{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:56:40Z","timestamp":1788955000721,"version":"build-2803163510"},"reference-count":143,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004923","name":"AFM-T\u00e9l\u00e9thon","doi-asserted-by":"publisher","award":["Grant 2019 to Annamaria De Luca"],"award-info":[{"award-number":["Grant 2019 to Annamaria De Luca"]}],"id":[{"id":"10.13039\/501100004923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Among the severe side effects induced by cisplatin chemotherapy, muscle wasting is the most relevant one. This effect is a major cause for a clinical decline of cancer patients, since it is a negative predictor of treatment outcome and associated to increased mortality. However, despite its toxicity even at low doses, cisplatin remains the first-line therapy for several types of solid tumors. Thus, effective pharmacological treatments counteracting or minimizing cisplatin-induced muscle wasting are urgently needed. The dissection of the molecular pathways responsible for cisplatin-induced muscle dysfunction gives the possibility to identify novel promising therapeutic targets. In this context, the use of animal model of cisplatin-induced cachexia is very useful. Here, we report an update of the most relevant researches on the mechanisms underlying cisplatin-induced muscle wasting and on the most promising potential therapeutic options to preserve muscle mass and function.<\/jats:p>","DOI":"10.3390\/ijms21041242","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T10:09:57Z","timestamp":1581674997000},"page":"1242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies"],"prefix":"10.3390","volume":"21","author":[{"given":"Elena","family":"Conte","sequence":"first","affiliation":[{"name":"Department of Pharmacy-Drug Sciences, University of Bari, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-276X","authenticated-orcid":false,"given":"Elena","family":"Bresciani","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3709-6574","authenticated-orcid":false,"given":"Laura","family":"Rizzi","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1882-3502","authenticated-orcid":false,"given":"Ornella","family":"Cappellari","sequence":"additional","affiliation":[{"name":"Department of Pharmacy-Drug Sciences, University of Bari, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Pharmacy-Drug Sciences, University of Bari, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Torsello","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Liantonio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy-Drug Sciences, University of Bari, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","article-title":"The resurgence of platinum-based cancer chemotherapy","volume":"7","author":"Kellad","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2174\/138161210791209009","article-title":"Novel metals and metal complexes as platform for cancer therapy","volume":"16","author":"Frezza","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccr.2005.10.004","article-title":"Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia","volume":"8","author":"Acharyya","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Berardi, E. (2017). Muscular Dystrophies and Cancer Cachexia: Similarities in Chronic Skeletal Muscle Degeneration. J. Funct. Morphol. Kinesiol., 2.","DOI":"10.3390\/jfmk2040039"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1210\/en.2007-0828","article-title":"Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia","volume":"149","author":"Garcia","year":"2008","journal-title":"Endocrinology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00280-007-0597-2","article-title":"Effect of N-acetylcysteine route of administration on chemoprotection against cisplatin-induced toxicity in rat models","volume":"62","author":"Dickey","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.taap.2014.05.001","article-title":"Mechanisms of cisplatin-induced muscle atrophy","volume":"278","author":"Sakai","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12020-016-1184-2","article-title":"JMV2894, a novel growth hormone secretagogue, accelerates body mass recovery in an experimental model of cachexia","volume":"58","author":"Bresciani","year":"2017","journal-title":"Endocrine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jcsm.12185","article-title":"Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia","volume":"8","author":"Conte","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.biopha.2013.08.005","article-title":"Malnutrition, anorexia and cachexia in cancer patients: A mini-review on pathogenesis and treatment","volume":"67","author":"Nicolini","year":"2013","journal-title":"Biomed. Pharmcother."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-981-13-1435-3_10","article-title":"Ubiquitin-Proteasome Pathway and Muscle Atrophy","volume":"1088","author":"Khalil","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1","volume":"307","author":"Bodine","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1210\/en.2004-0406","article-title":"Role of the insulin-like growth factor I decline in the induction of atrogin-1\/MAFbx during fasting and diabetes","volume":"145","author":"Dehoux","year":"2004","journal-title":"Endocrinology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.mad.2006.07.005","article-title":"Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle","volume":"127","author":"Clavel","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4161\/cbt.12.4.15954","article-title":"FoxO family members in cancer","volume":"12","author":"Zhang","year":"2011","journal-title":"Cancer Biol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Penna, F., Costamagna, D., Fanzani, A., Bonelli, G., Baccino, F.M., and Costelli, P. (2010). Muscle wasting and impaired myogenesis in tumor bearing mice are prevented by ERK inhibition. