{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:07:27Z","timestamp":1780672047218,"version":"3.54.1"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Damage to kidney cells can occur due to a variety of ischemic and toxic insults and leads to inflammation and cell death, which can result in acute kidney injury (AKI) [...]<\/jats:p>","DOI":"10.3390\/ijms21031164","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T09:25:21Z","timestamp":1581413121000},"page":"1164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Kidney Inflammation, Injury and Regeneration"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-3312","authenticated-orcid":false,"given":"Patrick C.","family":"Baer","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine III, University Hospital, Goethe-University, 60596 Frankfurt\/M., Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Koch","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine III, University Hospital, Goethe-University, 60596 Frankfurt\/M., Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Geiger","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine III, University Hospital, Goethe-University, 60596 Frankfurt\/M., Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, L., Fu, X., Gui, T., Wang, T., Wang, Z., Kullak-Ublick, G.A., and Gai, Z. (2019). Effects of farnesiferol B on ischemia-reperfusion-induced renal damage, inflammation, and NF-\u03baB signaling. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246280"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mocker, A., Hilgers, K.F., Cordasic, N., Wachtveitl, R., Menendez-Castro, C., Woelfle, J., Hartner, A., and Fahlbusch, F.B. (2019). Renal chemerin expression is induced in models of hypertensive nephropathy and glomerulonephritis and correlates with markers of inflammation and fibrosis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246240"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mizuno, Y., Yamamotoya, T., Nakatsu, Y., Ueda, K., Matsunaga, Y., Inoue, M.-K., Sakoda, H., Fujishiro, M., Ono, H., and Kikuchi, T. (2019). Xanthine oxidase inhibitor febuxostat exerts an anti-inflammatory action and protects against diabetic nephropathy development in KK-Ay obese diabetic mice. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194680"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chang, C.-J., Wang, P.-C., Huang, T.-C., and Taniguchi, A. (2019). Change in renal glomerular collagens and glomerular filtration barrier-related proteins in a dextran sulfate sodium-induced colitis mouse model. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061458"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Frese, J., Kettwig, M., Zappel, H., Hofer, J., Gr\u00f6ne, H.-J., Nagel, M., Sunder-Plassmann, G., Kain, R., Neuweiler, J., and Gross, O. (2019). Kidney injury by variants in the COL4A5 gene aggravated by polymorphisms in slit diaphragm genes causes focal segmental glomerulosclerosis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030519"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tapparo, M., Bruno, S., Collino, F., Togliatto, G., Deregibus, M.C., Provero, P., Wen, S., Quesenberry, P.J., and Camussi, G. (2019). Renal regenerative potential of extracellular vesicles derived from miRNA-engineered mesenchymal stromal cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102381"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chang, W.-S., Shen, T.-C., Yeh, W.-L., Yu, C.-C., Lin, H.-Y., Wu, H.-C., Tsai, C.-W., and Bau, D.-T. (2019). Contribution of inflammatory cytokine interleukin-18 genotypes to renal cell carcinoma. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071563"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Schiffer, L., Wiehler, F., Br\u00e4sen, J.H., Gwinner, W., Greite, R., Kreimann, K., Thorenz, A., Derlin, K., Teng, B., and Rong, S. (2019). Chemokine CXCL13 as a new systemic biomarker for B-cell involvement in acute T cell-mediated kidney allograft rejection. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102552"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yang, J.Y.C., Sarwal, R.D., Fervenza, F.C., Sarwal, M.M., and Lafayette, R.A. (2019). Noninvasive urinary monitoring of progression in IgA nephropathy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184463"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Baer, P.C., Koch, B., Freitag, J., Schubert, R., and Geiger, H. (2020). No Cytotoxic and inflammatory effects of empagliflozin and dapagliflozin on primary renal proximal tubular epithelial cells under diabetic conditions in vitro. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020391"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Castellano, G., Stasi, A., Franzin, R., Sallustio, F., Divella, C., Spinelli, A., Netti, G.S., Fiaccadori, E., Cantaluppi, V., and Crovace, A. (2019). LPS-binding protein modulates acute renal fibrosis by inducing pericyte-to-myofibroblast trans-differentiation through TLR-4 signaling. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153682"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chang, J.-F., Yeh, J.-C., Ho, C.-T., Liu, S.-H., Hsieh, C.-Y., Wang, T.-M., Chang, S.-W., Lee, I.-T., Huang, K.-Y., and Wang, J.