesis","volume":"56","author":"Lakner","year":"2012","journal-title":"Hepatol."},{"key":"ref_92","unstructured":"Xueyong, Z. (2015). Primary Studies on the emu-miR-71 as Inhibiting Molecule of the Potential Drug Target Nemo-Like Kinase in Echinococcus Multilocularis Metacestode, Lanzhou Veterinary Research Institute."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fimmu.2017.00056","article-title":"Potential Value of miR-221\/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases","volume":"8","author":"Song","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.intimp.2013.07.022","article-title":"Strategies of Echinococcus species responses to immune attacks: Implications for therapeutic tool development","volume":"17","author":"Zheng","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12943-019-0997-z","article-title":"CD103-positive CSC exosome promotes EMT of clear cell renal cell carcinoma: Role of remote MiR-19b-3p","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s13577-019-00298-6","article-title":"Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3\/STAT3 pathway to promote osteosarcoma cell growth and invasion","volume":"33","author":"Du","year":"2019","journal-title":"Hum. Cell"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"10165","DOI":"10.1002\/jcb.27357","article-title":"Long noncoding RNA MALAT1 alleviates lipopolysaccharide-induced inflammatory injury by upregulating microRNA-19b in murine chondrogenic ATDC5 cells","volume":"119","author":"Pan","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13071-016-1562-x","article-title":"Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression","volume":"9","author":"Zhang","year":"2016","journal-title":"Parasit. Vectors"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhang, C., Wei, X., Blagosklonov, O., Lv, G., Lu, X., Mantion, G., Vuitton, D.A., Wen, H., and Lin, R. (2013). TGF-beta and TGF-beta\/Smad signaling in the interactions between Echinococcus multilocularis and its hosts. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055379"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Wang, J., Lin, R., Zhang, W., Li, L., Gottstein, B., Blagosklonov, O., L\u00fc, G., Zhang, C., Lu, X., and Vuitton, D.A. (2014). Transcriptional Profiles of Cytokine\/Chemokine Factors of Immune Cell-Homing to the Parasitic Lesions: A Comprehensive One-Year Course Study in the Liver of E. multilocularis-Infected Mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091638"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: From microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"D130","DOI":"10.1093\/nar\/gku1063","article-title":"Rfam 12.0: Updates to the RNA families database","volume":"43","author":"Nawrocki","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/gb-2010-11-8-r90","article-title":"Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites","volume":"11","author":"Betel","year":"2010","journal-title":"Genome Boil."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.cell.2006.07.031","article-title":"A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes","volume":"126","author":"Miranda","year":"2006","journal-title":"Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gkl243","article-title":"RNAhybrid: microRNA target prediction easy, fast and flexible","volume":"34","author":"Rehmsmeier","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"D153","DOI":"10.1093\/nar\/gku1215","article-title":"DIANA-TarBase v7.0: Indexing more than half a million experimentally supported miRNA:mRNA interactions","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3389\/fmicb.2017.00929","article-title":"Genome-Wide Transcriptome Analysis Reveals Extensive Alternative Splicing Events in the Protoscoleces of Echinococcus granulosus and Echinococcus multilocularis","volume":"8","author":"Liu","year":"2017","journal-title":"Front Microbiol."},{"key":"ref_108","unstructured":"Shanghai Chinese Human Genome Center (2013). Echinococcus Granulosus Small RNA Transcriptome, Yun Bai."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/nar\/gkr688","article-title":"miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades","volume":"40","author":"Friedlander","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1534\/g3.112.004820","article-title":"How to Design a Genetic Mating Scheme: A Basic Training Package for Drosophila Genetics","volume":"3","author":"Roote","year":"2013","journal-title":"G3 Genes Genomes Genet."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/3\/730\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:20:36Z","timestamp":1760361636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/3\/730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,22]]},"references-count":110,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["ijms21030730"],"URL":"https:\/\/doi.org\/10.3390\/ijms21030730","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,22]]}}}