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013604"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/excr.1999.4465","article-title":"Tumor necrosis factor-alpha and basic fibroblast growth factor differentially inhibit the insulin-like growth factor-I induced expression of myogenin in C2C12 myoblasts","volume":"249","author":"Layne","year":"1999","journal-title":"Exp. Cell Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jcsm.12023","article-title":"Garcia Ghrelin prevents tumour- and cisplatin-induced muscle wasting: Characterization of multiple mechanisms involved","volume":"6","author":"Chen","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/SPC.0b013e328359b681","article-title":"Mechanisms for maintaining muscle","volume":"6","author":"Banerjee","year":"2012","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/jcsm.12438","article-title":"Inhibition of myostatin improves muscle atrophy in oculopharyngeal muscular dystrophy (OPMD)","volume":"10","author":"Harish","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/mt.2014.221","article-title":"Development of novel activin-targeted therapeutics","volume":"23","author":"Chen","year":"2015","journal-title":"Mol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"C1258","DOI":"10.1152\/ajpcell.00105.2009","article-title":"Myostatin reduces Akt\/TORC1\/p70S6K signaling, inhibiting myoblast differentiation and myotube size","volume":"296","author":"Trendelenburg","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2174\/138161213804547295","article-title":"Synergistic antiproliferative and antiangiogenic effects of EGFR and mTOR inhibitors","volume":"19","author":"Porcelli","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.09.027","article-title":"IKKbeta\/NFkappaB activation causes severe muscle wasting in mice","volume":"119","author":"Cai","year":"2004","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"E729","DOI":"10.1152\/ajpendo.00060.2012","article-title":"Role of IGF-I and the TNF\u03b1\/NF-kB pathway in the induction of muscle atrogenes by acute inflammation","volume":"303","author":"Schakman","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00109-008-0373-8","article-title":"Nuclear factor-kappa B signaling in skeletal muscle atrophy","volume":"86","author":"Li","year":"2008","journal-title":"J. Mol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jamcollsurg.2004.04.015","article-title":"Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer","volume":"199","author":"Camp","year":"2004","journal-title":"J. Am. Coll. Surg."},{"key":"ref_29","first-page":"139","article-title":"Chemotherapy-induced muscle wasting: Association with NF-kB and cancer cachexia","volume":"18","author":"Damrauer","year":"2008","journal-title":"Basic Appl. Myol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/978-981-13-1435-3_16","article-title":"The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging","volume":"1088","author":"Zhang","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.15252\/embj.201796697","article-title":"Molecular definitions of autophagy and related processes","volume":"36","author":"Galluzzi","year":"2017","journal-title":"EMBO J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"Sandri","year":"2004","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","article-title":"Akt promotes cell survival by phosphory-lating and inhibiting a Forkhead transcription factor","volume":"96","author":"Brunet","year":"1999","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.febslet.2010.01.056","article-title":"Autophagy in Skeletal Muscle","volume":"584","author":"Sandri","year":"2010","journal-title":"FEBS Lett."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-13504-y","article-title":"Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia","volume":"7","author":"Sirago","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.taap.2010.11.003","article-title":"Cisplatin triggers atrophy of skeletal C2C12 myotubes via impairment of Akt signalling pathway and subsequent increment activity of proteasome and autophagy systems","volume":"250","author":"Fanzani","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3390\/ijms16011066","article-title":"Ca2+-dependent regulations and signaling in skeletal muscle: From electro-mechanical coupling to adaptation","volume":"16","author":"Gehlert","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1152\/physrev.1997.77.4.901","article-title":"Store depletion and calcium influx","volume":"77","author":"Parekh","year":"1997","journal-title":"Physiol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1469-7793.2001.0185b.x","article-title":"Depletion of Ca2+ in the sarcoplasmic reticulum stimulates Ca2+ entry into mouse skeletal muscle fibres","volume":"533","author":"Kurebayashi","year":"2001","journal-title":"J. