{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:13:29Z","timestamp":1792548809620,"version":"4.5.0"},"reference-count":207,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM007133"],"award-info":[{"award-number":["GM007133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS102698"],"award-info":[{"award-number":["NS102698"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Drosophila melanogaster provides a powerful genetic model system in which to investigate the molecular mechanisms underlying neurodegenerative diseases. In this review, we discuss recent progress in Drosophila modeling Alzheimer\u2019s Disease, Parkinson\u2019s Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington\u2019s Disease, Ataxia Telangiectasia, and neurodegeneration related to mitochondrial dysfunction or traumatic brain injury. We close by discussing recent progress using Drosophila models of neural regeneration and how these are likely to provide critical insights into future treatments for neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/ijms21093055","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T05:05:32Z","timestamp":1588050332000},"page":"3055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Modeling Neurodegenerative Disorders in Drosophila melanogaster"],"prefix":"10.3390","volume":"21","author":[{"given":"Harris","family":"Bolus","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassi","family":"Crocker","sequence":"additional","affiliation":[{"name":"Genetics Graduate Training Program, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison, WI 53705, USA"},{"name":"Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Boekhoff-Falk","sequence":"additional","affiliation":[{"name":"Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin\u2013Madison, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-028X","authenticated-orcid":false,"given":"Stanislava","family":"Chtarbanova","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuron.2011.09.021","article-title":"Genetic manipulation of genes and cells in the nervous system of the fruit fly","volume":"72","author":"Simpson","year":"2011","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mohr, S.E., and Perrimon, N. 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