{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:28:03Z","timestamp":1793604483123,"version":"4.5.0"},"reference-count":57,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Curcumin, an herbal naturally occurring polyphenol, has recently been proposed for the treatment of neurodegenerative, neurological and cancer diseases due to its pleiotropic effect. Recent studies indicated that dysbiosis is associated with the abovementioned and other diseases, and gut microflora may be a new potential therapeutic target. The new working hypothesis that could explain the curative role of curcumin, despite its limited availability, is that curcumin acts indirectly on the brain, affecting the \u201cgut\u2013brain\u2013microflora axis\u201d, a complex two-way system in which the gut microbiome and its composition, are factors that preserve and determine brain health. It is therefore suspected that curcumin and its metabolites have a direct regulatory effect on gut microflora and vice versa, which may explain the paradox between curcumin\u2019s poor bioavailability and its commonly reported therapeutic effects. Curcumin and its metabolites can have health benefits by eliminating intestinal microflora dysbiosis. In addition, curcumin undergoes enzymatic modifications by bacteria, forming pharmacologically more active metabolites than their parent, curcumin. In this review, we summarize a number of studies that highlight the interaction between curcumin and gut microbiota and vice versa, and we consider the possibility of microbiome-targeted therapies using curcumin, particularly in disease entities currently without causal treatment.<\/jats:p>","DOI":"10.3390\/ijms21031055","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T02:59:18Z","timestamp":1580957958000},"page":"1055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Mutual Two-Way Interactions of Curcumin and Gut Microbiota"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-1356","authenticated-orcid":false,"given":"Ryszard","family":"Pluta","sequence":"first","affiliation":[{"name":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Januszewski","sequence":"additional","affiliation":[{"name":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"U\u0142amek-Kozio\u0142","sequence":"additional","affiliation":[{"name":"Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5114\/fn.2015.52405","article-title":"Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: Is there a role for the curcumin?","volume":"53","author":"Pluta","year":"2015","journal-title":"Folia Neuropathol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pluta, R., U\u0142amek-Kozio\u0142, M., and Czuczwar, S.J. (2018). Neuroprotective and neurological\/cognitive enhancement effects of curcumin after brain ischemia injury with Alzheimer\u2019s disease phenotype. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19124002"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Dei Cas, M., and Ghidoni, R. (2019). Dietary curcumin: Correlation between bioavailability and health potential. Nutrients, 11.","DOI":"10.3390\/nu11092147"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1080\/10408398.2018.1478388","article-title":"Bidirectional interactions between dietary curcumin and gut microbiota","volume":"59","author":"Shen","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Maiti, P., and Dunbar, G.L. (2018). Use of curcumin, a natural polyphenol for targeting molecular pathways in treating age-related neurodegenerative diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061637"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3233\/JAD-170512","article-title":"Protective effects of indian spice curcumin against amyloid beta in Alzheimer\u2019s disease","volume":"61","author":"Reddy","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Xu, X.Y., Meng, X., Li, S., Gan, R.Y., Li, Y., and Li, H.B. (2018). Bioactivity, health benefits, and related molecular mechanisms of curcumin: Current progress, challenges, and perspectives. Nutrients, 10.","DOI":"10.3390\/nu10101553"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Bachmeier, B.E., and Melchart, D. (2019). Therapeutic effects of curcumin\u2014From traditional past to present and future clinical applications. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153757"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bielak-Zmijewska, A., Grabowska, W., Ciolko, A., Bojko, A., Kosieniak, G., Bijoch, L., and Sikora, E. (2019). The role of curcumin in the modulation of ageing. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051239"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Del Prado-Audelo, M.L., Caballero-Flor\u00e1n, I.H., Meza-Toledo, J.A., Mendoza-Mu\u00f1oz, N., Gonz\u00e1lez-Torres, M., Benjam\u00edn Flor\u00e1n, B., Cort\u00e9s, H., and Leyva-G\u00f3mez, G. (2019). Formulations of curcumin nanoparticles for brain diseases. Biomolecules, 9.","DOI":"10.3390\/biom9020056"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kotha, R.R., and Luthria, L.D. (2019). Curcumin: Biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules, 24.","DOI":"10.3390\/molecules24162930"},{"key":"ref_12","first-page":"659","article-title":"Role of colonic microbiota in colorectal carcinogenesis: A systematic review","volume":"107","year":"2015","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.tips.2015.11.010","article-title":"Intestinal microbiota and metabolic diseases: Pharmacological implications","volume":"37","author":"Shen","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-160884","article-title":"Alzheimer\u2019s disease