{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:15:28Z","timestamp":1787048128117,"version":"build-2736575974"},"reference-count":113,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T00:00:00Z","timestamp":1581120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Industry-University Joint Research Program","award":["HUCXY-2016-010"],"award-info":[{"award-number":["HUCXY-2016-010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Helicobacter pylori is a well-known pathogen that is highly prevalent in the world population, and H. pylori infection is potentially hazardous to humans because of its relationship to various gastrointestinal diseases, such as gastric ulcers, chronic gastritis, and gastric carcinoma. Therefore, the clinical guidelines recommend taking antibiotic therapy to eradicate the pathogen, which usually leads to the desired therapeutic effect. However, some failure cases of this therapy indicate that the increasing antibiotic resistance and side effects may affect the therapeutic effect. Here we propose that using probiotics as supplementation for antibiotic therapy may provide an extra help. Recent studies have shown that probiotic supplementation therapy has promising application prospects; it can enhance the antibiotic effect to achieve a better therapeutic result and maintain the balance of the host gastrointestinal microbiota. In summary, under global conditions of increasing H. pylori prevalence, probiotic supplementation therapy is worthy of further studies for future clinical application.<\/jats:p>","DOI":"10.3390\/ijms21031136","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T11:48:51Z","timestamp":1581335331000},"page":"1136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Using Probiotics as Supplementation for Helicobacter pylori Antibiotic Therapy"],"prefix":"10.3390","volume":"21","author":[{"given":"Jianfu","family":"Ji","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 201100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 201100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrgastro.2016.195","article-title":"Population screening and treatment of Helicobacter pylori infection","volume":"14","author":"Ford","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/apt.13497","article-title":"Review article: The global emergence of Helicobacter pylori antibiotic resistance","volume":"43","author":"Thung","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3748\/wjg.v20.i3.673","article-title":"Probiotics for the treatment of Helicobacter pylori infection in children","volume":"20","author":"Pacifico","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/14789450.2017.1331739","article-title":"Application of proteomics to the study of Helicobacter pylori and implications for the clinic","volume":"14","author":"Bernardini","year":"2017","journal-title":"Expert Rev. Proteom."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","article-title":"Management of Helicobacter pylori infection-the Maastricht V\/Florence consensus report","volume":"66","author":"Malfertheiner","year":"2017","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e12464","DOI":"10.1111\/hel.12464","article-title":"The effect of eradication of Helicobacter pylori on gastric cancer prevention in healthy asymptomatic populations","volume":"23","author":"Bae","year":"2018","journal-title":"Helicobacter"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dang, Y., Reinhardt, J.D., Zhou, X., and Zhang, G. (2014). The effect of probiotics supplementation on Helicobacter pylori eradication rates and side effects during eradication therapy: A meta-analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111030"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/ajg.2016.563","article-title":"ACG Clinical Guideline: Treatment of Helicobacter pylori Infection","volume":"112","author":"Chey","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3409820","DOI":"10.1155\/2019\/3409820","article-title":"Role of probiotics in Helicobacter pylori eradication: Lessons from a study of Lactobacillus reuteri strains DSM 17938 and ATCC PTA 6475 (Gastrus\u00ae) and a proton-pump inhibitor","volume":"2019","author":"Dore","year":"2019","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/10408363.2019.1648377","article-title":"Non-antibiotic therapy for Clostridioides difficile infection: A review","volume":"56","author":"Yang","year":"2019","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fcimb.2019.00288","article-title":"Antibacterial Activity of Bifidobacterium breve Against Clostridioides difficile","volume":"9","author":"Yang","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3748\/wjg.v24.i1.139","article-title":"Probiotic monotherapy and Helicobacter pylori eradication: A systematic review with pooled-data analysis","volume":"24","author":"Losurdo","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1523-5378.2008.00593.x","article-title":"Inhibition of Helicobacter pylori infection in humans