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.nbd.2012.05.002","article-title":"Kv1.1 knock-in ataxic mice exhibit spontaneous myokymic activity exacerbated by fatigue, ischemia and low temperature","volume":"47","author":"Brunetti","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nbd.2008.06.002","article-title":"Premature stop codons in a facilitating EF-hand splice variant of CaV2.1 cause episodic ataxia type 2","volume":"32","author":"Graves","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12192-017-0795-8","article-title":"Oxidative protein modification alters proteostasis under acute hypobaric hypoxia in skeletal muscles: A comprehensive in vivo study","volume":"22","author":"Agrawal","year":"2017","journal-title":"Cell Stress Chaperones"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s12079-018-0477-z","article-title":"Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications","volume":"12","author":"Agrawal","year":"2018","journal-title":"J. Cell. Commun. Signal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1152\/physrev.2000.80.3.1215","article-title":"Calcium ion in skeletal muscle: Its crucial role for muscle function, plasticity, and disease","volume":"80","author":"Berchtold","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cvr\/cvs157","article-title":"Regulation and physiological roles of the calpain system in muscular disorders","volume":"96","author":"Sorimachi","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fphys.2015.00422","article-title":"Mitochondrial quality control and muscle mass maintenance","volume":"6","author":"Romanello","year":"2016","journal-title":"Front. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1152\/physiol.00039.2014","article-title":"Mitochondria, muscle health, and exercise with advancing age","volume":"30","author":"Carter","year":"2015","journal-title":"Physiology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"F367","DOI":"10.1152\/ajprenal.00571.2013","article-title":"Mitochondrial dysfunction in the pathophysiology of renal diseases","volume":"306","author":"Che","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bbamcr.2017.03.006","article-title":"Molecular regulation of mitochondrial dynamics in cardiac disease","volume":"1864","author":"Nan","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"E31","DOI":"10.1152\/ajpendo.00609.2011","article-title":"Mitochondrial signaling contributes to disuse muscle atrophy","volume":"303","author":"Powers","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.1080405","article-title":"Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling","volume":"300","author":"Wood","year":"2003","journal-title":"Science"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Azadmanesh, J., and Borgstahl, G. (2018). A review of the catalytic mechanism of human manganese superoxide dismutase. Antioxidants, 7.","DOI":"10.3390\/antiox7020025"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1681\/ASN.2008060628","article-title":"IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting","volume":"20","author":"Zhang","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2018.07.010","article-title":"Platinum-induced Muscle Wasting in Cancer Chemotherapy: Mechanisms and Potential Targets for Therapeutic Intervention","volume":"208","author":"Ferreira","year":"2018","journal-title":"Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/0026-0495(87)90132-6","article-title":"Whole body lipid and energy metabolism in the cancer patient","volume":"36","author":"Legaspi","year":"1987","journal-title":"Metabolism"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1172\/JCI114854","article-title":"Whole-body lipolysis and triglyceride-fatty acid cycling in cachectic patients with esophageal cancer","volume":"86","author":"Klein","year":"1990","journal-title":"J. Clin. Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0026-0495(86)90145-9","article-title":"Cancer cachexia and the rate of whole body lipolysis in man","volume":"35","author":"Jeevanandam","year":"1986","journal-title":"Metabolism"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/cncr.23802","article-title":"Lipolysis not inflammation, cell death, or lipogenesis is involved in adipose tissue loss in cancer cachexia","volume":"113","author":"Ryden","year":"2008","journal-title":"Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1198973","article-title":"Adipose triglyceride lipase contributes to cancer-associated cachexia","volume":"333","author":"Das","year":"2011","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1210\/en.2013-1179","article-title":"Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice","volume":"154","author":"Garcia","year":"2013","journal-title":"Endocrinology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1021\/jm900720m","article-title":"Identification and characterization of a small molecule inhibitor of fatty acid binding proteins","volume":"52","author":"Hertzel","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/89076","article-title":"Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis","volume":"7","author":"Makowski","year":"2001","journal-title":"Nat. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1073\/pnas.96.10.5528","article-title":"Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein","volume":"96","author":"Shen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jcsm.12010","article-title":"Understanding and managing cancer-related weight loss and anorexia: Insights from a systematic review of qualitative research","volume":"6","author":"Cooper","year":"2015","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3389\/fncel.2019.00205","article-title":"The role of gherlin in regulating synaptic function and plasticity of feeding associated circuits","volume":"13","author":"Serrenho","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"BSR20181061","DOI":"10.1042\/BSR20181061","article-title":"Ghrelin, a gastrointestinal hormone, regulates energy balance and lipid metabolism","volume":"38","author":"Lv","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.brainres.2018.01.024","article-title":"Hunger, ghrelin and the gut","volume":"1693","author":"Davis","year":"2018","journal-title":"Brain Res."