{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:50:42Z","timestamp":1792795842469,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis is a chronic inflammatory cutaneous disease, characterized by activated plasmacytoid dendritic cells, myeloid dendritic cells, Th17 cells, and hyperproliferating keratinocytes. Recent studies revealed skin-resident cells have pivotal roles in developing psoriatic skin lesions. The balance in effector T cells and regulatory T cells is disturbed, leading Foxp3-positive regulatory T cells to produce proinflammatory IL-17. Not only acquired but also innate immunity is important in psoriasis pathogenesis, especially in triggering the disease. Group 3 innate lymphoid cell are considered one of IL-17-producing cells in psoriasis. Short chain fatty acids produced by gut microbiota stabilize expression of Foxp3 in regulatory T cells, thereby stabilizing their function. The composition of gut microbiota influences the systemic inflammatory status, and associations been shown with diabetes mellitus, cardiovascular diseases, psychomotor diseases, and other systemic inflammatory disorders. Psoriasis has been shown to frequently comorbid with diabetes mellitus, cardiovascular diseases, psychomotor disease and obesity, and recent report suggested the similar abnormality in gut microbiota as the above comorbid diseases. However, the precise mechanism and relation between psoriasis pathogenesis and gut microbiota needs further investigation. This review introduces the recent advances in psoriasis research and tries to provide clues to solve the mysterious relation of psoriasis and gut microbiota.<\/jats:p>","DOI":"10.3390\/ijms21072582","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T03:40:19Z","timestamp":1586403619000},"page":"2582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-1803","authenticated-orcid":false,"given":"Mayumi","family":"Komine","sequence":"first","affiliation":[{"name":"Department of Dermatology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan"},{"name":"Department of Biochemistry, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2017.07.007","article-title":"Psoriasis: A mixed autoimmune and autoinflammatory disease","volume":"49","author":"Liang","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2017.08.008","article-title":"Atopic dermatitis and psoriasis: Two different immune diseases or one spectrum?","volume":"48","author":"Krueger","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ced.13227","article-title":"T-helper immune phenotype may underlie \u2018paradoxical\u2019 tumour necrosis factor-\u03b1 inhibitor therapy-related psoriasiform dermatitis","volume":"43","author":"Moy","year":"2018","journal-title":"Clin. Exp. Derm."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.it.2012.11.005","article-title":"The IL-23\/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses","volume":"34","author":"Lowes","year":"2013","journal-title":"Trends Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1159\/000455840","article-title":"Psoriasis and Obesity","volume":"232","author":"Jensen","year":"2016","journal-title":"Dermatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"269rv1","DOI":"10.1126\/scitranslmed.3010641","article-title":"Resident memory T cells in human health and disease","volume":"7","author":"Clark","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1084\/jem.20031482","article-title":"Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha","volume":"199","author":"Boyman","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4049\/jimmunol.176.7.4431","article-title":"The vast majority of CLA+ T cells are resident in normal skin","volume":"176","author":"Clark","year":"2006","journal-title":"J. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fimmu.2014.00294","article-title":"Characterization and functional properties of gastric tissue-resident memory T cells from children, adults, and the elderly","volume":"5","author":"Booth","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9229","DOI":"10.1073\/pnas.1318731111","article-title":"Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory","volume":"111","author":"Okhrimenko","year":"2014","journal-title":"Proc. Nat. Acad. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/mi.2013.67","article-title":"Lung niches for the generation and maintenance of tissue-resident memory T cells","volume":"7","author":"Turner","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1681\/ASN.2008101127","article-title":"Functional effector memory T cells enrich the peritoneal cavity of patients treated with peritoneal dialysis","volume":"20","author":"Roberts","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Purwar, R., Campbell, J., Murphy, G., Richards, W.G., Clark, R.A., and Kupper, T.S. (2011). Resident Memory T Cells (T(RM)) Are Abundant in Human Lung: Diversity, Function, and Antigen Specificity. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016245"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1046\/j.1365-2133.2002.04743.x","article-title":"Anti-E-selectin is ineffective in the treatment of psoriasis: A randomized trial","volume":"146","author":"Bhushan","year":"2002","journal-title":"Br. J. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.4049\/jimmunol.1302313","article-title":"Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis","volume":"192","author":"Cheuk","year":"2014","journal-title":"J. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1172\/JCI93396","article-title":"Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing \u03b1\u03b2 T cell clones","volume":"127","author":"Matos","year":"2017","journal-title":"J. Clin. Invest."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.jaci.2018.08.048","article-title":"A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis","volume":"143","author":"Hoffer","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nri3349","article-title":"Innate lymphoid cells--how did we miss them?","volume":"13","author":"Walker","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni.2534","article-title":"Human type 1 lymphoid cells accumulate in inflamed mucosal tissues","volume":"14","author":"Bernink","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/jid.2013.477","article-title":"Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis","volume":"134","author":"Villanova","year":"2014","journal-title":"J. Investig. Derm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41419-019-1540-2","article-title":"ILC3 function as a double-edged sword in inflammatory bowel diseases","volume":"10","author":"Zeng","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.4049\/jimmunol.1700596","article-title":"Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis","volume":"200","author":"Soare","year":"2018","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jaci.2018.02.015","article-title":"Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin","volume":"142","author":"Keren","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.it.2016.08.012","article-title":"Induced Regulatory T Cells: Their Development, Stability, and Applications","volume":"37","author":"Kanamori","year":"2016","journal-title":"Trends Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jaut.2017.07.002","article-title":"Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications","volume":"83","author":"Nakatsukasa","year":"2017","journal-title":"J. Autoimmun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41574-019-0312-5","article-title":"New aspects of vitamin D metabolism and action - addressing the skin as source and target","volume":"16","author":"Bikle","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1096\/fj.13-242040","article-title":"ROR\u03b1 and ROR \u03b3 are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D","volume":"28","author":"Slominski","year":"2014","journal-title":"FASEB J."