{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:40:20Z","timestamp":1792024820981,"version":"4.4.0"},"reference-count":300,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed at reducing the prevalence of these conditions in the population are limited to a safer lifestyle including physical\/mental exercise, a reduced caloric intake, and a proper diet in a convivial environment. The claimed health benefits of the Mediterranean and Asian diets have been confirmed in many clinical trials and epidemiological surveys. These diets are characterized by several features, including low meat consumption, the intake of oils instead of fats as lipid sources, moderate amounts of red wine, and significant amounts of fresh fruit and vegetables. In particular, the latter have attracted popular and scientific attention for their content, though in reduced amounts, of a number of molecules increasingly investigated for their healthy properties. Among the latter, plant polyphenols have raised remarkable interest in the scientific community; in fact, several clinical trials have confirmed that many health benefits of the Mediterranean\/Asian diets can be traced back to the presence of significant amounts of these molecules, even though, in some cases, contradictory results have been reported, which highlights the need for further investigation. In light of the results of these trials, recent research has sought to provide information on the biochemical, molecular, epigenetic, and cell biology modifications by plant polyphenols in cell, organismal, animal, and human models of cancer, metabolic, and neurodegenerative pathologies, notably Alzheimer\u2019s and Parkinson disease. The findings reported in the last decade are starting to help to decipher the complex relations between plant polyphenols and cell homeostatic systems including metabolic and redox equilibrium, proteostasis, and the inflammatory response, establishing an increasingly solid molecular basis for the healthy effects of these molecules. Taken together, the data currently available, though still incomplete, are providing a rationale for the possible use of natural polyphenols, or their molecular scaffolds, as nutraceuticals to contrast aging and to combat many associated pathologies.<\/jats:p>","DOI":"10.3390\/ijms21041250","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T10:09:57Z","timestamp":1581674997000},"page":"1250","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":415,"title":["Healthy Effects of Plant Polyphenols: Molecular Mechanisms"],"prefix":"10.3390","volume":"21","author":[{"given":"Manuela","family":"Leri","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d, University of Florence, Viale Morgagni 50, 50134 Florence, Italy"},{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health, University of Firenze, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Scuto","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97-95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Ontario","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97-95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0478-985X","authenticated-orcid":false,"given":"Vittorio","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences, University of Catania, Torre Biologica, Via Santa Sofia, 97-95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health and Health Science, University of Massachusetts, Amherst, MA 01003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bucciantini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d, University of Florence, Viale Morgagni 50, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Stefani","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d, University of Florence, Viale Morgagni 50, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/biof.1171","article-title":"Beneficial properties of natural phenols: Highlight on protection against pathological conditions associated with amyloid aggregation","volume":"40","author":"Stefani","year":"2014","journal-title":"BioFactors"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1017\/S1368980011002515","article-title":"Mediterranean diet pyramid today. Science and cultural updates. Mediterranean Diet Foundation Expert Group","volume":"14","author":"Berry","year":"2011","journal-title":"Public Health Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","article-title":"Flavonoids: Antioxidants or signalling molecules?","volume":"36","author":"Williams","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2165\/00002512-200118090-00004","article-title":"Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment","volume":"18","author":"Halliwell","year":"2001","journal-title":"Drugs Aging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3945\/ajcn.110.007369","article-title":"Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population","volume":"93","author":"Tangney","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_6","first-page":"313","article-title":"Polyphenols: Chemistry, dietary sources, metabolism and nutritional significance","volume":"56","author":"Bravo","year":"1998","journal-title":"Nutr. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1248\/cpb.59.803","article-title":"Naturally Occurring Iridoids and Secoiridoids. An Updated Review, Part 4","volume":"59","author":"Dinda","year":"2011","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1248\/cpb.55.159","article-title":"Naturally Occurring Iridoids. A Review, Part 1","volume":"55","author":"Dinda","year":"2007","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/ejlt.200800268","article-title":"Variations of the iridoid oleuropein in Italian olive varieties during growth and maturation","volume":"111","author":"Ranalli","year":"2009","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/1438-9312(200210)104:9\/10<602::AID-EJLT602>3.0.CO;2-X","article-title":"Contribution of phenolic compounds in virgin olive oil quality","volume":"104","author":"Servili","year":"2002","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3164\/jcbn.16-120","article-title":"Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4","volume":"61","author":"Fujiwara","year":"2017","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1021\/acs.biochem.7b00199","article-title":"Olive Component Oleuropein Promotes \u03b2-Cell Insulin Secretion and Protects \u03b2-Cells from Amylin Amyloid-Induced Cytotoxicity","volume":"56","author":"Wu","year":"2017","journal-title":"Biochemistry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1021\/cn400024q","article-title":"Olive-oil-derived oleocanthal enhances \u03b2-amyloid clearance as a potential neuroprotective mechanism against Alzheimer\u2019s disease: In vitro and in vivo studies","volume":"4","author":"Abuznait","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Grossi, C., Rigacci, S., Ambrosini, S., Ed Dami, T., Luccarini, I., Traini, C., Failli, P., Berti, A., Casamenti, F., and Stefani, M. (2013). The polyphenol oleuropein aglycone protects TgCRNDmice against A\u03b2 plaque pathology. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071702"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1021\/np300384h","article-title":"Modulation of tau protein fibrillization by oleocanthal","volume":"75","author":"Monti","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jnutbio.2009.04.010","article-title":"Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin","volume":"8","author":"Rigacci","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.neuint.2011.02.010","article-title":"Oleuropein and derivatives from olives as Tau aggregation inhibitors","volume":"58","author":"Daccache","year":"2011","journal-title":"Neurochem. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jnutbio.2015.07.022","article-title":"Extra-virgin olive oil attenuates amyloid-\u03b2 and tau pathologies in the brains of TgSwDI mice","volume":"26","author":"Qosa","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2019.04.015","article-title":"Oleuriopein aglycone and hydroxytyrosol interfere differently with toxic A\u03b21-aggregation","volume":"129","author":"Leri","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neuint.2016.03.005","article-title":"Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity","volume":"96","author":"Yu","year":"2016","journal-title":"Neurochem. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3233\/JAD-171124","article-title":"Diet supplementation with hydroxytyrosol ameliorates brain pathology and restores cognitive functions in a mouse model of amyloid-\u03b2 deposition","volume":"63","author":"Nardiello","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrn4019","article-title":"Hippocampal insulin resistance and cognitive dysfunction","volume":"16","author":"Biessels","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fnins.2015.00204","article-title":"Aberrant insulin signaling in Alzheimer\u2019s disease: Current knowledge","volume":"9","author":"Bedse","year":"2015","journal-title":"Front. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/mnfr.201300195","article-title":"Epigenetic effects of natural polyphenols: A focus on SIRT1-mediated mechanisms","volume":"58","author":"Ayissi","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_25","unstructured":"Bartolini, G., and Petruccelli, R. (2002). Classifications, Origins, Diffusion and History of the Olive, Rome Food and Agricolture Organisation in the United Nations."