},{"key":"ref_70","first-page":"611","article-title":"Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice","volume":"123","author":"Porporato","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.regpep.2012.06.003","article-title":"Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice","volume":"178","author":"Sugiyama","year":"2012","journal-title":"Regul. Pept."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1002\/cncr.27430","article-title":"Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients: A prospective, randomized, placebo-controlled phase 2 study","volume":"118","author":"Hiura","year":"2012","journal-title":"Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1007\/s000180050257","article-title":"Growth hormone-releasing peptide (GHRP)","volume":"54","author":"Bowers","year":"1998","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/edrv.18.5.0316","article-title":"Peptidomimetic regulation of growth hormonesecretion","volume":"18","author":"Smith","year":"1997","journal-title":"Endocr. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1385\/ENDO:14:1:087","article-title":"Biologic activities of growth hormone secretagogues in humans","volume":"14","author":"Ghigo","year":"2001","journal-title":"Endocrine"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/300276a0","article-title":"Characterization of a growth hormone-releasing factor from a human pancreatic islet tumor","volume":"300","author":"Rivier","year":"1982","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1053\/beem.2002.0213","article-title":"Ghrelin and synthetic GH secretagogues","volume":"116","author":"Arvat","year":"2002","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_79","first-page":"437","article-title":"Ghrelin","volume":"44","author":"Nogueiras","year":"2015","journal-title":"Mol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.273.5277.974","article-title":"A receptor in pituitary and hypothalamus that functions in growth hormone release","volume":"273","author":"Howard","year":"1996","journal-title":"Science"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0014-2999(98)00677-3","article-title":"Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release","volume":"360","author":"Torsello","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.RES.0000016164.02525.B4","article-title":"CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart","volume":"90","author":"Bodart","year":"2002","journal-title":"Circ. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1210\/en.2006-0975","article-title":"Growth hormone-releasing peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes","volume":"148","author":"Demers","year":"2007","journal-title":"Endocrinology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000105141","article-title":"Heterogeneity of ghrelin\/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin\/GHS receptors","volume":"86","author":"Muccioli","year":"2007","journal-title":"Neuroendocrinology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"E486","DOI":"10.1152\/ajpendo.00196.2004","article-title":"Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats","volume":"288","author":"Granado","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1152\/ajpendo.00308.2007","article-title":"GH-releasing peptide-2 administration prevents liver inflammatory response in endotoxemia","volume":"294","author":"Granado","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1002\/jnr.22088","article-title":"Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils","volume":"87","author":"Bulgarelli","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Lucchi, C., Curia, G., Vinet, J., Gualtieri, F., Bresciani, E., Locatelli, V., Torsello, A., and Biagini, G. (2013). Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of Status epilepticus. PLoS ONE, 88.","DOI":"10.1371\/journal.pone.0072716"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1021\/jm0704550","article-title":"Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations","volume":"50","author":"Moulin","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref_90","first-page":"11","article-title":"GH-releasing peptides and bone","volume":"28","author":"Cocchi","year":"2005","journal-title":"J. Endocrinol. Investig."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000048225","article-title":"Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats","volume":"75","author":"Sibilia","year":"2002","journal-title":"Neuroendocrinology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.peptides.2004.08.001","article-title":"Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat","volume":"25","author":"Sibilia","year":"2004","journal-title":"Peptides"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1111\/nmo.12459","article-title":"New ghrelin agonist, HM01 alleviates constipation and L-dopa-delayed gastric emptying in 6-hydroxydopamine rat model of Parkinson\u2019s disease","volume":"26","author":"Karasawa","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1152\/ajpheart.01042.2004","article-title":"GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure","volume":"289","author":"Xu","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1210\/en.2012-1404","article-title":"Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in vitro ischemia\/reperfusion heart","volume":"153","author":"Ma","year":"2012","journal-title":"Endocrinology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/ENDO:14:1:109","article-title":"Hexarelin, but not growth hormone, protects heart from damage induced in vitro by calcium deprivation