{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:31:37Z","timestamp":1789439497749,"version":"build-2803163510"},"reference-count":77,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Malignant mesothelioma is an infrequent tumor that initiates from the mesothelial cells lining of body cavities. The great majority of mesotheliomas originate in the pleural cavity, while the remaining cases initiate in the peritoneal cavity, in the pericardial cavity or on the tunica vaginalis. Usually, mesotheliomas grow in a diffuse pattern and tend to enclose and compress the organs in the various body cavities. Mesothelioma incidence is increasing worldwide and still today, the prognosis is very poor, with a reported median survival of approximately one year from presentation. Thus, the development of alternative and more effective therapies is currently an urgent requirement. The aim of this review article was to describe recent findings about the anti-cancer activity of curcumin and some of its derivatives on mesotheliomas. The potential clinical implications of these findings are discussed.<\/jats:p>","DOI":"10.3390\/ijms21051839","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T05:37:34Z","timestamp":1583732254000},"page":"1839","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Curcumin as an Anticancer Agent in Malignant Mesothelioma: A Review"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-3842","authenticated-orcid":false,"given":"Alfonso","family":"Baldi","sequence":"first","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania \u201cL. Vanvitelli\u201d, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3905-6154","authenticated-orcid":false,"given":"Antonio","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Maiorano","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"},{"name":"Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19019, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy"},{"name":"Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19019, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/bmj.38176.444745.63","article-title":"The learning curve","volume":"329","author":"Treasure","year":"2004","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/156800910790980232","article-title":"Biological agents involved in malignant mesothelioma: Relevance as biomarkers or therapeutic targets","volume":"10","author":"Crispi","year":"2010","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.21037\/tlcr.2018.08.03","article-title":"Update on the management of malignant peritoneal mesothelioma","volume":"7","author":"Sugarbaker","year":"2018","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1158\/1078-0432.CCR-06-1056","article-title":"Piroxicam and cisplatin in a mouse model of peritoneal mesothelioma","volume":"12","author":"Spugnini","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/01913120500313143","article-title":"Macroscopic, Histologic, Immunohistochemical and Ultrastructural Features of Mesothelioma","volume":"30","author":"Hammar","year":"2006","journal-title":"Ultrastruct. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jtho.2015.11.005","article-title":"World Health Organization Committee for Tumors of the Pleura. The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification","volume":"11","author":"Churg","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5858\/arpa.2017-0124-RA","article-title":"Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement from the International Mesothelioma Interest Group","volume":"142","author":"Husain","year":"2018","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e000461","DOI":"10.1136\/jitc-2019-000461","article-title":"Current evidence and future perspectives of immune-checkpoint inhibitors in unresectable malignant pleural mesothelioma","volume":"8","author":"Hotta","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/j.biocel.2006.07.002","article-title":"Human malignant mesothelioma: Molecular mechanisms of pathogenesis and progression","volume":"38","author":"Spugnini","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-9966-27-6","article-title":"Piroxicam and intracavitary platinum-based chemotherapy for the treatment of advanced mesothelioma in pets: Preliminary observations","volume":"27","author":"Spugnini","year":"2008","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/MCP.0b013e328302851d","article-title":"Malignant mesothelioma 2008","volume":"14","author":"Zervos","year":"2008","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1378\/chest.103.4.1268","article-title":"AIDS and malignant mesothelioma--is there a connection?","volume":"103","author":"Behling","year":"1993","journal-title":"Chest"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-4598-9-27","article-title":"Synergistic effect of gefitinib and rofecoxib in mesothelioma cells","volume":"9","author":"Stoppoloni","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.lungcan.2010.03.005","article-title":"Antiproliferative effect of Aurora kinase targeting in mesothelioma","volume":"70","author":"Crispi","year":"2010","journal-title":"Lung Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/JTO.0b013e31820cdd6f","article-title":"Aromatase inhibitor exemestane has antiproliferative effects on human mesothelioma cells","volume":"6","author":"Stoppoloni","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Baldi, A., Piccolo, M.T., Boccellino, M.R., Donizetti, A., Cardillo, I., La Porta, R., Quagliuolo, L., Spugnini, E.P., Cordero, F., and Citro, G. (2011). Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023569"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.1002\/jcp.26485","article-title":"Effects of treatment with Maraviroc a CCR5 inhibitor on a human hepatic stellate cell line","volume":"233","author":"Coppola","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/S1470-2045(18)30100-1","article-title":"Novel therapies for malignant pleural mesothelioma","volume":"19","author":"Scherpereel","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/jcb.25169","article-title":"Different impact of antiretroviral drugs on bone differentiation in an in vitro model","volume":"116","author":"Esposito","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/14712598.2017.1309387","article-title":"Are tumor-infiltrating lymphocytes protagonists or background actors in patient selection for cancer immunotherapy?","volume":"17","author":"Ascierto","year":"2017","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_22","first-page":"443","article-title":"Cell-cycle molecules in mesothelioma: An overview","volume":"26","author":"Spugnini","year":"2007","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1245\/s10434-011-2171-8","article-title":"Clinical impact of extrapleural pneumonectomy for malignant pleural mesothelioma","volume":"19","author":"Ambrogi","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2174\/1871520615666150113123039","article-title":"Combined anticancer therapies: An overview of the latest applications","volume":"15","author":"Piccolo","year":"2015","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"23268","DOI":"10.1002\/jcp.28893","article-title":"A red orange and lemon by-products extract rich in anthocyanins inhibits the progression of diabetic nephropathy","volume":"234","author":"Damiano","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1002\/jcp.29425","article-title":"Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats","volume":"235","author":"Damiano","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2174\/1574892809666140619154838","article-title":"Combination of phytochemicals as adjuvants for cancer therapy","volume":"9","author":"Ho","year":"2014","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/jcp.25995","article-title":"Antitumoral potential, antioxidant activity and carotenoid content of two Southern Italy tomato cultivars extracts: San Marzano and Corbarino","volume":"233","author":"Barone","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1756-9966-33-24","article-title":"CELLFOOD induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways","volume":"33","author":"Nuvoli","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"20091","DOI":"10.3390\/molecules191220091","article-title":"The chemistry of curcumin: From extraction to therapeutic agent","volume":"19","author":"Priyadarsini","year":"2014","journal-title":"Molecules"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.biotechadv.2014.04.004","article-title":"curcumin, a component of golden spice: From bedside to bench and back","volume":"32","author":"Prasad","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","article-title":"Curcumin, an active component of turmeric (Curcuma longa) and its effects on health","volume":"57","author":"Kocaadam","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_33","first-page":"1050","article-title":"Curcumin (Turmeric) and cancer","volume":"21","author":"Unlu","year":"2016","journal-title":"J. BUON"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.cell.2007.08.024","article-title":"From exotic spice to modern drug?","volume":"130","author":"Singh","year":"2007","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s00018-008-7452-4","article-title":"Curcumin: From ancient medicine to current clinical trials","volume":"65","author":"Hatcher","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1211\/jpp.61.01.0018","article-title":"Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia: Influence of disease state","volume":"61","author":"Qin","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cbi.2019.03.031","article-title":"Effects of curcumin and its adjuvant on TPC1 thyroid cell line","volume":"305","author":"Esposito","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Perna, A., De Luca, A., Adelfi, L., Pasquale, T., Varriale, B., and Esposito, T. (2018). Effects of different extracts of curcumin on TPC1 papillary thyroid cancer cell line. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2125-9"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"108729","DOI":"10.1016\/j.cbi.2019.108729","article-title":"Therapeutic effects of turmeric in several diseases: An overview","volume":"310","author":"Hay","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00011-016-1004-4","article-title":"Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt","volume":"66","author":"Zhou","year":"2017","journal-title":"Inflamm. Res."},{"key":"ref_41","first-page":"217","article-title":"Small leucine rich proteoglycans are differently distributed in normal and pathological endometrium","volume":"29","author":"Lucariello","year":"2015","journal-title":"In Vivo"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/138945011794815356","article-title":"Targets of curcumin","volume":"12","author":"Hongyu","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0304-3835(85)90159-4","article-title":"Potential anticancer activity of turmeric (Curcuma longa)","volume":"29","author":"Kuttan","year":"1985","journal-title":"Cancer Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/nutrit\/nuu064","article-title":"curcumin and cancer: Barriers to obtaining a health claim","volume":"73","author":"Jessay","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"15954","DOI":"10.1074\/jbc.M608189200","article-title":"curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction","volume":"282","author":"Bhattacharyya","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1158\/0008-5472.CAN-06-2583","article-title":"Tumor-induced oxidative stress perturbs nuclear factor-kappaB activity-augmenting tumor necrosis factor-alpha-mediated T-cell death: Protection by curcumin","volume":"67","author":"Bhattacharyya","year":"2007","journal-title":"Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"25284","DOI":"10.1074\/jbc.M414645200","article-title":"Thioredoxin reductase is irreversibly modified by curcumin\u2014A novel molecular mechanism for its anticancer