by Lactobacillus reuteri ATCC 55730 and effect on eradication therapy: A pilot study","volume":"13","author":"Francavilla","year":"2008","journal-title":"Helicobacter"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1472-765X.2008.02416.x","article-title":"Isolation of lactobacilli with probiotic properties from the human stomach","volume":"47","author":"Ryan","year":"2008","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canlet.2017.11.009","article-title":"Gastric microbiota: An emerging player in Helicobacter pylori-induced gastric malignancies","volume":"414","author":"Espinoza","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10644","DOI":"10.3748\/wjg.v21.i37.10644","article-title":"Are probiotics useful in Helicobacter pylori eradication?","volume":"21","author":"Homan","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_17","first-page":"1151","article-title":"Probiotic effect on Helicobacter pylori attachment and inhibition of inflammation in human gastric epithelial cells","volume":"18","author":"Song","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1128\/IAI.73.3.1584-1589.2005","article-title":"Rapid loss of motility of Helicobacter pylori in the gastric lumen In Vivo","volume":"73","author":"Schreiber","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/1541-4337.12355","article-title":"Natural Products for the Prevention and Management of Helicobacter pylori Infection","volume":"17","author":"Liu","year":"2018","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrmicro3016","article-title":"Life in the human stomach: Persistence strategies of the bacterial pathogen Helicobacter pylori","volume":"11","author":"Salama","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e00001","DOI":"10.1128\/MMBR.00001-18","article-title":"Helicobacter pylori biofilm formation and its potential role in pathogenesis","volume":"82","author":"Hathroubi","year":"2018","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"914791","DOI":"10.1155\/2015\/914791","article-title":"Biofilm formation by Helicobacter pylori and its involvement for antibiotic resistance","volume":"2015","author":"Yonezawa","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3748\/wjg.v23.i7.1163","article-title":"Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics","volume":"23","author":"Attaran","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.micpath.2019.04.030","article-title":"Effect of Helicobacter pylori biofilm formation on susceptibility to amoxicillin, metronidazole and clarithromycin","volume":"132","author":"Yonezawa","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/1462-2920.13222","article-title":"How Helicobacter pylori senses, targets and interacts with the gastric epithelium","volume":"18","author":"Keilberg","year":"2016","journal-title":"Environ. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Debowski, A.W., Walton, S.M., Chua, E.-G., Tay, A.C.-Y., Liao, T., Lamichhane, B., Himbeck, R., Stubbs, K.A., Marshall, B.J., and Fulurija, A. (2017). Helicobacter pylori gene silencing In Vivo demonstrates urease is essential for chronic infection. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006464"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.chom.2015.07.002","article-title":"Chemodetection and destruction of host urea allows Helicobacter pylori to locate the epithelium","volume":"18","author":"Huang","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mib.2017.11.019","article-title":"Colonization, localization, and inflammation: The roles of H. pylori chemotaxis In Vivo","volume":"41","author":"Johnson","year":"2018","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1128\/IAI.73.3.1820-1827.2005","article-title":"Colonization and inflammation deficiencies in Mongolian gerbils infected by Helicobacter pylori chemotaxis mutants","volume":"73","author":"McGee","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1128\/IAI.70.4.1984-1990.2002","article-title":"Helicobacter pylori uses motility for initial colonization and to attain robust infection","volume":"70","author":"Ottemann","year":"2002","journal-title":"Infect. Immun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/mmi.13218","article-title":"Helicobacter pylori strains vary cell shape and flagellum number to maintain robust motility in viscous environments","volume":"99","author":"Hardcastle","year":"2016","journal-title":"Mol. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fcimb.2016.00159","article-title":"Adhesion and invasion of gastric mucosa epithelial cells by Helicobacter pylori","volume":"6","author":"Huang","year":"2016","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.gassur.2005.12.009","article-title":"Presence and density of Helicobacter pylori biofilms in human gastric mucosa in patients with peptic ulcer disease","volume":"10","author":"Coticchia","year":"2006","journal-title":"J. Gastrointest. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/btpr.2339","article-title":"In vitro effect of clarithromycin and alginate lyase against Helicobacter pylori biofilm","volume":"32","author":"Bugli","year":"2016","journal-title":"Biotechnol. Prog."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yonezawa, H., Osaki, T., Hanawa, T., Kurata, S., Ochiai, K., and Kamiya, S. (2013). Impact of Helicobacter pylori Biofilm Formation on Clarithromycin Susceptibility and Generation of Resistance Mutations. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073301"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1523-5378.1997.tb00067.x","article-title":"Catalase and superoxide dismutase secreted from Helicobacter pylori","volume":"2","author":"Mori","year":"1997","journal-title":"Helicobacter"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/sj.bjp.0703468","article-title":"Cytotoxicity associated with induction of nitric oxide synthase in rat duodenal epithelial cells in vivo by lipopolysaccharide of Helicobacter pylori: Inhibition by superoxide dismutase","volume":"130","author":"Lamarque","year":"2000","journal-title":"Brit. J. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1574-6968.2000.tb08965.x","article-title":"Identification and molecular analysis of superoxide dismutase isoforms in Helicobacter pylori","volume":"183","author":"Bereswill","year":"2000","journal-title":"Fems Microbiol. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1128\/IAI.69.6.4034-4040.2001","article-title":"Superoxide dismutase-deficient mutants of Helicobacter pylori are hypersensitive to oxidative stress and defective in host colonization","volume":"69","author":"Seyler","year":"2001","journal-title":"Infect. Immun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12929-018-0466-9","article-title":"The impacts of H. pylori virulence factors on the development of gastroduodenal diseases","volume":"25","author":"Chang","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s00253-018-09580-3","article-title":"Probiotic therapy in Helicobacter pylori infection: A potential strategy against a serious pathogen?","volume":"103","author":"Qureshi","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.micpath.2018.02.016","article-title":"Influence of Helicobacter pylori virulence factors CagA and VacA on pathogenesis of gastrointestinal disorders","volume":"117","author":"Nejati","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.3748\/wjg.v25.i33.4870","article-title":"Helicobacter pylori virulence genes","volume":"25","author":"Sterbenc","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.chom.2014.02.008","article-title":"Helicobacter pylori CagA and gastric cancer: A paradigm for hit-and-run carcinogenesis","volume":"15","author":"Hatakeyama","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"McClain, M.S., Beckett, A.C., and Cover, T.L. (2017). Helicobacter pylori vacuolating toxin and gastric cancer. Toxins, 9.","DOI":"10.3390\/toxins9100316"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e12544","DOI":"10.1111\/hel.12544","article-title":"Helicobacter pylori VacA, a distinct toxin exerts diverse functionalities in numerous cells: An overview","volume":"24","author":"Chauhan","year":"2019","journal-title":"Helicobacter"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.meegid.2018.02.022","article-title":"Genetic populations and virulence factors of Helicobacter pylori","volume":"60","author":"Kabamba","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ansari, S., and Yamaoka, Y. (2017). Survival of Helicobacter pylori in gastric acidic territory. Helicobacter, 22.","DOI":"10.1111\/hel.12386"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e12573","DOI":"10.1111\/hel.12573","article-title":"Helicobacter pylori urease induces pro-inflammatory effects and differentiation of human endothelial cells: Cellular and molecular mechanism","volume":"24","author":"Souza","year":"2019","journal-title":"Helicobacter"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jgar.2016.11.008","article-title":"Helicobacter pylori treatment: New perspectives using current experience","volume":"8","year":"2017","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cimid.2019.02.010","article-title":"Are probiotics useful for therapy of Helicobacter pylori diseases?","volume":"64","author":"Eslami","year":"2019","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/j.gastro.2015.01.040","article-title":"Helicobacter pylori update: Gastric cancer, reliable therapy, and possible benefits","volume":"148","author":"Graham","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e12554","DOI":"10.1111\/hel.12554","article-title":"Relative potency of proton-pump inhibitors, Helicobacter pylori therapy cure rates, and meaning of double-dose PPI","volume":"24","author":"Graham","year":"2019","journal-title":"Helicobacter"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fcimb.2017.00168","article-title":"Novel and Effective Therapeutic Regimens for Helicobacter pylori in an Era of Increasing Antibiotic