{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:19:05Z","timestamp":1790659145558,"version":"4.1.0"},"reference-count":114,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["2017-CE15-0024-01"],"award-info":[{"award-number":["2017-CE15-0024-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["PJA 20161204724"],"award-info":[{"award-number":["PJA 20161204724"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The presence of premature termination codons (PTCs) in transcripts is dangerous for the cell as they encode potentially deleterious truncated proteins that can act with dominant-negative or gain-of-function effects. To avoid the synthesis of these shortened polypeptides, several RNA surveillance systems can be activated to decrease the level of PTC-containing mRNAs. Nonsense-mediated mRNA decay (NMD) ensures an accelerated degradation of mRNAs harboring PTCs by using several key NMD factors such as up-frameshift (UPF) proteins. Another pathway called nonsense-associated altered splicing (NAS) upregulates transcripts that have skipped disturbing PTCs by alternative splicing. Thus, these RNA quality control processes eliminate abnormal PTC-containing mRNAs from the cells by using positive and negative responses. In this review, we describe the general mechanisms of NMD and NAS and their respective involvement in the decay of aberrant immunoglobulin and TCR transcripts in lymphocytes.<\/jats:p>","DOI":"10.3390\/ijms21041335","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T04:06:01Z","timestamp":1582085161000},"page":"1335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes"],"prefix":"10.3390","volume":"21","author":[{"given":"Jean-Marie","family":"Lambert","sequence":"first","affiliation":[{"name":"Unit CNRS 7276 - INSERM U1262\u2014Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-2198","authenticated-orcid":false,"given":"Mohamad Omar","family":"Ashi","sequence":"additional","affiliation":[{"name":"Unit CNRS 7276 - INSERM U1262\u2014Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivine","family":"Srour","sequence":"additional","affiliation":[{"name":"Unit CNRS 7276 - INSERM U1262\u2014Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-8515","authenticated-orcid":false,"given":"Laurent","family":"Delpy","sequence":"additional","affiliation":[{"name":"Unit CNRS 7276 - INSERM U1262\u2014Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Sauli\u00e8re","sequence":"additional","affiliation":[{"name":"Unit CNRS 7276 - INSERM U1262\u2014Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1242\/jcs.181008","article-title":"Nonsense-Mediated mRNA decay in humans at a glance","volume":"129","author":"Kurosaki","year":"2016","journal-title":"J. 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