activity","volume":"280","author":"Fang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11010-006-9302-8","article-title":"Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin","volume":"296","author":"Limtrakul","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/ijc.25670","article-title":"Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo","volume":"129","author":"Howells","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/carcin\/bgv006","article-title":"curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer","volume":"36","author":"Toden","year":"2015","journal-title":"Carcinogenesis"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13046-017-0661-7","article-title":"Curcumin synergizes with 5-fluorouracil by impairing AMPK\/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice","volume":"36","author":"Zhang","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/bjc.2015.359","article-title":"Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: The role of curcumin on pSTAT3 and Nrf-2 signalling","volume":"113","author":"Fetoni","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"86374","DOI":"10.18632\/oncotarget.13413","article-title":"Re-purposing of curcumin as an anti-metastatic agent for the treatment of epithelial ovarian cancer: In vitro model using cancer stem cell enriched ovarian cancer spheroids","volume":"7","author":"He","year":"2016","journal-title":"Oncotarget"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.canlet.2008.03.025","article-title":"Curcumin and cancer: An \u201cold-age\u201d disease with an \u201cage-old\u201d solution","volume":"267","author":"Anand","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1158\/1940-6207.CAPR-12-0410","article-title":"New perspectives of curcumin in cancer prevention","volume":"6","author":"Park","year":"2013","journal-title":"Cancer Prev. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1345\/aph.1M533","article-title":"Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers","volume":"44","author":"Chen","year":"2010","journal-title":"Ann. Pharmacother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: Problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Tomeh, M.A., Hadianamrei, R., and Zhao, X. (2019). A Review of curcumin and Its Derivatives as Anticancer Agents. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051033"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.colsurfb.2016.11.036","article-title":"Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art","volume":"150","author":"Hussain","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejpb.2015.03.005","article-title":"Curcumin loaded PLGA-poloxamer blend nanoparticles induce cell cycle arrest in mesothelioma cells","volume":"93","author":"Mayol","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11010-011-0878-2","article-title":"Curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis","volume":"357","author":"Wang","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/ptr.4645","article-title":"Curcumin induces autophagy in ACC-MESO-1 cells","volume":"26","author":"Yamauchi","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1158\/1940-6207.CAPR-13-0259","article-title":"Curcumin: A double hit on malignant mesothelioma","volume":"7","author":"Miller","year":"2014","journal-title":"Cancer Prev. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijpharm.2017.01.049","article-title":"Nano-precipitated curcumin loaded particles: Effect of carrier size and drug complexation with (2-hydroxypropyl)-beta-cyclodextrin on their biological performances","volume":"520","author":"Serri","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"34405","DOI":"10.18632\/oncotarget.14907","article-title":"Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line","volume":"8","author":"Masuelli","year":"2017","journal-title":"Oncotarget"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-consumption: The interplay of autophagy and apoptosis","volume":"15","author":"Baehrecke","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","article-title":"Self-eating and self-killing: Crosstalk between autophagy and apoptosis","volume":"8","author":"Maiuri","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"57552","DOI":"10.18632\/oncotarget.15744","article-title":"Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma","volume":"8","author":"Pouliquen","year":"2017","journal-title":"Oncotarget"},{"key":"ref_70","first-page":"2531","article-title":"Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma","volume":"53","author":"Zhang","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s13046-019-1368-8","article-title":"curcumin C3 complex\u00ae\/Bioperine\u00ae has antineoplastic activity in mesothelioma: An in vitro and in vivo analysis","volume":"38","author":"Filosa","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.ctim.2014.07.006","article-title":"Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial","volume":"22","author":"Panahi","year":"2014","journal-title":"Complement. Ther. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Giordano, A., and Tommonaro, G. (2019). Curcumin and Cancer. Nutrients, 11.","DOI":"10.3390\/nu11102376"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jcp.25505","article-title":"Novel Instruments for the Implementation of Electrochemotherapy Protocols: From Bench Side to Veterinary Clinic","volume":"232","author":"Spugnini","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/jcp.24548","article-title":"Definition of novel electrochemotherapy parameters and validation of their in vitro and in vivo effectiveness","volume":"229","author":"Spugnini","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.cvsm.2019.04.006","article-title":"Electrochemotherapy in Veterinary Oncology: State-of-the-Art and Perspectives","volume":"49","author":"Spugnini","year":"2019","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2174\/156800961601151218155340","article-title":"Electrochemotherapy as First Line Cancer Treatment: Experiences from Veterinary Medicine in Developing Novel Protocols","volume":"16","author":"Spugnini","year":"2016","journal-title":"Curr. 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