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.abb.2014.03.006","article-title":"Components of a standardized olive leaf dry extract (Ph. Eur.) promote hypothiocyanate production by lactoperoxidase","volume":"549","author":"Flemmig","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.phymed.2010.10.021","article-title":"Olea europaea leaf (Ph. Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase","volume":"18","author":"Flemming","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-2004-815483","article-title":"Anti-inflammatory compounds of plant origin. Part II. Modulation of pro-inflammatory cytokines, chemokines and adhesion molecules","volume":"70","author":"Calixto","year":"2004","journal-title":"Planta Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/1389450117666160112113930","article-title":"Natural Polyphenols and their Synthetic Analogs as Emerging Anticancer Agents","volume":"18","author":"Colomer","year":"2017","journal-title":"Curr. Drug Targets"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2478\/acph-2019-0052","article-title":"Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs","volume":"69","author":"Toric","year":"2019","journal-title":"Acta Pharm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1586\/14737175.2015.986101","article-title":"Nutraceuticals and amyloid neurodegenerative diseases: A focus on natural polyphenols","volume":"15","author":"Rigacci","year":"2014","journal-title":"Exp. Rev. Neurother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1021\/acschemneuro.9b00241","article-title":"Biophysical and in vivo studies identify a new natural-based polyphenol, counteracting A\u03b2 oligomerization in vitro and A\u03b2 oligomer-mediated memory impairment and neuroinflammation in an acute mouse model of Alzheimer\u2019s disease","volume":"10","author":"Tomaselli","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Curti, V., Zaccaria, V., Tsetegho Sokeng, A.J., Dacrema, M., Masiello, I., Mascaro, A., D\u2019Antona, G., and Daglia, M. (2019). Bioavailability and In Vivo Antioxidant Activity of a Standardized Polyphenol Mixture Extracted from Brown Propolis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051250"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1208\/s12249-019-1349-4","article-title":"Preparation, Characterization, and In vitro Evaluation of Curcumin- and Resveratrol-Loaded Solid Lipid Nanoparticles","volume":"20","author":"Gumireddy","year":"2019","journal-title":"AAPS Pharm. Sci. Tech."},{"key":"ref_35","first-page":"461","article-title":"A Novel Self-Microemulsifying System for the Simultaneous Delivery and Enhanced Oral Absorption of Curcumin and Resveratrol","volume":"83","author":"Jaisamut","year":"2017","journal-title":"Planta Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Chimento, A., De Amicis, F., Sirianni, R., Sinicropi, M.S., Puoci, F., Casaburi, I., Saturnino, C., and Pezzi, V. (2019). Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061381"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/jn\/132.3.409","article-title":"Olive oil phenols are absorbed in humans","volume":"132","author":"Vissers","year":"2002","journal-title":"J. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/mnfr.201200795","article-title":"Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract","volume":"57","author":"Thorstensen","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00394-013-0604-9","article-title":"Bioavailability of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: Comparison between pre- and postmenopausal women","volume":"53","author":"Larrosa","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neurobiolaging.2014.08.029","article-title":"Oleuropein aglycone protects against pyroglutamylated-amyloid-\u03b2 toxicity: Biochemical, epigenetic and functional correlates","volume":"36","author":"Luccarini","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jff.2018.04.028","article-title":"Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells","volume":"46","author":"Ventura","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.phrs.2019.03.005","article-title":"Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of ots effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases","volume":"143","author":"Cano","year":"2019","journal-title":"Pharm. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/14737175.2017.1245617","article-title":"Olive polyphenols: New promising agents to combat aging-associated neurodegeneration","volume":"17","author":"Casamenti","year":"2017","journal-title":"Exp. Rev. Neurother."},{"key":"ref_44","first-page":"216","article-title":"Mediterranean diet and mild cognitive impairment","volume":"66","author":"Scarmeas","year":"2009","journal-title":"Arch. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1208\/s12248-012-9444-4","article-title":"Highly stabilized curcumin nanoparticles tested in an in vitro blood-brain barrier model and in Alzheimer\u2019s disease Tgmice","volume":"15","author":"Cheng","year":"2013","journal-title":"AAPS J."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Keys (1980). Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease, Harvard University Press.","DOI":"10.4159\/harvard.9780674497887"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.CIR.99.6.779","article-title":"Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: Final report of the Lyon Diet Heart Study","volume":"99","author":"Salen","year":"1999","journal-title":"Circulation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000253483","article-title":"Olive oil and cognition: Results from the three-city study","volume":"28","author":"Berr","year":"2009","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/jnnp-2012-304792","article-title":"Mediterranean diet improves cognition: The PREDIMED-NAVARRA randomised trial","volume":"84","author":"Clavero","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s12263-014-0393-7","article-title":"Genotype patterns at CLU, CR1, PICALM and APOE, cognition and Mediterranean diet: The PREDIMED-NAVARRA trial","volume":"9","author":"Galbete","year":"2014","journal-title":"Genes Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3233\/JAD-2012-111799","article-title":"Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk","volume":"29","author":"Quintana","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.atherosclerosis.2011.06.050","article-title":"PREDIMED Investigators. Carotid intima-media thickness changes with Mediterranean diet: A randomized trial (PREDIMED-Navarra)","volume":"219","author":"Irimia","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Guasch-Ferr\u00e9, M., Hu, F.B., Mart\u00ednez-Gonz\u00e1lez, M.A., Fit\u00f3, M., Bull\u00f3, M., Estruch, R., Ros, E., Corella, D., Recondo, J., and G\u00f3mez-Gracia, E. (2014). Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study. BMC Med., 12.","DOI":"10.1186\/1741-7015-12-78"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2572606","DOI":"10.1155\/2016\/2572606","article-title":"Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study","volume":"2016","author":"Guo","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1001\/jamainternmed.2015.4838","article-title":"Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial","volume":"175","author":"Toledo","year":"2015","journal-title":"JAMA Int. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/ejhf.61","article-title":"Effect of the Mediterranean diet on heart failure biomarkers: A randomized sample from the PREDIMED trial","volume":"16","author":"Estruch","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/ejcn.2013.130","article-title":"Olive oil has a beneficial effect on impaired glucose regulation and other cardiometabolic risk factors. Di@bet.es study","volume":"67","author":"Soriguer","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3945\/ajcn.115.112029","article-title":"Olive oil consumption and risk of type diabetes in US women","volume":"102","author":"Hruby","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1038\/nutd.2015.23","article-title":"Extra virgin olive oil use is associated with improved post-prandial blood glucose and LDL-cholesterol in healthy subjects","volume":"5","author":"Violi","year":"2015","journal-title":"Nutr. Diabetes"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"333","DOI":"10.7326\/0003-4819-145-5-200609050-00006","article-title":"The effect of polyphenols in olive oil on heart disease risk factors: A randomized trial","volume":"145","author":"Covas","year":"2006","journal-title":"Ann. Int. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.3945\/jn.115.211557","article-title":"Olive Oil Polyphenols Decrease LDL Concentrations and LDL Atherogenicity in Men in a Randomized Controlled Trial","volume":"145","author":"Remaley","year":"2015","journal-title":"J. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1161\/ATVBAHA.114.303374","article-title":"Olive oil polyphenols enhance high-density lipoprotein function in humans. A randomized controlled trial","volume":"34","author":"Subirana","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"PREDIMED Study Investigators. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Camargo, A., Ruano, J., Fernandez, J.M., Parnell, L.D., Jimenez, A., Santos-Gonzalez, M., Marin, C., Perez-Martinez, P., Uceda, M., and Lopez-Miranda, J. (2010). Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. BMC Genom., 11.","DOI":"10.1186\/1471-2164-11-253"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/mnfr.201100533","article-title":"The postprandial inflammatory response after ingestion of heated oils in obese persons is reduced by the presence of phenol compounds","volume":"56","author":"Camargo","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00508-012-0307-x","article-title":"Ginkgo biloba extract EGb in the treatment of dementia: A pharmacoeconomic analysis of the Austrian setting","volume":"125","author":"Rainer","year":"2013","journal-title":"Wien Klin. Wochenschr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jpsychires.2012.03.003","article-title":"Ginkgo biloba extract EGb 761\u00ae in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of mg","volume":"46","author":"Herrschaft","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"ref_68","first-page":"209","article-title":"Alleviating neuropsychiatric symptoms in dementia: The effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial. Neuropsychiatr","volume":"7","author":"Bachinskaya","year":"2011","journal-title":"Dis. Treat."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.archger.2013.04.002","article-title":"Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans","volume":"57","author":"Molina","year":"2013","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1080\/10408398.2018.1470491","article-title":"The effect of high-polyphenol extra virgin olive oil on cardiovascular risk factors: A systematic review and meta-analysis","volume":"59","author":"George","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/CIRCRESAHA.118.313348","article-title":"The Mediterranean Diet and Cardiovascular Health","volume":"124","author":"Gea","year":"2019","journal-title":"Circ. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1017\/S0029665112002959","article-title":"Potential benefits of adherence to the Mediterranean diet on cognitive health","volume":"72","author":"Samieri","year":"2013","journal-title":"Proc. Nutr. Soc."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Knight, A., Bryan, J., Wilson, C., Hodgson, J., and Murphy, K. (2015). A randomised controlled intervention trial evaluating the efficacy of a Mediterranean dietary pattern on cognitive function and psychological wellbeing in healthy older adults: The MedLey study. BMC Geriatr., 15.","DOI":"10.1186\/s12877-015-0054-8"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1001\/jamainternmed.2015.1668","article-title":"Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial","volume":"175","author":"Corella","year":"2015","journal-title":"JAMA Int. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1755-5949.2010.00147.x","article-title":"Curcumin and Alzheimer\u2019s Disease","volume":"16","author":"Hamaguchi","year":"2010","journal-title":"CNS Neurosci. Ther."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/jcp.0b013e318160862c","article-title":"Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease","volume":"28","author":"Baum","year":"2008","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/alzrt146","article-title":"Oral curcumin for Alzheimer\u2019s disease: Tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study","volume":"4","author":"Ringman","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1475-2891-11-79","article-title":"Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people","volume":"11","author":"DiSilvestro","year":"2012","journal-title":"Nutr. J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/med.21565","article-title":"Health benefits of resveratrol: Evidence from clinical studies","volume":"39","author":"Singh","year":"2019","journal-title":"Med. Res. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.2010.05853.x","article-title":"Clinical trials of resveratrol","volume":"1215","author":"Patel","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_81","first-page":"122","article-title":"The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: A pilot randomized, placebo-controlled clinical trial","volume":"4","author":"Walker","year":"2018","journal-title":"J. Clin. Transl. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/ptr.6124","article-title":"The association between green tea consumption and breast cancer risk: A systematic review and meta-analysis","volume":"32","author":"Salehi","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00392-012-0463-z","article-title":"Green tea halts progression of cardiac transthyretin amyloidosis: An observational report","volume":"101","author":"Kristen","year":"2012","journal-title":"Clin. Res. Cardiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2165\/11591310-000000000-00000","article-title":"The role of phytochemicals in the treatment and prevention of dementia","volume":"28","author":"Howes","year":"2011","journal-title":"Drugs Aging"},{"key":"ref_85","first-page":"1","article-title":"Prevention of breast cancer by dietary polyphenols-role of cancer stem cells","volume":"11","author":"Gu","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_86","first-page":"1","article-title":"Total polyphenol intake and breast cancer risk in the SUN cohort","volume":"27","author":"Gardeazabal","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"21519","DOI":"10.1002\/jcp.28777","article-title":"Natural flavonoids for the prevention of colon cancer: A comprehensive review of preclinical and clinical studies","volume":"234","author":"Afshari","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4154185","DOI":"10.1155\/2018\/4154185","article-title":"Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action","volume":"2018","author":"Alam","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1089\/jmf.2011.0243","article-title":"Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats","volume":"15","author":"Wainstein","year":"2012","journal-title":"J. Med. Food"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"De Bock, M., Derraik, J.G.B., Brennan, C.M., Biggs, J.B., Morgan, P.E., Hodgkinson, S.C., Hofman, P.L., and Cutfield, W.S. (2013). Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: A randomized, placebo-controlled, crossover trial. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057622"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00394-016-1188-y","article-title":"Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: A randomized controlled trial","volume":"56","author":"Lockyer","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1017\/S0007114515001269","article-title":"Secoiridoids delivered as olive leaf extract onduce acute improvements in human vascular function and reduction of an inflammatory cytokine: A randomized, double-blind, placebo-controlled, crioss over trial","volume":"114","author":"Lockyer","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.bbalip.2016.07.003","article-title":"Genes and miRNA expression signatures in peripheral blood mononuclear cells in healthy subjects and patients with metabolic syndrome after acute intake of extra virgin olive oil","volume":"1861","author":"Vacca","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Scoditti, E., Carpi, S., Massaro, M., Pellegrino, M., Polini, B., Carluccio, M.A., Wabitsch, M., Verri, T., Nieri, P., and De Caterina, R. (2019). Hydroxytyrosol modulates adipocyte gene and miRNA expression under inflammatory condition. Nutrients, 11.","DOI":"10.3390\/nu11102493"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2459\/JCM.0000000000000816","article-title":"Effects of postprandial hydroxytyrosol and derivates on oxidation of LDL, cardiometabolic state and gene expression: A nurtrigenomic approach for cardiovascular prevention","volume":"20","author":"Perrone","year":"2019","journal-title":"J. Cardiovasc. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1178638819882739","DOI":"10.1177\/1178638819882739","article-title":"The effect of dietary polyphenols on circulating cardiovascular disease biomarkers and iron status: A systematic review","volume":"12","author":"Speer","year":"2019","journal-title":"Nutr. Metab. Insights"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Carlos, S., De La Fuente-Arrillaga, C., Bes-Rastrollo, M., Razquin, C., Rico-Camp\u00e0, A., Mart\u00ednez-Gonz\u00e1lez, M., and Ruiz-Canela, A. (2018). Mediterranean Diet and Health Outcomes in the SUN Cohort. Nutrients, 10.","DOI":"10.3390\/nu10040439"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2007.08.007","article-title":"Hormesis Defined","volume":"7","author":"Mattson","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Calabrese, E.J. (2019). Hormesis and Ginkgo biloba (GB): Numerous biological effects of GB are mediated via hormesis. Ageing Res. Rev.","DOI":"10.1016\/j.arr.2020.101019"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1177\/0960327110383625","article-title":"Resveratrol commonly displays hormesis: Occurrence and biomedical significance","volume":"29","author":"Calabrese","year":"2010","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.fct.2019.04.053","article-title":"Curcumin and hormesis with particular emphasis on neural cells","volume":"129","author":"Calabrese","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yrtph.2011.06.003","article-title":"The hormesis database: The occurrence of hormetic dose responses in the toxicological literature","volume":"61","author":"Calabrese","year":"2011","journal-title":"Reg. Toxicol. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3109\/10408444.2013.808172","article-title":"Hormetic mechanisms","volume":"43","author":"Calabrese","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/ptr.5128","article-title":"The effects of low and high concentrations of luteolin on cultured human endothelial cells under normal and glucotoxic conditions: Involvement of integrin-linked kinase and cyclooxygenase-2","volume":"28","author":"Abbasi","year":"2014","journal-title":"Phtyother. Res."},{"key":"ref_105","first-page":"118","article-title":"Biphasic response to luteolin in MG-osteobalst-like cells under high glucose-induced oxidative stress","volume":"41","author":"Abbasi","year":"2016","journal-title":"IJMS"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejphar.2018.10.003","article-title":"Ferulic acid exerts concentration-dependent anti-apoptotic and neuronal differentiation-inducing effects in PCand mouse neural stem cells","volume":"741","author":"Moghadam","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4103\/1995-7645.248322","article-title":"Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model","volume":"11","author":"Woo","year":"2018","journal-title":"Asian Pacif. J. Trop. Med."},{"key":"ref_108","first-page":"129","article-title":"Cellular stress response, redox status, and vitagenes in glaucoma: A systemic oxidant disorderlinked to Alzheimer\u2019s disease","volume":"5","author":"Cornelius","year":"2014","journal-title":"Front. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ng1248","article-title":"Keap1-null mutation leads to post-natal lethality due to constitutive Nrfactivation","volume":"35","author":"Wakabayashi","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_110","first-page":"1763","article-title":"Cellular stress responses, the hormesis paradigm, and vitagenes: Novel targets for therapeutic intervention in neurodegenerative disorders","volume":"13","author":"Calabrese","year":"2010","journal-title":"Antioxid. RedoxSignal."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12979-017-0108-1","article-title":"Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer\u2019s disease and Alzheimer-linked pathologies: Modulation by nutritional mushrooms","volume":"15","author":"Pennisi","year":"2018","journal-title":"Immun. Ageing"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Scuto, M., Di Mauro, P., Ontario, M.L., Amato, C., Modafferi, S., Ciavardelli, D., Trovato Salinaro, A., Maiolino, L., and Calabrese, V. (2019). Nutritional Mushroom Treatment in Meniere\u2019s Disease with Coriolus versicolor: A Rationale for Therapeutic Intervention inNeuroinflammation and Antineurodegeneration. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010284"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/0960327107083417","article-title":"Hormesis and disease resistance: Activation of cellular stressresponse pathways","volume":"27","author":"Mattson","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1742-4933-10-41","article-title":"Cellular stress response, sirtuins and UCP proteins in Alzheimer disease: Role of vitagenes","volume":"10","author":"Cornelius","year":"2013","journal-title":"Immun. Ageing"},{"key":"ref_115","first-page":"75","article-title":"The hemeoxygenase\/biliverdin reductase system: A potential drug target in Alzheimers disease","volume":"27","author":"Mancuso","year":"2013","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.mito.2018.08.001","article-title":"Metabolic features and regulation of the healing cycle-A new modelfor chronic disease pathogenesis and treatment","volume":"46","author":"Naviaux","year":"2019","journal-title":"Mitochondrion"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Scuto, M.C., Mancuso, C., Tomasello, B., Laura Ontario, M., Cavallaro, A., Frasca, F., Maiolino, L., Trovato Salinaro, A., Calabrese, E.J., and Calabrese, V. (2019). Curcumin, Hormesis and the Nervous System. Nutrients, 11.","DOI":"10.3390\/nu11102417"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.canlet.2015.04.010","article-title":"Modulation of inflamma- tion by low and high doses of ionizing radiation: Implications for benign and malign diseases","volume":"368","author":"Frey","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s00066-015-0848-9","article-title":"Study of the anti- inflammatory effect of low-dose radiation. The contribution of biphasic regulation of the antioxidative system in endothelial cells","volume":"191","author":"Large","year":"2015","journal-title":"Strahlenther. Onkol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/cei.12344","article-title":"Low and moderate doses of ionizing radiation up to Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function","volume":"179","author":"Wunderlich","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12979-016-0078-8","article-title":"Redox modulation of cellular stress response and lipoxin Aexpression by Hericium Erinaceus in rat brain: Relevance to Alzheimer\u2019s disease pathogenesis","volume":"13","author":"Trovato","year":"2016","journal-title":"Immun. Ageing"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.neuro.2015.09.012","article-title":"Redox modulation of cellular stress response and lipoxin Aexpression by Coriolus versicolor in rat brain: Relevance to Alzheimer\u2019s disease pathogenesis","volume":"53","author":"Trovato","year":"2016","journal-title":"Neurotoxicology"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2017.10.379","article-title":"Aging and Parkinson\u2019s Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis","volume":"115","author":"Calabrese","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.102.035048","article-title":"Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention","volume":"304","author":"Liu","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s12035-013-8475-x","article-title":"The NLRPinflammasome in Alzheimer\u2019s disease","volume":"48","author":"Tan","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Freeman, D., Cedillos, R., Choyke, S., Lukic, Z., McGuire, K., Marvin, S., Burrage, A.M., Sudholt, S., Rana, A., and O\u2019Connor, C. (2013). Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxy-gen species following endocytosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062143"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRPis activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PSmice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Codolo, G., Plotegher, N., Pozzobon, T., Brucale, M., Tessari, I., Bubacco, L., and de Bernard, M. (2013). Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055375"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10571-012-9880-9","article-title":"Oleuropein, an anti-oxidant polyphenol constituent of olivepromotes \u03b1-secretase cleavage of the amyloid precursor protein (A\u03b2PP)","volume":"33","author":"Kostomoiri","year":"2013","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/cbic.201100123","article-title":"Polyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid \u03b2","volume":"12","author":"Ladiwala","year":"2011","journal-title":"Chembiochem"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/1028415X.2017.1317449","article-title":"Oleuropein isolated from Fraxinus rhynchophylla inhibits glutamate-induced neuronal cell death by attenuating mitochondrial dysfunction","volume":"21","author":"Kim","year":"2018","journal-title":"Nutr. Neurosci."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Diomede, L., Rigacci, S., Romeo, M., Stefani, M., and Salmona, M. (2013). Oleuropein Aglycone Protects Transgenic, C. elegans Strains Expressing A\u03b2by Reducing Plaque Load and Motor Deficit. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058893"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00210-019-01678-3","article-title":"Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats","volume":"392","author":"Shibani","year":"2019","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00394-006-0596-9","article-title":"Is dopamine behind the health benefits of red wine?","volume":"45","author":"Covas","year":"2006","journal-title":"Eur. J. Nutr."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0006-2952(95)02092-6","article-title":"Reduction of dihydroxyphenylacetic acid by a novel enzyme in the rat brain","volume":"50","author":"Xu","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s11064-016-1959-0","article-title":"3,4-Dihydroxyphenylethanol (Hydroxytyrosol) Mitigates the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PCCells","volume":"41","author":"Goldstein","year":"2016","journal-title":"Neurochem. Res."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Jinsmaa, Y., Isonaka, R., Sharabi, Y., and Goldstein, D. (2019). 