{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:50:26Z","timestamp":1791435026321,"version":"4.3.3"},"reference-count":66,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The growing number of studies on metallothioneins (MTs), cysteine-rich metal-binding proteins, have been disclosing new functions of these proteins. Thanks to their inducibility, they were considered to play a pivotal role in regulating trace metals homeostasis and in detoxification from heavy metals; nowadays, it is known that they are involved in various physiological and pathological processes, such as regulation of apoptosis, elimination of free radicals, and protection of nucleic acids against toxic insults. MT induction has been demonstrated following stress factors other than heavy metals, such as endocrine-disrupting chemicals, insecticides, and herbicides. However, retrieved data are often controversial: in some cases, xenobiotics elicit MT expression and synthesis; under different conditions, they lead to a decrease in cellular MT content. This review describes the MT response to dichlorodiphenyltrichloroethane (DDT) contamination in mammalian tissues. In particular, attention focuses on changes in MT expression, synthesis, and localization in rat liver, kidneys, and testes following oral administration of dichlorodiphenyldichloroethylene (DDE), the main metabolite of DDT, under normal dietary conditions or in combination with a high fat diet potentially able to increase the cellular uptake of this lipophilic pesticide. The potential connection between MT expression and synthesis, lipophilic substances and trace metals availability is also discussed.<\/jats:p>","DOI":"10.3390\/ijms21051903","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T11:59:36Z","timestamp":1583841576000},"page":"1903","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Exposure to Dichlorodiphenyldichloroethylene (DDE) and Metallothionein Levels in Rats Fed with Normocaloric or High-Fat Diet: A Review"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-4694","authenticated-orcid":false,"given":"Vincenzo","family":"Migliaccio","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biology \u201cAdolfo Zambelli\u201d, University of Salerno, 84084 Fisciano (Sa), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-8030","authenticated-orcid":false,"given":"Lill\u00e0","family":"Lionetti","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cAdolfo Zambelli\u201d, University of Salerno, 84084 Fisciano (Sa), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Putti","sequence":"additional","affiliation":[{"name":"Department of Biology, University Federico II, 80126 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8186-9722","authenticated-orcid":false,"given":"Rosaria","family":"Scudiero","sequence":"additional","affiliation":[{"name":"Department of Biology, University Federico II, 80126 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/S0021-9258(18)64017-7","article-title":"Metallothionein: A cadmium and zinc-containign protein from equine renal cortex. II. Physico-chemical properties","volume":"236","author":"Kagi","year":"1961","journal-title":"J. Biol. Chem."},{"key":"ref_2","first-page":"109","article-title":"Toxicological significance of metallothionein","volume":"52","author":"Webb","year":"1987","journal-title":"Exp. Suppl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0162-0134(01)00347-6","article-title":"Advances in the structure and chemistry of metallothioneins","volume":"88","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3390\/biom4020435","article-title":"Metallothioneins, unconventional proteins from unconventional animals: A long journey from nematodes to mammals","volume":"4","author":"Isani","year":"2014","journal-title":"Biomolecules"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1039\/C8MT00165K","article-title":"Metallothionein diversity and distribution in the tree of life: A multifunctional protein","volume":"10","author":"Ziller","year":"2018","journal-title":"Metallomics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00018-002-8454-2","article-title":"Metallothionein: The multipurpose protein","volume":"59","author":"Coyle","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_7","first-page":"193","article-title":"Regulation of metallothionein gene expression","volume":"14","author":"Andrews","year":"1990","journal-title":"Prog. Food Nutr. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0378-1119(01)00609-6","article-title":"Structural and functional analysis of metal regulatory elements in the promoter region of genes encoding metallothionein isoforms in the Antarctic fish Chionodraco hamatus (icefish)","volume":"274","author":"Scudiero","year":"2001","journal-title":"Gene"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Moleirinho, A., Carneiro, J., Matthiesen, R., Silva, R.M., Amorim, A., and Azevedo, L. (2011). Gains, losses and changes of function after gene duplication: Study of the metallothionein family. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018487"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1073\/pnas.89.14.6333","article-title":"MT-III, a brain-specific member of the metallothionein gene family","volume":"89","author":"Palmiter","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7250","DOI":"10.1021\/bi00189a029","article-title":"Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia","volume":"33","author":"Quaife","year":"1994","journal-title":"Biochemistry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"32835","DOI":"10.1074\/jbc.M102151200","article-title":"A new insight into metallothionein (MT) classification and evolution. The in vivo and in vitro metal binding features of Homarus americanus recombinant MT","volume":"276","author":"Valls","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00775-011-0827-2","article-title":"Zn- and Cu-thioneins: A functional classification for metallothioneins?","volume":"16","author":"Palacios","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1039\/c3mt00123g","article-title":"Mammalian MT1 and MT2 metallothioneins differ in their metal binding abilities","volume":"5","author":"Artells","year":"2013","journal-title":"Metallomics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1039\/C8MT00285A","article-title":"Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE","volume":"11","author":"Comes","year":"2019","journal-title":"Metallomics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3748\/wjg.v13.i7.993","article-title":"Metallothionein: An overview","volume":"13","author":"Thirumoorthy","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-3-30","article-title":"Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes","volume":"3","author":"Lee","year":"2010","journal-title":"Mol. Brain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00775-011-0823-6","article-title":"Mammalian metallothionein in toxicology, cancer, and cancer chemotherapy","volume":"16","author":"Namdarghanbari","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5603\/FHC.a2015.0009","article-title":"Metallothioneins in the lung cancer","volume":"53","author":"Werynska","year":"2015","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-27472-0_1","article-title":"Metallothioneins in normal and cancer cells","volume":"218","author":"Dziegiel","year":"2016","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ju\u00e1rez-Rebollar, D., Rios, C., Nava-Ru\u00edz, C., and M\u00e9ndez-Armenta, M. (2017). Metallothionein in brain disorders. Oxid. Med. Cell. Longev.","DOI":"10.1155\/2017\/5828056"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/bj2910193","article-title":"Metallothionein protects DNA from oxidative damage","volume":"291","author":"Chubatsu","year":"1993","journal-title":"Biochem. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3109\/10715761003692511","article-title":"Protective effect of metallothionein on oxidative stress-induced DNA damage","volume":"44","author":"Chiaverini","year":"2010","journal-title":"Free Radic. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cbpc.2006.09.004","article-title":"Cadmium distribution and metallothionein expression in lizard tissues following acute and chronic cadmium intoxication","volume":"144","author":"Trinchella","year":"2006","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10661-009-0948-z","article-title":"Heavy metals bioaccumulation and metallothionein content in tissues of the sea bream Sparus aurata from three different fish farming systems","volume":"165","author":"Trinchella","year":"2010","journal-title":"Environ. Monit. Assess."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.crvi.2014.05.003","article-title":"Evaluation of cadmium, lead and metallothionein contents in the tissues of mussels (Mytilus galloprovincialis) from the Campania coast (Italy): Levels and seasonal trends","volume":"337","author":"Scudiero","year":"2014","journal-title":"C. R. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.aquatox.2016.01.009","article-title":"Histological changes, apoptosis and metallothionein levels in Triturus carnifex (Amphibia, Urodela) exposed to environmental cadmium concentrations","volume":"173","author":"Capaldo","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"ref_28","first-page":"90","article-title":"Metallothionein expression and synthesis in the testis of the lizard Podarcis sicula under natural conditions and following estrogenic exposure","volume":"61","author":"Verderame","year":"2017","journal-title":"Eur. J. Histochem."