-Y. (2019). Targeting ROS and cPLA2\/COX2 expressions ameliorated renal damage in obese mice with endotoxemia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184393"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Andrianova, N.V., Buyan, M.I., Zorova, L.D., Pevzner, I.B., Popkov, V.A., Babenko, V.A., Silachev, D.N., Plotnikov, E.Y., and Zorov, D.B. (2019). Kidney cells regeneration: Dedifferentiation of tubular epithelium, resident stem cells and possible niches for renal progenitors. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246326"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Priante, G., Gianesello, L., Ceol, M., Del Prete, D., and Anglani, F. (2019). Cell death in the kidney. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143598"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Giuliani, K.T.K., Kassianos, A.J., Healy, H., and Gois, P.H.F. (2019). Pigment nephropathy: Novel insights into inflammasome-mediated pathogenesis. Int. J. Mol. Sci., 20.","DOI":"10.20944\/preprints201904.0208.v1"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Moreno, J.A., Sevillano, \u00c1., Guti\u00e9rrez, E., Guerrero-Hue, M., V\u00e1zquez-Carballo, C., Yuste, C., Herencia, C., Garc\u00eda-Caballero, C., Praga, M., and Egido, J. (2019). Glomerular hematuria: Cause or consequence of renal inflammation?. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092205"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, T., Fu, X., Chen, Q., Patra, J.K., Wang, D., Wang, Z., and Gai, Z. (2019). Arachidonic acid metabolism and kidney inflammation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153683"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wu, P.-K., Yeh, S.-C., Li, S.-J., and Kang, Y.-N. (2019). Efficacy of polyunsaturated fatty acids on inflammatory markers in patients undergoing dialysis: A systematic review with network meta-analysis of randomized clinical trials. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153645"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Guzzi, F., Cirillo, L., Roperto, R.M., Romagnani, P., and Lazzeri, E. (2019). Molecular mechanisms of the acute kidney injury to chronic kidney disease transition: An updated view. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194941"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ignarski, M., Islam, R., and M\u00fcller, R.-U. (2019). Long non-coding RNAs in kidney disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133276"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sievers, L.K., and Eckardt, K.-U. (2019). Molecular mechanisms of kidney injury and repair in arterial hypertension. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092138"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Taub, M. (2019). Salt inducible kinase signaling networks: Implications for acute kidney injury and therapeutic potential. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133219"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bochon, B., Kozubska, M., Suryga\u0142a, G., Witkowska, A., Ku\u017aniewicz, R., Grzeszczak, W., and Wystrychowski, G. (2019). Mesenchymal stem cells-potential applications in kidney diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102462"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lee, K.-H., Tseng, W.-C., Yang, C.-Y., and Tarng, D.-C. (2019). The anti-inflammatory, anti-oxidative, and anti-apoptotic benefits of stem cells in acute ischemic kidney injury. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143529"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yun, C.W., and Lee, S.H. (2019). Potential and therapeutic efficacy of cell-based therapy using mesenchymal stem cells for acute\/chronic kidney disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071619"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lee, J.H., Kim, D., Oh, Y.S., and Jun, H.-S. (2019). Lysophosphatidic acid signaling in diabetic nephropathy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112850"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Matoba, K., Takeda, Y., Nagai, Y., Kawanami, D., Utsunomiya, K., and Nishimura, R. (2019). Unraveling the role of inflammation in the pathogenesis of diabetic kidney disease. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143393"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Nin\u010devi\u0107, V., Omanovi\u0107 Kolari\u0107, T., Rogulji\u0107, H., Kizivat, T., Smoli\u0107, M., and Bili\u0107 \u0106ur\u010di\u0107, I. (2019). Renal benefits of SGLT 2 inhibitors and GLP-1 receptor agonists: Evidence supporting a paradigm shift in the medical management of type 2 diabetes. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20235831"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Van der Hauwaert, C., Glowacki, F., Pottier, N., and Cauffiez, C. (2019). Non-coding RNAs as new therapeutic targets in the context of renal fibrosis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20081977"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/3\/1164\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:56:24Z","timestamp":1760172984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/3\/1164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,10]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["ijms21031164"],"URL":"https:\/\/doi.org\/10.3390\/ijms21031164","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,10]]}}}