3,4-Dihydroxyphenylacetaldehyde is more efficient than dopamine in oligomerizing and quinonizing alpha-synuclein. J. Pharmacol. Exp. Ther.","DOI":"10.1124\/jpet.119.262246"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2174\/1567205012666150710114430","article-title":"Mediterranean Diet and Risk of Dementia","volume":"12","author":"Safouris","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/ebmed-2015-110237","article-title":"Mediterranean diet may reduce Alzheimer\u2019s risk","volume":"20","author":"Psaltopoulou","year":"2015","journal-title":"Evid. Based. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1002\/mnfr.201600332","article-title":"Hydroxytyrosol mildly improve cognitive function independent of APP processing inAPP\/PSmice","volume":"60","author":"Peng","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Palazzi, L., Leri, M., Cesaro, S., Stefani, M., Bucciantini, M., and Polverino de Laureto, P. (2019). Insight into the molecular mechanism underlying the inhibition of \u03b1-synuclein aggregation by hydroxytyrosol. Biochem. Pharmacol., in press.","DOI":"10.1016\/j.bcp.2019.113722"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"4070935","DOI":"10.1155\/2018\/4070935","article-title":"Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice","volume":"2018","author":"Reutzel","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ejphar.2018.07.043","article-title":"Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2\/HO-axis in SH-SY5Y cells","volume":"834","author":"Sakata","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1017\/S0007114515000884","article-title":"Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db\/db mice: Role of AMP-activated protein kinase activation","volume":"113","author":"Zheng","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuropharm.2016.11.010","article-title":"Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrfpathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats","volume":"113","author":"Sun","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/ptr.5339","article-title":"Role of Hydroxytyrosol-dependent Regulation of HO-Expression in Promoting Wound Healing of Vascular Endothelial Cells via NrfDe Novo Synthesis and Stabilization","volume":"29","author":"Zrelli","year":"2015","journal-title":"Phytother. Res."},{"key":"ref_147","first-page":"1493","article-title":"Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis","volume":"17","author":"Wei","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jnutbio.2018.03.014","article-title":"Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2\/HOand JAK\/STAT signaling pathways","volume":"57","author":"Montoya","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ejmech.2016.11.001","article-title":"Design, synthesis of allosteric peptide activator for human SIRTand its biological evaluation in cellular model of Alzheimer\u2019s disease","volume":"127","author":"Kumar","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuron.2014.01.028","article-title":"SIRTin neurodevelopment and brain senescence","volume":"81","author":"Herskovits","year":"2014","journal-title":"Neuron"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nature09271","article-title":"A novel pathway regulates memory and plasticity via SIRTand miR-134","volume":"466","author":"Gao","year":"2010","journal-title":"Nature"},{"key":"ref_152","first-page":"4035","article-title":"Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy","volume":"17","author":"Zhi","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_153","first-page":"1531","article-title":"Hydroxytyrosol promotes autophagy by regulating SIRTagainst advanced oxidation protein product-induced NADPH oxidase and inflammatory response","volume":"44","author":"Sun","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"110817","DOI":"10.1016\/j.fct.2019.110817","article-title":"Melatonin, protocatechuic acid and hydroxytyrosol effects on vitagenes system against alpha-synuclein toxicity","volume":"134","author":"Cerezo","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1139\/cjpp-2016-0676","article-title":"Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through the SIRT1-mediated signaling pathway","volume":"96","author":"Wang","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/1566524017666170421151940","article-title":"Hydroxytyrosol Attenuates LPS-Induced Acute Lung Injury in Mice by Regulating Autophagy and Sirtuin Expression","volume":"17","author":"Yang","year":"2017","journal-title":"Curr. Mol. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12079-014-0253-7","article-title":"Sex hormonal regulation and hormesis in aging and longevity: Role of vitagenes","volume":"8","author":"Calabrese","year":"2014","journal-title":"J. Cell. Commun. Signal."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/tox.22844","article-title":"Di (2-ethylhexyl) phthalate targets the thioredoxin system and the oxidative branch of the pentose phosphate pathway in liver of Balb\/c mice","volume":"35","author":"Amara","year":"2020","journal-title":"Environ Toxicol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1039\/C5FO00097A","article-title":"Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PCcells","volume":"6","author":"Peng","year":"2015","journal-title":"Food Funct."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.chembiol.2011.09.008","article-title":"HSF1-dependent upregulation of Hspby sulfhydryl-reactive inducers of the KEAP1\/NRF2\/ARE pathway","volume":"18","author":"Zhang","year":"2011","journal-title":"Chem. Biol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2015.10.016","article-title":"Sulforaphane exerts its anti-inflammatory effect against amyloid-\u03b2 peptide via STAT-dephosphorylation and activation of Nrf2\/HO-cascade in human THP-macrophages","volume":"38","author":"An","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e1800240","DOI":"10.1002\/mnfr.201800240","article-title":"Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-\u03b2 and Tau in a Mouse Model of Alzheimer\u2019s Disease","volume":"62","author":"Lee","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","article-title":"Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer\u2019s disease","volume":"14","author":"Moussa","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.bbrc.2013.05.025","article-title":"Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway","volume":"435","author":"Zhao","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neuro.2018.11.009","article-title":"Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1\/DREAM\/PDYN pathway","volume":"71","author":"Laudati","year":"2019","journal-title":"Neurotoxicology"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"8791832","DOI":"10.1155\/2017\/8791832","article-title":"Resveratrol Attenuates Microglial Activation via SIRT1-SOCSPathway","volume":"2017","author":"Zhang","year":"2017","journal-title":"Evid. Based. Complement Alternat. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"4602715","DOI":"10.1155\/2017\/4602715","article-title":"SIRTActivation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice","volume":"2017","author":"Ma","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11064-017-2421-7","article-title":"Resveratrol attenuates the cytotoxicity induced by amyloid-\u03b2 1\u2013in PCcells by upregulating heme oxygenase-via the PI3K\/Akt\/Nrfpathway","volume":"43","author":"Hui","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.toxicon.2019.03.022","article-title":"Resveratrol inhibits aflatoxin B1-induced oxidative stress and apoptosis in bovine mammary epithelial cells and is involved the Nrfsignaling pathway","volume":"164","author":"Zhou","year":"2019","journal-title":"Toxicon"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1089\/dna.2018.4308","article-title":"Resveratrol Suppresses A\u03b2-Induced Microglial Activation Through the TXNIP\/TRX\/NLRPSignaling Pathway","volume":"38","author":"Feng","year":"2019","journal-title":"DNA Cell Biol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fphar.2019.01298","article-title":"The HemeOxygenase\/Biliverdin Reductase System as Effector of the Neuroprotective Outcomes of Herb-BasedNutritionalSupplements","volume":"10","author":"Mhillaj","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cbi.2019.01.010","article-title":"Curcumin analogues attenuate A\u03b2 25\u2014Induced oxidative stress in PCcells via Keap1\/Nrf2\/HO-signaling pathways","volume":"305","author":"Xu","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.4049\/jimmunol.1701495","article-title":"Curcumin Suppresses IL-1\u03b2 Secretion and Prevents Inflammation through Inhibition of the NLRPInflammasome","volume":"200","author":"Yin","year":"2018","journal-title":"J. Immunol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1074\/jbc.M112.393751","article-title":"Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice","volume":"288","author":"Ma","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/gerona\/61.5.505","article-title":"ILSA Working Group. Metabolic syndrome, diabetes, and cardiovascular disease in an elderly Caucasian cohort: The Italian Longitudinal Study on Aging","volume":"61","author":"Maggi","year":"2006","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1872208311666170227112013","article-title":"The Metabolic Syndrome and the Relevance of Nutrients for its