histological and behavioral manifestations in transgenic mice correlate with specific gut microbiome state","volume":"56","author":"Shen","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Di Meo, F., Margarucci, S., Galderisi, U., Crispi, S., and Peluso, G. (2019). Curcumin, gut microbiota, and neuroprotection. Nutrients, 11.","DOI":"10.3390\/nu11102426"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1361780","DOI":"10.1080\/16546628.2017.1361780","article-title":"Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications","volume":"61","author":"Shen","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00044.2014","article-title":"Chemoprevention in gastrointestinal physiology and disease. Natural products and microbiome","volume":"307","author":"Greiner","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/0022034516668847","article-title":"Clinical, immune, and microbiome traits of gingivitis and periimplant mucositis","volume":"96","author":"Schincaglia","year":"2017","journal-title":"J. Dental. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1097\/MIB.0000000000000522","article-title":"The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention","volume":"21","author":"McFadden","year":"2015","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-5793(03)00099-1","article-title":"Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases","volume":"538","author":"Rashmi","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.1158\/1078-0432.CCR-05-0171","article-title":"Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells","volume":"11","author":"Strier","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_22","first-page":"4487","article-title":"Novel micelle formulation of curcumin for enhancing antitumor activity and inhibiting colorectal cancer stem cells","volume":"7","author":"Wang","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_23","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1158\/1078-0432.CCR-04-0744","article-title":"Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance","volume":"10","author":"Sharma","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.canlet.2007.03.005","article-title":"Curcumin for chemoprevention of colon cancer","volume":"255","author":"Johnson","year":"2007","journal-title":"Cancer Lett."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ohno, M., Nishida, A., Sugitani, Y., Nishino, K., Inatomi, O., Sugimoto, M., Kawahara, M., and Andoh, A. (2017). Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells. PLOS ONE, 12.","DOI":"10.1371\/journal.pone.0185999"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.cgh.2015.02.019","article-title":"Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial","volume":"13","author":"Lang","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2174\/1381612822666151112145033","article-title":"Dietary supplement therapies for inflammatory bowel disease: Crohn\u2019s disease and ulcerative colitis","volume":"22","author":"Parian","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_29","first-page":"627","article-title":"Effect of curcumin on atherosclerosis in apoE\/LDLR-double knockout mice","volume":"56","author":"Olszanecki","year":"2005","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"C438","DOI":"10.1152\/ajpcell.00235.2016","article-title":"Curcumin improves intestinal barrier function: Modulation of intracellular signaling, and organization of tight junctions","volume":"312","author":"Wang","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bereswill, S., Mu\u00f1oz, M., Fischer, A., Plickert, R., Haag, L.M., Otto, B., K\u00fchl, A.A., Loddenkemper, C., G\u00f6bel, U.B., and Heimesaat, M.M. (2010). Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015099"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Ghosh, S.S., Bie, J.H., Wang, J., and Ghosh, S. (2014). Oral supplementation with non-absorbable antibiotics or curcumin attenuates Western diet-induced atherosclerosis and glucose intolerance in LDLR-\/- mice - Role of intestinal permeability and macrophage activation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108577"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2515690X18790725","DOI":"10.1177\/2515690X18790725","article-title":"Effects of turmeric and curcumin dietary supplementation on human gut microbiota: A double-blind, randomized, placebo-controlled pilot study","volume":"23","author":"Peterson","year":"2018","journal-title":"J. Evid. Based Integr. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Chen, Y., Xiang, L., Wang, Z., Xiao, G.G., and Hu, J. (2017). Effect of curcumin on the diversity of gut microbiota in ovariectomized rats. Nutrients, 9.","DOI":"10.3390\/nu9101146"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1039\/C7FO01242J","article-title":"Curcumin as a functional food-derived factor: Degradation products, metabolites, bioactivity, and future perspectives","volume":"9","author":"Tsuda","year":"2018","journal-title":"Food Funct."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1367984","DOI":"10.1155\/2018\/1367984","article-title":"Gut microbiota as a prospective therapeutic target for curcumin: A review of mutual influence","volume":"2018","author":"Zam","year":"2018","journal-title":"J. Nutr. