{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:19:07Z","timestamp":1790666347562,"version":"4.1.0"},"reference-count":129,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Small intestinal bacterial overgrowth (SIBO) is a condition hallmarked by an increase in the concentration of colonic-type bacteria in the small bowel. Watery diarrhea, bloating, abdominal pain and distension are the most common clinical manifestations. Additionally, malnutrition and vitamin (B12, D, A, and E) as well as minerals (iron and calcium) deficiency may be present. SIBO may mask or worsen the history of some diseases (celiac disease, irritable bowel disease), may be more common in some extra-intestinal disorders (scleroderma, obesity), or could even represent a pathogenetic link with some diseases, in which a perturbation of intestinal microbiota may be involved. On these bases, we performed a review to explore the multiple links between SIBO and digestive and extra-intestinal diseases.<\/jats:p>","DOI":"10.3390\/ijms21103531","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T02:43:42Z","timestamp":1589769822000},"page":"3531","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["The Influence of Small Intestinal Bacterial Overgrowth in Digestive and Extra-Intestinal Disorders"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-3287","authenticated-orcid":false,"given":"Giuseppe","family":"Losurdo","sequence":"first","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"},{"name":"PhD Course in Organs and Tissues Transplantation and Cellular Therapies, Department of Emergency and Organ Transplantation, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio Salvatore","family":"D\u2019Abramo","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Indellicati","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lillo","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7275-5080","authenticated-orcid":false,"given":"Enzo","family":"Ierardi","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Di Leo","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Emergency and Organ Transplantation, University \u201cAldo Moro\u201d of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.3748\/wjg.v16.i24.2978","article-title":"Small intestinal bacterial overgrowth syndrome","volume":"16","author":"Bures","year":"2010","journal-title":"World J. 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