Onset","volume":"11","author":"Schnack","year":"2017","journal-title":"Recent Pat. Biotechnol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/eurpub\/13.suppl_1.24","article-title":"European food availability databank based on household budget surveys: The Data Food Networking initiative","volume":"13","author":"Trichopoulou","year":"2003","journal-title":"Eur. J. Public Health"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJM200105033441801","article-title":"Prevention of type diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance","volume":"344","author":"Tuomilehto","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/s00125-006-0198-3","article-title":"High-fibre, low-fat diet predicts long-term weight loss and decreased type diabetes risk: The Finnish Diabetes Prevention Study","volume":"49","author":"Peltonen","year":"2006","journal-title":"Diabetologia"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3390\/ijms11041365","article-title":"Impact of dietary polyphenols on carbohydrate metabolism","volume":"11","author":"Hanhineva","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cca.2009.12.022","article-title":"Postprandial apolipoprotein Bis associated with asymptomatic peripheral arterial disease: A study in patients with type diabetes and controls","volume":"411","author":"Valdivielso","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.amjcard.2007.03.107","article-title":"Postprandial hyperglycemia\/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor","volume":"100","author":"Bell","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.2337\/diacare.25.10.1845","article-title":"Fasting and postchallenge glycemia and cardiovascular disease risk: The Framingham offspring study","volume":"25","author":"Meigs","year":"2002","journal-title":"Diabetes Care"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2337\/dc11-1593","article-title":"High fat intake leads to acute postprandial exposure to circulating endotoxin in type diabetic subjects","volume":"35","author":"Harte","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1160\/TH16-11-0857","article-title":"Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production","volume":"117","author":"Nocella","year":"2017","journal-title":"Thromb. Haemost."},{"key":"ref_186","first-page":"359","article-title":"Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats","volume":"26","author":"Virk","year":"2013","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.atherosclerosis.2014.05.954","article-title":"Extra virgin olive oil blunt postprandial oxidative stress via NOXdown-regulation","volume":"35","author":"Carnevale","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00394-018-1718-x","article-title":"Gut-derived lipopolysaccharides increase post-prandial oxidative stress via Noxactivation in patients with impaired fasting glucose tolerance: Effect of extra-virgin olive oil","volume":"58","author":"Carnevale","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1089\/jmf.2007.531","article-title":"Human glycemic response and phenolic content of unsweetened cranberry juice","volume":"11","author":"Wilson","year":"2008","journal-title":"J. Med. Food"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Calahorra, J., Shenk, J., Wielanga, V.H., Verweij, V., Geenen, B., Dederen, P.J., Peinado, M.A., Siles, E., Wiesmann, M., and Kiliaan, A.J. (2019). Hydroxytyroaol, the major phenolic compound of olive oil, as as acute therapeutic strategy after ischemic stroke. Nutrients, 11.","DOI":"10.3390\/nu11102430"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jams.2012.10.005","article-title":"\u03b1-Glucosidase and \u03b1-amylase inhibitory activity of Senna surattensis","volume":"6","author":"Thilagam","year":"2013","journal-title":"J. Acupunct. Meridian Stud."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7555\/JBR.31.20160164","article-title":"Postprandial hyperglycemia and postprandial hypertriglyceridemia in type diabetes","volume":"33","author":"Hiyoshi","year":"2019","journal-title":"J. Biomed. Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3177\/jnsv.52.149","article-title":"Inhibition of alpha-glucosidase and alpha-amylase by flavonoids","volume":"52","author":"Tadera","year":"2006","journal-title":"J. Nutr. Sci. Vitaminol. (Tokyo)"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1021\/jf0627672","article-title":"alpha-Glucosidase inhibitory profile of catechins and theaflavins","volume":"55","author":"Matsui","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/emm.2007.25","article-title":"Resveratrol stimulates glucose transport in C2Cmyotubes by activating AMP-activated protein kinase","volume":"39","author":"Park","year":"2007","journal-title":"Exp. Mol. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"15252","DOI":"10.1074\/jbc.M110496200","article-title":"Flavonoid inhibition of sodium-dependent vitamin C transporter (SVCT1) and glucose transporter isoform (GLUT2), intestinal transporters for vitamin C and Glucose","volume":"277","author":"Song","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.febslet.2004.12.099","article-title":"Dietary polyphenols decrease glucose uptake by human intestinal Caco-cells","volume":"579","author":"Johnston","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/jnr.24244","article-title":"Hormetic approaches to the treatment of Parkinson\u2019s disease: Perspectives and possibilities","volume":"96","author":"Calabrese","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jnutbio.2009.02.003","article-title":"Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin","volume":"21","author":"Montagut","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1023\/B:MCBI.0000028743.75669.ab","article-title":"Momordica charantia fruit juice stimulates glucose and amino acid uptakes in Lmyotubes","volume":"261","author":"Cummings","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1021\/jf401190y","article-title":"Black soybean seed coat extract ameliorates hyperglycemia and insulin sensitivity via the activation of AMP-activated protein kinase in diabetic mice","volume":"61","author":"Kurimoto","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.jnutbio.2013.06.003","article-title":"Recent advances in understanding the anti-diabetic actions of dietary flavonoids","volume":"24","author":"Babu","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.phymed.2009.09.007","article-title":"Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat lmuscle cells exposed to dexamethasone condition","volume":"17","author":"Zhang","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2016.03.026","article-title":"Evaluation of hypocholesterolemic effect of oleuropein in cholesterol-fed rats","volume":"252","author":"Hadrich","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.2337\/diabetes.49.11.1751","article-title":"Triggering and amplifying pathways of regulation of insulin secretion by glucose","volume":"49","author":"Henquin","year":"2000","journal-title":"Diabetes"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1021\/jf902618v","article-title":"Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity through activating IRSand AMPK signaling in rat pancreatic beta cells","volume":"57","author":"Cai","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030048","article-title":"Roles of -AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis","volume":"375","author":"Rutter","year":"2003","journal-title":"Biochem. J."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/mpa.0b013e31811ed0d2","article-title":"Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor \u03baB activation","volume":"35","author":"Kim","year":"2007","journal-title":"Pancreas"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.lfs.2011.08.012","article-title":"Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in T3-Lcells","volume":"89","author":"Drira","year":"2011","journal-title":"Life Sci."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jnutbio.2009.03.012","article-title":"Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-Ladipocytes","volume":"21","author":"Hao","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNFprotein kinases: Conserved guardians of cellular energy","volume":"8","author":"Hardie","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrc1974","article-title":"mTOR and cancer: Insights into a complex relationship","volume":"6","author":"Sabatini","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature05828","article-title":"Energy-dependent regulation of cell structure by AMP-activated protein kinase","volume":"447","author":"Lee","year":"2007","journal-title":"Nature"},{"key":"ref_215","first-page":"2217","article-title":"Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA\/LKB1\/AMPK pathway","volume":"11","author":"Huang","year":"2019","journal-title":"Aging (Albany N. Y.)"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"35344","DOI":"10.18632\/oncotarget.6119","article-title":"Oleuropein aglycone induces autophagy via the AMPK\/mTOR signalling pathway: A mechanistic insight","volume":"6","author":"Rigacci","year":"2015","journal-title":"Oncotarget"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/BJ20040955","article-title":"Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase","volume":"384","author":"Bronner","year":"2004","journal-title":"Biochem. J."