{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:34:44Z","timestamp":1791221684975,"version":"4.1.0"},"reference-count":173,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Omega-3 (\u03c9-3) and omega-6 (\u03c9-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of \u03c9-3 and \u03c9-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined \u03c9-6, gamma-linolenic acid (GLA), and \u03c9-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.<\/jats:p>","DOI":"10.3390\/ijms21030741","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T10:36:02Z","timestamp":1579775762000},"page":"741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":358,"title":["Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2673-8113","authenticated-orcid":false,"given":"Anamaria","family":"Bali\u0107","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine University of Zagreb, \u0160alata 4, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domagoj","family":"Vla\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology and Optometry, General Hospital Dubrovnik, Ulica dr. Roka Mi\u0161eti\u0107a 2, 20000 Dubrovnik, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"\u017du\u017eul","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Zagreb, \u0160alata 3, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Marinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine University of Zagreb, \u0160alata 4, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zrinka","family":"Bukvi\u0107 Mokos","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine University of Zagreb, \u0160alata 4, 10 000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0021-9258(20)78281-5","article-title":"A new deficiency disease produced by the rigid exclusion of fat from the diet","volume":"82","author":"Burr","year":"1929","journal-title":"J. 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