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Scudiero, R., Verderame, M., Motta, C.M., and Simoniello, P. (2017). Unravelling the role of metallothionein on development, reproduction and detoxification in the wall lizard Podarcis sicula. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071569"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.gene.2011.05.026","article-title":"Impact of deltamethrin exposure on mRNA expression levels of metallothionein A, B and cytochrome P450 1A in rainbow trout muscles","volume":"484","author":"Ceyhun","year":"2011","journal-title":"Gene"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/tox.10153","article-title":"Metallothionein induction in aquatic oligochaete Tubifex tubifex exposed to herbicide isoproturon","volume":"19","author":"Mosleh","year":"2004","journal-title":"Environ. Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3109\/1547691X.2014.980924","article-title":"Paraquat reduces natural killer cell activity via metallothionein induction","volume":"12","author":"Lim","year":"2015","journal-title":"J. Immunotoxicol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Verderame, M., and Scudiero, R. (2019). How glyphosate impairs liver condition in the field lizard Podarcis siculus (Rafinesque-Schmaltz, 1810): Histological and molecular evidence. Biomed. Res. Int., 4746283.","DOI":"10.1155\/2019\/4746283"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00316511","article-title":"The debate on DDT","volume":"29","author":"Deichmann","year":"1972","journal-title":"Arch. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"N\u00e1jera, J.A., Gonz\u00e1lez-Silva, M., and Alonso, P.L. (2011). Some lessons for the future from the Global Malaria Eradication Programme (1955\u20131969). PLoS Med., 8.","DOI":"10.1371\/journal.pmed.1000412"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tox.2012.11.015","article-title":"Persistent organochlorinated pesticides and mechanisms of their toxicity","volume":"307","author":"Mrema","year":"2013","journal-title":"Toxicology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"23763","DOI":"10.1007\/s11356-017-9911-7","article-title":"Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa","volume":"24","author":"Yohannes","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11356-011-0561-x","article-title":"The occurrence and environmental effect of persistent organic pollutants (POPs) in Taurus Mountains soils","volume":"19","author":"Turgut","year":"2012","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/00288233.1997.9513247","article-title":"Microbial degradation of DDT and its residues\u2014A review","volume":"40","author":"Aislabie","year":"1997","journal-title":"N. Z. J. Agric. Res."},{"key":"ref_40","first-page":"7","article-title":"Global surveillance of DDT and DDE levels in human tissues","volume":"16","author":"Jaga","year":"2003","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/03601230500364674","article-title":"Metabolism of DDT in different tissues of young rats","volume":"41","author":"Tebourbi","year":"2006","journal-title":"J. Environ. Sci. Health B"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"9331","DOI":"10.1021\/acs.est.5b02078","article-title":"Concentrations of persistent organic pollutants in California children\u2019s whole blood and residential dust","volume":"49","author":"Whitehead","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.aquatox.2005.10.011","article-title":"Protein carbonylation and heat shock response in Ruditapes decussatus following p,p\u2019-dichlorodiphenyldichloroethylene (DDE) exposure: A proteomic approach reveals that DDE causes oxidative stress","volume":"77","author":"Dowling","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.reprotox.2010.09.010","article-title":"Differential effects of p,p\u2019-DDE on testis and liver mitochondria: Implications for reproductive toxicology","volume":"31","author":"Mota","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12958-017-0259-0","article-title":"p,p\u2019-DDT induces testicular oxidative stress-induced apoptosis in adult rats","volume":"15","author":"Marouani","year":"2017","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4149\/gpb_2016050","article-title":"Involvment of oxidative stress in the mechanism of p,p\u2019-DDT-induced nephrotoxicity in adult rats","volume":"36","author":"Marouani","year":"2017","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Migliaccio, V., Scudiero, R., Sica, R., Lionetti, L., and Putti, R. (2019). Oxidative stress and mitochondrial uncoupling protein 2 expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215955"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Migliaccio, V., Di Gregorio, I., Putti, R., and Lionetti, L. (2019). Mitochondrial involvement in the adaptive response to chronic exposure to environmental pollutants and high-fat feeding in a rat liver and testis. Cells, 