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jchromb.2015.01.014","article-title":"Application of ultraperformance liquid chromatography coupled with quadrupole time-offlight mass spectrometry to identify curcumin metabolites produced by human intestinal bacteria","volume":"985","author":"Lou","year":"2015","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed Life Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1021\/acs.jafc.7b00943","article-title":"Curcuminoid demethylation as an alternative metabolism by human intestinal microbiota","volume":"65","author":"Burapan","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3109\/09637486.2015.1095865","article-title":"The degradation of curcuminoids in a human faecal fermentation model","volume":"66","author":"Tan","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"11005","DOI":"10.1021\/jf5031168","article-title":"Degradation of curcuminoids by in vitro pure culture fermentation","volume":"62","author":"Tan","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1412814","DOI":"10.1080\/16546628.2017.1412814","article-title":"Biotransformation of food spice curcumin by gut bacterium Bacillus megaterium DCMB-002 and its pharmacological implications","volume":"61","author":"An","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_42","first-page":"15","article-title":"Survival of bifidobacteria and other selected intestinal bacteria in TPY medium supplemented with curcumin as assessed in vitro","volume":"4","author":"Jazayeri","year":"2009","journal-title":"Int. J. Probiotics Prebiotics"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s12010-013-0256-5","article-title":"Microbial transformation of curcumin to its derivatives with a novel pichia kudriavzevii ZJPH0802 strain","volume":"170","author":"Zhang","year":"2013","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3109\/10242422.2010.532870","article-title":"Microbial transformation of curcumin by rhizopus chinensis","volume":"28","author":"Zhang","year":"2010","journal-title":"Biocatal. Biotransform."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1248\/cpb.59.1042","article-title":"Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus diaporthe sp. Associated with curcuma longa","volume":"59","author":"Maehara","year":"2011","journal-title":"Chem. Pharm. Bull. Tokyo"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1073\/pnas.1016217108","article-title":"Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism","volume":"108","author":"Hassaninasab","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/biof.1042","article-title":"Curcumin uptake and metabolism","volume":"39","author":"Metzler","year":"2013","journal-title":"Biofactors"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0006-2952(96)00302-4","article-title":"Involvement of the beta-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin","volume":"52","author":"Sugiyama","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1039\/C3FO60370A","article-title":"Chemopreventative effects of tetrahydrocurcumin on human diseases","volume":"1","author":"Wu","year":"2014","journal-title":"Food Funct."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.3892\/mmr.2014.3079","article-title":"Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-\u03baB as potential target","volume":"11","author":"Zhao","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Yan, F.S., Sun, J.L., Xie, W.H., Shen, L., and Ji, H.F. (2018). Neuroprotective effects and mechanisms of curcumin-Cu(II) and -Zn(II) complexes systems and their pharmacological implications. Nutrients, 10.","DOI":"10.3390\/nu10010028"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"U\u0142amek-Kozio\u0142, M., Czuczwar, S.J., Januszewski, S., and Pluta, R. (2020). Substantiation for the use of curcumin during the development of neurodegeneration after brain ischemia. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020517"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"19011","DOI":"10.1038\/s41598-019-55419-w","article-title":"Toxic tau oligomers modulated by novel curcumin derivatives","volume":"9","author":"Puangmalai","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Song, J.X., Malampati, S., Zeng, Y., Durairajan, S.S.K., Yang, C.B., Tong, B.C., Iyaswamy, A., Shang, W.B., Sreenivasmurthy, S.G., and Zhu, Z. (2019). A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and tau pathology in Alzheimer\u2019s disease models. Aging Cell., e13069.","DOI":"10.1111\/acel.13069"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Park, C.H., Song, J.H., Kim, S.N., Lee, J.H., Lee, H.J., Kang, K.S., and Lim, H.H. (2019). Neuroprotective effects of tetrahydrocurcumin against glutamate-induced oxidative stress in hippocampal HT22 cells. Molecules, 25.","DOI":"10.3390\/molecules25010144"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Caruso Bavisotto, C., Marino Gammazza, A., Lo Cascio, F., Mocciaro, E., Vitale, A.M., Vergilio, G., Pace, A., Cappello, F., and Campanella, C. (2020). Palumbo Piccionello, A. Curcumin affects HSP60 folding activity and levels in neuroblastoma cells. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020661"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11010-019-03670-0","article-title":"Potential therapeutic effects of antagonizing adenosine A2A receptor, curcumin and niacin in rotenone-induced Parkinson\u2019s disease mice model","volume":"465","author":"Motawi","year":"2020","journal-title":"Mol. Cell Biochem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/3\/1055\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:55:00Z","timestamp":1760172900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/3\/1055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":57,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["ijms21031055"],"URL":"https:\/\/doi.org\/10.3390\/ijms21031055","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,5]]}}}