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Slominski, A.T., Kim, T.K., Janjetovic, Z., Bro\u017cyna, A.A., \u017bmijewski, M.A., Xu, H., Sutter, T.R., Tuckey, R.C., Jetten, A.M., and Crossman, D.K. (2018). Differential and Overlapping Effects of 20,23(OH)2D3 and 1,25(OH)2D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)2D3. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103072"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/imm.12747","article-title":"Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells","volume":"152","author":"Shiokawa","year":"2017","journal-title":"Immunology"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yamazaki, S., Maruyama, A., Okada, K., Matsumoto, M., Morita, A., and Seya, T. (2012). Dendritic cells from oral cavity induce Foxp3(+) regulatory T cells upon antigen stimulation. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051665"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4049\/jimmunol.1701056","article-title":"Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin","volume":"200","author":"Yamazaki","year":"2018","journal-title":"J. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature14452","article-title":"TH17 cells transdifferentiate into regulatory T cells during resolution of inflammation","volume":"523","author":"Gagliani","year":"2015","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000238305","article-title":"Circulating CD4+CD25brightFOXP3+ T cells are up-regulated by biological therapies and correlate with the clinical response in psoriasis patients","volume":"219","author":"Quaglino","year":"2009","journal-title":"Dermatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jdermsci.2008.09.011","article-title":"Bath-PUVA therapy induces circulating regulatory T cells in patients with psoriasis","volume":"53","author":"Saito","year":"2009","journal-title":"J. Derm. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1038\/jid.2011.139","article-title":"Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin","volume":"131","author":"Bovenschen","year":"2011","journal-title":"J. Invest. Derm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrmicro.2016.17","article-title":"The microbial pharmacists within us: A metagenomic view of xenobiotic metabolism","volume":"14","author":"Spanogiannopoulos","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3389\/fmicb.2017.01936","article-title":"Role of Gut Microbiota on Cardio-Metabolic Parameters and Immunity in Coronary Artery Disease Patients with and without Type-2 Diabetes Mellitus","volume":"8","author":"Elena","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Larsen, N., Vogensen, F.K., van den Berg, F.W., Nielsen, D.S., Andreasen, A.S., Pedersen, B.K., Al-Soud, W.A., S\u00f8rensen, S.J., Hansen, L.H., and Jakobsen, M. (2010). Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009085"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3796359","DOI":"10.1155\/2017\/3796359","article-title":"Association Study of Gut Flora in Coronary Heart Disease through High-Throughput Sequencing","volume":"2017","author":"Cui","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00380-016-0841-y","article-title":"Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: Gut microbiota could be a diagnostic marker of coronary artery disease","volume":"32","author":"Emoto","year":"2017","journal-title":"Heart Vessel."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.coph.2013.09.008","article-title":"Gut microbiota, enteroendocrine functions and metabolism","volume":"13","author":"Cani","year":"2013","journal-title":"Curr. Opin. Pharm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3389\/fimmu.2015.00639","article-title":"The Treg\/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome","volume":"6","author":"Omenetti","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbrc.2018.11.021","article-title":"IFN-\u03b3, IL-17A, or zonulin rapidly increase the permeability of the blood-brain and small intestinal epithelial barriers: Relevance for neuro-inflammatory diseases","volume":"507","author":"Rahman","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fphys.2019.00428","article-title":"The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release","volume":"10","author":"Martin","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/jamadermatol.2014.5585","article-title":"Identification of Bacterial DNA in the Peripheral Blood of Patients With Active Psoriasis","volume":"151","author":"Such","year":"2015","journal-title":"Jama Derm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1038\/s41598-018-22125-y","article-title":"Gut microbial composition in patients with psoriasis","volume":"8","author":"Climent","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/bjd.17931","article-title":"Gut microbiota dysbiosis in a cohort of patients with psoriasis","volume":"181","author":"Delgado","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/art.38892","article-title":"Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease","volume":"67","author":"Scher","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"10166","DOI":"10.1038\/ncomms10166","article-title":"Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction","volume":"6","author":"Jiang","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/ncomms3384","article-title":"Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity","volume":"4","author":"Li","year":"2013","journal-title":"Nat Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.2337\/db14-1213","article-title":"Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPAR\u03b3-Dependent Switch From Lipogenesis to Fat Oxidation","volume":"64","author":"Bleeker","year":"2015","journal-title":"Diabetes"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3389\/fmicb.2018.01459","article-title":"The Gut Microbiome as a Major Regulator of the Gut-Skin Axis","volume":"9","author":"Salem","year":"2018","journal-title":"Front. Microbiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/7\/2582\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:16:32Z","timestamp":1760174192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/21\/7\/2582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":54,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["ijms21072582"],"URL":"https:\/\/doi.org\/10.3390\/ijms21072582","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,8]]}}}