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"30778","DOI":"10.1074\/jbc.M205213200","article-title":"The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase","volume":"277","author":"Marsin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fimmu.2019.00345","article-title":"Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1","volume":"10","author":"Campbell","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fct.2013.12.015","article-title":"Thymoquinone induces heme oxygenase-expression in HaCaT cells via Nrf2\/ARE activation: Akt and AMPK\u03b1 as upstream targets","volume":"65","author":"Kundu","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cotox.2018.05.002","article-title":"mTOR\/AMPK signaling in the brain: Cell metabolism, proteostasis and survival","volume":"8","author":"Schroder","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.2337\/db08-1512","article-title":"Activation of the AMPK-FOXOpathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin","volume":"58","author":"Li","year":"2009","journal-title":"Diabetes"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK(hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"12374","DOI":"10.1096\/fj.201900841R","article-title":"AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR","volume":"33","author":"Collodet","year":"2019","journal-title":"FASEB J."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1139\/o02-156","article-title":"Activation of the glucose transporter GLUTby insulin","volume":"80","author":"Furtado","year":"2002","journal-title":"Biochem. Cell Biol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1210\/er.2003-0011","article-title":"Regulated membrane trafficking of the insulin-responsive glucose transporter in adipocytes","volume":"25","author":"Watson","year":"2004","journal-title":"Endocr. Rev."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(03)00929-2","article-title":"TSCmediates cellular energy response to control cell growth and survival","volume":"115","author":"Inoki","year":"2003","journal-title":"Cell"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2010.05.003","article-title":"Regulation of SIRTin cellular functions: Role of polyphenols","volume":"501","author":"Chung","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cellsig.2016.06.018","article-title":"Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue","volume":"28","author":"Zhao","year":"2016","journal-title":"Cell Signal."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.mito.2011.05.014","article-title":"Decreased heat shock protein expression and altered autophagy in human cells harboring A8344G mitochondrial DNA mutation","volume":"11","author":"Chen","year":"2011","journal-title":"Mitochondrion"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"20110409","DOI":"10.1098\/rstb.2011.0409","article-title":"Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders","volume":"368","author":"Carra","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4161\/auto.7.1.13935","article-title":"Small heat shock proteins, protein degradation and protein aggregation diseases","volume":"7","author":"Vos","year":"2011","journal-title":"Autophagy"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.molcel.2009.01.021","article-title":"Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates","volume":"33","author":"Korolchuk","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fimmu.2014.00403","article-title":"Exosomes and autophagy: Coordinated mechanisms for the maintenance of cellular fitness","volume":"5","author":"Baixauli","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-biochem-060614-033955","article-title":"The Biology of Proteostasis in Aging and Disease","volume":"84","author":"Labbadia","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: Controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41568-018-0020-9","article-title":"Adapting to stress\u2014Chaperome networks in cancer","volume":"18","author":"Joshi","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/jpet.106.102319","article-title":"Specific plasma membrane binding sites for polyphenols, including resveratrol, in the rat brain","volume":"318","author":"Han","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tcb.2012.07.004","article-title":"Resveratrol as a calorie restriction mimetic: Therapeutic implications","volume":"22","author":"Chung","year":"2012","journal-title":"Trends Cell Biol."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Lan, F., Weikel, K.A., Cacicedo, J.M., and Ido, Y. (2017). Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application. Nutrients, 9.","DOI":"10.3390\/nu9070751"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3892\/ijo.2012.1325","article-title":"Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells","volume":"40","author":"Miki","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/mc.22324","article-title":"Singh Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIMand the mTOR pathway","volume":"55","author":"Selvaraj","year":"2016","journal-title":"Mol. Carcinog."},{"key":"ref_243","doi-asserted-by":"crossref","unstructured":"Fu, Y., Chang, H., Peng, X., Bai, Q., Yi, L., Zhou, Y., Zhu, J., and Mi, M. (2014). Resveratrol Inhibits Breast Cancer Stem-Like Cells and Induces Autophagy via Suppressing Wnt\/\u03b2-catenin Signaling Pathway. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102535"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"Villa-Cuesta, E., Boylan, J.N.M., Tatar, M., and Gruppuso, P.A. (2011). Resveratrol inhibits protein translation in hepatic cells. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0029513"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3109\/0886022X.2016.1149774","article-title":"Regulation of eIF\u201d\u03b1 expression and renal interstitial fibrosis by resveratrol in rat renal tissue after unilateral uretral obstruction","volume":"38","author":"Zhang","year":"2016","journal-title":"Ren. Fail."},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Maiti, P., and Dunbar, G.L. (2018). Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061637"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2009.01.031","article-title":"Induction of heat shock response by curcumin in human leukemia cells","volume":"279","author":"Teiten","year":"2009","journal-title":"Cancer Lett."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1752-153X-5-33","article-title":"Chemical analysis of Greek pollen\u2014Antioxidant, antimicrobial and proteasome activation properties","volume":"5","author":"Graikou","year":"2011","journal-title":"Chem. Cent. J."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.canlet.2007.10.037","article-title":"Green tea catechin as a chemical chaperone in cancer prevention","volume":"261","author":"Kuzuhara","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/archneur.1997.00550180070015","article-title":"Dietary antioxidants and Parkinson disease. The Rotterdam Study","volume":"54","author":"Breteler","year":"1997","journal-title":"Arch. Neurol."},{"key":"ref_251","first-page":"8067592","article-title":"Oleuropein aglycone protects against MAO-A-induced autophagy impairment and cardiomyocyte death through activation of TFEB","volume":"2018","author":"Miceli","year":"2018","journal-title":"Oxid. Med. Cell. Long."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"416","DOI":"10.14348\/molcells.2015.2268","article-title":"NrfExpression and Apoptosis in Quercetin-treated Malignant Mesothelioma Cells","volume":"38","author":"Lee","year":"2015","journal-title":"Mol. Cells"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"8786","DOI":"10.1128\/MCB.23.23.8786-8794.2003","article-title":"Antioxidants enhance mammalian proteasome expression through the Keap1-Nrfsignaling pathway","volume":"23","author":"Kwak","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jnutbio.2016.12.011","article-title":"Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K\/AKT\/mTOR and STAT signaling pathways","volume":"41","author":"Granato","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn0410-405","article-title":"Manipulating the brain with epigenetics","volume":"13","author":"Korzus","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jjco\/hyi088","article-title":"Diagnostic and therapeutic applications of epigenetics","volume":"35","author":"Miyamoto","year":"2005","journal-title":"Jap. J. Clin. Oncol."},{"key":"ref_257","first-page":"17","article-title":"Epigenetic therapy: A new development in pharmacology","volume":"123","author":"Peedicayil","year":"2006","journal-title":"Indian J. Med. Res."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000324358","article-title":"Dietary polyphenols, deacetylases and chromatin remodeling in inflammation","volume":"3","author":"Rahman","year":"2010","journal-title":"J. Nutrigenet. Nutrigenom."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2741\/3919","article-title":"Epigenetic mechanisms of plant-derived anticancer drugs","volume":"17","author":"Ghantous","year":"2012","journal-title":"Front. Biosci."