{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:52:42Z","timestamp":1790023962696,"version":"4.0.1"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 2601"],"award-info":[{"award-number":["FOR 2601"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Phosphorus (P) is an essential component for all living beings. Low P diets prompt phenotypic and molecular adaptations to maintain P homeostasis and increase P utilization (PU). Knowledge of the molecular mechanisms of PU is needed to enable targeted approaches to improve PU efficiency and thus lower P excretion in animal husbandry. In a previous population study, Japanese quail were subjected to a low P diet lacking mineral P and exogenous phytase. Individual PU was determined based on total P intake and excretion. A subset of 20 extreme siblings discordant for PU was selected to retrieve gene expression patterns of ileum (n = 10 per PU group). Sequencing reads have been successfully mapped to the current Coturnix japonica reference genome with an average mapping rate of 86%. In total, 640 genes were found to be differentially abundant between the low and high PU groups (false discovery rate \u2264 0.05). Transcriptional patterns suggest a link between improved PU and mitochondrial energy metabolism, accelerated cell proliferation of enterocytes, and gut integrity. In assessing indicators of the efficient use of macro- and micronutrients, further research on turnover and proliferation rates of intestinal cells could provide an approach to improve P efficiency in poultry species.<\/jats:p>","DOI":"10.3390\/ijms21082762","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:01:39Z","timestamp":1587042099000},"page":"2762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6835-7562","authenticated-orcid":false,"given":"Michael","family":"Oster","sequence":"first","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-0434","authenticated-orcid":false,"given":"Henry","family":"Reyer","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3214-2498","authenticated-orcid":false,"given":"Nares","family":"Trakooljul","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Weber","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xi","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-6255","authenticated-orcid":false,"given":"Eduard","family":"Mur\u00e1ni","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-1057","authenticated-orcid":false,"given":"Siriluck","family":"Ponsuksili","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-7889","authenticated-orcid":false,"given":"Markus","family":"Rodehutscord","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6450-1160","authenticated-orcid":false,"given":"J\u00f6rn","family":"Bennewitz","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, University of Hohenheim, 70599 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9523-6790","authenticated-orcid":false,"given":"Klaus","family":"Wimmers","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany"},{"name":"Faculty of Agricultural and Environmental Sciences, University Rostock, 18059 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1152\/physiol.00034.2008","article-title":"Novel mechanisms in the regulation of phosphorus homeostasis","volume":"24","author":"Berndt","year":"2009","journal-title":"Physiology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Just, F., Oster, M., B\u00fcsing, K., Borgelt, L., Mur\u00e1ni, E., Ponsuksili, S., Wolf, P., and Wimmers, K. 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