{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:21:20Z","timestamp":1790652080367,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T00:00:00Z","timestamp":1580774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III- of the Spanish Ministry of Economy and Competitiveness, and the European Union through the \u201cFondo Europeo de Desarrollo Regional (FEDER)\u201d.","award":["PI17\/01549"],"award-info":[{"award-number":["PI17\/01549"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oxidative stress has a strong impact on the development of retinal diseases such as age-related macular degeneration (AMD). Plasma rich in growth factors (PRGF) is a novel therapeutic approach in ophthalmological pathologies. The aim of this study was to analyze the antioxidant effect of PRGF in retinal epithelial cells (EPR) in in vitro and ex vivo retinal phototoxicity models. In vitro analyses were performed on ARPE19 human cell line. Viability and mitochondrial status were assessed in order to test the primary effects of PRGF. GSH level, and protein and gene expression of the main antioxidant pathway (Keap1, Nrf2, GCL, HO-1, and NQO1) were also studied. Ex vivo analyses were performed on rat RPE, and HO-1 and Nrf2 gene and protein expression were evaluated. The results show that PRGF reduces light insult by stimulating the cell response against oxidative damage and modulates the antioxidant pathway. We conclude that PRGF\u2019s protective effect could prove useful as a new therapy for treating neurodegenerative disorders such as AMD.<\/jats:p>","DOI":"10.3390\/ijms21031021","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T03:18:48Z","timestamp":1580872728000},"page":"1021","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Antioxidant Role of PRGF on RPE Cells after Blue Light Insult as a Therapy for Neurodegenerative Diseases"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0171-1851","authenticated-orcid":false,"given":"Carlota","family":"Su\u00e1rez-Barrio","sequence":"first","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega. Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica &amp; Universidad de Oviedo, 33012 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Avenida de Roma s\/n., 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-7254","authenticated-orcid":false,"given":"Susana","family":"del Olmo-Aguado","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega. Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica &amp; Universidad de Oviedo, 33012 Oviedo, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, Avenida de Roma s\/n., 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-9318","authenticated-orcid":false,"given":"Eva","family":"Garc\u00eda-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega. Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica &amp; Universidad de Oviedo, 33012 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"BTI Biotechnology Institute, 01007 Vitoria, Spain"},{"name":"University Institute for Regenerative Medicine and Oral Implantology\u2014UIRMI (UPV\/EHU\u2014Fundaci\u00f3n Eduardo Anitua), 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Muruzabal","sequence":"additional","affiliation":[{"name":"BTI Biotechnology Institute, 01007 Vitoria, Spain"},{"name":"University Institute for Regenerative Medicine and Oral Implantology\u2014UIRMI (UPV\/EHU\u2014Fundaci\u00f3n Eduardo Anitua), 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Anitua","sequence":"additional","affiliation":[{"name":"BTI Biotechnology Institute, 01007 Vitoria, Spain"},{"name":"University Institute for Regenerative Medicine and Oral Implantology\u2014UIRMI (UPV\/EHU\u2014Fundaci\u00f3n Eduardo Anitua), 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Baamonde-Arbaiza","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega. 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