{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:15:47Z","timestamp":1790608547473,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010016","name":"Nottingham Trent University","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/100010016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004435","name":"Universidad de Navarra","doi-asserted-by":"publisher","award":["PIUNA"],"award-info":[{"award-number":["PIUNA"]}],"id":[{"id":"10.13039\/501100004435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008049","name":"Fundaci\u00f3n Banco Santander","doi-asserted-by":"publisher","award":["Mobility grant"],"award-info":[{"award-number":["Mobility grant"]}],"id":[{"id":"10.13039\/100008049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>AGAP2 (Arf GAP with GTP-binding protein-like domain, Ankyrin repeat and PH domain 2) isoform 2 is a protein that belongs to the Arf GAP (GTPase activating protein) protein family. These proteins act as GTPase switches for Arfs, which are Ras superfamily members, being therefore involved in signaling regulation. Arf GAP proteins have been shown to participate in several cellular functions including membrane trafficking and actin cytoskeleton remodeling. AGAP2 is a multi-tasking Arf GAP that also presents GTPase activity and is involved in several signaling pathways related with apoptosis, cell survival, migration, and receptor trafficking. The increase of AGAP2 levels is associated with pathologies as cancer and fibrosis. Transforming growth factor beta-1 (TGF-\u03b21) is the most potent pro-fibrotic cytokine identified to date, currently accepted as the principal mediator of the fibrotic response in liver, lung, and kidney. Recent literature has described that the expression of AGAP2 modulates some of the pro-fibrotic effects described for TGF-\u03b21 in the liver. The present review is focused on the interrelated molecular effects between AGAP2 and TGF\u03b21 expression, presenting AGAP2 as a new player in the signaling of this pro-fibrotic cytokine, thereby contributing to the progression of hepatic fibrosis.<\/jats:p>","DOI":"10.3390\/ijms21041400","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T03:20:03Z","timestamp":1582168803000},"page":"1400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["AGAP2: Modulating TGF\u03b21-Signaling in the Regulation of Liver Fibrosis"],"prefix":"10.3390","volume":"21","author":[{"given":"Amaia","family":"Navarro-Corcuera","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Navarra, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1517-7859","authenticated-orcid":false,"given":"Eduardo","family":"Ansorena","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Navarra, 31008 Pamplona, Spain"},{"name":"IdiSNA\u2014Navarra Institute for Health Research, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9144-8809","authenticated-orcid":false,"given":"Cristina","family":"Montiel-Duarte","sequence":"additional","affiliation":[{"name":"The John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham NG11 8NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda J.","family":"Iraburu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Genetics, University of Navarra, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nrm3117","article-title":"ARF family G proteins and their regulators: Roles in membrane transport, development and disease","volume":"12","author":"Donaldson","year":"2011","journal-title":"Nat. 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