replenishment","volume":"14","author":"Torsello","year":"2001","journal-title":"Endocrine"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1210\/en.2002-221048","article-title":"Ghrelin plays a minor role in the physiological control of cardiac function in the rat","volume":"144","author":"Torsello","year":"2003","journal-title":"Endocrinology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e13699","DOI":"10.14814\/phy2.13699","article-title":"Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction","volume":"66","author":"McDonald","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-2999(02)01934-9","article-title":"Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery","volume":"448","author":"Broglio","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1388-9842(01)00223-9","article-title":"GH-independent cardiotropic activities of hexarelin in patients with severe left ventricular dysfunction due to dilated and ischemic cardiomyopathy","volume":"44","author":"Imazio","year":"2002","journal-title":"Eur. J. Heart Fail."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1152\/ajpregu.00044.2016","article-title":"The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats","volume":"311","author":"Borner","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Villars, F.O., Pietra, C., Giuliano, C., Lutz, T.A., and Riediger, T. (2017). Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18050986"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejphar.2017.05.036","article-title":"Z-505 hydrochloride, an orally active ghrelin agonist, attenuates the progression of cancer cachexia via anabolic hormones in Colon 26 tumor-bearing mice","volume":"811","author":"Yoshimura","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/0024-3205(94)00510-9","article-title":"GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats","volume":"54","author":"Deghenghi","year":"1994","journal-title":"Life Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.freeradbiomed.2015.12.031","article-title":"The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass","volume":"98","author":"Rom","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000365947","article-title":"Role of PGC-1\u03b1 in sarcopenia: Etiology and potential intervention\u2014A mini-review","volume":"61","author":"Ji","year":"2015","journal-title":"Gerontology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lungcan.2017.07.023","article-title":"Anamorelin for advanced non-small-cell lung cancer with cachexia: Systematic review and meta-analysis","volume":"112","author":"Nishie","year":"2017","journal-title":"Lung Cancer"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3","DOI":"10.21037\/apm.2018.12.01","article-title":"Cancer cachexia is defined by an ongoing loss of skeletal muscle mass","volume":"8","author":"Baracos","year":"2019","journal-title":"Ann. Palliat. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"E591","DOI":"10.1152\/ajpendo.00073.2004","article-title":"IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1","volume":"287","author":"Sacheck","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jnutbio.2007.05.006","article-title":"Mechanisms through which sulfur amino acids control protein metabolism and oxidative status","volume":"19","author":"Metayer","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"9893","DOI":"10.1007\/s00253-014-6156-y","article-title":"Methionine production\u2014A critical review","volume":"98","author":"Willke","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1017\/S0022215113000947","article-title":"Mechanisms of cisplatin ototoxicity: Theoretical review","volume":"127","author":"Silveira","year":"2013","journal-title":"J. Laryngol. Otol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ntt.2015.07.004","article-title":"Assessment of d-methionine protecting cisplatin-induced otolith toxicity by vestibular-evoked myogenic potential tests, ATPase activities and oxidative state in guinea pigs","volume":"51","author":"Lo","year":"2015","journal-title":"Neurotoxicol. Teratol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1055\/s-0040-1715719","article-title":"The effect of D-methionine on cochlear oxidative state with and without cisplatin administration: Mechanisms of otoprotection","volume":"14","author":"Campbell","year":"2003","journal-title":"J. Am. Acad. Audiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.taap.2006.02.014","article-title":"D-Methionine attenuated cisplatin-induced vestibulotoxicity through altering ATPase activities and oxidative stress in guinea pigs","volume":"215","author":"Cheng","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/hed.25115","article-title":"Double-blind placebo-controlled multicenter phase II trial to evaluate d-methionine in preventing\/reducing oral mucositis induced by radiation and chemotherapy for head and neck cancer","volume":"40","author":"Hamstra","year":"2018","journal-title":"Head Neck"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.phrs.2008.01.001","article-title":"Selection of agents for prevention of cisplatin-induced hepatotoxicity","volume":"5757","author":"Liao","year":"2008","journal-title":"Pharmacol. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12640-014-9503-y","article-title":"D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat","volume":"27","author":"Hinduja","year":"2015","journal-title":"Neurotox. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/1534735417753543","article-title":"Protective Effect of d-Methionine on Body Weight Loss, Anorexia, and Nephrotoxicity in Cisplatin-Induced Chronic Toxicity in Rats","volume":"17","author":"Lin","year":"2018","journal-title":"Integr. Cancer"},{"key":"ref_120","first-page":"1758835918821021","article-title":"d-methionine alleviates cisplatin-induced mucositis by restoring the gut microbiota structure and improving intestinal inflammation","volume":"11","author":"Wu","year":"2019","journal-title":"Adv. Med. Oncol."