{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:11:30Z","timestamp":1788613890699,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Project","award":["2017YFC1702105"],"award-info":[{"award-number":["2017YFC1702105"]}]},{"name":"Jilin Province Health Science and Technology Capacity Improvement Project","award":["2019Q015"],"award-info":[{"award-number":["2019Q015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the Panax genus, possesses good anti-inflammatory activity. The study aimed to investigate the gastroprotective effect of ocotillol on acetic acid-induced GU rats. The serum levels of endothelin-1 (ET-1) and nitric oxide (NO), the gastric mucosa levels of epidermal growth factor, superoxide dismutase and NO were assessed. Hematoxylin and eosin staining of gastric mucosa for pathological changes and immunohistochemical staining of ET-1, epidermal growth factor receptors and inducible nitric oxide synthase were evaluated. A UPLC-QTOF-MS-based serum metabolomics approach was applied to explore the latent mechanism. A total of 21 potential metabolites involved in 7 metabolic pathways were identified. The study helps us to understand the pathogenesis of GU and to provide a potential natural anti-ulcer agent.<\/jats:p>","DOI":"10.3390\/ijms21072577","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T03:40:19Z","timestamp":1586403619000},"page":"2577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0694-4059","authenticated-orcid":false,"given":"Cuizhu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"},{"name":"School of Pharmaceutical Sciences, Jilin University, Fujin Road 1266, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuze","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6640-0846","authenticated-orcid":false,"given":"Alan Chen-Yu","family":"Hsu","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Faculty of Health and Medicine, The University of Newcastle, Newcastle, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinluan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, 3031RM Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4020-879X","authenticated-orcid":false,"given":"Jinping","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jilin University, Fujin Road 1266, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingya","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jilin University, Fujin Road 1266, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0871-3454","authenticated-orcid":false,"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.7754\/Clin.Lab.2019.190433","article-title":"Significance of Serological Gastric Biopsy in Different Gastric Mucosal Lesions: An Observational Study","volume":"65","author":"Dong","year":"2019","journal-title":"Clin. 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