8.","DOI":"10.3390\/cells8080834"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.biopha.2017.03.063","article-title":"Hepatoprotective activity of Rhus oxyacantha root cortex extract against DDT-induced liver injury in rats","volume":"90","author":"Barka","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10534-010-9351-z","article-title":"Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs","volume":"23","author":"Breljak","year":"2010","journal-title":"Biometals"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/tox.22072","article-title":"p,p\u2019-DDE damages spermatogenesis via phospholipid hydroperoxide glutathione peroxidase depletion and mitochondria apoptosis pathway","volume":"31","author":"Quan","year":"2016","journal-title":"Environ. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.scitotenv.2018.04.305","article-title":"Alterations in oxidative responses and post-translational modification caused by p,p\u2019-DDE in Mus spretus testes reveal Cys oxidation status in proteins related to cell-redox homeostasis and male fertility","volume":"636","author":"Alhama","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1742-7843.2005.pto_199.x","article-title":"Effects of concurrent exposure to tributyltin and 1,1-dichloro-2,2bis(p-chlorophenyl)ethylene(p,p\u2019-DDE) on immature male wistar rats","volume":"97","author":"Makita","year":"2005","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.crvi.2016.11.003","article-title":"Age-related changes of metallothionein 1\/2 and metallothionein 3 expression in rat brain","volume":"340","author":"Scudiero","year":"2017","journal-title":"C. R. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/tox.22683","article-title":"Combined effects of DDE and hyperlipidic diet on metallothionein expression and synthesis in rat tissues","volume":"34","author":"Migliaccio","year":"2019","journal-title":"Environ. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Migliaccio, V., Sica, R., Scudiero, R., Simoniello, P., Putti, R., and Lionetti, L. (2019). Physiological adaptation to simultaneous chronic exposure to high-fat diet and dichlorodipheniletylhene (DDE) in wistar rat testis. Cells, 8.","DOI":"10.3390\/cells8050443"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/09553000050028904","article-title":"Protection from radiation-induced DNA single-strand breaks by induction of nuclear metallothionein","volume":"76","author":"Vukovic","year":"2000","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.crvi.2018.07.002","article-title":"Role of estrogen receptors, P450 aromatase, PCNA and p53 in high-fat-induced impairment of spermatogenesis in rats","volume":"341","author":"Verderame","year":"2018","journal-title":"CR Biol."},{"key":"ref_60","first-page":"411","article-title":"Stress proteins as molecular biomarkers for environmental toxicology","volume":"77","author":"Ryan","year":"1996","journal-title":"EXS"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Pedrini-Martha, V., Niederwanger, M., Kopp, R., Schnegg, R., and Dallinger, R. (2016). Physiological, diurnal and stress-related variability of cadmium-metallothionein gene expression in land snails. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150442"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Wolide, A.D., Zawdie, B., Alemayehu, T., and Tadesse, S. (2017). Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients: A cross sectional study. BMC Endocr. Disord., 17.","DOI":"10.1186\/s12902-017-0217-z"},{"key":"ref_63","first-page":"131","article-title":"The significance of the nuclear and cytoplasmic localization of metallothionein in human liver and tumor cells","volume":"102","author":"Cherian","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Klaasen, C. (1999). The nuclear-cytoplasmic presence of Metallothionein in cells during differentiation and development. Metallothionein IV, Birkha\u00fcser.","DOI":"10.1007\/978-3-0348-8847-9"},{"key":"ref_65","first-page":"347","article-title":"Nuclear localization of metallothionein during cell proliferation and differentiation","volume":"46","author":"Cherian","year":"2000","journal-title":"Cell. Mol. Biol. (Noisy-le-Grand)"},{"key":"ref_66","first-page":"357","article-title":"Nuclear trafficking of metallothionein: Possible mechanisms and current knowledge","volume":"46","author":"Ogra","year":"2000","journal-title":"Cell. Mol. Biol. (Noisy-le-Grand)"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/5\/1903\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:05:54Z","timestamp":1760173554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/5\/1903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,10]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["ijms21051903"],"URL":"https:\/\/doi.org\/10.3390\/ijms21051903","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,10]]}}}