},{"key":"ref_121","first-page":"1534735419828832","article-title":"D-Methionine Ameliorates Cisplatin-Induced Muscle Atrophy via Inhibition of Muscle Degradation Pathway","volume":"18","author":"Wu","year":"2019","journal-title":"Integr. Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2009.06.002","article-title":"The potential protective effects of taurine on coronary heart disease","volume":"208","author":"Koenig","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.yexcr.2011.11.008","article-title":"ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin","volume":"318","author":"Rovetta","year":"2012","journal-title":"Exp. Cell Res."},{"key":"ref_124","first-page":"45","article-title":"Taurine and skeletal muscle ion channels","volume":"483","author":"Pierno","year":"2000","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12967-015-0610-1","article-title":"Taurine: The appeal of a safe amino acid for skeletal muscle disorders journal of trasnational medicine","volume":"13","author":"Pierno","year":"2015","journal-title":"J. Transl. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00421-008-0937-x","article-title":"Dissociation between force and maximal Na+, K+\u2014ATPase activity in rat fast-twitch skeletal muscle with fatiguing in vitro stimulation","volume":"105","author":"Goodman","year":"2009","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Stacchiotti, A., Rovetta, F., Ferroni, M., Corsetti, G., Lavazza, A., Sberveglieri, G., and Aleo, M.F. (2014). Taurine rescues cisplatin-induced muscle atrophy in vitro: A morphological study. Oxidative Med. Cell. Longev., 840951.","DOI":"10.1155\/2014\/840951"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.1073\/pnas.151270098","article-title":"Regulation of myostatin activity and muscle growth","volume":"98","author":"Lee","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/387083a0","article-title":"Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily members","volume":"387","author":"McPherron","year":"1997","journal-title":"Nature"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/321776a0","article-title":"Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid","volume":"321","author":"Vale","year":"1986","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0006-291X(86)80400-4","article-title":"A homodimer of the beta-subunits of inhibin A stimulates the secretion of pituitary follicle stimulating hormone","volume":"138","author":"Ling","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"a021881","DOI":"10.1101\/cshperspect.a021881","article-title":"Activins and Inhibins: Roles in Development, Physiology, and Disease","volume":"8","author":"Namwanje","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1210\/me.2008-0290","article-title":"Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators","volume":"22","author":"Souza","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1073\/pnas.0505996102","article-title":"Regulation of muscle growth by multiple ligands signaling through activin type II receptors","volume":"102","author":"Lee","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"464","DOI":"10.2337\/db10-0801","article-title":"Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet","volume":"60","author":"Tan","year":"2011","journal-title":"Diabetes"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nature01154","article-title":"Functional improvement of dystrophic muscle by myostatin blockade","volume":"420","author":"Bogdanovich","year":"2002","journal-title":"Nature"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","article-title":"Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival","volume":"142","author":"Zhou","year":"2010","journal-title":"Cell"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/mt.2014.90","article-title":"Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy","volume":"22","author":"Relizani","year":"2014","journal-title":"Mol. Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13395-015-0060-8","article-title":"Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice","volume":"5","author":"Latres","year":"2015","journal-title":"Skelet. Muscle"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S2213-8587(15)00298-3","article-title":"Myostatin antibody (LY2495655) in older weak fallers: A proof-of-concept, randomised, phase 2 trial","volume":"3","author":"Becker","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13395-016-0098-2","article-title":"ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments","volume":"6","author":"Hatakeyama","year":"2016","journal-title":"Skelet. Muscle"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: Understanding the molecular basis","volume":"14","author":"Argiles","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrclinonc.2012.99","article-title":"Reducing the toxicity of cancer therapy: Recognizing needs, taking action","volume":"9","author":"Cleeland","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/4\/1242\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:57:25Z","timestamp":1760173045000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/4\/1242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":143,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["ijms21041242"],"URL":"https:\/\/doi.org\/10.3390\/ijms21041242","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,13]]}}}