{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:56:09Z","timestamp":1791996969868,"version":"4.4.0"},"reference-count":243,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["3383, 4004, 5952, 9533"],"award-info":[{"award-number":["3383, 4004, 5952, 9533"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in the interaction of the ER with other organelles. Calcium is accumulated in the ER by sarco\/endoplasmic reticulum calcium ATPases (SERCA enzymes) that generate by active, ATP-dependent transport, a several thousand-fold calcium ion concentration gradient between the cytosol (low nanomolar) and the ER lumen (high micromolar). SERCA enzymes are coded by three genes that by alternative splicing give rise to several isoforms, which can display isoform-specific calcium transport characteristics. SERCA expression levels and isoenzyme composition vary according to cell type, and this constitutes a mechanism whereby ER calcium homeostasis is adapted to the signaling and metabolic needs of the cell, depending on its phenotype, its state of activation and differentiation. As reviewed here, in several normal epithelial cell types including bronchial, mammary, gastric, colonic and choroid plexus epithelium, as well as in mature cells of hematopoietic origin such as pumps are simultaneously expressed, whereas in corresponding tumors and leukemias SERCA3 expression is selectively down-regulated. SERCA3 expression is restored during the pharmacologically induced differentiation of various cancer and leukemia cell types. SERCA3 is a useful marker for the study of cell differentiation, and the loss of SERCA3 expression constitutes a previously unrecognized example of the remodeling of calcium homeostasis in tumors.<\/jats:p>","DOI":"10.3390\/ijms21093351","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T10:01:18Z","timestamp":1589191278000},"page":"3351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Endoplasmic Reticulum Calcium Pumps and Tumor Cell Differentiation"],"prefix":"10.3390","volume":"21","author":[{"given":"Bela","family":"Papp","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, UMR U976, Institut Saint-Louis, 75010 Paris, France"},{"name":"Institut de Recherche Saint-Louis, H\u00f4pital Saint-Louis, Universit\u00e9 de Paris, 75010 Paris, France"},{"name":"CEA, DRF-Institut Francois Jacob, Department of Hemato-Immunology Research, H\u00f4pital Saint-Louis, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Launay","sequence":"additional","affiliation":[{"name":"EA481, UFR Sant\u00e9, Universit\u00e9 de Bourgogne Franche-Comt\u00e9, 25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-8987","authenticated-orcid":false,"given":"Pascal","family":"G\u00e9l\u00e9bart","sequence":"additional","affiliation":[{"name":"Department of Clinical Science-Hematology Section, Haukeland University Hospital, University of Bergen, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atousa","family":"Arbabian","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Innovation Vaccins, Institut Pasteur de Paris, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-9376","authenticated-orcid":false,"given":"Agnes","family":"Enyedi","sequence":"additional","affiliation":[{"name":"Second Department of Pathology, Semmelweis University, 1091 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0101","authenticated-orcid":false,"given":"Jean-Philippe","family":"Brouland","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo D.","family":"Carosella","sequence":"additional","affiliation":[{"name":"CEA, DRF-Institut Francois Jacob, Department of Hemato-Immunology Research, H\u00f4pital Saint-Louis, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homa","family":"Adle-Biassette","sequence":"additional","affiliation":[{"name":"AP-HP, Service d\u2019Anatomie et Cytologie Pathologiques, H\u00f4pital Lariboisi\u00e8re, 75010 Paris, France"},{"name":"Universit\u00e9 de Paris, NeuroDiderot, Inserm UMR 1141, 75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: Dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. 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