Resistance","volume":"7","author":"Hu","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/QCO.0000000000000396","article-title":"Antibiotic resistance in Helicobacter pylori","volume":"30","author":"Alba","year":"2017","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_56","first-page":"1","article-title":"Effects of anti-H. pylori triple therapy and a probiotic complex on intestinal microbiota in duodenal ulcer","volume":"9","author":"Wu","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.3389\/fmicb.2019.01902","article-title":"Shifts in the human gut microbiota structure caused by quadruple Helicobacter pylori eradication therapy","volume":"10","author":"Olekhnovich","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Cornejo-Pareja, I., Mart\u00edn-N\u00fa\u00f1ez, G., Roca-Rodr\u00edguez, M., Cardona, F., Coin-Arag\u00fcez, L., S\u00e1nchez-Alcoholado, L., Guti\u00e9rrez-Repiso, C., Mu\u00f1oz-Garach, A., Fern\u00e1ndez-Garc\u00eda, J., and Moreno-Indias, I. (2019). H. pylori Eradication treatment alters gut microbiota and GLP-1 secretion in humans. J. Clin. Med., 8.","DOI":"10.3390\/jcm8040451"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/gutjnl-2015-310376","article-title":"Proton pump inhibitors affect the gut microbiome","volume":"65","author":"Imhann","year":"2016","journal-title":"Gut"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gutjnl-2015-310861","article-title":"Proton pump inhibitors alter the composition of the gut microbiota","volume":"65","author":"Jackson","year":"2016","journal-title":"Gut"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Chen, Y.H., Tsai, W.H., Wu, H.Y., Chen, C.Y., Yeh, W.L., Chen, Y.H., Hsu, H.Y., Chen, W.W., Chen, Y.W., and Chang, W.W. (2019). Probiotic Lactobacillus spp. act Against Helicobacter pylori-induced Inflammation. J. Clin. Med., 8.","DOI":"10.3390\/jcm8010090"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jbiosc.2018.04.003","article-title":"Antagonistics of Lactobacillus plantarum ZDY2013 against Helicobacter pylori SS1 and its infection in vitro in human gastric epithelial AGS cells","volume":"126","author":"Zhao","year":"2018","journal-title":"J. Biosci. Bioeng."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1080\/13102818.2018.1515599","article-title":"Effects of Lactobacillus on the inhibition of Helicobacter pylori growth","volume":"32","author":"Sun","year":"2018","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/mbo3.252","article-title":"A highly acid-resistant novel strain of Lactobacillus johnsonii No. 1088 has antibacterial activity, including that against Helicobacter pylori, and inhibits gastrin-mediated acid production in mice","volume":"4","author":"Aiba","year":"2015","journal-title":"Microbiologyopen"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Aiba, Y., Ishikawa, H., Tokunaga, M., and Komatsu, Y. (2017). Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No.1088. FEMS Microbiol. Lett., 364.","DOI":"10.1093\/femsle\/fnx102"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1590\/S0100-736X2015000400007","article-title":"Effect of Lactobacillus sp isolates supernatant on Escherichia coli O157:H7 enhances the role of organic acids production as a factor for pathogen control","volume":"35","author":"Poppi","year":"2015","journal-title":"Pesqui. Veterin\u00e1ria Bras."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jmii.2014.04.014","article-title":"Lactobacillus pentosus strain LPS16 produces lactic acid, inhibiting multidrug-resistant Helicobacter pylori","volume":"49","author":"Zheng","year":"2016","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"812S","DOI":"10.1093\/jn\/137.3.812S","article-title":"Helicobacter pylori and probiotics","volume":"137","author":"Blum","year":"2007","journal-title":"J. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1365-2672.2007.03279.x","article-title":"Isolation, taxonomic identification and hydrogen peroxide production by Lactobacillys delbrueckii subsp lactis T31, isolated from Mongolian yoghurt: Inhibitory activity on food-borne pathogens fool-borne pathogens","volume":"103","author":"Batdorj","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.foodcont.2018.11.004","article-title":"Anti-biofilm effect of crude bacteriocin derived from Lactobacillus brevis DF01 on Escherichia coli and Salmonella Typhimurium","volume":"98","author":"Kim","year":"2019","journal-title":"Food Control"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4315\/0362-028X-66.1.3","article-title":"Antagonism of Helicobacter pylori by bacteriocins of lactic acid bacteria","volume":"66","author":"Kim","year":"2003","journal-title":"J. Food Prot."},{"key":"ref_72","first-page":"469","article-title":"Bacteriocin-like inhibitory activities of seven Lactobacillus delbrueckii subsp","volume":"65","author":"Boyanova","year":"2017","journal-title":"bulgaricus strains against antibiotic susceptible and resistant Helicobacter pylori strains. Lett. Appl. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s12602-017-9342-2","article-title":"In Vitro antimicrobial activity and downregulation of virulence gene expression on Helicobacter pylori by reuterin","volume":"10","year":"2018","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1574-695X.2002.tb00541.x","article-title":"Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri","volume":"32","author":"Mukai","year":"2002","journal-title":"Fems Immunol. Med Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1128\/IAI.00163-16","article-title":"Lactobacilli reduce Helicobacter pylori attachment to host gastric epithelial cells by inhibiting adhesion gene expression","volume":"84","author":"Maudsdotter","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/apm.12237","article-title":"Saccharomyces boulardii expresses neuraminidase activity selective for alpha2,3-linked sialic acid that decreases Helicobacter pylori adhesion to host cells","volume":"122","author":"Sakarya","year":"2014","journal-title":"APMIS"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0016-5085(00)70360-X","article-title":"Inhibition of gastric mucin synthesis by Helicobacter pylori","volume":"118","author":"Byrd","year":"2000","journal-title":"Gastroenterology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41591-019-0439-x","article-title":"The pros, cons, and many unknowns of probiotics","volume":"25","author":"Suez","year":"2019","journal-title":"Nat. Med."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Yang, Y.-J., Chuang, C.-C., Yang, H.-B., Lu, C.-C., and Sheu, B.-S. (2012). Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NF\u039aB pathways. BMC Microbiol., 12.","DOI":"10.1186\/1471-2180-12-38"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/hel.12105","article-title":"Anti-inflammatory properties of gastric-derived Lactobacillus plantarum XB7 in the context of Helicobacter pylori infection","volume":"19","author":"Thiraworawong","year":"2014","journal-title":"Helicobacter"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cgh.2018.09.028","article-title":"Prebiotics and probiotics in digestive health","volume":"17","author":"Quigley","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/j.1651-2227.2005.tb01848.x","article-title":"Effect of regular ingestion of Saccharomyces boulardii plus inulin or Lactobacillus acidophilus LB in children colonized by Helicobacter pylori","volume":"94","author":"Gotteland","year":"2005","journal-title":"Acta Paediatr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"S531","DOI":"10.1016\/S0016-5085(19)38215-0","article-title":"Efficacy and Safety of Lactobacillus reuteri in Helicobacter pylori Infection","volume":"156","author":"Fonseca","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/01.mcg.0000173855.77191.44","article-title":"Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H-pylori in children\u2014A prospective randomized double-blind study","volume":"39","author":"Sykora","year":"2005","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/j.1440-1746.2011.06985.x","article-title":"Effect of pretreatment with Lactobacillus gasseri OLL2716 on first-line Helicobacter pylori eradication therapy","volume":"27","author":"Deguchi","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/MEG.0b013e32830d0eff","article-title":"Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: A systematic review and meta-analysis of randomized-controlled trials","volume":"21","author":"Sachdeva","year":"2009","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e12529","DOI":"10.1111\/hel.12529","article-title":"Probiotic supplementation with Lactobacillus plantarum and Pediococcus acidilactici for Helicobacter pylori therapy: A randomized, double-blind, placebo-controlled trial","volume":"23","author":"McNicholl","year":"2018","journal-title":"Helicobacter"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/jac\/dki136","article-title":"Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli","volume":"55","author":"Marcusson","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Feng, Z.-H., Fan, L., Yang, J., Huo, X.-Y., Guo, Y., Zhang, Y., and Lan, C.-H. (2019). Mutant selection window of clarithromycin for clinical isolates of Helicobacter pylori. BMC Microbiol., 19.","DOI":"10.1186\/s12866-019-1558-8"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.addr.2014.10.027","article-title":"Therapeutic strategies to combat antibiotic resistance","volume":"78","author":"Brooks","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.phymed.2008.06.008","article-title":"Synergism between natural products and antibiotics against infectious diseases","volume":"15","author":"Hemaiswarya","year":"2008","journal-title":"Phytomedicine"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/C9NP00011A","article-title":"Synergy and antagonism in natural product extracts: When 1 + 1 does not equal 2","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd2683","article-title":"Mechanisms of drug combinations: Interaction and network perspectives","volume":"8","author":"Jia","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_94","first-page":"e63121","article-title":"Synergistic or antagonistic effects of probiotics and antibiotics-alone or in combination- on antimicrobial-resistant Pseudomonas aeruginosa isolated from burn wounds","volume":"13","author":"Khodaii","year":"2018","journal-title":"Arch. Clin. Infect. Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.3389\/fmicb.2018.02953","article-title":"Effect of Bifidobacterium breve in Combination With Different Antibiotics on Clostridium difficile","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.mib.2013.06.013","article-title":"Bacterial biofilm development as a multicellular adaptation: Antibiotic resistance and new therapeutic strategies","volume":"16","author":"Reffuveille","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3389\/fmicb.2019.00846","article-title":"Potential Role of Biofilm Formation in the Development of Digestive Tract Cancer With Special Reference to Helicobacter pylori Infection","volume":"10","author":"Rizzato","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Ge, X., Cai, Y., Chen, Z., Gao, S., Geng, X., Li, Y., Li, Y., Jia, J., and Sun, Y. (2018). Bifunctional enzyme spot is involved in biofilm formation of Helicobacter pylori with multidrug resistance by upregulating efflux pump Hp1174 (gluP). Antimicrob. Agents Chemother., 62.","DOI":"10.1128\/AAC.00957-18"},{"key":"ref_99","first-page":"27","article-title":"The role of biofilm formation in pathogenesis of Helicobacter pylori infections","volume":"1","author":"Biernat","year":"2013","journal-title":"Prz. Gastroenterol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Hathroubi, S., Zerebinski, J., and Ottemann, K.M. (2018). Helicobacter pylori biofilm involves a multigene stress-biased response, including a structural role for flagella. mBio, 9.","DOI":"10.1128\/mBio.01973-18"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cgh.2010.05.006","article-title":"Biofilm demolition and antibiotic treatment to eradicate resistant Helicobacter pylori: A Clinical Trial","volume":"8","author":"Cammarota","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s10529-019-02694-2","article-title":"Lactobacillus rhamnosus GG microcapsules inhibit Escherichia coli biofilm formation in coculture","volume":"41","author":"Song","year":"2019","journal-title":"Biotechnol. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.foodres.2019.04.067","article-title":"Lactobacillus strains inhibit biofilm formation of Salmonella sp. isolates from poultry","volume":"123","author":"Merino","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12275-019-8538-4","article-title":"Lipoteichoic acids of lactobacilli inhibit Enterococcus faecalis biofilm formation and disrupt the preformed biofilm","volume":"57","author":"Jung","year":"2019","journal-title":"J. Microbiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1093\/jac\/dkx265","article-title":"Synergistic antibiotic activity against planktonic and biofilm-embedded Streptococcus agalactiae, Streptococcus pyogenes and Streptococcus oralis","volume":"72","author":"Trampuz","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.medmal.2013.10.002","article-title":"Probiotics, gut microbiota and health","volume":"44","author":"Butel","year":"2014","journal-title":"Med. Mal. Infect."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nri.2016.42","article-title":"Gut microbiota, metabolites and host immunity","volume":"16","author":"Rooks","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: An integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.celrep.2016.01.017","article-title":"Helicobacter pylori infection affects local and distant microbial populations and host responses","volume":"14","author":"Kienesberger","year":"2016","journal-title":"Cell Rep."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"S535","DOI":"10.1016\/S0016-5085(19)38226-5","article-title":"Changes of gastric corpus microbiota after Helicobacter Pylori eradication: A long term follow up study","volume":"156","author":"Shin","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrgastro.2010.117","article-title":"Probiotics and the gut microbiota in intestinal health and disease","volume":"7","author":"Gareau","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-50054-x","article-title":"Assoc. between the relative abundance of gastric microbiota and the risk of gastric cancer: A case-control study","volume":"9","author":"Gunathilake","year":"2019","journal-title":"Sci. Rep."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/3\/1136\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:56:01Z","timestamp":1760172961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/3\/1136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,8]]},"references-count":113,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["ijms21031136"],"URL":"https:\/\/doi.org\/10.3390\/ijms21031136","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,8]]}}}