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2217\/epi.11.71","article-title":"Epigenetic diet: Impact on the epigenome and cancer","volume":"3","author":"Hardy","year":"2011","journal-title":"Epigenomics"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJMra072067","article-title":"Epigenetics in cancer","volume":"358","author":"Esteller","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_263","first-page":"76","article-title":"Dual targeting of epigenetic therapy in cancer","volume":"1775","author":"Hellebrekers","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.celrep.2017.01.074","article-title":"SirtRegulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l","volume":"18","author":"Heo","year":"2017","journal-title":"Cell Rep."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.4161\/cc.7.23.7164","article-title":"Comparing and contrasting the roles of AMPK and SIRTin metabolic tissues","volume":"7","author":"Fulco","year":"2008","journal-title":"Cell Cycle"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12944-017-0464-z","article-title":"Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1\/AMPK\u03b1\/SREBPsignaling pathway","volume":"16","author":"Wang","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/gcc.22154","article-title":"Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells","volume":"53","author":"Xie","year":"2014","journal-title":"Geneschromosomes Cancer"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Kala, R., Shah, H.N., Martin, S.L., and Tollefsbol, T.O. (2015). Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRTand DNMT enzyme expression, including SIRT1-dependent \u03b3-H2AX and telomerase regulation in triple-negative breast cancer. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1693-z"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.biopha.2019.01.035","article-title":"Quercetin based derivatives as sirtuin inhibitors","volume":"111","author":"Heger","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2217\/epi.13.57","article-title":"Epigenetic effects of green tea polyphenols in cancer","volume":"5","author":"Henning","year":"2013","journal-title":"Epigenomics"},{"key":"ref_271","first-page":"7563","article-title":"Tea polyphenol (\u2013)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines","volume":"63","author":"Fang","year":"2003","journal-title":"Cancer Res."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1470-2045(09)70003-8","article-title":"Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study","volume":"10","author":"Fenaux","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/28886","article-title":"Transcriptional activators direct histone acetyltransferase complexes to nucleosomes","volume":"394","author":"Utley","year":"1998","journal-title":"Nature"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1038\/sj.onc.1210599","article-title":"HATs and HDACs: From structure, function and regulation to novel strategies for therapy and prevention","volume":"26","author":"Yang","year":"2007","journal-title":"Oncogene"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"1800228","DOI":"10.1002\/mnfr.201800228","article-title":"Heterocyclic analogs of sulforaphane trigger DNA damage and impede DNA repair in colon cancer cells: Interplay of HATs and HDACs","volume":"62","author":"Okonkwo","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1158\/0008-5472.CAN-08-2442","article-title":"Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation","volume":"69","author":"Choi","year":"2009","journal-title":"Cancer Res."},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"Xiao, X., Shi, D., Liu, L., Wang, J., Xie, X., Kang, T., and Deng, W. (2011). Quercetin suppresses cyclooxygenase-expression and angiogenesis through inactivation of Psignaling. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0022934"},{"key":"ref_279","first-page":"583","article-title":"Quercetin induces FasL-related apoptosis, in part, through promotion of histone Hacetylation in human leukemia HL-cells","volume":"25","author":"Lee","year":"2011","journal-title":"Oncol. Rep."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1016\/j.ejca.2012.02.067","article-title":"Enhancing the anticancer effect of the histone deacetylase inhibitor by activating transglutaminase","volume":"48","author":"Ling","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"ref_281","first-page":"12","article-title":"Epigenetic reactivation of estrogen receptor-\u03b1 (ER\u03b1) by genistein enhances hormonal therapy sensitivity in ER\u03b1-negative breast cancer","volume":"4","author":"Li","year":"2013","journal-title":"Mol. Cancer"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/cncr.24662","article-title":"Genistein reverses hypermethylation and induces active histone modifications in tumor suppressor gene B-Cell translocation gene in prostate cancer","volume":"116","author":"Majid","year":"2010","journal-title":"Cancer"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/carcin\/bgp042","article-title":"BTGtumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer","volume":"30","author":"Majid","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0895-3988(09)60019-2","article-title":"Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-induced by palmitate in 3T3-Ladipocytes through NF-kappa B and JNK pathway","volume":"22","author":"Wang","year":"2009","journal-title":"Biomed. Environ. Sci."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10849","article-title":"An epigenetic blockade of cognitive functions in the neurodegenerating brain","volume":"483","author":"Rei","year":"2012","journal-title":"Nature"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.neurobiolaging.2012.12.028","article-title":"Disruption of neocortical histone Hhomeostasis by soluble A\u03b2: Implications for Alzheimer\u2019s disease","volume":"34","author":"Lithner","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ajpath.2013.05.005","article-title":"Pyroglutamate-amyloid-\u03b2 deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models","volume":"183","author":"Frost","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/nm.1872","article-title":"Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer\u2019s disease-like pathology","volume":"14","author":"Schilling","year":"2008","journal-title":"Nat. Med."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/ijc.23590","article-title":"Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells","volume":"123","author":"Kikuno","year":"2008","journal-title":"Int. J. Cancer"},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Juli, G., Oliverio, M., Bellizzi, D., Gallo Cantafio, M.E., Grillone, K., Passarino, G., Colica, C., Nardi, M., Rossi, M., and Procopio, A. (2019). Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma. Cancers, 11.","DOI":"10.3390\/cancers11070990"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/onc.2011.354","article-title":"DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer","volume":"31","author":"Esteller","year":"2012","journal-title":"Oncogene"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1056\/NEJMoa050995","article-title":"A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia","volume":"353","author":"Calin","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.molcel.2007.05.010","article-title":"Transactivation of miR-34a by pbroadly influences gene expression and promotes apoptosis","volume":"26","author":"Chang","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.molcel.2007.05.017","article-title":"Transcriptional activation of miR-34a contributes to p53-mediated apoptosis","volume":"26","author":"Marciano","year":"2007","journal-title":"Mol. Cell"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jnutbio.2008.12.003","article-title":"Epigallocatechin gallate up-regulation of miR-and induction of apoptosis in human cancer cells","volume":"21","author":"Tsang","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.03.017","article-title":"Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells","volume":"1454","author":"Chakrabarti","year":"2012","journal-title":"Brain Res."},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Milenkovic, D., Deval, C., Gouranton, E., Landrier, J.F., Scalbert, A., Morand, C., and Mazur, A. (2012). Modulation of miRNA expression by dietary polyphenols in apoE deficient mice: A new mechanism of the action of polyphenols. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0029837"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1158\/1535-7163.MCT-07-2272","article-title":"Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells","volume":"7","author":"Sun","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/jnr.24396","article-title":"GABA-containing compound gammapyrone protects against brain impairments in Alzheimer\u2019s disease model male rats and prevents mitochondrial dysfunction in cell culture","volume":"97","author":"Pilipenko","year":"2019","journal-title":"J. Neurosci. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/4\/1250\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:57:37Z","timestamp":1760173057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/4\/1250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,13]]},"references-count":300,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["ijms21041250"],"URL":"https:\/\/doi.org\/10.3390\/ijms21041250","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,13]]}}}